Abstract：
:Identification of critical receptors in seizure controlling brain regions may facilitate the development of more efficacious pharmacological therapies against nerve agent intoxication. In the present study, a number of drugs with anticonvulsant potency were microinfused into the perirhinal cortex (PRC) or posterior piriform cortex (PPC) in rats. The drugs used exert cholinergic antagonism (scopolamine), glutamatergic antagonism (ketamine, NBQX), both cholinergic and glutamatergic antagonism (procyclidine, caramiphen), or GABAergic agonism (muscimol). The results showed that in the PRC anticonvulsant efficacy against soman-induced seizures (subcutaneously administered) was achieved by procyclidine or NBQX, but not by ketamine, scopolamine, caramiphen, or muscimol (Experiment 1). Hence, both muscarinic and glutamatergic NMDA receptors had to be antagonized simultaneously or AMPA receptors alone, suggesting increased glutamatergic activation in the PRC before onset of seizures. In the PPC, anticonvulsant effects were assured by scopolamine or muscimol, but not by procyclidine, caramiphen, NBQX, or ketamine (Experiment 2). Thus, muscarinic and GABA(A) receptors appear to be the critical ones in the PPC. Microinfusion of soman into the PRC or PPC resulted in sustained seizure activity in the majority of the rats of both infusion categories. The rhinal structures encompassed in this study apparently have critical functions as both control and trigger sites for nerve agent-evoked seizures.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Myhrer T,Enger S,Aas Pdoi
10.1016/j.neuro.2009.10.002subject
Has Abstractpub_date
2010-01-01 00:00:00pages
147-53issue
1eissn
0161-813Xissn
1872-9711pii
S0161-813X(09)00225-3journal_volume
31pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Domoic acid is a neurotoxin produced by algae and is found in seafood during harmful algal blooms. As a glutamate agonist, domoic acid inappropriately stimulates excitatory activity in neurons. At high doses, this leads to seizures and brain lesions, but it is unclear how lower, asymptomatic exposures disrupt neuronal...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.08.004
更新日期：2016-09-01 00:00:00
abstract：:Ethanol is a widely consumed drug that acts on the central nervous system (CNS), modifying several signal transduction pathways activated by hormones and neurotransmitters. The zebrafish is an experimental model for the study of human diseases and the use of this species in biochemical and behavioral studies on alcoho...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.05.010
更新日期：2011-12-01 00:00:00
abstract：:Previous investigations have presented evidence for an increased prevalence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if there was a correlation between mercury exposure and cognitive effects in a Norwegian population of dental workers, and if so, to quantify the o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.04.012
更新日期：2009-11-01 00:00:00
abstract：:The ubiquitous functional roles of brain catecholamines have led to the notion that in vitro neurochemical changes in these systems may predict neurotoxicity. Conversely, others have argued that the appropriate use of neurochemical methods is for testing specific hypotheses that are developed based on observed phenome...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1987-04-01 00:00:00
abstract：:The chemosensory effects of propionic acid (PA) in humans have not been conclusively studied and there is no established occupational exposure limit (OEL) in Germany. In addition to sensory irritation caused by PA, it was hypothesized that the annoying odor of PA might interfere with the performance results. There wer...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuro.2009.08.009
更新日期：2009-11-01 00:00:00
abstract：:To determine changes in response to N-methyl-D-aspartate (NMDA) and kainic acid (KA) in cerebellar granule cells of offspring of lead-exposed mothers, pregnant rats received 0.25% lead acetate in their drinking water 2 days after mating. The control animals were given sodium acetate (0.125%) in their drinking water. T...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1998-02-01 00:00:00
abstract：:Questionnaires are one of the most common methodologies used in research on neurobehavioural effects in occupational and environmental health, most commonly for gathering information on demographic characteristics, psychological or neurological symptoms, mood state, or exposure to hazards. Questionnaires are self-repo...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2006.03.009
更新日期：2007-03-01 00:00:00
abstract：:Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammato...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.06.012
更新日期：2018-07-01 00:00:00
abstract：:During early pregnancy, iodine deficiency (ID) is linked to adverse effects on child motor and psychomotor function. Maternal marginal ID has become a common public health problem. It is unclear whether marginal ID influences the development of the cerebellum or its underlying mechanisms. Thus, the purpose of this stu...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.08.004
更新日期：2018-09-01 00:00:00
abstract：BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acet...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.09.011
更新日期：2019-12-01 00:00:00
abstract：:The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offspring, but little research has been done regarding paternal THC...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.01.009
更新日期：2020-05-01 00:00:00
abstract：:An injection of trimethyltin (TMT) into adult male Wistar rats produced a transient hyperirritability and aggressive behavior. When these effects of the drug subsided, the rats were still markedly impaired in performance of a spatial memory task examined in a watermaze. Activity of neurons in the hippocampus of these ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the neurobehavioral effects produced by low levels of lead in wild animals. Herein we describe the neurobehavioral effects of lead on learning using herring gulls (Larus arge...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.01.005
更新日期：2005-08-01 00:00:00
abstract：:The development of comprehensive quantitative models as alternatives to risk assessment based on uncertainty factors will require many steps, among them consideration of the relationships between the health endpoints which are measured in laboratory animals and humans. Sensory evoked potentials are measures of sensory...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:Electron microscopy has been used to characterize the products of the reactions of aluminum with DNA under three different conditions, one of which, pH 5 and Al (III)/DNA(P) ratio of 0.4, has been previously shown to produce reversible interstrand crosslinking in double-stranded DNA molecules. Under this condition, al...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1989-07-01 00:00:00
abstract：BACKGROUND:In children treated for hematological malignancies, a transient elevation of the neurodegenerative marker Tau was found in the cerebrospinal fluid (CSF). In the first part of this study, CSF-Tau, CSF-Phospho-Tau, and CSF-Neuromodulin (CSF-NM) were measured in a heterogeneous group of patients presenting in t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2003.12.001
更新日期：2004-03-01 00:00:00
abstract：:Amyloid-beta, (Abeta) is a cytotoxic peptide implicated in the pathology of Alzheimers disease. The antioxidant enzyme catalase has been suggested to protect against Abeta cytotoxicity in both neuronal and non-neuronal cell types. Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(01)00064-x
更新日期：2001-12-01 00:00:00
abstract：:As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child IQ were collected by trained psychologists. The Wechsler Pre-school and Primary Scale of Intelligence - Revised UK edition (WPPSI) was used at age 4 years in a subsample of children enrolled in ALSPAC (the Children in Focus coho...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.07.025
更新日期：2017-09-01 00:00:00
abstract：:The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiol...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：:It has been suggested that exposure to pesticides might be involved in the etiology of Parkinson's disease (PD). We conducted an updated systematic review of the epidemiologic literature over the past decade on the relationship between pesticide exposure and PD, using the MEDLINE database. Despite methodological diffe...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2012.05.011
更新日期：2012-10-01 00:00:00
abstract：:Neural cell cultures were used to investigate the effects of acute and chronic ethanol exposure on electric membrane properties (EMP) of adult mouse dorsal root ganglion (DRG) neurons. These results in combination with results from additional experiments involving chronic exposure to hyposomotic medium provided furthe...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Neuron-specific in vitro screening strategies have the potential to accelerate the evaluation of chemicals for neurotoxicity. We examined neurite outgrowth as a measure of neuronal response with a commercially available rat cortex progenitor cell model, where cells were exposed to a chemical during a period of cell di...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.06.010
更新日期：2012-10-01 00:00:00
abstract：:Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse di...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.06.005
更新日期：2013-09-01 00:00:00
abstract：:Drinking water manganese (WMn) is a potential threat to children's health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their academic achievement lit...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.12.002
更新日期：2012-01-01 00:00:00
abstract：:The subchronic neurotoxic effects of isobutanol were studied by exposing Sprague-Dawley rats to isobutanol vapor concentrations of 0, 250, 1000, and 2500 ppm for 6 hrs/day, 5 days/wk, for 3 months. A comprehensive set of neurotoxicity tests (functional observational battery, motor activity, perfusion fixation neuropat...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-12-01 00:00:00
abstract：:In a previous in vitro study, we demonstrated the protective effects of a new drug, 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride (KHG26377), against glutamate-induced excitotoxicity in cultured glial cells. In this study, we explored the possible mechanisms underlying the neuroprotective and anti-inflammat...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.07.001
更新日期：2013-09-01 00:00:00
abstract：:Application of the widely used immunosuppressant (ISS) cyclosporine (CsA) is severely limited by a number of serious side-effects such as kidney and neurotoxicity. As we have shown before, CsA exhibits metabolic toxicity in brain-models. The macrolide ISSs sirolimus (SRL) and everolimus (RAD) are capable of modulating...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2010.10.006
更新日期：2011-01-01 00:00:00
abstract：AIMS:The aim of the present study was to evaluate the toxicity of magnetic iron oxide nanoparticles (MIONs) which were synthesized using carob leaf extract on various brain areas of Wistar rats. MAIN METHODS:Carob leaf synthesized-MIONs were characterized using different techniques: Dynamic Light Scattering (DLS), Tra...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.12.014
更新日期：2020-03-01 00:00:00
