Temporal effects of newly developed oximes (K027, K048) on malathion-induced acetylcholinesterase inhibition and lipid peroxidation in mouse prefrontal cortex.

Abstract:

:The potency of newly developed asymmetric bispyridinium oximes (K027, K048) in reactivating acetylcholinesterase and in eliminating oxidative stress induced by acute exposure to malathion was evaluated in mouse prefrontal cortex using in vivo methods. Malathion (1g/kg, dissolved in saline) was administered subcutaneously. The asymmetric bispyridinium oximes K027 or K048 (1/4 of LD(50), dissolved in saline, i.p.) were administered immediately after malathion and atropine sulfate (20mg/kg, dissolved in saline, i.p.). Control group received saline instead of malathion and antidotes. Acetylcholinesterase activity and biochemical parameters related to oxidative stress (glutathione levels, glutathione peroxidase and glutathione reductase activity and lipid peroxidation) were evaluated in mouse prefrontal cortex at two different time points (3 or 24 h after malathion poisoning). Malathion administration markedly inhibited cortical acetylcholinesterase activity (around 55%) at 3h after malathion challenge and such inhibition was maintained till 24 h after poisoning. Although neither atropine sulfate nor oximes were able to eliminate cortical acetylcholinesterase inhibition at 3h after malathion poisoning, K027 (in combination with atropine) completely eliminated the inhibitory effect of malathion exposure on cortical acetylcholinesterase activity at 24 h after malathion administration. K048 (in combination with atropine) significantly decreased acetylcholinesterase inhibition at 24 h after malathion poisoning. Even though glutathione levels and glutathione peroxidase and glutathione reductase activities were not affected, malathion administration markedly increased lipid peroxidation in the prefrontal cortex at 24 h after poisoning and the oxime K027 (in combination with atropine) was able to significantly decrease such phenomenon. Thus, our results clearly demonstrate that the newly developed asymmetric bispyridinium oximes K027 and K048 are able to reverse malathion-induced acetylcholinesterase inhibition in mouse prefrontal cortex. Moreover, the ameliorative effect of the oxime K027 on the increased lipid peroxidation observed at 24 h after malathion poisoning suggests a potential link between the hyperstimulation of cholinergic system and oxidative stress in the mouse prefrontal cortex after malathion exposure.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

da Silva AP,Farina M,Franco JL,Dafre AL,Kassa J,Kuca K

doi

10.1016/j.neuro.2007.10.005

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

184-9

issue

1

eissn

0161-813X

issn

1872-9711

pii

S0161-813X(07)00220-3

journal_volume

29

pub_type

杂志文章
  • Neurofilament protein crosslinking in gamma-diketone neuropathy: in vitro and in vivo studies using the seaworm myxicola infundibulum.

    abstract::Neurofilament (NF) protein crosslinking has been proposed as the ultimate pathogenetic mechanism underlying the neuropathies caused by the gamma-diketones 2,5-hexanedione (HD) and 3,4-dimethyl-2,5-hexanedione (DMHD). Mammalian models have been used to investigate this hypothesis, but alternative experimental models ar...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: St Clair MB,Anthony DC,Wikstrand CJ,Graham DG

    更新日期:1989-01-01 00:00:00

  • Results from eleven years of neurological health surveillance at a manganese oxide and salt producing plant.

    abstract::In 1983, Roels et al. (1987a, b) collected blood and urine samples and conducted neurological testing of workers at a manganese oxide and salt producing plant in Belgium, and at a nearby chemical plant. Workers from the manganese plant performed significantly worse than workers from the chemical plant on tests of shor...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Crump KS,Rousseau P

    更新日期:1999-04-01 00:00:00

  • Synergism between insecticides permethrin and propoxur occurs through activation of presynaptic muscarinic negative feedback of acetylcholine release in the insect central nervous system.

    abstract::Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta a...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2006.01.011

    authors: Corbel V,Stankiewicz M,Bonnet J,Grolleau F,Hougard JM,Lapied B

    更新日期:2006-07-01 00:00:00

  • Perinatal exposure to polychlorinated biphenyls alters excitatory synaptic transmission and short-term plasticity in the hippocampus of the adult rat.

    abstract::Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with cognitive deficits in humans and laboratory animals. Previous work has demonstrated a reduced capacity to support long-term potentiation (LTP) in animals exposed to a PCB mixture, Aroclor 1254 (A1254) via the dam in utero and throughou...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/S0161-813X(03)00073-1

    authors: Gilbert ME

    更新日期:2003-12-01 00:00:00

  • Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat.

    abstract::The ability of a supralethal dose of chlorpyrifos to produce delayed neuropathy was examined using assessments of clinical signs, electromyography (EMG), motor nerve conduction velocity (MNCV), lymphocyte neuropathy target esterase activity (LNTE), and histologic changes in nervous system tissues. Cats were exposed to...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Fikes JD,Zachary JF,Parker AJ,Beasley VR

    更新日期:1992-10-01 00:00:00

  • Acute cardiorespiratory effects of intracisternal injections of mercuric chloride.

    abstract::The present studies were conducted to changes arising from mercury poisoning in the central nervous system (CNS), with a focus on determining the receptors and neurotransmitters involved. Currently, little is known regarding the neurological basis of the cardiopulmonary effects of mercury poisoning. We evaluated chang...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2011.02.006

    authors: Azevedo BF,Futuro Neto Hde A,Stefanon I,Vassallo DV

    更新日期:2011-06-01 00:00:00

  • The use of neuroimaging techniques for clinical detection of neurotoxicity: a review.

    abstract::Although toxins exert their impact on a molecular level, they may yield molar effects by affecting areas large enough to be visualized by neuroimaging techniques. Therefore, neuroimaging of the brain may be used to render the macroscopic sequelae of neurotoxins visible. Toxic agents may induce brain edema or atrophy, ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Lang CJ

    更新日期:2000-10-01 00:00:00

  • Galantamine prevents long-lasting suppression of excitatory synaptic transmission in CA1 pyramidal neurons of soman-challenged guinea pigs.

    abstract::Galantamine, a drug currently approved for the treatment of Alzheimer's disease, has recently emerged as an effective pretreatment against the acute toxicity and delayed cognitive deficits induced by organophosphorus (OP) nerve agents, including soman. Since cognitive deficits can result from impaired glutamatergic tr...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2014.07.005

    authors: Alexandrova EA,Alkondon M,Aracava Y,Pereira EF,Albuquerque EX

    更新日期:2014-09-01 00:00:00

  • Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans.

    abstract::In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode Ca...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2019.07.002

    authors: Smith LL,Ryde IT,Hartman JH,Romersi RF,Markovich Z,Meyer JN

    更新日期:2019-09-01 00:00:00

  • A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells.

    abstract::Nickel, a known occupational/environmental hazard, may cross the placenta and reach appreciable concentrations in various fetal organs, including the brain. The aim of this study was to investigate whether nickel interferes with the process of neuronal differentiation. Following a 4 week treatment with retinoic acid (...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.01.001

    authors: Ceci C,Barbaccia ML,Pistritto G

    更新日期:2015-03-01 00:00:00

  • Postpartum exposure to triethyl tin produces long-term alterations in responsiveness to apomorphine.

    abstract::Male and female rat pups were exposed to a single dose of triethyl tin (TET) or ethanol vehicle on day 5 postnatally and tested for responsiveness to apomorphine as adults. TET-exposed animals displayed an increased response to the stereotypic effects of 1 mg/kg of apomorphine. Female rats exposed neonatally to TET ha...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Harry GJ,Tilson HA

    更新日期:1982-07-01 00:00:00

  • Chronic low-level lead exposure in monkeys does not affect simple reaction time.

    abstract::Simple visual reaction time was measured in a group of adult monkeys (Macaca fascicularis) dosed continuously with lead from birth onward, and in matched controls. Blood lead concentrations had been stable for 6 years at 33 micrograms/dl at the time of testing. The monkey was required to make contact with a stainless ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Rice DC

    更新日期:1988-04-01 00:00:00

  • Device for monitoring locomotor activity of 120 animals: motility of offspring of dams exposed to haloperidol.

    abstract::A device using four infra-red light photocells per cage which monitor simultaneously the motility of 120 individual rodents, was developed at our institute. The measuring interval can be chosen freely, the starting time may be set freely and the test may last several weeks. The motility of the offspring (day 35-39) of...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Thiel R,Chahoud I,Schwabe R,Neubert D

    更新日期:1989-10-01 00:00:00

  • The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.

    abstract::Chronic exposure to Mn results in the development of a neurological disorder known as manganism characterized by neurological deficits resembling that seen in Parkinsonism. Although dopaminergic neurons within the nigrostriatal pathway appear intact, Mn-induced irregularities in DA transmission have been observed incl...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2013.01.002

    authors: Roth JA,Li Z,Sridhar S,Khoshbouei H

    更新日期:2013-03-01 00:00:00

  • Qualitative and quantitative comparability of human and animal developmental neurotoxicants: a workshop summary.

    abstract::A Workshop on the Qualitative and Quantitative Comparability of Human and Animal Developmental Neurotoxicity was held in Williamsburg, Va. on April 11-13, 1989. Based upon data presented at the Workshop, the degree of qualitative and quantitative comparability between data obtained from humans and experimental animals...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Rees DC,Francis EZ,Kimmel CA

    更新日期:1990-07-01 00:00:00

  • Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells.

    abstract::Chlorpyrifos (CPF) is an organophosphorus pesticide that can damage the central nervous system in children upon exposure. Taxifolin (Tax) exerts protective effects against neurotoxins; however, the mechanism has not yet been illustrated. The current study used BV2 cells to investigate the protective mechanism underlyi...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2019.05.010

    authors: Zhang C,Zhan J,Zhao M,Dai H,Deng Y,Zhou W,Zhao L

    更新日期:2019-09-01 00:00:00

  • Transiently impaired neurogenesis in MPTP mouse model of Parkinson's disease.

    abstract::It is still being debated whether neurogenesis in the subventricular zone (SVZ) is enhanced in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injury in the adult mouse brain. Our previous studies provided evidence that MPTP induces apoptosis of migrating neuroblasts (neural progenitor cells, A cells) ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.07.007

    authors: He XJ,Nakayama H

    更新日期:2015-09-01 00:00:00

  • Age-related effects of chlorpyrifos on acetylcholine release in rat brain.

    abstract::Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE). Young animals are markedly more sensitive than adults to the acute toxicity of CPF. We evaluated acetylcholine (ACh) release and its muscarinic receptor-mediated regulation (i.e. muscarinic au...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(00)00009-7

    authors: Won YK,Liu J,Olivier K Jr,Zheng Q,Pope CN

    更新日期:2001-02-01 00:00:00

  • Multiple dose exposure effects on the tissue distribution of lead in the preweanling rat.

    abstract::The time dependent tissue/organ distribution of Pb resulting from repeated intragastric exposure of the preweanling rat to Pb acetate was investigated. On the day of parturition, 12 dams were assigned randomly either to control (nonhandled) or Pb-treated groups and their litters were culled to 8 pups. On days 6, 9, 12...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Massaro EJ,Miller GD,Massaro TF

    更新日期:1984-10-01 00:00:00

  • Toxic risks and nutritional benefits of traditional diet on near visual contrast sensitivity and color vision in the Brazilian Amazon.

    abstract:BACKGROUND:Visual functions are known to be sensitive to toxins such as mercury (Hg) and lead (Pb), while omega-3 fatty acids (FA) and selenium (Se) may be protective. In the Tapajós region of the Brazilian Amazon, all of these elements are present in the local diet. OBJECTIVE:Examine how near visual contrast sensitiv...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2013.04.010

    authors: Fillion M,Lemire M,Philibert A,Frenette B,Weiler HA,Deguire JR,Guimarães JR,Larribe F,Barbosa F Jr,Mergler D

    更新日期:2013-07-01 00:00:00

  • Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium.

    abstract::It is widely recognized that prolonged increases in reactive oxygen species (ROS) and intracellular free calcium ([Ca2+]i) are part of a signaling pathway leading to cell death. ROS production resulting in oxidative stress and disruption of calcium homeostasis leading to increases in [Ca2+]i have been described as ear...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Mundy WR,Freudenrich TM

    更新日期:2000-12-01 00:00:00

  • Inhibition of muscarinic receptor- and G-protein-dependent phosphoinositide metabolism in cerebrocortical membranes from neonatal rats by ethanol.

    abstract::Phosphoinositide (PtdIns) metabolism activated by cholinergic muscarinic receptors appears to play a role in brain development and has been recently suggested as a possible biochemical target for the developmental neurotoxicity of ethanol (EtOH). Recent experimental evidence indicates that, in rat brain, muscarinic re...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Candura SM,Manzo L,Costa LG

    更新日期:1992-04-01 00:00:00

  • Internalization of titanium dioxide nanoparticles by glial cells is given at short times and is mainly mediated by actin reorganization-dependent endocytosis.

    abstract::Many nanoparticles (NPs) have toxic effects on multiple cell lines. This toxicity is assumed to be related to their accumulation within cells. However, the process of internalization of NPs has not yet been fully characterized. In this study, the cellular uptake, accumulation, and localization of titanium dioxide nano...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.08.013

    authors: Huerta-García E,Márquez-Ramírez SG,Ramos-Godinez Mdel P,López-Saavedra A,Herrera LA,Parra A,Alfaro-Moreno E,Gómez EO,López-Marure R

    更新日期:2015-12-01 00:00:00

  • Performance alterations associated with occupational exposure to manganese--a meta-analysis.

    abstract::The review aimed at quantifying the evidence of performance effects resulting from occupational exposure to manganese. Epidemiological studies published between 1987 and 2008 were analyzed. The approach was based on the meta-analytical method of effect size estimates and sought to contribute to the following issues: (...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.neuro.2009.05.001

    authors: Meyer-Baron M,Knapp G,Schäper M,van Thriel C

    更新日期:2009-07-01 00:00:00

  • Assessment of neurotoxicity induced by oral administration of chlordecone (Kepone) in the mouse.

    abstract::Neurotoxicity in the mouse was produced following oral administration of chlordecone at 10, 25 and 50 mg/kg/day in corn oil vehicle. Hyperexcitability and tremors were observed on the 1st, 4th and 9th day after the administration of chlordecone at 50, 25 and 10 mg/kg/day, respectively, and mortality occurred on the 5t...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Huang TP,Ho IK,Mehendale HM

    更新日期:1981-01-01 00:00:00

  • Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy.

    abstract::Oxidative stress is believed to play a key role in the degeneration of dopaminergic neurons in the substantia nigra (SN) of Parkinson's disease (PD) patients. An important biochemical feature of PD is a significant early depletion in levels of the thiol antioxidant compound glutathione (GSH) which may lead to the gene...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(02)00035-9

    authors: Bharat S,Cochran BC,Hsu M,Liu J,Ames BN,Andersen JK

    更新日期:2002-10-01 00:00:00

  • Not all boronic acids with a five-membered cycle induce tremor, neuronal damage and decreased dopamine.

    abstract::Several striatal toxins can be used to induce motor disruption. One example is MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), whose toxicity is accepted as a murine model of parkinsonism. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mi...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2017.06.004

    authors: Pérez-Rodríguez M,García-Mendoza E,Farfán-García ED,Das BC,Ciprés-Flores FJ,Trujillo-Ferrara JG,Tamay-Cach F,Soriano-Ursúa MA

    更新日期:2017-09-01 00:00:00

  • Selective changes in gene expression in cortical regions sensitive to amphetamine during the neurodegenerative process.

    abstract::Gene expression profiles in several brain regions of adult male rats were evaluated following a d-amphetamine (AMPH) exposure paradigm previously established to produce AMPH neurotoxicity. Escalating doses of AMPH (5-30 mg/kg) were given over the course of 16 h per day in an 18 degrees C environment for 2 days. This p...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2003.08.005

    authors: Bowyer JF,Harris AJ,Delongchamp RR,Jakab RL,Miller DB,Little AR,O'Callaghan JP

    更新日期:2004-06-01 00:00:00

  • Effects of repeated hydrogen sulphide (H2S) exposure on learning and memory in the adult rat.

    abstract::The effects of repeated exposure (125 ppm) of hydrogen sulphide (H2S) on learning and memory in the rat were investigated. A 16-arm radial arm maze (RAM) was used to examine neurobehavioural functioning in a series of three experiments. Experiment 1 involved training animals on a complex spatial maze task, prior to a ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(01)00016-x

    authors: Partlo LA,Sainsbury RS,Roth SH

    更新日期:2001-04-01 00:00:00

  • Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of α7 nicotinic receptor, glutamate and oxidative stress.

    abstract::Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of th...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2018.04.011

    authors: Mónaco NM,Bartos M,Dominguez S,Gallegos C,Bras C,Esandi MDC,Bouzat C,Giannuzzi L,Minetti A,Gumilar F

    更新日期:2018-07-01 00:00:00