Abstract:
:Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of potential hazard in addition to environmental and industrial sources of exposure. In assessing requirements and the health effects of variations in dietary mineral levels, the tissue concentrations of the elements can be very useful. The interpretation of tissue mineral levels is tempered by factors that may influence the metabolism of the element of concern as well as by the correlations of intake and tissue levels with physiological effects. For elements that have been studied most extensively and for which reliable analytical methods exist, a multiplicity of interactions have been shown. The practical significance of these interactions for humans is an area of active research. With reliable analytical methods for additional elements, it is anticipated that important advances will be made relative to those chemical elements and their action both as nutrients and as toxicants.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Fox MRsubject
Has Abstractpub_date
1983-10-01 00:00:00pages
113-20issue
3eissn
0161-813Xissn
1872-9711journal_volume
4pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Previous work has indicated that the neurotoxic action of environmentally relevant levels of lead (Pb) on dopaminergic neurons is primarily presynaptic in nature and related to impaired regulation of dopamine (DA) synthesis and decreased DA release. This study was conducted to assess the functional integrity of the re...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract::Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.07.009
更新日期:2018-09-01 00:00:00
abstract::The contribution of environmental toxicants to the etiology and risk of Parkinson's disease (PD) has been clearly established, with organochlorine insecticides routinely shown to damage the nigrostriatal dopamine pathway. Although PD is generally considered an adult onset disease, it has been postulated that exposure ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.07.008
更新日期:2014-09-01 00:00:00
abstract::Protein phosphorylation represents a major post-translational mechanism through which numerous physiological processes are regulated. In the central nervous system, many extracellular messengers appear to exert their effects by regulating the intracellular concentration of specific second messengers which in turn acti...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.06.013
更新日期:2016-09-01 00:00:00
abstract::Traditionally, gamma-diketone neuropathy is classified as a distal axonopathy and has been characterized by giant axonal swellings in CNS and PNS tissues. These swellings contain neurofilamentous masses and are associated with thinning and retraction of the myelin sheath. It has been proposed that this axonopathy is c...
journal_title:Neurotoxicology
pub_type: 评论,杂志文章,评审
doi:
更新日期:1997-01-01 00:00:00
abstract::Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment inte...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2011.12.014
更新日期:2012-01-01 00:00:00
abstract::A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::The effects of lead (0.0, 0.1, or 1 microM) on subcellular sites in primary astroglial cultures were quantitated with the use of vital fluorescent probes (fluorescence bioassays). Evaluation of cellular glutathione levels with monochlorobimane revealed a reduction in glutathione content after only 7 hr of Pb treatment...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1993-07-01 00:00:00
abstract::Alterations in cytoskeletal proteins such as the perikaryal accumulation of neurofilaments (NFs) occur in a number of human neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis and may contribute to their debilitating effects. The administration of aluminum s...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Prior studies demonstrate a critical role for mesolimbic dopamine systems, particularly nucleus accumbens, in the mediation of fixed interval (FI) schedule-controlled behavior and an enhancement of nucleus accumbens dopamine activity as a mechanism of chronic postweaning lead (Pb)-induced increases in Fl response rate...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00059-1
更新日期:2002-09-01 00:00:00
abstract::Manganese (Mn) over-exposure in occupational settings is associated with basal ganglia toxicity and a movement disorder characterized by parkinsonism (i.e., the signs and symptoms of Parkinson disease). A simple test to help non-neurologists identify workers with clinical Mn neurotoxicity represents an unmet need. In ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.02.009
更新日期:2018-01-01 00:00:00
abstract::The spatial and temporal patterns of spontaneous synchronous Ca2+ oscillations (SCOs) regulate physiological pathways that influence neuronal development, excitability, and health. Hippocampal neuronal cultures (HN) and neuron/glia co-cultures (HNG) produced from neonatal mice were loaded with Fluo-4/AM and SCOs recor...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.10.015
更新日期:2017-01-01 00:00:00
abstract::The subchronic neurotoxic effects of isobutanol were studied by exposing Sprague-Dawley rats to isobutanol vapor concentrations of 0, 250, 1000, and 2500 ppm for 6 hrs/day, 5 days/wk, for 3 months. A comprehensive set of neurotoxicity tests (functional observational battery, motor activity, perfusion fixation neuropat...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.09.009
更新日期:2016-12-01 00:00:00
abstract::In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode Ca...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.07.002
更新日期:2019-09-01 00:00:00
abstract::Cytoskeletal alteration is a key factor in neurodegenerative processes like Alzheimer's or Parkinson's disease. Colchicine is a microtubule-disrupting agent that binds to tubuline, inhibiting microtubule assembly, and which triggers apoptosis. The present research describes the transcriptional activation of molecules ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.11.007
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND:Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. OBJECTIVES:To examine whether exposure to resin-based composite restorations is associated with neuropsychological de...
journal_title:Neurotoxicology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuro.2012.08.001
更新日期:2012-10-01 00:00:00
abstract::Previous work has demonstrated that continual exposure to 0.2% lead (Pb) beginning at birth diminishes depolarization-induced hippocampal glutamate (GLU) and GABA release in vivo. The present study sought to extend these findings by examining Pb-induced changes as a function of exposure period. Rats were continually e...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::In order to shorten the list of candidate drugs with anticonvulsant potential against nerve agents, critical subreceptors in seizure controlling brain regions should be specified. Epileptiform activity does not spread randomly throughout the brain, but appears to be generated and propagated by specific anatomical rout...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2010.07.002
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Methanol is a widely used industrial short-chain aliphatic alcohol with known neurotoxic properties. Mass poisoning outbreaks due to the consumption of methanol-adulterated alcoholic drinks present a challenge to healthcare providers due to the high mortality and serious central nervous system (CNS) damage i...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.04.010
更新日期:2020-07-01 00:00:00
abstract::Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of th...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.04.011
更新日期:2018-07-01 00:00:00
abstract::Vanadium-containing products are manufactured and widely used in the modern industry. Yet the neurobehavioral toxicity due to occupational exposure to vanadium remained elusive. This cross-sectional study was designed to examine the neurotoxic effects of occupational vanadium exposure. A total of 463 vanadium-exposed ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.02.008
更新日期:2013-05-01 00:00:00
abstract:BACKGROUND:Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Nav) channels have not been well-evaluated in all the mammalian Nav isoforms. OBJECTIVE:Here we compare the well-studied ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.12.005
更新日期:2017-05-01 00:00:00
abstract::The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00049-4
更新日期:2003-08-01 00:00:00
abstract::As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child IQ were collected by trained psychologists. The Wechsler Pre-school and Primary Scale of Intelligence - Revised UK edition (WPPSI) was used at age 4 years in a subsample of children enrolled in ALSPAC (the Children in Focus coho...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.07.025
更新日期:2017-09-01 00:00:00
abstract::Although it is well known that lead (Pb2+0 acutely blocks voltage-gated calcium currents (VGCCs) in mammalian neurons, little is known about the long-term effects of continuous exposure to this metal on VGCCs. In the present study, the effects of chronic lead exposure on VGCCs (with barium ions as the charge carrier) ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Various aspects of locomotor activity were measured, using a crossed photobeam cage, in young rhesus monkeys (M. mulatta) whose mothers had been fed low levels of polychlorinated biphenyls (PCBs, Aroclor 1248) both before and during gestation and nursing. In Exp. 1, a group of young monkeys whose mothers had been fed ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-10-01 00:00:00
abstract::The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.01.004
更新日期:2006-07-01 00:00:00
abstract:BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00