Physiological assesment of vestibular function and toxicity in humans and animals.

Abstract:

:Physiological methods that can be similarly recorded in humans and animals have a major role in sensory toxicology, as they provide a bridge between human sensory perception data and the molecular and cellular data obtained in animal studies. Vestibular toxicity research lags well behind other sensory systems in many aspects, including the availability of methods for functional assessment in animals that could be robustly translated to human significance. Here we review the methods available for the assessment of vestibular function in both humans and laboratory animals, with an emphasis on their similarity or divergence, to highlight their potential utility for the predictive assessment of vestibular toxicity.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Llorens J,Callejo A,Greguske EA,Maroto AF,Cutillas B,Martins-Lopes V

doi

10.1016/j.neuro.2018.02.003

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

204-212

eissn

0161-813X

issn

1872-9711

pii

S0161-813X(18)30032-9

journal_volume

66

pub_type

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