Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.

Abstract:

:Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the levels of total lipids, phospholipids, cholesterol and cerebrosides, and protein, but ganglioside concentration was significantly increased in various areas of the brain. Loss of body weight observed in this study could be attributed to the loss of appetite; loss of nutrients and wasting of tissues. It is likely that large amount of body water was lost through diarrhoea. Gas liquid chromatography has revealed that oleic acid, linoleic acid, linolenic acid, and arachidonic acid were preferentially lost in the brain of vanadium-exposed rats. Thin layer chromatography further proved degradation of individual lipids. Sphingomyelin was substantially decreased followed by phosphatidyl choline and phosphatidyl ethanolamine, but phosphatidyl serine and phosphatidyl inositol were slightly affected. Our recent work has demonstrated vanadium-induced stimulation of lipid peroxidation in the various regions of the rat brain. It is speculative that deterioration of myelin sheath by vanadium exposure contributed to preferential lipid loss but lesser loss of protein. These studies also indicate that vanadium-induced stimulation of lipid peroxidation is characterized by a selective loss of brain polyunsaturated fatty acids and thus comprehensive degradation of lipids in the different regions of the rat brain. However, the mechanism involved in the elevation of ganglioside levels is not yet fully understood. It is concluded that these perturbations produced damage to the associated physiological functions leading to CNS functions.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Sasi MM,Haider SS,el-Fakhri M,Ghwarsha KM

subject

Has Abstract

pub_date

1994-07-01 00:00:00

pages

413-20

issue

2

eissn

0161-813X

issn

1872-9711

journal_volume

15

pub_type

更正并重新发布的文章,杂志文章
  • The molecular basis of microtubule stability in neurons.

    abstract::Microtubule (Mt) populations show large differences in dynamic properties (i.e., turnover rates) among cell types, and even within the same cell type at different stages of the cell cycle or stages of differentiation. These differences in dynamic properties are correlated with altered sensitivity to Mt-disassembling d...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Falconer MM,Vaillant A,Reuhl KR,Laferrière N,Brown DL

    更新日期:1994-04-01 00:00:00

  • Overview of REACH: Issues Involved in the Registration of Metals.

    abstract::New European legislation known as REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) was introduced in 2007 to increase the speed at which the health and/or environmental risks of industrial chemicals were being assessed and managed (REACH (EC) No 1907/2006). REACH consolidated earlier chemic...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2020.01.010

    authors: Armstrong V,Karyakina NA,Nordheim E,Arnold I,Krewski D

    更新日期:2020-02-10 00:00:00

  • Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead.

    abstract::This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.neuro.2007.03.007

    authors: Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

    更新日期:2007-05-01 00:00:00

  • Glia and fetal alcohol syndrome.

    abstract::Glial cells and their interactions with neurons play vital roles during the ontogeny of the nervous system and in the adult brain. Alcohol intake during pregnancy can cause mental retardation and neurobehavioral disorders as well as fetal alcohol syndrome (FAS). Clinical and experimental evidence indicate that in uter...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:10.1016/s0161-813x(01)00037-7

    authors: Guerri C,Pascual M,Renau-Piqueras J

    更新日期:2001-10-01 00:00:00

  • Development of recombinant human nerve growth factor (rhNGF) as a treatment for peripheral neuropathic disease.

    abstract::Since its discovery over thirty years ago, the role played by Nerve Growth Factor (NGF) in the development and maintenance of sympathetic and sensory neurons of the peripheral nervous system has been well established and extensively studied. In addition, the existing data suggest that NGF may offer neuroprotection to ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Rogers BC

    更新日期:1996-10-01 00:00:00

  • Evaluation of N-butylbenzenesulfonamide (NBBS) neurotoxicity in Sprague-Dawley male rats following 27-day oral exposure.

    abstract::N-Butylbenzenesulfonamide (NBBS) is widely used as a plasticizer in polyacetals, polyamides, and polycarbonates and has been found in ground water and effluent from wastewater treatment sites. The compound is lipophilic and distributes rapidly to the brain but also clears rapidly and shows little evidence of accumulat...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2012.07.002

    authors: Rider CV,Janardhan KS,Rao D,Morrison JP,McPherson CA,Harry GJ

    更新日期:2012-12-01 00:00:00

  • The protective effects of sumatriptan on vincristine - induced peripheral neuropathy in a rat model.

    abstract::Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammato...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2018.06.012

    authors: Khalilzadeh M,Panahi G,Rashidian A,Hadian MR,Abdollahi A,Afshari K,Shakiba S,Norouzi-Javidan A,Rahimi N,Momeny M,Dehpour AR

    更新日期:2018-07-01 00:00:00

  • Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures.

    abstract::Extracellular acetylcholine (ACh) levels were determined, by intracranial microdialysis, in medial septum, amygdala and hippocampus (CA1, CA3, dentate gyrus) of rats during seizures induced by systemic administration of soman (pinacolyl methylphosphonofluoridate), a potent inhibitor of acetylcholinesterase (AChE). In ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Lallement G,Carpentier P,Collet A,Baubichon D,Pernot-Marino I,Blanchet G

    更新日期:1992-10-01 00:00:00

  • Paternal factors in neurodevelopmental toxicology: THC exposure of male rats causes long-lasting neurobehavioral effects in their offspring.

    abstract::The potential health risks of cannabis are of growing concern, including effects on reproduction and development. Extensive research has investigated risks associated with maternal exposure to THC during gestation and its impacts on the development of offspring, but little research has been done regarding paternal THC...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2020.01.009

    authors: Holloway ZR,Hawkey AB,Pippin E,White H,Wells C,Kenou B,Rezvani AH,Murphy SK,Levin ED

    更新日期:2020-05-01 00:00:00

  • Inhibition of spontaneous GABAergic transmission by trimethylolpropane phosphate.

    abstract::Trimethylolpropane phosphate (TMPP) is a neuroactive organophosphate generated during partial pyrolysis of a synthetic ester turbine engine lubricant. While TMPP had been shown to have little affinity for acetylcholinesterase, previous binding studies and 6Cl- flux measurements have implicated TMPP as an antagonist of...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Kao WY,Liu QY,Ma W,Ritchie GD,Lin J,Nordholm AF,Rossi J 3rd,Barker JL,Stenger DA,Pancrazio JJ

    更新日期:1999-10-01 00:00:00

  • Evoked potentials are modified by long term exposure to trichloroethylene.

    abstract::Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Blain L,Lachapelle P,Molotchnikoff S

    更新日期:1992-04-01 00:00:00

  • Prenatal exposure to the organophosphate pesticide chlorpyrifos and childhood tremor.

    abstract:BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.09.004

    authors: Rauh VA,Garcia WE,Whyatt RM,Horton MK,Barr DB,Louis ED

    更新日期:2015-12-01 00:00:00

  • Glutathione-mediated neuroprotection against methylmercury neurotoxicity in cortical culture is dependent on MRP1.

    abstract::Methylmercury (MeHg) exposure at high concentrations poses significant neurotoxic threat to humans worldwide. The present study investigated the mechanisms of glutathione-mediated attenuation of MeHg neurotoxicity in primary cortical culture. MeHg (5 μM) caused depletion of mono- and disulfide glutathione in neuronal,...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2012.03.004

    authors: Rush T,Liu X,Nowakowski AB,Petering DH,Lobner D

    更新日期:2012-06-01 00:00:00

  • Inhibition of catalase activity with 3-amino-triazole enhances the cytotoxicity of the Alzheimer's amyloid-beta peptide.

    abstract::Amyloid-beta, (Abeta) is a cytotoxic peptide implicated in the pathology of Alzheimers disease. The antioxidant enzyme catalase has been suggested to protect against Abeta cytotoxicity in both neuronal and non-neuronal cell types. Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(01)00064-x

    authors: Milton NG

    更新日期:2001-12-01 00:00:00

  • Delayed effects of developmental exposure to low levels of the aryl hydrocarbon receptor agonist 3,3',4,4',5-pentachlorobiphenyl (PCB126) on adult zebrafish behavior.

    abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway. In humans, perinatal exposure to dioxin-like PCBs is associated with neurodevelopmental toxicity in child...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.11.012

    authors: Glazer L,Hahn ME,Aluru N

    更新日期:2016-01-01 00:00:00

  • Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs.

    abstract::Galantamine, a drug currently approved for the treatment of Alzheimer's disease, has recently emerged as an effective pretreatment against the acute toxicity and delayed cognitive deficits induced by organophosphorus (OP) nerve agents, including soman. Since cognitive deficits can result from impaired glutamatergic tr...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2014.07.005

    authors: Alexandrova EA,Alkondon M,Aracava Y,Pereira EF,Albuquerque EX

    更新日期:2014-09-01 00:00:00

  • Responses to N-methyl-D-aspartate and kainic acid in cerebellar granule cells of lead-exposed rat pups.

    abstract::To determine changes in response to N-methyl-D-aspartate (NMDA) and kainic acid (KA) in cerebellar granule cells of offspring of lead-exposed mothers, pregnant rats received 0.25% lead acetate in their drinking water 2 days after mating. The control animals were given sodium acetate (0.125%) in their drinking water. T...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Lim DK,Ho IK

    更新日期:1998-02-01 00:00:00

  • Selenium from dietary sources and motor functions in the Brazilian Amazon.

    abstract::Selenium (Se) is a well-known anti-oxidant with a critical role in the proper functioning of nervous and muscle functions. Se deficiency has been associated with both cognitive and neuromotor impairment, while sensory and motor deficits have been attributed to excess Se. In the Lower Tapajós Region of the Brazilian Am...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2011.04.005

    authors: Lemire M,Fillion M,Frenette B,Passos CJ,Guimarães JR,Barbosa F Jr,Mergler D

    更新日期:2011-12-01 00:00:00

  • Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex.

    abstract::The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating acetylcholinesterase and in eliminating oxidative stress induced by acute exposure to malathion was evaluated in mouse prefrontal cortex using in vivo methods. Malathion (1g/kg, dissolved in saline) was administered subcutaneou...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2007.10.005

    authors: da Silva AP,Farina M,Franco JL,Dafre AL,Kassa J,Kuca K

    更新日期:2008-01-01 00:00:00

  • Neurotoxicity of manganese: Indications for future research and public health intervention from the Manganese 2016 conference.

    abstract::Manganese is an essential trace element, but also at high levels a neurotoxicant. Manganese neurotoxicity has been extensively studied since its discovery in highly exposed workers. The International conference MANGANESE2016 held at the Icahn School of Medicine at Mount Sinai in New York provided relevant updates on m...

    journal_title:Neurotoxicology

    pub_type: 社论

    doi:10.1016/j.neuro.2018.01.002

    authors: Lucchini RG,Aschner M,Landrigan PJ,Cranmer JM

    更新日期:2018-01-01 00:00:00

  • Characterization of the antiapoptotic effect of copper sulfate on striatal and midbrain damage induced by MPP+ in rats.

    abstract::1-Methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity produces cellular damage resembling that encountered in Parkinson's disease. The mechanisms of cellular death after MPP+ include the participation of oxidative stress in the loss of dopaminergic neurons. Among the mechanisms of defense against oxidative stre...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2020.10.011

    authors: Islas-Cortez M,Rios C,Rubio-Osornio M,Zamudio S,Orozco-Suarez S,Mendez-Armenta M,Nava-Ruiz C,Diaz-Ruiz A

    更新日期:2021-01-01 00:00:00

  • Uptake of trace amounts of aluminum into the brain from drinking water.

    abstract::Throughout the world, alum (aluminum sulfate) is used in municipal water treatment plants to clarify water. Alum treatment usually removes aluminosilicate particles from drinking water but can substantially increase its soluble aluminum content (Zhang et al., 1994; Tran et al., 1993; Kopp, 1970). Soluble aluminum is t...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Walton J,Tuniz C,Fink D,Jacobsen G,Wilcox D

    更新日期:1995-04-01 00:00:00

  • Zebrafish as a model for investigating developmental lead (Pb) neurotoxicity as a risk factor in adult neurodegenerative disease: a mini-review.

    abstract::Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological studies indicate cognitive decline and neurobehavioral alterations in children associated with lower dose environmental Pb ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuro.2014.03.008

    authors: Lee J,Freeman JL

    更新日期:2014-07-01 00:00:00

  • Identification of neuronal target areas for nerve agents and specification of receptors for pharmacological treatment.

    abstract::In order to shorten the list of candidate drugs with anticonvulsant potential against nerve agents, critical subreceptors in seizure controlling brain regions should be specified. Epileptiform activity does not spread randomly throughout the brain, but appears to be generated and propagated by specific anatomical rout...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuro.2010.07.002

    authors: Myhrer T

    更新日期:2010-12-01 00:00:00

  • Influence of exposure period on in vivo hippocampal glutamate and GABA release in rats chronically exposed to lead.

    abstract::Previous work has demonstrated that continual exposure to 0.2% lead (Pb) beginning at birth diminishes depolarization-induced hippocampal glutamate (GLU) and GABA release in vivo. The present study sought to extend these findings by examining Pb-induced changes as a function of exposure period. Rats were continually e...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Lasley SM,Green MC,Gilbert ME

    更新日期:1999-08-01 00:00:00

  • Effects of dietary mineral levels on metabolism and requirements.

    abstract::Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Fox MR

    更新日期:1983-10-01 00:00:00

  • Epigenetic influence of environmentally neurotoxic metals.

    abstract::Continuous globalization and industrialization have ensured metals are an increasing aspect of daily life. Their usefulness in manufacturing has made them vital to national commerce, security and global economy. However, excess exposure to metals, particularly as a result of environmental contamination or occupational...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuro.2020.08.005

    authors: Ijomone OM,Ijomone OK,Iroegbu JD,Ifenatuoha CW,Olung NF,Aschner M

    更新日期:2020-12-01 00:00:00

  • Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain.

    abstract::The current study was aimed to characterize for the first time the alterations in the characteristic neuro-inflammatory markers triggered by sarin exposure in the rat's brain, and to investigate its dependency on seizure duration. Centrally mediated seizures are a common consequence of exposure to organophosphates (OP...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2005.11.009

    authors: Chapman S,Kadar T,Gilat E

    更新日期:2006-03-01 00:00:00

  • Comparative electrophysiological aspects of aluminum actions on central neurons and neuronal synapses of invertebrate and vertebrate animals.

    abstract::Aluminum compounds (Al) increased the membrane potential (Em) and decreased the input resistance (Rin) of identified snail neurons. The neuronal excitability increased after Al withdrawal in the washing period. Cumulative Al applications caused dose-dependent modulation of Em and Rin in most of the studied neurons. Tw...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Zsíros V,Rojik I,Kovács T,Csóti T,Erdélyi L

    更新日期:1998-08-01 00:00:00

  • Hyperglycemia exacerbates antiretroviral drug combination induced blood-brain barrier endothelial toxicity.

    abstract::In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB) endothelial function. Immortalized human brain microvascular endothelial cell line (hCMEC/D3) was exposed to azidothymidine (AZT; a nucleoside reverse transcrip...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2016.06.011

    authors: Prasad S,Sajja RK,Kaisar MA,Cucullo L

    更新日期:2016-09-01 00:00:00