Abstract:
:Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-like macrophages in jejunum of diabetic rats. The rats were randomly distributed into six groups: normoglycemic control (N), diabetic control (D) and either normoglycemic or diabetic groups treated with quercetin-loaded microcapsules at a dose of 10 mg kg-1 (NQ10 and DQ10, respectively) or 100 mg kg-1 (NQ100 and DQ100, respectively). After 60 days, the jejunum was collected. Whole mounts were immunostained for Ano1, nNOS and CD206, and oxidative stress levels and total antioxidant capacity of the jejunum were measured. Diabetes led to a loss of ICC and nitrergic neurons, but increased numbers of M2-like macrophages and elevated levels of oxidative stress were seen in diabetic animals. High-dose administration of quercetin (100 mg kg-1) further aggravated the diabetic condition (DQ100) but this treatment resulted in harmful effects on healthy rats (NQ100), pointing to a pro-oxidant activity. However, low-dose administration of quercetin (10 mg kg-1) gave rise to antioxidant and protective effects on ICC, nNOS, macrophages and oxidative/antioxidant status in DQ100, but NQ100 displayed infrequent negative outcomes in normoglycemic animals. Microencapsulation of the quercetin may become promising alternatives to reduce diabetes-induced oxidative stress but antioxidant therapies should be careful used under healthy status to avoid toxic effects.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Vieira-Frez FC,Sehaber-Sierakowski CC,Perles JVCM,Bossolani GDP,Verri WA Jr,Nascimento RCD,Guarnier FA,Bordini HP,Blegniski FP,Martins HA,de Souza SRG,Lima FGDM,Lima MM,Silva BT,Iwanaga CC,Zanoni JNdoi
10.1016/j.neuro.2020.01.011subject
Has Abstractpub_date
2020-03-01 00:00:00pages
193-204eissn
0161-813Xissn
1872-9711pii
S0161-813X(20)30019-Xjournal_volume
77pub_type
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