Action of alpha-tocopherol on vanadium-stimulated lipid peroxidation in rat brain.

Abstract:

:Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions. However, administration of alpha-tocopherol (335 or 585 mg/kg) in combination with sodium metavanadate decreased the vanadium-stimulated lipid peroxidation. Results revealed that vanadium directly triggered peroxidative reaction and alpha-tocopherol protected against vanadium-stimulated lipid peroxidation.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Haider SS,el-Fakhri M

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

79-85

issue

1

eissn

0161-813X

issn

1872-9711

journal_volume

12

pub_type

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