Abstract：
:Pyridoxine, a water-soluble vitamin, produces a sensory neuronopathy when administered in high doses to dogs. Beagles who received a daily oral dose of 300 mg/kg of pyridoxol hydrochloride developed a swaying gait within 9 days. They eventually became unable to walk, but were not weak. Animals were sacrificed at intervals up to 78 days. Morphological examination revealed widespread neuronal degeneration in the dorsal root ganglia and the Gasserian ganglia. Cytoplasmic changes were first observed after 8 days and consisted of small, electronlucent vacuoles that subsequently coalesced leading to death of the cells. Degeneration of sensory nerve fibers in peripheral nerves, dorsal columns of the spinal cord and the descending spinal tract of the trigeminal nerve was apparent. The pathogenesis of these changes is unclear, but may, in part, reflect the selective permeability of blood vessels in the peripheral ganglia. It is apparent that the peripheral neuropathy previously attributed to pyridoxine actually represents a toxic, peripheral sensory neuronopathy.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Krinke G,Schaumburg HH,Spencer PS,Suter J,Thomann P,Hess Rsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
13-24issue
1eissn
0161-813Xissn
1872-9711journal_volume
2pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.01.011
更新日期：2006-07-01 00:00:00
abstract：:Both acute and chronic lead exposure have been found to inhibit transmission at chemical synapses, possibly by interfering with inward calcium current. We have found that chronic lead exposure slightly reduces input resistance and greatly reduces the junctional resistance between two strongly electrically coupled neur...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2019.07.007
更新日期：2019-09-01 00:00:00
abstract：:Nickel, a known occupational/environmental hazard, may cross the placenta and reach appreciable concentrations in various fetal organs, including the brain. The aim of this study was to investigate whether nickel interferes with the process of neuronal differentiation. Following a 4 week treatment with retinoic acid (...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.01.001
更新日期：2015-03-01 00:00:00
abstract：:Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.04.005
更新日期：2011-12-01 00:00:00
abstract：:Vanadium-containing products are manufactured and widely used in the modern industry. Yet the neurobehavioral toxicity due to occupational exposure to vanadium remained elusive. This cross-sectional study was designed to examine the neurotoxic effects of occupational vanadium exposure. A total of 463 vanadium-exposed ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.02.008
更新日期：2013-05-01 00:00:00
abstract：:Free radical-induced brain oxidative injury is thought to play a role in the etiology and pathogenesis of neurodegenerative disorders. Iron (Fe) can catalyze the Fenton reaction and mediate hydroxyl radical (HO.) generation to initiate lipid peroxidation (LP). The neurotoxin aluminum (Al) can facilitate Fe-mediated LP...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1995-10-01 00:00:00
abstract：:Sensitivity of in-life parameters, biochemical endpoints, and susceptibility of various areas of the chicken nervous system to delayed neuropathy induced by tri-orthocresyl phosphate (TOCP) was assessed. Groups of hens were exposed to a single oral dose of TOCP of 0, 50, 200 or 500 mg/kg and the animals observed for 2...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
abstract：:Throughout the world, alum (aluminum sulfate) is used in municipal water treatment plants to clarify water. Alum treatment usually removes aluminosilicate particles from drinking water but can substantially increase its soluble aluminum content (Zhang et al., 1994; Tran et al., 1993; Kopp, 1970). Soluble aluminum is t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.09.004
更新日期：2015-12-01 00:00:00
abstract：:Developmental exposure to lead (Pb) has long been associated with reductions in intellectual function in children and behavioral impairments in animal models of learning and memory. We have used long-term potentiation (LTP) in the dentate gyrus of the Pb-exposed rats to determine the potential of a reduced capacity fo...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：:The chemosensory effects of propionic acid (PA) in humans have not been conclusively studied and there is no established occupational exposure limit (OEL) in Germany. In addition to sensory irritation caused by PA, it was hypothesized that the annoying odor of PA might interfere with the performance results. There wer...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章
doi：10.1016/j.neuro.2009.08.009
更新日期：2009-11-01 00:00:00
abstract：:Methylmercury (MeHg) toxicity in humans manifests deficits in neurological function. Cases of prenatal exposure to mercury have established that the developing nervous system is most highly susceptible to perturbation by MeHg. At a cellular level, MeHg-induced defects result from altered neuronal proliferation, migrat...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.04.005
更新日期：2006-12-01 00:00:00
abstract：:Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases (GSTs) have been described in the human population in the past decade. For example, one or more PM have been identified in human CYP1A1, CYP1B1, CYP2C9, CYP2C18, CYP2D6, and CYP2E1. Recent ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-02-01 00:00:00
abstract：:Continuous globalization and industrialization have ensured metals are an increasing aspect of daily life. Their usefulness in manufacturing has made them vital to national commerce, security and global economy. However, excess exposure to metals, particularly as a result of environmental contamination or occupational...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2020.08.005
更新日期：2020-12-01 00:00:00
abstract：:Neurite loss is an early event in neurodegenerative diseases; therefore, the regeneration of the network of neurites constitutes an interesting strategy of treatment for such disorders. Neurotrophic factors play a critical role in neuronal regeneration, but their clinical use is limited by their inability to cross the...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.09.007
更新日期：2014-12-01 00:00:00
abstract：:Previous work has indicated that the neurotoxic action of environmentally relevant levels of lead (Pb) on dopaminergic neurons is primarily presynaptic in nature and related to impaired regulation of dopamine (DA) synthesis and decreased DA release. This study was conducted to assess the functional integrity of the re...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Monoamine oxidase (MAO) isoenzymes play a major role in regulating the concentration of several bioactive amines, including serotonin and catecholamines. Both in the nervous system and in peripheral organs, MAOs can potentially modulate all the processes involving these bioactive amines. In the present article, we rev...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/S0161-813X(03)00095-0
更新日期：2004-01-01 00:00:00
abstract：:For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.06.005
更新日期：2012-08-01 00:00:00
abstract：:Parkinson disease is a specific form of neurodegeneration characterized by a loss of nigra-striatal dopaminergic neurons in the midbrain of humans. The disease is also characterized by an increase in oxidative stress and a loss of glutathione in the midbrain region. A potential link between all these factors is the ox...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.07.006
更新日期：2009-11-01 00:00:00
abstract：:Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during deve...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.03.013
更新日期：2012-06-01 00:00:00
abstract：:The development of comprehensive quantitative models as alternatives to risk assessment based on uncertainty factors will require many steps, among them consideration of the relationships between the health endpoints which are measured in laboratory animals and humans. Sensory evoked potentials are measures of sensory...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:ω-Agatoxin-IVA is a well known P/Q-type Ca(2+) channel blocker and has been shown to affect presynaptic Ca(2+) currents as well postsynaptic potentials. P/Q-type voltage gated Ca(2+) channels play a vital role in presynaptic neurotransmitter release and thus play a role in action potential generation. Monitoring spont...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.03.002
更新日期：2013-07-01 00:00:00
abstract：:In aquatic ecosystems, mercury can become methylated and act as a potent environmental toxin, producing developmental and neurotoxic effects in a variety of species, including frogs. Molecular indicators provide a means of assessing exposure to methylmercury and for understanding how it and other environmental toxins ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/...
journal_title：Neurotoxicology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuro.2017.10.005
更新日期：2018-03-01 00:00:00
abstract：:The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The Faroe Islands study is a prospective study designed to assess the neurological and behavioral consequences of in utero exposure to methylmercury (meHg). Maternal exposure to meHg was through consumption of fish and intermittent higher-level exposure through pilot whale meat, while consumption of pilot whale blubbe...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:Lead (Pb(2+)) is a pollutant commonly found in the environment. It causes a wide variety of detrimental effects on developing central nervous system. However, the mechanisms of its neurotoxicity remained to be elucidated. In hippocampus, the muscarinic cholinergic system modulates certain forms of synaptic transmissio...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.11.003
更新日期：2007-05-01 00:00:00
abstract：:Diethyldithiocarbamate (DDC) has been shown to enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal dopamine depletion in mice. Surprisingly, although DDC is a prototypic member of a class of compounds called dithiocarbamates (DTCs) that are widely used in industry and agriculture, only one stu...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
