Abstract：
:Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case of mitoxantrone therapy in the first trimester and during the pregnancy. A 41-year-old woman affected with multiple sclerosis, conceived during therapy and continued mitoxantrone until 29 weeks and 3 days of her pregnancy. She delivered by cesarean section at 39 weeks a growth restricted female baby weighing 1950g without evidence of congenital malformations.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
De Santis M,Straface G,Cavaliere AF,Rosati P,Batocchi AP,Caruso Adoi
10.1016/j.neuro.2006.10.002subject
Has Abstractpub_date
2007-05-01 00:00:00pages
696-7issue
3eissn
0161-813Xissn
1872-9711pii
S0161-813X(06)00252-Xjournal_volume
28pub_type
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