Abstract:
:Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acetaldehyde accumulation is associated with the reinforcing properties of EtOH, this study sought to determine brain CAT and ALDH2 expression in limbic areas of control and Pb-exposed animals after voluntary EtOH intake. Thirty-five-day-old rats perinatally exposed to 220 ppm Pb were offered with water or increasing EtOH solutions (2-10% v/v) during 28 days until postnatal day (PND) 63. Once intake was stable, the animals were administered: 1) saline (SAL; test days 21-24 or 21-28, as corresponds), or 2) a CAT inhibitor: 3-amine 1, 2, 4-triazole (AT; 250 mg/kg intraperitoneally [i.p.], 5 h before the last eight EtOH intake sessions -test days 21-24 and 25-28), or 3) a CAT booster: 3-nitropropionic acid (3NPA; 20 mg/kg subcutaneously [s.c.], 45 min before the last four EtOH intake sessions -test days 25-28). Two additional groups were centrally-administered cyanamide (CY, an ALDH2 inhibitor, 0.3 mg i.c.v. immediately before the last four EtOH sessions, test days 25-28) or its corresponding vehicle (VEH). Lead exposure increased EtOH intake, an effect potentiated in both groups by 3NPA or CY pretreatments and reduced by AT, albeit selectivity in the Pb group. Catalase abundance in limbic areas parallels these observations in the Pb group, showing higher CAT expression in all areas after EtOH consumption respect to the controls, an effect prevented by AT administration. In contrast, ALDH2 expression was reduced in the Pb animals after EtOH intake, with CY potentiating this effect in all brain areas under study. Based on these results and on previous evidences, we suggest that Pb exposure promotes acetaldehyde accumulation in limbic regions, providing some insights into the mechanism of action that underlies the vulnerability to the excessive EtOH consumption reported in these animals.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Mattalloni MS,Deza-Ponzio R,Albrecht PA,Fernandez-Hubeid LE,Cancela LM,Virgolini MBdoi
10.1016/j.neuro.2019.09.011subject
Has Abstractpub_date
2019-12-01 00:00:00pages
174-185eissn
0161-813Xissn
1872-9711pii
S0161-813X(19)30101-9journal_volume
75pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Exposure to chlorpyrifos (CPF) during the late preweanling period in rats inhibits the endocannabinoid metabolizing enzymes fatty acid hydrolase (FAAH) and monoacylglycerol lipase (MAGL), resulting in accumulation of their respective substrates anandamide (AEA) and 2-arachidonylglycerol (2-AG). This occurs at 1.0mg/kg...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.11.016
更新日期:2017-03-01 00:00:00
abstract::Tolerance to the toxic effects of exposure to the organophosphate acetylcholinesterase inhibitor, disulfoton, was induced by giving multiple, sublethal doses of the compound to male rats. Tolerance was judged to have been induced when toxic signs of exposure, including weight loss, were reversed or diminished. Binding...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-12-01 00:00:00
abstract::Selenium (Se) supplementation in the nutritionally relevant range counteracts methylmercury (MeHg) toxicity. Since Se tends to be abundant in fish, MeHg exposures alone may not provide an accurate index of risk from fish consumption. Molar ratios of MeHg:Se in the diets and Hg:Se in tissues of exposed individuals may ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2008.07.007
更新日期:2008-09-01 00:00:00
abstract::The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating acetylcholinesterase and in eliminating oxidative stress induced by acute exposure to malathion was evaluated in mouse prefrontal cortex using in vivo methods. Malathion (1g/kg, dissolved in saline) was administered subcutaneou...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.10.005
更新日期:2008-01-01 00:00:00
abstract::The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00049-4
更新日期:2003-08-01 00:00:00
abstract::Bisphenol A (BPA) is a ubiquitous environmental chemical that has been linked to behavioral differences in children and shown to impact critical neurodevelopmental processes in animal models. Though data is emerging, we still have an incomplete picture of how BPA disrupts neurodevelopment; in particular, how its impac...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.12.007
更新日期:2021-01-01 00:00:00
abstract::Despite the large body of experimental evidence demonstrating the neuroprotective properties of 17beta-estradiol (17beta-E2) both in vitro and in vivo experimental models of neuronal injury, the exact mechanisms implicated in neuroprotection have not been fully delineated. Some experimental evidence highlight a role f...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2005.01.009
更新日期:2005-10-01 00:00:00
abstract::Vanadium-containing products are manufactured and widely used in the modern industry. Yet the neurobehavioral toxicity due to occupational exposure to vanadium remained elusive. This cross-sectional study was designed to examine the neurotoxic effects of occupational vanadium exposure. A total of 463 vanadium-exposed ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.02.008
更新日期:2013-05-01 00:00:00
abstract::To study the effects from low level exposure to manganese, 30 men at steel smelting works and 60 nonexposed reference subjects, were neurophysiologically examined using: (i) Electroencephalogram (EEG), Event related auditory evoked potential (AEP/P300), Brain stem auditory evoked potential (BAEP) and diadochokinesomet...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.01.011
更新日期:2006-07-01 00:00:00
abstract::Lead (Pb(2+)) is a pollutant commonly found in the environment. It causes a wide variety of detrimental effects on developing central nervous system. However, the mechanisms of its neurotoxicity remained to be elucidated. In hippocampus, the muscarinic cholinergic system modulates certain forms of synaptic transmissio...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.11.003
更新日期:2007-05-01 00:00:00
abstract::Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pre...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00058-5
更新日期:2003-08-01 00:00:00
abstract::The mechanism of action of acrylamide (ACR) in producing a central-peripheral distal axonopathy is unknown. We have tested the hypothesis that ACR inhibition of enzymes of oxidative metabolism is responsible for compromise of the energy supply, thereby producing the neuropathy. A single 50 mg/kg i.p. dose of ACR resul...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1986-04-01 00:00:00
abstract::Methylmercury (MeHg) toxicity in humans manifests deficits in neurological function. Cases of prenatal exposure to mercury have established that the developing nervous system is most highly susceptible to perturbation by MeHg. At a cellular level, MeHg-induced defects result from altered neuronal proliferation, migrat...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.04.005
更新日期:2006-12-01 00:00:00
abstract::Drinking water manganese (WMn) is a potential threat to children's health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their academic achievement lit...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.12.002
更新日期:2012-01-01 00:00:00
abstract::The authors carried out neurological examination, visual evoked potentials (VEP) examination, and electromyography (EMG) on 77 workers, aged 21-61 yrs, who were exposed occupationally to Hgo vapors for 1-20 yrs (mean 9 yrs). The mean air-borne concentration of Hgo was 0.25 mg/m3 (range 0.02-1.00 mg m3), and the mean H...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.07.009
更新日期:2018-09-01 00:00:00
abstract::A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.12.014
更新日期:2021-01-02 00:00:00
abstract::This evaluative review covers the neurotoxic effects of toluene. General health effects of toluene are also discussed in more limited detail. A brief description of chemical properties and environmental prevalence is given, followed by a review of pharmacokinetic data. General health effects include lethality, growth,...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1981-11-01 00:00:00
abstract::Metals are involved in different pathophysiological mechanisms associated with neurodegenerative diseases (NDDs), including Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS). The aim of this study was to review the effects of the essential metals zinc (Zn), copper (Cu), manganese (Mn) and ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2019.07.007
更新日期:2019-09-01 00:00:00
abstract::Mercury (Hg) is considered one of the worlds most toxic metals. Current thinking suggests that exposure to mercury occurs primarily from seafood contamination and rare catastrophic events. Recently, another common source of exposure has been identified. Thimerosal (TMS), a preservative found in many infant vaccines, c...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(01)00067-5
更新日期:2001-10-01 00:00:00
abstract::beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1985-01-01 00:00:00
abstract::Exposure to anesthetic gases is known to alter certain structures and functions of the central nervous system. As the effects of long-term exposure on balance control mechanisms have been the subject of few investigations, these were evaluated in 53 operating room personnel exposed to anesthetic gases and in 53 non-ex...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.11.002
更新日期:2005-03-01 00:00:00
abstract::In a pilot study, serum dopamine beta-hydroxylase (DBH), platelets monoamine oxidase type B (MAO B) activities and basal plasma prolactin (PRL) were measured, among 10 workers occupationally exposed to toluene and 10 control subjects, preceding and immediately following vacation. Six exposed subjects were employed in ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Gene expression profiles in several brain regions of adult male rats were evaluated following a d-amphetamine (AMPH) exposure paradigm previously established to produce AMPH neurotoxicity. Escalating doses of AMPH (5-30 mg/kg) were given over the course of 16 h per day in an 18 degrees C environment for 2 days. This p...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2003.08.005
更新日期:2004-06-01 00:00:00
abstract::It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to eva...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.10.002
更新日期:2018-01-01 00:00:00
abstract::It has been hypothesised that some motor neuron diseases may result from lead (Pb) being retrogradely transported in axons from muscle to spinal cord. To test this hypothesis, we injected mice in the right hindlimb with 0.1 ml of 0.25% or 2.5% Pb. In some animals the sciatic nerve was cut before injection. Pb levels w...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1994-07-01 00:00:00
abstract::Gulf War Illness (GWI) manifests a multitude of symptoms, including neurological and immunological, and approximately a third of the 1990-1991 Gulf War (GW) veterans suffer from it. This study sought to characterize the acute neurochemical (monoamine) and neuroinflammatory profiles of two established GWI animal models...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.12.012
更新日期:2020-03-01 00:00:00
abstract::Neurotoxicology is entering a new phase in how it views and practices risk assessment. Perhaps more than any of the other disciplines that comprise the science of toxicology, it has been compelled to consider a daunting array of factors other than those directly coupled to chemical and dose, and the age and sex of the...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2008.04.004
更新日期:2008-09-01 00:00:00