当前位置： SCI文献检索 > NEUROTOXICOLOGY期刊下所有文献 > In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints.

In vitro developmental neurotoxicity (DNT) testing: relevant models and endpoints.

Abstract：

:Environmental chemicals have a potential impact on children's health as the developing brain is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that very complex processes of cell development and maturation take place within a tightly controlled time frame. So different stages of brain development are susceptible to toxic effects at different time points. Additionally the adult brain is well protected against chemicals by the blood brain barrier (BBB) whereas the placenta only partially protects against harmful chemical exposure. Many metals easily cross the placenta and BBB barrier since even after the birth BBB is not entirely differentiated (until about 6 months after birth). Additionally, the susceptibility of infants and children is due to increased exposure, augmented absorption rates, and less efficient ability of defense mechanism in comparison to adults. The In Vitro Session during the 12th International Neurotoxicology Association meeting (Jerusalem, June, 2009) provided the opportunity to discuss the new challenges that have to be faced to create new type of safety assessments for regulatory requirements. The integration of various tests into testing strategies as well as combination of information-rich approaches with bioinformatics was discussed. Furthermore relevant models and endpoints for developmental neurotoxicity (DNT) evaluation using in vitro approach were presented. The primary neuronal cultures of cerebellar granule cells (CGCs) as well as 3D aggregate model and the possible application of human embryonic and adult stem cells was discussed pointing out the potential of these models to be used for DNT testing. The presented systems are relevant for DNT evaluation as the key processes of brain development such cell proliferation, migration and neuronal/glial differentiation are present. Furthermore, emerging technologies such as gene expression, electrical activity measurements and metabonomics have been identified as promising tools. In a combination with other assays the in vitro approach could be included into a DNT intelligent testing strategy to speed up the process of DNT evaluation mainly by initial prioritization of chemicals with DNT potential for further testing.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Bal-Price AK,Hogberg HT,Buzanska L,Lenas P,van Vliet E,Hartung T

doi

10.1016/j.neuro.2009.11.006

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

545-54

issue

5

eissn

0161-813X

issn

1872-9711

pii

S0161-813X(09)00271-X

journal_volume

31

pub_type

杂志文章

相关文献

NEUROTOXICOLOGY文献大全
  • Using self-report measures in neurobehavioural toxicology: can they be trusted?

    abstract：:Questionnaires are one of the most common methodologies used in research on neurobehavioural effects in occupational and environmental health, most commonly for gathering information on demographic characteristics, psychological or neurological symptoms, mood state, or exposure to hazards. Questionnaires are self-repo...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuro.2006.03.009

    authors： Williamson A

    更新日期：2007-03-01 00:00:00

  • The enigma of parkinsonism in chronic borderline mercury intoxication, resolved by challenge with penicillamine.

    abstract：:A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Finkelstein Y,Vardi J,Kesten MM,Hod I

    更新日期：1996-04-01 00:00:00

  • Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks.

    abstract：:ω-Agatoxin-IVA is a well known P/Q-type Ca(2+) channel blocker and has been shown to affect presynaptic Ca(2+) currents as well postsynaptic potentials. P/Q-type voltage gated Ca(2+) channels play a vital role in presynaptic neurotransmitter release and thus play a role in action potential generation. Monitoring spont...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2013.03.002

    authors： Knaack GL,Charkhkar H,Hamilton FW,Peixoto N,O'Shaughnessy TJ,Pancrazio JJ

    更新日期：2013-07-01 00:00:00

  • δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system.

    abstract：:There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage batte...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2011.03.006

    authors： Zheng G,Tian L,Liang Y,Broberg K,Lei L,Guo W,Nilsson J,Bergdahl IA,Skerfving S,Jin T

    更新日期：2011-08-01 00:00:00

  • Application of in vitro neurotoxicity testing for regulatory purposes: Symposium III summary and research needs.

    abstract：:Prediction of neurotoxic effects is a key feature in the toxicological profile of many compounds and therefore is required by regulatory testing schemes. Nowadays neurotoxicity assessment required by the OECD and EC test guidelines is based solely on in vivo testing, evaluating mainly effects on neurobehavior and neur...

    journal_title：Neurotoxicology

    pub_type：

    doi：10.1016/j.neuro.2008.02.008

    authors： Bal-Price AK,Suñol C,Weiss DG,van Vliet E,Westerink RH,Costa LG

    更新日期：2008-05-01 00:00:00

  • Animal models of autism spectrum disorders: information for neurotoxicologists.

    abstract：:Recent findings derived from large-scale datasets and biobanks link multiple genes to autism spectrum disorders. Consequently, novel rodent mutants with deletions, truncations and in some cases, overexpression of these candidate genes have been developed and studied both behaviorally and biologically. At the Annual Ne...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2009.07.002

    authors： Halladay AK,Amaral D,Aschner M,Bolivar VJ,Bowman A,DiCicco-Bloom E,Hyman SL,Keller F,Lein P,Pessah I,Restifo L,Threadgill DW

    更新日期：2009-09-01 00:00:00

  • Lead-induced changes in dopamine D1 sensitivity: modulation by drug discrimination training.

    abstract：:Prior studies have reported that Pb exposure results in enhanced sensitivity to both D1 and D2 dopamine agonists as indicated by left shifts of the dose-effect functions for the discrimination of these agonists from saline in drug discrimination procedures (Cory-Slechta and Widzowski, 1991). To further determine mecha...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Cory-Slechta DA,Pokora MJ,Fox RA,O'Mara DJ

    更新日期：1996-07-01 00:00:00

  • Resistance of mouse primary microglia and astrocytes to acrylonitrile-induced oxidative stress.

    abstract：:Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2017.09.013

    authors： Caito S,Park M,Aschner M

    更新日期：2017-12-01 00:00:00

  • Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese.

    abstract：:Manganese (Mn)-deficiency or Mn-excess can lead to adverse biological consequences. Central nervous system tissues, rich in dopaminergic neurons, are the targets whether the Mn gains entrance by inhalation, oral ingestion, or intravenous administration. Risk assessments with Mn need to ensure that brain concentrations...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：

    authors： Andersen ME,Gearhart JM,Clewell HJ 3rd

    更新日期：1999-04-01 00:00:00

  • Impact of gestational and lactational phthalate exposure on hypothalamic content of amino acid neurotransmitters and FSH secretion in peripubertal male rats.

    abstract：:This study investigated the effect of the pre- and perinatal exposure to di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that regulate reproduction in peripubertal male rats. DEHP at dose of 3 and 30mg/kg bw/day was administered orally to female rat since pregnancy onset until weaning. The male lit...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2010.06.006

    authors： Carbone S,Szwarcfarb B,Ponzo O,Reynoso R,Cardoso N,Deguiz L,Moguilevsky JA,Scacchi P

    更新日期：2010-12-01 00:00:00

  • Inhalation of 1-bromopropane causes excitation in the central nervous system of male F344 rats.

    abstract：:The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/S0161-813X(03)00049-4

    authors： Honma T,Suda M,Miyagawa M

    更新日期：2003-08-01 00:00:00

  • The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.

    abstract：:Chronic exposure to Mn results in the development of a neurological disorder known as manganism characterized by neurological deficits resembling that seen in Parkinsonism. Although dopaminergic neurons within the nigrostriatal pathway appear intact, Mn-induced irregularities in DA transmission have been observed incl...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2013.01.002

    authors： Roth JA,Li Z,Sridhar S,Khoshbouei H

    更新日期：2013-03-01 00:00:00

  • Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

    abstract：:A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2009.06.009

    authors： Manning-Boğ AB,Schüle B,Langston JW

    更新日期：2009-11-01 00:00:00

  • Breathing and heart rate during experimental solvent exposure of young adults with self-reported multiple chemical sensitivity (sMCS).

    abstract：:This paper deals with the assumption that young adults with self-reported multiple chemical sensitivity (sMCS) show a heightened sensitivity of autonomic functions during experimental solvent exposure. Male sMCS-subjects were selected (out of n=274) on the base of a German questionnaire on chemical and environmental s...

    journal_title：Neurotoxicology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/S0161-813X(02)00213-9

    authors： Haumann K,Kiesswetter E,van Thriel C,Blaszkewicz M,Golka K,Seeber A

    更新日期：2003-03-01 00:00:00

  • Inhibition of aldehyde detoxification in CNS mitochondria by fungicides.

    abstract：:Among the several converging factors leading to Parkinson's disease, epidemiological studies indicate a correlation between Parkinson's disease (PD) with living in a rural area and/or exposure to agricultural pesticides. In this present study, we examined the potential of multiple agricultural pesticides for their abi...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2006.08.008

    authors： Leiphon LJ,Picklo MJ Sr

    更新日期：2007-01-01 00:00:00

  • Acute exposure to lead acetate activates microglia and induces subsequent bystander neuronal death via caspase-3 activation.

    abstract：:Lead is one of the major pollutants of environment and is highly toxic to the functioning of central nervous system (CNS). The chronic exposure of this heavy metal is debilitating to the functional behavior of an organism. Studies have shown that acute exposure to Pb can lead to glial activation and secretion of cyto-...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2014.02.002

    authors： Kumawat KL,Kaushik DK,Goswami P,Basu A

    更新日期：2014-03-01 00:00:00

  • A potential role for altered protein phosphorylation in the mediation of developmental neurotoxicity.

    abstract：:Protein phosphorylation represents a major post-translational mechanism through which numerous physiological processes are regulated. In the central nervous system, many extracellular messengers appear to exert their effects by regulating the intracellular concentration of specific second messengers which in turn acti...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：

    authors： O'Callaghan JP

    更新日期：1994-04-01 00:00:00

  • Phthalates and neurotoxic effects on hippocampal network plasticity.

    abstract：:Phthalates are synthetically derived chemicals used as plasticizers in a variety of common household products. They are not chemically bound to plastic polymers and over time, easily migrate out of these products and into the environment. Experimental investigations evaluating the biological impact of phthalate exposu...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuro.2015.02.008

    authors： Holahan MR,Smith CA

    更新日期：2015-05-01 00:00:00

  • c-Fos immunoreactivity in the pig brain following deoxynivalenol intoxication: focus on NUCB2/nesfatin-1 expressing neurons.

    abstract：:Deoxynivalenol (DON), produced by the cereal-contaminating Fusarium fungi, is a major trichothecene responsible for mycotoxicoses in farm animals, including swine. The main effect of DON-intoxication is food intake reduction and the consequent body weight loss. The present study aimed to identify brain structures acti...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2012.10.020

    authors： Gaigé S,Bonnet MS,Tardivel C,Pinton P,Trouslard J,Jean A,Guzylack L,Troadec JD,Dallaporta M

    更新日期：2013-01-01 00:00:00

  • Strategies to limit brain injury and promote recovery of function.

    abstract：:Neurotoxicology integrates the best aspects of pharmacology, neuroscience, and toxicology and has established unique approaches, questions, and model systems. It has contributed to (i) isolating the multitude of environmental factors that damage the nervous system, (ii) characterizing the nature of the insult in both ...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：

    authors： Walsh TJ,Kelly RM,Stackman RW

    更新日期：1994-10-01 00:00:00

  • Depletion of striatal dopamine by the N-oxide of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

    abstract：:The N-oxide of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is the major metabolite found in vivo and excreted in urine after the parenteral administration of the neurotoxicant, MPTP. In mice (C57BL/6), stereotaxic injection of MPTP N-oxide (15 micrograms) into the neostriatum produced dopamine (DA) depletion s...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Lau YS,Fung YK,Trobough KL,Cashman JR,Wilson JA

    更新日期：1991-07-01 00:00:00

  • Neurophysiologic effects of chemical agent hydrolysis products on cortical neurons in vitro.

    abstract：:The neurophysiologic effects of chemical agent hydrolysis products were examined on cultured cortical neurons using multielectrode array (MEA) recording and the whole-cell patch clamp technique. Measurement of neuronal network extracellular potentials showed that the primary hydrolysis product of soman, pinacolyl meth...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/s0161-813x(01)00028-6

    authors： Pancrazio JJ,Keefer EW,Ma W,Stenger DA,Gross GW

    更新日期：2001-06-01 00:00:00

  • Anti- and pro-oxidant effects of quercetin stabilized by microencapsulation on interstitial cells of Cajal, nitrergic neurons and M2-like macrophages in the jejunum of diabetic rats.

    abstract：:Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2020.01.011

    authors： Vieira-Frez FC,Sehaber-Sierakowski CC,Perles JVCM,Bossolani GDP,Verri WA Jr,Nascimento RCD,Guarnier FA,Bordini HP,Blegniski FP,Martins HA,de Souza SRG,Lima FGDM,Lima MM,Silva BT,Iwanaga CC,Zanoni JN

    更新日期：2020-03-01 00:00:00

  • Ammonia at pathophysiologically relevant concentrations activates kynurenic acid synthesis in cultured astrocytes and neurons.

    abstract：:The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2006.01.004

    authors： Wejksza K,Rzeski W,Turski WA,Hilgier W,Dybel A,Albrecht J

    更新日期：2006-07-01 00:00:00

  • Clinical, biochemical, electrophysiologic, and histologic assessment of chlorpyrifos induced delayed neuropathy in the cat.

    abstract：:The ability of a supralethal dose of chlorpyrifos to produce delayed neuropathy was examined using assessments of clinical signs, electromyography (EMG), motor nerve conduction velocity (MNCV), lymphocyte neuropathy target esterase activity (LNTE), and histologic changes in nervous system tissues. Cats were exposed to...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Fikes JD,Zachary JF,Parker AJ,Beasley VR

    更新日期：1992-10-01 00:00:00

  • Olfactory adaptation, threshold shift and recovery at low levels of exposure to methyl isobutyl ketone (MIBK).

    abstract：:The anatomic position of olfactory receptors renders them vulnerable to airborne pollutants. Chamber inhalation studies have shown dose-dependent olfactory adaptation and temporary olfactory threshold perception shift for particular inhaled substances. The present study was undertaken to examine olfactory perception t...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Gagnon P,Mergler D,Lapare S

    更新日期：1994-10-01 00:00:00

  • Prenatal exposure to alcohol impairs social play behavior in adolescent male mice.

    abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2020.05.007

    authors： de Ávila MAP,Gonçalves RM,Nascimento ECC,Cabral LDM,Vilela FC,Giusti-Paiva A

    更新日期：2020-07-01 00:00:00

  • Respiratory manganese particle size, time-course and neurobehavioral outcomes in workers at a manganese alloy production plant.

    abstract：:The progression of manganism with chronic exposure to airborne manganese (Mn) is not well understood. Here, we further investigate the findings on exposure and neurobehavioral outcomes of workers from a silico- and ferromanganese production plant and non-exposed workers from the same community in 1990 and 2004, using ...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2014.03.015

    authors： Park RM,Bouchard MF,Baldwin M,Bowler R,Mergler D

    更新日期：2014-12-01 00:00:00

  • Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures.

    abstract：:The spatial and temporal patterns of spontaneous synchronous Ca2+ oscillations (SCOs) regulate physiological pathways that influence neuronal development, excitability, and health. Hippocampal neuronal cultures (HN) and neuron/glia co-cultures (HNG) produced from neonatal mice were loaded with Fluo-4/AM and SCOs recor...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2016.10.015

    authors： Cao Z,Xu J,Hulsizer S,Cui Y,Dong Y,Pessah IN

    更新日期：2017-01-01 00:00:00

  • Effects of dietary mineral levels on metabolism and requirements.

    abstract：:Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Fox MR

    更新日期：1983-10-01 00:00:00