Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.


:Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the levels of total lipids, phospholipids, cholesterol and cerebrosides, and protein, but ganglioside concentration was significantly increased in various areas of the brain. Loss of body weight observed in this study could be attributed to the loss of appetite; loss of nutrients and wasting of tissues. It is likely that large amount of body water was lost through diarrhoea. Gas liquid chromatography has revealed that oleic acid, linoleic acid, linolenic acid, and arachidonic acid were preferentially lost in the brain of vanadium-exposed rats. Thin layer chromatography further proved degradation of individual lipids. Sphingomyelin was substantially decreased followed by phosphatidyl choline and phosphatidyl ethanolamine, but phosphatidyl serine and phosphatidyl inositol were slightly affected. Our recent work has demonstrated vanadium-induced stimulation of lipid peroxidation in the various regions of the rat brain. It is speculative that deterioration of myelin sheath by vanadium exposure contributed to preferential lipid loss but lesser loss of protein. These studies also indicate that vanadium-induced stimulation of lipid peroxidation is characterized by a selective loss of brain polyunsaturated fatty acids and thus comprehensive degradation of lipids in the different regions of the rat brain. However, the mechanism involved in the elevation of ganglioside levels is not yet fully understood. It is concluded that these perturbations produced damage to the associated physiological functions leading to CNS functions.






Sasi MM,Haider SS,el-Fakhri M,Ghwarsha KM


Has Abstract


1994-07-01 00:00:00












  • The molecular basis of microtubule stability in neurons.

    abstract::Microtubule (Mt) populations show large differences in dynamic properties (i.e., turnover rates) among cell types, and even within the same cell type at different stages of the cell cycle or stages of differentiation. These differences in dynamic properties are correlated with altered sensitivity to Mt-disassembling d...


    pub_type: 杂志文章,评审


    authors: Falconer MM,Vaillant A,Reuhl KR,Laferrière N,Brown DL

    更新日期:1994-04-01 00:00:00

  • Overview of REACH: Issues Involved in the Registration of Metals.

    abstract::New European legislation known as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) was introduced in 2007 to increase the speed at which the health and/or environmental risks of industrial chemicals were being assessed and managed (REACH (EC) No 1907/2006). REACH consolidated earlier chemic...


    pub_type: 杂志文章


    authors: Armstrong V,Karyakina NA,Nordheim E,Arnold I,Krewski D

    更新日期:2020-02-10 00:00:00

  • Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead.

    abstract::This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

    更新日期:2007-05-01 00:00:00

  • Glia and fetal alcohol syndrome.

    abstract::Glial cells and their interactions with neurons play vital roles during the ontogeny of the nervous system and in the adult brain. Alcohol intake during pregnancy can cause mental retardation and neurobehavioral disorders as well as fetal alcohol syndrome (FAS). Clinical and experimental evidence indicate that in uter...


    pub_type: 杂志文章,评审


    authors: Guerri C,Pascual M,Renau-Piqueras J

    更新日期:2001-10-01 00:00:00

  • Development of recombinant human nerve growth factor (rhNGF) as a treatment for peripheral neuropathic disease.

    abstract::Since its discovery over thirty years ago, the role played by Nerve Growth Factor (NGF) in the development and maintenance of sympathetic and sensory neurons of the peripheral nervous system has been well established and extensively studied. In addition, the existing data suggest that NGF may offer neuroprotection to ...


    pub_type: 杂志文章,评审


    authors: Rogers BC

    更新日期:1996-10-01 00:00:00

  • Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure.

    abstract::N-Butylbenzenesulfonamide (NBBS) is widely used as a plasticizer in polyacetals, polyamides, and polycarbonates and has been found in ground water and effluent from wastewater treatment sites. The compound is lipophilic and distributes rapidly to the brain but also clears rapidly and shows little evidence of accumulat...


    pub_type: 杂志文章


    authors: Rider CV,Janardhan KS,Rao D,Morrison JP,McPherson CA,Harry GJ

    更新日期:2012-12-01 00:00:00

  • The protective effects of sumatriptan on vincristine - induced peripheral neuropathy in a rat model.

    abstract::Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammato...


    pub_type: 杂志文章


    authors: Khalilzadeh M,Panahi G,Rashidian A,Hadian MR,Abdollahi A,Afshari K,Shakiba S,Norouzi-Javidan A,Rahimi N,Momeny M,Dehpour AR

    更新日期:2018-07-01 00:00:00

  • Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures.

    abstract::Extracellular acetylcholine (ACh) levels were determined, by intracranial microdialysis, in medial septum, amygdala and hippocampus (CA1, CA3, dentate gyrus) of rats during seizures induced by systemic administration of soman (pinacolyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase (AChE). In ...


    pub_type: 杂志文章


    authors: Lallement G,Carpentier P,Collet A,Baubichon D,Pernot-Marino I,Blanchet G

    更新日期:1992-10-01 00:00:00

  • Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.

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    pub_type: 杂志文章


    authors: Holloway ZR,Hawkey AB,Pippin E,White H,Wells C,Kenou B,Rezvani AH,Murphy SK,Levin ED

    更新日期:2020-05-01 00:00:00

  • Inhibition of spontaneous GABAergic transmission by trimethylolpropane phosphate.

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    pub_type: 杂志文章


    authors: Kao WY,Liu QY,Ma W,Ritchie GD,Lin J,Nordholm AF,Rossi J 3rd,Barker JL,Stenger DA,Pancrazio JJ

    更新日期:1999-10-01 00:00:00

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    pub_type: 杂志文章


    authors: Blain L,Lachapelle P,Molotchnikoff S

    更新日期:1992-04-01 00:00:00

  • Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor.

    abstract:BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...


    pub_type: 杂志文章


    authors: Rauh VA,Garcia WE,Whyatt RM,Horton MK,Barr DB,Louis ED

    更新日期:2015-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Rush T,Liu X,Nowakowski AB,Petering DH,Lobner D

    更新日期:2012-06-01 00:00:00

  • Inhibition of catalase activity with 3-amino-triazole enhances the cytotoxicity of the Alzheimer's amyloid-beta peptide.

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    pub_type: 杂志文章


    authors: Milton NG

    更新日期:2001-12-01 00:00:00

  • Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior.

    abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway. In humans, perinatal exposure to dioxin-like PCBs is associated with neurodevelopmental toxicity in child...


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    authors: Glazer L,Hahn ME,Aluru N

    更新日期:2016-01-01 00:00:00

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    authors: Alexandrova EA,Alkondon M,Aracava Y,Pereira EF,Albuquerque EX

    更新日期:2014-09-01 00:00:00

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    更新日期:1998-02-01 00:00:00

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    更新日期:2008-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Islas-Cortez M,Rios C,Rubio-Osornio M,Zamudio S,Orozco-Suarez S,Mendez-Armenta M,Nava-Ruiz C,Diaz-Ruiz A

    更新日期:2021-01-01 00:00:00

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    pub_type: 杂志文章


    authors: Walton J,Tuniz C,Fink D,Jacobsen G,Wilcox D

    更新日期:1995-04-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Lee J,Freeman JL

    更新日期:2014-07-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Myhrer T

    更新日期:2010-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Lasley SM,Green MC,Gilbert ME

    更新日期:1999-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Fox MR

    更新日期:1983-10-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Ijomone OM,Ijomone OK,Iroegbu JD,Ifenatuoha CW,Olung NF,Aschner M

    更新日期:2020-12-01 00:00:00

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    pub_type: 杂志文章


    authors: Chapman S,Kadar T,Gilat E

    更新日期:2006-03-01 00:00:00

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    pub_type: 杂志文章


    authors: Zsíros V,Rojik I,Kovács T,Csóti T,Erdélyi L

    更新日期:1998-08-01 00:00:00

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    pub_type: 杂志文章


    authors: Prasad S,Sajja RK,Kaisar MA,Cucullo L

    更新日期:2016-09-01 00:00:00