Abstract：
:Studies on the toxicokinetics and biochemical effects of acrylamide are reviewed in regard to their implications concerning the mechanism of acrylamide induced neuropathy. Specifically, investigations of the effects of acrylamide on several glycolytic enzymes including neuron-specific enolase and glyceraldehyde-3-phosphate dehydrogenase are evaluated. Both of these enzymes are decreased in activity in animals exhibiting clinical signs of neuropathy induced by acrylamide. The significance of these findings in terms of the mechanism of action of acrylamide is discussed.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Howland RDsubject
Has Abstractpub_date
1985-01-01 00:00:00pages
7-15issue
4eissn
0161-813Xissn
1872-9711journal_volume
6pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:In order to shorten the list of candidate drugs with anticonvulsant potential against nerve agents, critical subreceptors in seizure controlling brain regions should be specified. Epileptiform activity does not spread randomly throughout the brain, but appears to be generated and propagated by specific anatomical rout...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2010.07.002
更新日期：2010-12-01 00:00:00
abstract：:The purpose of this study was to determine whether the regional brain biogenic amine levels in adult rats were altered by pre- and post-natal exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). Pregnant rats were daily orally exposed to 70 mg/kg per day of 2,4-D from gestation day (GD) 16 to post-partum day (PPD) 23. ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(02)00156-0
更新日期：2003-01-01 00:00:00
abstract：:The early effects of 6-OHDA as a Parkinsonian model in rodents are relevant since pharmacological and toxicological points of view, as they can explain the acute and chronic deleterious events occurring in the striatum. In this study, we focused our attention on the neurochemical and motor dysfunction produced after a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2010.07.003
更新日期：2010-12-01 00:00:00
abstract：:Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological studies indicate cognitive decline and neurobehavioral alterations in children associated with lower dose environmental Pb ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2014.03.008
更新日期：2014-07-01 00:00:00
abstract：:Nerve agents are deadly threats to military and civilian populations around the world. Nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. Excessive acetylcholine accumulation in synapses results in status e...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.07.001
更新日期：2012-10-01 00:00:00
abstract：:Phosphoinositide (PtdIns) metabolism activated by cholinergic muscarinic receptors appears to play a role in brain development and has been recently suggested as a possible biochemical target for the developmental neurotoxicity of ethanol (EtOH). Recent experimental evidence indicates that, in rat brain, muscarinic re...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:The ability of a supralethal dose of chlorpyrifos to produce delayed neuropathy was examined using assessments of clinical signs, electromyography (EMG), motor nerve conduction velocity (MNCV), lymphocyte neuropathy target esterase activity (LNTE), and histologic changes in nervous system tissues. Cats were exposed to...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Indiscriminate overuse or occupational exposure to agricultural chemicals can lead to neurotoxicity. Many pesticides act to impair mitochondrial function which can lead to exacerbation of neurodegeneration. Triazole fungicides are applied to grain, fruit, and vegetable crops to combat mold and fungi and their use is i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.06.009
更新日期：2020-09-01 00:00:00
abstract：:We have recently observed that DDT and a DDT metabolite, DDOH, conjugated to a fatty acid, palmitic acid, DDOH-PA, affects muscarinic cholinergic receptors (MAChR) in the neonatal mouse brain when given to suckling mice during rapid brain growth. This early exposure of the neonatal mouse also affects the behaviour of ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：:Gadolinium is a rare-earth lanthanide metal ion and is used as organic gadolinium complexes in magnetic resonance imaging (MRI). Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.10.003
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the str...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.08.004
更新日期：2018-01-01 00:00:00
abstract：:Aluminum is the most abundant metal and the third most common element in the earth's crust. It's toxicity has emerged as one of the most serious complications in the treatment of chronic renal failure. Aluminum lactate [Al(lac)3], at concentrations less than those affecting cell viability (< 5 mM) decreased the capabi...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:The development of new antiepileptic drugs is a high-risk/high-cost research field, which is made even riskier if the behavioral epileptic seizure profile is the unique approach on which the development is based. In order to increase the effectiveness of the screening conducted in the zebrafish model of status epilept...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.04.007
更新日期：2018-07-01 00:00:00
abstract：:Since its discovery over thirty years ago, the role played by Nerve Growth Factor (NGF) in the development and maintenance of sympathetic and sensory neurons of the peripheral nervous system has been well established and extensively studied. In addition, the existing data suggest that NGF may offer neuroprotection to ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1996-10-01 00:00:00
abstract：:This evaluative review covers the neurotoxic effects of toluene. General health effects of toluene are also discussed in more limited detail. A brief description of chemical properties and environmental prevalence is given, followed by a review of pharmacokinetic data. General health effects include lethality, growth,...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1981-11-01 00:00:00
abstract：:Perfluoroalkyl and polyfluoroalkyl substances are used in commercial applications and developmental exposure has been implicated in alterations in neurobehavioral functioning. While associations between developmental perfluorooctanoic acid (PFOA) exposure and human outcomes have been inconsistent, studies in experimen...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.11.008
更新日期：2017-01-01 00:00:00
abstract：:Long term or chronic exposure to lead is associated with cognitive and other deficits in humans, which may reflect lead-induced changes in synaptic development and function. We believe that Drosophila has great potential as a model system for studying such changes. To test this, we compared the structure of single, id...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(02)00095-5
更新日期：2003-01-01 00:00:00
abstract：:Neurite loss is an early event in neurodegenerative diseases; therefore, the regeneration of the network of neurites constitutes an interesting strategy of treatment for such disorders. Neurotrophic factors play a critical role in neuronal regeneration, but their clinical use is limited by their inability to cross the...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.09.007
更新日期：2014-12-01 00:00:00
abstract：:Several striatal toxins can be used to induce motor disruption. One example is MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), whose toxicity is accepted as a murine model of parkinsonism. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mi...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.06.004
更新日期：2017-09-01 00:00:00
abstract：:Many uncertainties remain today concerning effects of lead on the nervous system, particularly in regard to levels of lead exposure causing minimal brain dysfunction in children. Past studies in children have failed to define adequately the nature of the effect, the critical period and duration of exposure and the rol...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1984-10-01 00:00:00
abstract：:Neurotoxicology is entering a new phase in how it views and practices risk assessment. Perhaps more than any of the other disciplines that comprise the science of toxicology, it has been compelled to consider a daunting array of factors other than those directly coupled to chemical and dose, and the age and sex of the...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2008.04.004
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.09.004
更新日期：2015-12-01 00:00:00
abstract：:Prior studies demonstrate a critical role for mesolimbic dopamine systems, particularly nucleus accumbens, in the mediation of fixed interval (FI) schedule-controlled behavior and an enhancement of nucleus accumbens dopamine activity as a mechanism of chronic postweaning lead (Pb)-induced increases in Fl response rate...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(02)00059-1
更新日期：2002-09-01 00:00:00
abstract：:Treatment of metastatic tumors with ionic platinum compounds is hampered by the potent nephrotoxic, ototoxic and neurotoxic properties of these drugs. Recent studies have shown that sulfur-containing antioxidants relieve the dose limiting side effects of cis-diamminedichloroplatinum (CDDP), the most commonly used ioni...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-10-01 00:00:00
abstract：:The increasing use of illegal drugs by pregnant women causes a public health concern because it is associated with health risks for mothers and their developing children. One of such drugs is MDMA (3,4-methylenedioxymethamphetamine) or ecstasy due to its high consumption in relevant age and sex groups and its adverse ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.12.007
更新日期：2020-05-01 00:00:00
abstract：:Bortezomib is a proteasome inhibitor with a remarkable antitumor activity, used in the clinic as first line treatment for multiple myeloma. One hallmark of bortezomib mechanism of action in neoplastic cells is the inhibition of nuclear factor kappa B (NFκB), a transcription factor involved in cell survival and prolife...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.05.004
更新日期：2016-07-01 00:00:00
abstract：:Volatile organic solvents are frequently present in industrial atmospheres. Their lipophilic properties mean they quickly reach the brain following inhalation. Acute exposure to some solvents perturbs the middle ear reflex, which could jeopardize cochlear protection against loud noises. As the physiological mechanisms...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.05.007
更新日期：2019-09-01 00:00:00
abstract：:We have studied the effects of aliphatic, alicyclic, and aromatic C6-10 solvents on the formation of reactive oxygen species (ROS) in rat cerebellar granule cell cultures. ROS formation was assessed by monitoring oxidation of 2',7'-dichlorofluorescin (DCFH) to the fluorescent compound 2',7'-dichlorofluorescein (DCF). ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/S0161-813X(02)00010-4
更新日期：2002-12-01 00:00:00
abstract：:The developing neuroendocrine system is thought to be a sensitive target for a number of environmental chemicals. Many of these chemicals act, not by directly damaging macromolecules but through the inappropriate modulation of normal cellular processes that regulate cell growth and differentiation patterns. As our kno...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
