当前位置： SCI文献检索 > NEUROTOXICOLOGY期刊下所有文献 > Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders.

Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders.

Abstract：

:Development of the mammalian central nervous system is a complex process whose disruption may have severe and long-lasting consequences upon brain structure and function, potentially resulting in a neurodevelopmental disorder (NDD). Many NDDs are known to be genetic in origin, with symptom onset and their underlying mechanisms now known to be regulated during time-dependent windows or 'critical periods' during normal brain development. However, it is increasingly evident that similar disturbances to the developing nervous system may be caused by exposure to non-genetic, environmental factors. Strikingly, at least 200 industrially applied or produced chemicals have been associated with neurotoxicity in humans and exposure to these modifying compounds, through consumer products or environmental pollution, therefore poses serious threats to public health. Through a combination of human epidemiological and animal experimental studies, we identified developmental periods for increased vulnerability to environmentally-modifying compounds and determined whether and how exposure during specific sensitive time-windows could increase the risk for the NDDs of autism, ADHD or schizophrenia in the developing organism. We report that many environmental toxicants have distinct sensitive time-windows during which exposure may disrupt critical developmental events, thereby increasing the risk of developing NDDs. The majority of these time-windows occur prenatally rather than postnatally. We propose four underlying mechanisms that mediate pathogenesis, namely oxidative stress, immune system dysregulation, altered neurotransmission and thyroid hormone disruption. Given the complexity of underlying mechanisms and their prenatal inception, treatment options are currently limited. Thus, we conclude that preventing early exposure to environmental toxicants, by increasing public awareness and improving government and industry guidelines, may ultimately lead to a significant reduction in the incidence of NDDs.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Heyer DB,Meredith RM

doi

10.1016/j.neuro.2016.10.017

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

23-41

eissn

0161-813X

issn

1872-9711

pii

S0161-813X(16)30223-6

journal_volume

pub_type

杂志文章,评审

在线工具

Environmental toxicology: Sensitive periods of development and neurodevelopmental disorders.