Abstract：
:Neurotoxicology is entering a new phase in how it views and practices risk assessment. Perhaps more than any of the other disciplines that comprise the science of toxicology, it has been compelled to consider a daunting array of factors other than those directly coupled to chemical and dose, and the age and sex of the subject population. In epidemiological investigations, researchers are increasingly cognizant of the problems introduced by allegedly controlling for variables classified as confounders or covariates. In essence, they reason, the consequence is blurring or even concealing interactions of exposure with modifiers such as the individual's social ecology. Other researchers question the traditional practice of relying on values such as NOAELs when they are abstracted from a biological entity that in reality represents a multiplicity of intertwined systems. Although neurotoxicologists have come to recognize the complexities of assessing risk in all its dimensions, they still face the challenge of communicating this view to the health professions at large.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Weiss B,Cory-Slechta D,Gilbert SG,Mergler D,Miller E,Miller C,Newland MC,Rice D,Schettler Tdoi
10.1016/j.neuro.2008.04.004subject
Has Abstractpub_date
2008-09-01 00:00:00pages
883-90issue
5eissn
0161-813Xissn
1872-9711pii
S0161-813X(08)00053-3journal_volume
29pub_type
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