Asymmetrical development of the monoamine systems in 2,4-dichlorophenoxyacetic acid treated rats.

abstract：:Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...

journal_title：Neurotoxicology

authors： Lemire M,Fillion M,Frenette B,Passos CJ,Guimarães JR,Barbosa F Jr,Mergler D

更新日期：2011-12-01 00:00:00

abstract：:Galantamine, a drug currently approved for the treatment of Alzheimer's disease, has recently emerged as an effective pretreatment against the acute toxicity and delayed cognitive deficits induced by organophosphorus (OP) nerve agents, including soman. Since cognitive deficits can result from impaired glutamatergic tr...

journal_title：Neurotoxicology

authors： Alexandrova EA,Alkondon M,Aracava Y,Pereira EF,Albuquerque EX

更新日期：2014-09-01 00:00:00

abstract：:Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and ...

journal_title：Neurotoxicology

authors： Mezzaroba L,Alfieri DF,Colado Simão AN,Vissoci Reiche EM

更新日期：2019-09-01 00:00:00

abstract：:Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease is also characterized by an increase in oxidative stress and a loss of glutathione in the midbrain region. A potential link between all these factors is the ox...

journal_title：Neurotoxicology

authors： Linsenbardt AJ,Wilken GH,Westfall TC,Macarthur H

更新日期：2009-11-01 00:00:00

abstract：:Although toxins exert their impact on a molecular level, they may yield molar effects by affecting areas large enough to be visualized by neuroimaging techniques. Therefore, neuroimaging of the brain may be used to render the macroscopic sequelae of neurotoxins visible. Toxic agents may induce brain edema or atrophy, ...

journal_title：Neurotoxicology

authors： Lang CJ

更新日期：2000-10-01 00:00:00

abstract：:Paclitaxel, which is known to induce peripheral neuropathy in humans, was administered to BDF1 mice, and a neuropathological examination was then conducted. Paclitaxel was administered at a dose of 30 mg/kg once or several times at different intervals, 3 times, every 3 hours (q3hx3), every day (q1dx3), every 2 days (q...

journal_title：Neurotoxicology

authors： Mimura Y,Kato H,Eguchi K,Ogawa T

更新日期：2000-08-01 00:00:00

abstract：:Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG). This occurs at 1.0mg/kg...

journal_title：Neurotoxicology

authors： Carr RL,Armstrong NH,Buchanan AT,Eells JB,Mohammed AN,Ross MK,Nail CA

更新日期：2017-03-01 00:00:00

abstract：:The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...

journal_title：Neurotoxicology

authors： Wejksza K,Rzeski W,Turski WA,Hilgier W,Dybel A,Albrecht J

更新日期：2006-07-01 00:00:00

abstract：:Domoic acid is a neurotoxin produced by algae and is found in seafood during harmful algal blooms. As a glutamate agonist, domoic acid inappropriately stimulates excitatory activity in neurons. At high doses, this leads to seizures and brain lesions, but it is unclear how lower, asymptomatic exposures disrupt neuronal...

journal_title：Neurotoxicology

authors： Hiolski EM,Ito S,Beggs JM,Lefebvre KA,Litke AM,Smith DR

更新日期：2016-09-01 00:00:00

abstract：:Environmental chemicals have a potential impact on children's health as the developing brain is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that very complex processes of cell development and maturation take place within a t...

journal_title：Neurotoxicology

authors： Bal-Price AK,Hogberg HT,Buzanska L,Lenas P,van Vliet E,Hartung T

更新日期：2010-09-01 00:00:00

abstract：:A review of previous evidence suggests an association between early Pb exposure and hippocampal dysfunction. This report summarizes recent experiments conducted in both our laboratory and others' examining the effects of early Pb exposure on hippocampal morphological development, and behaviors characteristic of hippoc...

journal_title：Neurotoxicology

authors： Petit TL,Alfano DP,LeBoutillier JC

更新日期：1983-04-01 00:00:00

abstract：:Treatment of metastatic tumors with ionic platinum compounds is hampered by the potent nephrotoxic, ototoxic and neurotoxic properties of these drugs. Recent studies have shown that sulfur-containing antioxidants relieve the dose limiting side effects of cis-diamminedichloroplatinum (CDDP), the most commonly used ioni...

journal_title：Neurotoxicology

authors： Reser D,Rho M,Dewan D,Herbst L,Li G,Stupak H,Zur K,Romaine J,Frenz D,Goldbloom L,Kopke R,Arezzo J,Van De Water T

更新日期：1999-10-01 00:00:00

abstract：:It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to eva...

journal_title：Neurotoxicology

authors： Foster ML,Bartnikas TB,Maresca-Fichter HC,Mercadante C,Dash M,Miller C,Dorman DC

更新日期：2018-01-01 00:00:00

abstract：:Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in th...

journal_title：Neurotoxicology

authors： Amaraneni M,Pang J,Mortuza TB,Muralidhara S,Cummings BS,White CA,Vorhees CV,Zastre J,Bruckner JV

更新日期：2017-09-01 00:00:00

abstract：:Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to behavioral differences in children and shown to impact critical neurodevelopmental processes in animal models. Though data is emerging, we still have an incomplete picture of how BPA disrupts neurodevelopment; in particular, how its impac...

journal_title：Neurotoxicology

authors： Nguyen U,Tinsley B,Sen Y,Stein J,Palacios Y,Ceballos A,Welch C,Nzenkue K,Penn A,Murphy L,Leodones K,Casiquin J,Ivory I,Ghenta K,Danziger K,Widman E,Newman J,Triplehorn M,Hindi Z,Mulligan K

更新日期：2021-01-01 00:00:00

abstract：:Increasingly, the etiology of Parkinson's disease (PD) has been linked to exposures to environmental toxicants. This epidemiologic pilot study used a self-administered questionnaire among 34 PD cases and 22 other neurology clinic control patients. All subjects were at least 40 years old. Risk factors investigated incl...

journal_title：Neurotoxicology

authors： Wechsler LS,Checkoway H,Franklin GM,Costa LG

更新日期：1991-10-01 00:00:00

abstract：:Tetracycline (TC) was administered indirectly to rat pups through maternal milk, giving mothers diluted TC solutions as a single source of drinking water, during 13-16 days of postnatal age (PND) in Experiment 1. In Experiment 2, using rats of a different strain, TC dose and its application period were reduced from 0....

journal_title：Neurotoxicology

authors： Seo ML,Yamatodani A,Mizutani A,Kiyono S

更新日期：1993-04-01 00:00:00

abstract：:In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB) endothelial function. Immortalized human brain microvascular endothelial cell line (hCMEC/D3) was exposed to azidothymidine (AZT; a nucleoside reverse transcrip...

journal_title：Neurotoxicology

authors： Prasad S,Sajja RK,Kaisar MA,Cucullo L

更新日期：2016-09-01 00:00:00

abstract：:Long-term exposure to high manganese (Mn) levels can lead to Parkinson-like neurological disorders. Molecular mechanisms underlying Mn cytotoxicity have been not defined. It is known that Mn induces apoptosis in PC12 cells and that this involves the activation of some signal transduction pathways. Although the role of...

journal_title：Neurotoxicology

authors： Ferrara G,Gambelunghe A,Mozzi R,Marchetti MC,Migliorati G,Muzi G,Buratta S

更新日期：2013-12-01 00:00:00

abstract：:Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the neurobehavioral effects produced by low levels of lead in wild animals. Herein we describe the neurobehavioral effects of lead on learning using herring gulls (Larus arge...

journal_title：Neurotoxicology

authors： Burger J,Gochfeld M

更新日期：2005-08-01 00:00:00

abstract：:In order to shorten the list of candidate drugs with anticonvulsant potential against nerve agents, critical subreceptors in seizure controlling brain regions should be specified. Epileptiform activity does not spread randomly throughout the brain, but appears to be generated and propagated by specific anatomical rout...

journal_title：Neurotoxicology

authors： Myhrer T

更新日期：2010-12-01 00:00:00

abstract：:The effects of exposure to volatile organic compounds (VOCs), which are of concern to the EPA, are poorly understood, in part because of insufficient characterization of how human exposure duration impacts VOC effects. Two inhalation studies with multiple endpoints, one acute and one subchronic, were conducted to seek...

journal_title：Neurotoxicology

authors： Kodavanti PR,Royland JE,Moore-Smith DA,Besas J,Richards JE,Beasley TE,Evansky P,Bushnell PJ

更新日期：2015-12-01 00:00:00

abstract：:While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables. This study compared the effects of one and four days o...

journal_title：Neurotoxicology

authors： García-Cabrerizo R,García-Fuster MJ

更新日期：2015-07-01 00:00:00

abstract：:This study investigated the effect of the pre- and perinatal exposure to di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that regulate reproduction in peripubertal male rats. DEHP at dose of 3 and 30mg/kg bw/day was administered orally to female rat since pregnancy onset until weaning. The male lit...

journal_title：Neurotoxicology

authors： Carbone S,Szwarcfarb B,Ponzo O,Reynoso R,Cardoso N,Deguiz L,Moguilevsky JA,Scacchi P

更新日期：2010-12-01 00:00:00

abstract：:Exposure to soman, a toxic organophosphate nerve agent, causes severe adverse effects and long term changes in the peripheral and central nervous systems. The goal of this study was to evaluate the ability of prophylactic treatments to block the deleterious effects associated with soman poisoning. scopolamine, a class...

journal_title：Neurotoxicology

authors： Raveh L,Weissman BA,Cohen G,Alkalay D,Rabinovitz I,Sonego H,Brandeis R

更新日期：2002-05-01 00:00:00

abstract：:Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many ...

journal_title：Neurotoxicology

authors： Llorens J,Callejo A,Greguske EA,Maroto AF,Cutillas B,Martins-Lopes V

更新日期：2018-05-01 00:00:00

abstract：:Low-to-moderate level developmental and adult lead exposure produces retinal dysfunction and/or degeneration in humans and experimental animals. Although high level in vivo or in vitro lead disrupts blood-brain-barrier tight junctions and increases its permeability, the blood-retinal-barrier (BRB) has not been examine...

journal_title：Neurotoxicology

authors： Shen XF,Huang P,Fox DA,Lin Y,Zhao ZH,Wang W,Wang JY,Liu XQ,Chen JY,Luo WJ

更新日期：2016-12-01 00:00:00

abstract：:Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...

journal_title：Neurotoxicology

authors： Fox MR

更新日期：1983-10-01 00:00:00

abstract：:This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...

journal_title：Neurotoxicology

authors： Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

更新日期：2007-05-01 00:00:00

abstract：:It is still being debated whether neurogenesis in the subventricular zone (SVZ) is enhanced in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injury in the adult mouse brain. Our previous studies provided evidence that MPTP induces apoptosis of migrating neuroblasts (neural progenitor cells, A cells) ...

journal_title：Neurotoxicology

authors： He XJ,Nakayama H

更新日期：2015-09-01 00:00:00