Abstract：
:The recently published crystal structure of monoamine oxidase (MAO) B was a major breakthrough for structural and functional understanding of flavin containing amine oxidases: it opens a new era of research and provides new opportunities to those interested in the biochemistry and pharmacology of those important drug targets. In particular, it allowed accurate modeling of human MAO A, both proteins sharing over 70% sequence identity. In the present contribution, we summarize the efforts made in order to obtain structural information on the human MAO A, including sequence analysis, secondary structure predictions, and preliminary models obtained by fold recognition and comparative modeling based on proteins sharing low sequence identity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Léonard N,Lambert C,Depiereux E,Wouters Jdoi
10.1016/S0161-813X(03)00088-3subject
Has Abstractpub_date
2004-01-01 00:00:00pages
47-61issue
1-2eissn
0161-813Xissn
1872-9711pii
S0161-813X(03)00088-3journal_volume
25pub_type
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