Abstract：
:The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous activity, and a decrease in light evoked activity. In many experiments, light evoked responses were completely abolished. The changes in spontaneous activity were reversible over a period of about 5 hours following DFP injection. These results establish the retino-tectal pathway as a major target of DFP toxicity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Cheney PD,Kasser RJ,Holsapple Jsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
593-605issue
4eissn
0161-813Xissn
1872-9711journal_volume
8pub_type
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