Abstract:
:The in vitro and vivo effects of lead on the NMDA-receptors in adult and juvenile mice were studied by means of receptor binding assays. Adult female NMRI-mice received 100 and 1,000 ppm lead as nitrate in their drinking water for 30 and 90 days. Perinatal exposure was achieved by treating gestating mice from the 5th day post conception with 0, 100 or 1,000 ppm lead in their drinking water. Characterization of the NMDA N-methyl-D-aspartate)-receptor was carried out ex vivo using binding studies on homogenates of the forebrain with the non competitive NMDA-antagonist 3H-MK-801. In vitro, complete inhibition of the radioligand binding was found with half maximal inhibiting concentrations (IC50-values) of 19.7 +/- 2.6 microM (SEM) in absence of amino acids and 9.5 +/- 0.9 in presence of glutamate and glycine. These concentrations are in a range which could be achieved in vivo, e.g. the lead content in the forebrain of juvenile mice treated with 1,000 ppm lead was 10.0 +/- 1.8 mumol/kg wet weight. It was speculated that lead binds at the zinc binding site. In the presence of amino acids and divalent cations, such as calcium or magnesium, low lead concentrations lead to a significant increase in receptor affinity. Analysis of the saturation experiments carried out on forebrain homogenates of lead-treated animals showed a slight increase in receptor density of 13 or 15% with an unchanged Kd-value only in the adult animals treated with 100 ppm lead and in absence of stimulating amino acids.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Schulte S,Müller WE,Friedberg KDsubject
Has Abstractpub_date
1995-07-01 00:00:00pages
309-17issue
2eissn
0161-813Xissn
1872-9711journal_volume
16pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are becoming widespread environmental pollutants, as indicated by studies on sentinel animal species, as well as humans. Of particular concern are the reported increasingly high levels of PBDEs in human milk, as should be given that almos...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/S0161-813X(03)00020-2
更新日期:2003-06-01 00:00:00
abstract::Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pre...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00058-5
更新日期:2003-08-01 00:00:00
abstract::The purpose of this study was to determine whether the regional brain biogenic amine levels in adult rats were altered by pre- and post-natal exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). Pregnant rats were daily orally exposed to 70 mg/kg per day of 2,4-D from gestation day (GD) 16 to post-partum day (PPD) 23. ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00156-0
更新日期:2003-01-01 00:00:00
abstract::Mortality and morbidity by toxic metals is an important issue of occupational health. Lead is an ubiquitous heavy metal in our environment despite having no physiological role in biological systems. Being an homeostatic controller is expected that the autonomic nervous system would show a degree of impairment in lead ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.04.016
更新日期:2016-05-01 00:00:00
abstract::Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological studies indicate cognitive decline and neurobehavioral alterations in children associated with lower dose environmental Pb ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2014.03.008
更新日期:2014-07-01 00:00:00
abstract::Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2019.07.007
更新日期:2019-09-01 00:00:00
abstract::Previous investigations have presented evidence for an increased prevalence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if there was a correlation between mercury exposure and cognitive effects in a Norwegian population of dental workers, and if so, to quantify the o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.04.012
更新日期:2009-11-01 00:00:00
abstract::Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This study evaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatal exposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200mg/kg/day) from gestational day 5 to postna...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.07.002
更新日期:2014-09-01 00:00:00
abstract::Long-term exposure to high manganese (Mn) levels can lead to Parkinson-like neurological disorders. Molecular mechanisms underlying Mn cytotoxicity have been not defined. It is known that Mn induces apoptosis in PC12 cells and that this involves the activation of some signal transduction pathways. Although the role of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.07.006
更新日期:2013-12-01 00:00:00
abstract::The early effects of 6-OHDA as a Parkinsonian model in rodents are relevant since pharmacological and toxicological points of view, as they can explain the acute and chronic deleterious events occurring in the striatum. In this study, we focused our attention on the neurochemical and motor dysfunction produced after a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2010.07.003
更新日期:2010-12-01 00:00:00
abstract::We have developed an estrogen sensitive reporter gene assay and report here on its responsiveness to steroid hormones and several estrogenic contaminants, including pesticides and polychlorinated biphenyls (PCBs), GH4C1 rat pituitary cells were stably transfected with the reported gene ERE-TK-Luc which contains a luci...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Questionnaires are one of the most common methodologies used in research on neurobehavioural effects in occupational and environmental health, most commonly for gathering information on demographic characteristics, psychological or neurological symptoms, mood state, or exposure to hazards. Questionnaires are self-repo...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2006.03.009
更新日期:2007-03-01 00:00:00
abstract::Manganese is an essential trace element, but also at high levels a neurotoxicant. Manganese neurotoxicity has been extensively studied since its discovery in highly exposed workers. The International conference MANGANESE2016 held at the Icahn School of Medicine at Mount Sinai in New York provided relevant updates on m...
journal_title:Neurotoxicology
pub_type: 社论
doi:10.1016/j.neuro.2018.01.002
更新日期:2018-01-01 00:00:00
abstract::The acute biocidal effects of organophosphorus pesticides are a central feature of modern agricultural chemistry, and also define the concerns of regulatory toxicology. Less well known, but more complex and idiosyncratic, is the potential for some agents to produce a delayed and progressive polyneuropathy--Organophosp...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract::Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.04.005
更新日期:2011-12-01 00:00:00
abstract::3-iodo-l-tyrosine might play a role in Parkinson's disease since this molecule is able, at high concentration, to inhibit tyrosine-hydroxylase activity, the rate-limiting enzyme in dopamine biosynthesis. The possible Parkinson-like effects of 3-iodo-l-tyrosine were tested on three experimental approaches in mice: cult...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.06.002
更新日期:2018-07-01 00:00:00
abstract::Male and female rat pups were exposed to a single dose of triethyl tin (TET) or ethanol vehicle on day 5 postnatally and tested for responsiveness to apomorphine as adults. TET-exposed animals displayed an increased response to the stereotypic effects of 1 mg/kg of apomorphine. Female rats exposed neonatally to TET ha...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1982-07-01 00:00:00
abstract::Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.09.013
更新日期:2017-12-01 00:00:00
abstract::There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage batte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.03.006
更新日期:2011-08-01 00:00:00
abstract::Development of the mammalian central nervous system is a complex process whose disruption may have severe and long-lasting consequences upon brain structure and function, potentially resulting in a neurodevelopmental disorder (NDD). Many NDDs are known to be genetic in origin, with symptom onset and their underlying m...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2016.10.017
更新日期:2017-01-01 00:00:00
abstract::Ethanol is a widely consumed drug that acts on the central nervous system (CNS), modifying several signal transduction pathways activated by hormones and neurotransmitters. The zebrafish is an experimental model for the study of human diseases and the use of this species in biochemical and behavioral studies on alcoho...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.05.010
更新日期:2011-12-01 00:00:00
abstract::Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the levels of total lipi...
journal_title:Neurotoxicology
pub_type: 更正并重新发布的文章,杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.06.005
更新日期:2012-08-01 00:00:00
abstract::Prior studies demonstrate a critical role for mesolimbic dopamine systems, particularly nucleus accumbens, in the mediation of fixed interval (FI) schedule-controlled behavior and an enhancement of nucleus accumbens dopamine activity as a mechanism of chronic postweaning lead (Pb)-induced increases in Fl response rate...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00059-1
更新日期:2002-09-01 00:00:00
abstract::Pyridoxine, a water-soluble vitamin, produces a sensory neuronopathy when administered in high doses to dogs. Beagles who received a daily oral dose of 300 mg/kg of pyridoxol hydrochloride developed a swaying gait within 9 days. They eventually became unable to walk, but were not weak. Animals were sacrificed at inter...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::The occurrence of status epilepticus (SE) is considered the main cause of brain lesions and morphological alterations, such as hippocampal neuron loss, that result in chronic epilepsy. Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.02.010
更新日期:2012-06-01 00:00:00
abstract::The mechanism of action of acrylamide (ACR) in producing a central-peripheral distal axonopathy is unknown. We have tested the hypothesis that ACR inhibition of enzymes of oxidative metabolism is responsible for compromise of the energy supply, thereby producing the neuropathy. A single 50 mg/kg i.p. dose of ACR resul...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::New European legislation known as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) was introduced in 2007 to increase the speed at which the health and/or environmental risks of industrial chemicals were being assessed and managed (REACH (EC) No 1907/2006). REACH consolidated earlier chemic...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.010
更新日期:2020-02-10 00:00:00
abstract::Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.01.007
更新日期:2013-03-01 00:00:00