Abstract：
:Domoic acid is a neurotoxin produced by algae and is found in seafood during harmful algal blooms. As a glutamate agonist, domoic acid inappropriately stimulates excitatory activity in neurons. At high doses, this leads to seizures and brain lesions, but it is unclear how lower, asymptomatic exposures disrupt neuronal activity. Domoic acid has been detected in an increasing variety of species across a greater geographical range than ever before, making it critical to understand the potential health impacts of low-level exposure on vulnerable marine mammal and human populations. To determine whether prolonged domoic acid exposure altered neuronal activity in hippocampal networks, we used a custom-made 512 multi-electrode array with high spatial and temporal resolution to record extracellular potentials (spikes) in mouse organotypic brain slice cultures. We identified individual neurons based on spike waveform and location, and measured the activity and functional connectivity within the neuronal networks of brain slice cultures. Domoic acid exposure significantly altered neuronal spiking activity patterns, and increased functional connectivity within exposed cultures, in the absence of overt cellular or neuronal toxicity. While the overall spiking activity of neurons in domoic acid-exposed cultures was comparable to controls, exposed neurons spiked significantly more often in bursts. We also identified a subset of neurons that were electrophysiologically silenced in exposed cultures, and putatively identified those neurons as fast-spiking inhibitory neurons. These results provide evidence that domoic acid affects neuronal activity in the absence of cytotoxicity, and suggest that neurodevelopmental exposure to domoic acid may alter neurological function in the absence of clinical symptoms.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Hiolski EM,Ito S,Beggs JM,Lefebvre KA,Litke AM,Smith DRdoi
10.1016/j.neuro.2016.08.004subject
Has Abstractpub_date
2016-09-01 00:00:00pages
215-224eissn
0161-813Xissn
1872-9711pii
S0161-813X(16)30144-9journal_volume
56pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Effects of d-amphetamine on the renal outer medullary potassium (ROMK1) channels were tested in the Xenopus oocytes expression system. Xenopus oocytes were injected with mRNA coding for wild-type or mutant ROMK1 channels. Giant inside-out patch-clamp recordings were performed. d-Amphetamine inhibited the activity of R...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.05.002
更新日期：2008-07-01 00:00:00
abstract：:Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the p...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.11.008
更新日期：2018-03-01 00:00:00
abstract：:The recently published crystal structure of monoamine oxidase (MAO) B was a major breakthrough for structural and functional understanding of flavin containing amine oxidases: it opens a new era of research and provides new opportunities to those interested in the biochemistry and pharmacology of those important drug ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/S0161-813X(03)00088-3
更新日期：2004-01-01 00:00:00
abstract：:Okadaic acid (OKA) is one of the main polyether toxins produced by marine microalgae which causes diarrhetic shellfish poisoning. It is a selective and potent inhibitor of serine/threonine phosphatases 1 and 2A induces hyperphosphorylation of tau in vitro and in vivo. The reduced activity of phosphatases like, protein...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.05.002
更新日期：2013-07-01 00:00:00
abstract：:Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1983-10-01 00:00:00
abstract：AIMS:The aim of the present study was to evaluate the toxicity of magnetic iron oxide nanoparticles (MIONs) which were synthesized using carob leaf extract on various brain areas of Wistar rats. MAIN METHODS:Carob leaf synthesized-MIONs were characterized using different techniques: Dynamic Light Scattering (DLS), Tra...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.12.014
更新日期：2020-03-01 00:00:00
abstract：:In a series of experiments, prenatal administration of phenytoin to rats at non-embryotoxic and non-teratogenic doses produced offspring exhibiting large and enduring abnormalities in behavior. Plasma drug concentrations on the last day of exposure in the dams were within the human therapeutic range for anticonvulsant...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1986-07-01 00:00:00
abstract：:This paper describes the development of the protocol for the International Programme on Chemical Safety (IPCS)-sponsored Collaborative Study on Neurobehavioral Screening Methods, including background on the methods and chemicals selected, as well as details concerning the conduct of the collaborative study, including ...
journal_title：Neurotoxicology
pub_type： 杂志文章,多中心研究
doi：
更新日期：1997-01-01 00:00:00
abstract：:Amyloid-beta, (Abeta) is a cytotoxic peptide implicated in the pathology of Alzheimers disease. The antioxidant enzyme catalase has been suggested to protect against Abeta cytotoxicity in both neuronal and non-neuronal cell types. Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(01)00064-x
更新日期：2001-12-01 00:00:00
abstract：:Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1994-10-01 00:00:00
abstract：:The mechanism of action of acrylamide (ACR) in producing a central-peripheral distal axonopathy is unknown. We have tested the hypothesis that ACR inhibition of enzymes of oxidative metabolism is responsible for compromise of the energy supply, thereby producing the neuropathy. A single 50 mg/kg i.p. dose of ACR resul...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Nonylphenols (NP) are endocrine-disruptors known to be widely present in our environment. This study evaluated the effects of 4-n-NP on neurobehavioral development and memory capacity after perinatal exposure on the offspring rats. Dams were gavaged with 4-n-NP (0, 50 and 200mg/kg/day) from gestational day 5 to postna...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.07.002
更新日期：2014-09-01 00:00:00
abstract：:Exposure to soman, a toxic organophosphate nerve agent, causes severe adverse effects and long term changes in the peripheral and central nervous systems. The goal of this study was to evaluate the ability of prophylactic treatments to block the deleterious effects associated with soman poisoning. scopolamine, a class...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-813x(02)00005-0
更新日期：2002-05-01 00:00:00
abstract：:The toxicology of tin is almost entirely the toxicology of the organic compounds of tin, for the metal itself and its inorganic compounds appear to be nearly harmless for practical purposes. Furthermore, the neurotoxicity of organotin is essentially that of trimethyltin and triethyltin. ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1984-07-01 00:00:00
abstract：:The purpose the present study was to determine if tolerance is developed to all behavioural effects produced by a single high dose of chlorpyrifos (CPF). For this, the study was divided in two phases; in the first phase, we studied the time course of the effects produced by treatment with a high dose of CPF (250 mg/kg...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.01.013
更新日期：2007-05-01 00:00:00
abstract：:Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelin...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
abstract：:A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
abstract：:The notion that maternal personality characteristics influence cognitive development in their children has been grounded in stress moderation theory. Maternal personality traits, such as self-esteem, may buffer maternal stressors or lead to improved maternal-child interactions that directly impact neurodevelopment. Th...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.11.006
更新日期：2008-03-01 00:00:00
abstract：:The Faroe Islands study is a prospective study designed to assess the neurological and behavioral consequences of in utero exposure to methylmercury (meHg). Maternal exposure to meHg was through consumption of fish and intermittent higher-level exposure through pilot whale meat, while consumption of pilot whale blubbe...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:Female monkeys were dosed with 0, 10, 25 or 50 micrograms/kg/day of mercury as methylmercuric chloride. When blood levels reached equilibrium, females were bred to untreated males. A total of 5, 1, 2, and 5 live infants were born in the four dose groups, respectively. Infants were separated from their mothers at birth...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:ω-Agatoxin-IVA is a well known P/Q-type Ca(2+) channel blocker and has been shown to affect presynaptic Ca(2+) currents as well postsynaptic potentials. P/Q-type voltage gated Ca(2+) channels play a vital role in presynaptic neurotransmitter release and thus play a role in action potential generation. Monitoring spont...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.03.002
更新日期：2013-07-01 00:00:00
abstract：:Morphine is recommended by WHO as the analgesic of choice for effective treatment of moderate to severe cancer pain . Indeed spinally administered morphine at small doses injected intrathecally (i.t.) or intracerebroventricularly into animals produces a profound antinociception at both spinal and supraspinal sites. Co...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2004.12.011
更新日期：2005-10-01 00:00:00
abstract：:Microtubule (Mt) populations show large differences in dynamic properties (i.e., turnover rates) among cell types, and even within the same cell type at different stages of the cell cycle or stages of differentiation. These differences in dynamic properties are correlated with altered sensitivity to Mt-disassembling d...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：BACKGROUND:Prenatal exposure to p,p'-DDE is associated with impairments in motor development during the first year of life, with no related repercussions on mental or motor development at 12-30 months and with impairments in cognitive areas, but not in perceptual and motor areas at preschool age. However, its associati...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.12.011
更新日期：2015-03-01 00:00:00
abstract：:The popular recreational drug, 3,4-methylenedioxymethamphetamine (MDMA) is often taken as intermittent binges by adolescents at dance clubs. The neurobiological mechanisms that underlie MDMA-induced psychiatric conditions are still poorly understood. In the present study, mimicking adolescent patterns of administratio...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.07.002
更新日期：2007-11-01 00:00:00
abstract：:Studies on the toxicokinetics and biochemical effects of acrylamide are reviewed in regard to their implications concerning the mechanism of acrylamide induced neuropathy. Specifically, investigations of the effects of acrylamide on several glycolytic enzymes including neuron-specific enolase and glyceraldehyde-3-phos...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:Environmental chemicals have a potential impact on children's health as the developing brain is much more vulnerable to injury caused by different classes of chemicals than the adult brain. This vulnerability is partly due to the fact that very complex processes of cell development and maturation take place within a t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.11.006
更新日期：2010-09-01 00:00:00
abstract：:Long term or chronic exposure to lead is associated with cognitive and other deficits in humans, which may reflect lead-induced changes in synaptic development and function. We believe that Drosophila has great potential as a model system for studying such changes. To test this, we compared the structure of single, id...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(02)00095-5
更新日期：2003-01-01 00:00:00
abstract：:In order to develop a better understanding of the role environmental toxicants may play in the onset and progression of neurodegenerative diseases, it has become increasingly important to optimize sensitive methods for quickly screening toxicants to determine their ability to disrupt neuronal function. The nematode Ca...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.07.002
更新日期：2019-09-01 00:00:00
abstract：:Skeletal muscle and peripheral nerve of mice exposed to subacute doses of chlordecone were examined by electron microscopy to characterize the induced pathology. Adult mice were given daily ip doses of chlordecone for 8 days, then sacrificed on days 8, 15, and 35 of the experiment. Sciatic nerve and gluteal muscle wer...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1985-04-01 00:00:00
