Abstract:
:To determine changes in response to N-methyl-D-aspartate (NMDA) and kainic acid (KA) in cerebellar granule cells of offspring of lead-exposed mothers, pregnant rats received 0.25% lead acetate in their drinking water 2 days after mating. The control animals were given sodium acetate (0.125%) in their drinking water. The cerebellar granule cells were cultured from 8-day old pups. Changes in the levels of cytosolic Ca++ and cGMP and the release of glutamic acid were measured using fura-2 spectrofluorometer, radio-immunoassay, and HPLC, respectively. Increases in cytosolic Ca++ in response to 50 microM of NMDA and KA were less responsive (77%) in the lead exposed group as compared to that of the control group. However, the maximum responses to KA were not different. The NMDA- and KA-stimulated release of glutamate from cerebellar granule cells prepared from lead-exposed pups were also significantly reduced. While the NMDA-induced elevation of cGMP was not affected in the lead-exposed pups, the normal KA-induced increases in cGMP level in cerebellar granule cells of lead-exposed pups was not observed. The specific binding of [3H]MK-801 was significantly lower in cerebellar granule cells of the lead-exposed pups. These results indicate that lead exposure to the mother affects excitatory amino acid systems during the development of the offspring.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Lim DK,Ho IKsubject
Has Abstractpub_date
1998-02-01 00:00:00pages
49-55issue
1eissn
0161-813Xissn
1872-9711journal_volume
19pub_type
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