Abstract:
:Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the levels of total lipids, phospholipids, cholesterol and cerebrosides, and protein, but ganglioside concentration was significantly increased in various areas of the brain. Loss of body weight observed in this study could be attributed to the loss of appetite; loss of nutrients and wasting of tissues. It is likely that large amount of body water was lost through diarrhoea. Gas liquid chromatography has revealed that oleic acid, linoleic acid, linolenic acid, and arachidonic acid were preferentially lost in the brain of vanadium-exposed rats. Thin layer chromatography further proved degradation of individual lipids. Sphingomyelin was substantially decreased followed by phosphatidyl choline and phosphatidyl ethanolamine, but phosphatidyl serine and phosphatidyl inositol were slightly affected. Our recent work has demonstrated vanadium-induced stimulation of lipid peroxidation in the various regions of the rat brain. It is speculative that deterioration of myelin sheath by vanadium exposure contributed to preferential lipid loss but lesser loss of protein. These studies also indicate that vanadium-induced stimulation of lipid peroxidation is characterized by a selective loss of brain polyunsaturated fatty acids and thus comprehensive degradation of lipids in the different regions of the rat brain. However, the mechanism involved in the elevation of ganglioside levels is not yet fully understood. It is concluded that these perturbations produced damage to the associated physiological functions leading to CNS functions.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Sasi MM,Haider SS,el-Fakhri M,Ghwarsha KMsubject
Has Abstractpub_date
1994-07-01 00:00:00pages
413-20issue
2eissn
0161-813Xissn
1872-9711journal_volume
15pub_type
更正并重新发布的文章,杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Phosphoinositide (PtdIns) metabolism activated by cholinergic muscarinic receptors appears to play a role in brain development and has been recently suggested as a possible biochemical target for the developmental neurotoxicity of ethanol (EtOH). Recent experimental evidence indicates that, in rat brain, muscarinic re...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Pyridoxine, a water-soluble vitamin, produces a sensory neuronopathy when administered in high doses to dogs. Beagles who received a daily oral dose of 300 mg/kg of pyridoxol hydrochloride developed a swaying gait within 9 days. They eventually became unable to walk, but were not weak. Animals were sacrificed at inter...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-01-01 00:00:00
abstract::Previous investigations have presented evidence for an increased prevalence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if there was a correlation between mercury exposure and cognitive effects in a Norwegian population of dental workers, and if so, to quantify the o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.04.012
更新日期:2009-11-01 00:00:00
abstract::In addition to the long history of disease and death from natural toxicants in plants, there is a growing literature about the abundant levels and varieties of natural toxicants in our foods. These natural chemicals cause mutagenicity, carcinogenicity, teratogenicity, neurotoxicity and visceral organ toxicity in routi...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::Single subcutaneous injections of triphenyl phosphite (TPP) (62.5-500 mg/kg body weight) were made in the Japanese quail (Coturnix coturnix japonica). The extent and density of resultant central nervous system degeneration were mapped by using the Fink-Heimer silver impregnation method to selectively impregnate degene...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-04-01 00:00:00
abstract::Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by extensive degeneration of dopaminergic neurons in the nigrostriatal system. Neurochemical and neuropathological analyses clearly indicate that oxidative stress, mitochondrial dysfunction, neuroinflammation and impairment of the u...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2009.12.003
更新日期:2010-09-01 00:00:00
abstract::Ethanol is a widely consumed drug that acts on the central nervous system (CNS), modifying several signal transduction pathways activated by hormones and neurotransmitters. The zebrafish is an experimental model for the study of human diseases and the use of this species in biochemical and behavioral studies on alcoho...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.05.010
更新日期:2011-12-01 00:00:00
abstract::Exposure to soman, a toxic organophosphate nerve agent, causes severe adverse effects and long term changes in the peripheral and central nervous systems. The goal of this study was to evaluate the ability of prophylactic treatments to block the deleterious effects associated with soman poisoning. scopolamine, a class...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章
doi:10.1016/s0161-813x(02)00005-0
更新日期:2002-05-01 00:00:00
abstract::Sevoflurane, a commonly used inhaled anesthetic, can induce neuronal apoptosis in the developing rodent brain and correlate with functional neurological impairment later in life. However, the mechanisms underlying these deleterious effects of sevoflurane remain unclear and no effective treatment is currently available...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.11.003
更新日期:2015-01-01 00:00:00
abstract::The popular recreational drug, 3,4-methylenedioxymethamphetamine (MDMA) is often taken as intermittent binges by adolescents at dance clubs. The neurobiological mechanisms that underlie MDMA-induced psychiatric conditions are still poorly understood. In the present study, mimicking adolescent patterns of administratio...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.07.002
更新日期:2007-11-01 00:00:00
abstract::The separate and combined effects of successive administration of amantadine, 100 mg/kg, i.p., and chlorpromazine, 0.2 mg/kg, i.p., on motor activity and whole brain levels of certain biogenic amines and major metabolites were studied in four strains of mice. These were the albino ICR, the inbred BALB/C, C57BL/6 and t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::A Workshop on the Qualitative and Quantitative Comparability of Human and Animal Developmental Neurotoxicity was held in Williamsburg, Va. on April 11-13, 1989. Based upon data presented at the Workshop, the degree of qualitative and quantitative comparability between data obtained from humans and experimental animals...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract::Mercury is a heavy metal responsible for human intoxication worldwide and especially in the Amazon, where both natural and anthropogenic sources are responsible for exposure in riverine populations. Methylmercury is the most toxic specie of mercury with recognized neurotoxicity due to its affinity for the central nerv...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.07.018
更新日期:2018-09-01 00:00:00
abstract::The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.03.015
更新日期:2014-12-01 00:00:00
abstract::This paper deals with the assumption that young adults with self-reported multiple chemical sensitivity (sMCS) show a heightened sensitivity of autonomic functions during experimental solvent exposure. Male sMCS-subjects were selected (out of n=274) on the base of a German questionnaire on chemical and environmental s...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-813X(02)00213-9
更新日期:2003-03-01 00:00:00
abstract::Cisplatin activates multiple signal transduction pathways associated with cell survival and apoptosis in various cell types. The present study was undertaken to determine the role of extracellular signal-regulated protein kinase (ERK), a member of the mitogen-activated protein kinase family, in cisplatin-induced apopt...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.06.002
更新日期:2004-12-01 00:00:00
abstract::Various aspects of locomotor activity were measured, using a crossed photobeam cage, in young rhesus monkeys (M. mulatta) whose mothers had been fed low levels of polychlorinated biphenyls (PCBs, Aroclor 1248) both before and during gestation and nursing. In Exp. 1, a group of young monkeys whose mothers had been fed ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract::It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to eva...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.10.002
更新日期:2018-01-01 00:00:00
abstract::Current approaches to risk assessment regard it as a process that should embody both health and ecological risks, societal values, and cost-benefit analysis, that should seek the views of affected parties, and that should examine available options more holistically than in the past. Even with a single agent, manganese...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00
abstract::As obvious from the basic prerequisite of any particle in nanoscale, Zinc oxide nanoparticles (ZnO NPs) possess numerous tunable properties distinct from their bulk formulations. Emerging innovations in various sectors of nanotechnology are exploiting ZnO NPs largely. This inturn picks up the occasions of human exposu...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.04.008
更新日期:2019-07-01 00:00:00
abstract::In a pilot study, serum dopamine beta-hydroxylase (DBH), platelets monoamine oxidase type B (MAO B) activities and basal plasma prolactin (PRL) were measured, among 10 workers occupationally exposed to toluene and 10 control subjects, preceding and immediately following vacation. Six exposed subjects were employed in ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::This paper describes the development of the protocol for the International Programme on Chemical Safety (IPCS)-sponsored Collaborative Study on Neurobehavioral Screening Methods, including background on the methods and chemicals selected, as well as details concerning the conduct of the collaborative study, including ...
journal_title:Neurotoxicology
pub_type: 杂志文章,多中心研究
doi:
更新日期:1997-01-01 00:00:00
abstract::Chronic manganese (Mn) exposure can lead to neuroinflammation and neurological deficit, which resemble idiopathic Parkinson's disease (IPD). However, the precise mechanisms underlying Mn exposure-induced neurotoxicity remain incompletely understood. Microglia can become hyperactivated and plays a vital role in neuroin...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.04.001
更新日期:2018-01-01 00:00:00
abstract:AIM:This study examined the acute effects of severe monocrotophos (MCP) poisoning on AChE inhibition, mRNA expression and recovery of acetylcholinesterase activity in different regions of the rat brain. STUDY:Wistar rats were administered monocrotophos (0.8LD(50)) by oral gavage to elicit severe effects of acute poiso...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.07.010
更新日期:2012-10-01 00:00:00
abstract::The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offspring, but little research has been done regarding paternal THC...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.009
更新日期:2020-05-01 00:00:00
abstract::A device using four infra-red light photocells per cage which monitor simultaneously the motility of 120 individual rodents, was developed at our institute. The measuring interval can be chosen freely, the starting time may be set freely and the test may last several weeks. The motility of the offspring (day 35-39) of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1989-10-01 00:00:00
abstract::Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during deve...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.03.013
更新日期:2012-06-01 00:00:00
abstract::The present study was designed to examine the protective potential of hydroalcoholic extract of Vitis vinifera in ameliorating the alterations induced by aluminium (Al) on behavioural and neurochemical indices. Al was given orally (100mg/kg b.wt./day) whereas V. vinifera extract was administered through diet (400mg/kg...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.01.003
更新日期:2014-03-01 00:00:00
abstract::The present study was envisaged to investigate the neuroprotective potential of Allium cepa (A. cepa) in aluminium chloride induced neurotoxicity. Aluminium chloride (50 mg/kg/day) was administered orally in mice supplemented with different doses of A. cepa hydroethanolic extract for a period of 60 days. Various behav...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.04.007
更新日期:2015-07-01 00:00:00