Abstract:
:Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyclase is shown to be inhibited by trisubstituted organolead compounds as a consequence of competition with dopamine for the DA-1 receptor.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Wilson WEdoi
10.1016/0191-8869(82)90087-3subject
Has Abstractpub_date
1982-07-01 00:00:00pages
100-7issue
1eissn
0161-813Xissn
1872-9711journal_volume
3pub_type
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