Dopamine sensitive adenylate cyclase inactivation by organolead compounds.

Abstract:

:Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyclase is shown to be inhibited by trisubstituted organolead compounds as a consequence of competition with dopamine for the DA-1 receptor.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Wilson WE

doi

10.1016/0191-8869(82)90087-3

subject

Has Abstract

pub_date

1982-07-01 00:00:00

pages

100-7

issue

1

eissn

0161-813X

issn

1872-9711

journal_volume

3

pub_type

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