当前位置： SCI文献检索 > NEUROTOXICOLOGY期刊下所有文献 > Ethanol inhibition of reduced frequency-dependent rundown of calcium currents in acutely dissociated MS/nDB neurons from chronic in vivo lead-exposed adult rats.

Ethanol inhibition of reduced frequency-dependent rundown of calcium currents in acutely dissociated MS/nDB neurons from chronic in vivo lead-exposed adult rats.

Abstract：

:Although it is well known that lead (Pb2+0 acutely blocks voltage-gated calcium currents (VGCCs) in mammalian neurons, little is known about the long-term effects of continuous exposure to this metal on VGCCs. In the present study, the effects of chronic lead exposure on VGCCs (with barium ions as the charge carrier) were studied using whole-cell patch-clamp electrophysiological techniques in acutely dissociated medial septum (MS)/nucleus diagonal band (nDB) neurons. Neither peak, end current amplitudes, nor the current-voltage relationship were affected by chronic lead exposure. However, VGCCs repetitively evoked at frequent 6 s intervals displayed diminished whole-cell current rundown after 2 min of stimulation in cells from chronic Pb-exposed rats compared to cells from control Na-exposed rats. Because rundown after repetitive stimulation at a slower rate (20 s intervals) was not different between Pb-exposed and Na-exposed, reduced rundown at 6 s intervals was probably due to decreased slow inactivation of voltage-gated calcium channels. Interestingly, acute application of 60 mM ethanol reversed the reduced rundown in cells from Pb-exposed rats while having no effect on cells from Na-exposed rats. Clearly, acute ethanol treatment antagonized the effect of chronic lead exposure, unlike the additive interaction we observed previously with synaptic plasticity (Grover and Frye, 1996). Acute application of 1 microM Pb2+ completely blocked VGCCs similarly in neurons from Na-exposed and Pb-exposed rats. These findings do not suggest that major adaptive changes in VGCCs have occurred during chronic in vivo exposure to lead. But, subtle changes in channel efficiency only revealed under conditions of repetitive stimulation may exist, and are reversed by ethanol. These subtle changes may be sufficient to influence neuroplasticity such as LTP.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Grover CA,Jasek MC,Frye GD,Griffith WH

subject

Has Abstract

pub_date

1997-01-01 00:00:00

pages

179-90

issue

1

eissn

0161-813X

issn

1872-9711

journal_volume

18

pub_type

杂志文章

相关文献

NEUROTOXICOLOGY文献大全
  • The molecular basis of microtubule stability in neurons.

    abstract：:Microtubule (Mt) populations show large differences in dynamic properties (i.e., turnover rates) among cell types, and even within the same cell type at different stages of the cell cycle or stages of differentiation. These differences in dynamic properties are correlated with altered sensitivity to Mt-disassembling d...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：

    authors： Falconer MM,Vaillant A,Reuhl KR,Laferrière N,Brown DL

    更新日期：1994-04-01 00:00:00

  • Inhibition of fatty acid amide hydrolase by chlorpyrifos in juvenile rats results in altered exploratory and social behavior as adolescents.

    abstract：:The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids through the inhibition of fatty acid amide hydrolase (FAAH) and decr...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2020.01.002

    authors： Carr RL,Alugubelly N,de Leon K,Loyant L,Mohammed AN,Patterson ME,Ross MK,Rowbotham NE

    更新日期：2020-03-01 00:00:00

  • Interactions between lead and essential elements: a review.

    abstract：:Young children are especially susceptible to the toxic effects of lead. Although the effects of overt lead intoxication have been well studied, critical information on the long-term effects of low level lead exposure is lacking. The results of recent clinical studies indicate that "chronic" low level lead exposure dur...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：

    authors： Miller GD,Massaro TF,Massaro EJ

    更新日期：1990-04-01 00:00:00

  • Chronic exposure to anesthetic gases affects balance control in operating room personnel.

    abstract：:Exposure to anesthetic gases is known to alter certain structures and functions of the central nervous system. As the effects of long-term exposure on balance control mechanisms have been the subject of few investigations, these were evaluated in 53 operating room personnel exposed to anesthetic gases and in 53 non-ex...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2004.11.002

    authors： Vouriot A,Gauchard GC,Chau N,Nadif R,Mur JM,Perrin PP

    更新日期：2005-03-01 00:00:00

  • Inhibition of gamma-aminobutyric acid-stimulated chloride flux in mouse brain vesicles by polychlorocycloalkane and pyrethroid insecticides.

    abstract：:Selected polychlorocycloalkane and pyrethroid insecticides were evaluated as inhibitors of gamma-aminobutyric acid (GABA)-dependent chloride flux into mouse brain vesicles. The inhibitory potencies of the polychlorocycloalkane insecticides, measured as concentrations producing 50% inhibition, spanned a 1200-fold conce...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Bloomquist JR,Adams PM,Soderlund DM

    更新日期：1986-10-01 00:00:00

  • Alpha-linolenic acid is a potent neuroprotective agent against soman-induced neuropathology.

    abstract：:Nerve agents are deadly threats to military and civilian populations around the world. Nerve agents cause toxicity to peripheral and central sites through the irreversible inhibition of acetylcholinesterase, the enzyme that metabolizes acetylcholine. Excessive acetylcholine accumulation in synapses results in status e...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2012.07.001

    authors： Pan H,Hu XZ,Jacobowitz DM,Chen C,McDonough J,Van Shura K,Lyman M,Marini AM

    更新日期：2012-10-01 00:00:00

  • The genome-wide expression profile of Scrophularia ningpoensis-treated thapsigargin-stimulated U-87MG cells.

    abstract：:The endoplasmic reticulum (ER) is a principal site for protein synthesis, protein folding, calcium storage, and calcium signaling. Thapsigargin (TG), an inducer of ER stress, inhibits ER-associated Ca(2+)-ATPase and disrupts Ca(2+) homeostasis. ER stress plays an important pathogenetic role in Alzheimer's disease, Par...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2009.02.006

    authors： Sohn SH,Ko E,Jeon SB,Lee BJ,Kim SH,Dong MS,Lee DU,Kwak JH,Kim Y,Shin M,Hong M,Bae H

    更新日期：2009-05-01 00:00:00

  • Triphenyl phosphite-induced neuropathy in the avian forebrain: a silver impregnation study of the visual and auditory systems of the Japanese quail.

    abstract：:Single subcutaneous injections of triphenyl phosphite (TPP) (62.5-500 mg/kg body weight) were made in the Japanese quail (Coturnix coturnix japonica). The extent and density of resultant central nervous system degeneration were mapped by using the Fink-Heimer silver impregnation method to selectively impregnate degene...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Varghese RG,Bursian SJ,Tobias C,Tanaka D Jr

    更新日期：1995-04-01 00:00:00

  • Oxaliplatin treatment impairs extension of sensory neuron neurites in vitro through miR-204 overexpression.

    abstract：:Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2018.07.009

    authors： López-González MJ,Soula A,Landry M,Favereaux A

    更新日期：2018-09-01 00:00:00

  • Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study.

    abstract：:Dopamine (DA) and serotonin (5-HT) seem to be involved in several of the effects of ethanol (EtOH). Acetaldehyde (AcH), especially in the brain, induces effects that mimic those of EtOH. The purpose of this study was to investigate the effects of local perfusion of EtOH and AcH on extracellular DA and 5-HT in the dors...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2015.12.011

    authors： Jamal M,Ameno K,Miki T,Tanaka N,Ito A,Ono J,Takakura A,Kumihashi M,Kinoshita H

    更新日期：2016-01-01 00:00:00

  • Chronic ethanol treatment alters purine nucleotide hydrolysis and nucleotidase gene expression pattern in zebrafish brain.

    abstract：:Ethanol is a widely consumed drug that acts on the central nervous system (CNS), modifying several signal transduction pathways activated by hormones and neurotransmitters. The zebrafish is an experimental model for the study of human diseases and the use of this species in biochemical and behavioral studies on alcoho...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2011.05.010

    authors： Rico EP,Rosemberg DB,Langoni Ada S,Souto AA,Dias RD,Bogo MR,Bonan CD,Souza DO

    更新日期：2011-12-01 00:00:00

  • Decision rules for assessment of chronic solvent-induced encephalopathy: Results in 2370 patients.

    abstract：:For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2012.06.005

    authors： Verberk MM,van der Hoek JA,van Valen E,Wekking EM,van Hout MS,Hageman G,van der Laan G,van Dijk FJ

    更新日期：2012-08-01 00:00:00

  • Consequences of acute Nav1.1 exposure to deltamethrin.

    abstract：BACKGROUND:Pyrethroid insecticides are the most popular class of insecticides in the world, despite their near-ubiquity, their effects of delaying the onset of inactivation of voltage-gated sodium (Nav) channels have not been well-evaluated in all the mammalian Nav isoforms. OBJECTIVE:Here we compare the well-studied ...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2016.12.005

    authors： James TF,Nenov MN,Tapia CM,Lecchi M,Koshy S,Green TA,Laezza F

    更新日期：2017-05-01 00:00:00

  • Not all boronic acids with a five-membered cycle induce tremor, neuronal damage and decreased dopamine.

    abstract：:Several striatal toxins can be used to induce motor disruption. One example is MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), whose toxicity is accepted as a murine model of parkinsonism. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mi...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2017.06.004

    authors： Pérez-Rodríguez M,García-Mendoza E,Farfán-García ED,Das BC,Ciprés-Flores FJ,Trujillo-Ferrara JG,Tamay-Cach F,Soriano-Ursúa MA

    更新日期：2017-09-01 00:00:00

  • Glia and fetal alcohol syndrome.

    abstract：:Glial cells and their interactions with neurons play vital roles during the ontogeny of the nervous system and in the adult brain. Alcohol intake during pregnancy can cause mental retardation and neurobehavioral disorders as well as fetal alcohol syndrome (FAS). Clinical and experimental evidence indicate that in uter...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：10.1016/s0161-813x(01)00037-7

    authors： Guerri C,Pascual M,Renau-Piqueras J

    更新日期：2001-10-01 00:00:00

  • Effect of succimer chelation therapy on postural balance and gait outcomes in children with early exposure to environmental lead.

    abstract：:This study investigated the influence of succimer chelation therapy in eliminating and/or minimizing lead-associated impairments of motor functions such as postural balance and locomotion or gait activities. In this study, postural balance and functional locomotion or gait were quantitated in 161 children in Cincinnat...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.neuro.2007.03.007

    authors： Bhattacharya A,Shukla R,Auyang ED,Dietrich KN,Bornschein R

    更新日期：2007-05-01 00:00:00

  • Protective effect of betulin on cognitive decline in streptozotocin (STZ)-induced diabetic rats.

    abstract：:Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2016.09.009

    authors： Ma C,Long H

    更新日期：2016-12-01 00:00:00

  • Behavioral manifestations of prolonged lead exposure initiated at different stages of the life cycle: II. Delayed spatial alternation.

    abstract：:Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Cory-Slechta DA,Pokora MJ,Widzowski DV

    更新日期：1991-01-01 00:00:00

  • Peripheral polyneuropathy after acute methanol poisoning: Six-year prospective cohort study.

    abstract：BACKGROUND:Methanol is a widely used industrial short-chain aliphatic alcohol with known neurotoxic properties. Mass poisoning outbreaks due to the consumption of methanol-adulterated alcoholic drinks present a challenge to healthcare providers due to the high mortality and serious central nervous system (CNS) damage i...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2020.04.010

    authors： Kotikova K,Klepis P,Ridzon P,Hlusicka J,Navratil T,Rulisek J,Zak I,Zakharov S

    更新日期：2020-07-01 00:00:00

  • Cholinergic-opioid interactions at brainstem respiratory chemosensitive areas in cats.

    abstract：:Central respiratory chemosensitivity has been ascribed to CO2-sensitive neurons located on the ventral brainstem surface. The effects of cholinergic mechanisms on CO2-sensitive neuronal activity recorded extracellularly at the brainstem respiratory chemosensitive area at the caudal ventral medullary surface (cVMS) wer...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Trouth CO,Millis RM,Bernard DG,Pan Y,Whittaker JA,Archer PW

    更新日期：1993-01-01 00:00:00

  • Synergism between insecticides permethrin and propoxur occurs through activation of presynaptic muscarinic negative feedback of acetylcholine release in the insect central nervous system.

    abstract：:Although synergism between pesticides has been widely documented, the physiological mechanisms by which an insecticide synergizes another remains unclear. Toxicological and electrophysiological studies were carried out on two susceptible pest species (the mosquito Culex quinquefasciatus and the cockroach Periplaneta a...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2006.01.011

    authors： Corbel V,Stankiewicz M,Bonnet J,Grolleau F,Hougard JM,Lapied B

    更新日期：2006-07-01 00:00:00

  • ER chaperone-metal interactions: links to protein folding disorders.

    abstract：:Chaperones in the endoplasmic reticulum play vital roles in the folding, assembly, and post-translational modification of secretory proteins and also recycle, refold, or initiate degradation of misfolded proteins. Chaperone deficiencies in either amount or function are implicated in the etiology or pathogenesis of Alz...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,评审

    doi：10.1016/j.neuro.2012.02.007

    authors： Tiffany-Castiglioni E,Qian Y

    更新日期：2012-06-01 00:00:00

  • Prenatal exposure to alcohol impairs social play behavior in adolescent male mice.

    abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2020.05.007

    authors： de Ávila MAP,Gonçalves RM,Nascimento ECC,Cabral LDM,Vilela FC,Giusti-Paiva A

    更新日期：2020-07-01 00:00:00

  • Brain ethanol-metabolizing enzymes are differentially expressed in lead-exposed animals after voluntary ethanol consumption: Pharmacological approaches.

    abstract：:Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acet...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2019.09.011

    authors： Mattalloni MS,Deza-Ponzio R,Albrecht PA,Fernandez-Hubeid LE,Cancela LM,Virgolini MB

    更新日期：2019-12-01 00:00:00

  • Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens.

    abstract：:Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelin...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Ehrich M,Jortner BS,Gross WB

    更新日期：1985-04-01 00:00:00

  • Sensitivity of immature neurons in culture to metal-induced changes in reactive oxygen species and intracellular free calcium.

    abstract：:It is widely recognized that prolonged increases in reactive oxygen species (ROS) and intracellular free calcium ([Ca2+]i) are part of a signaling pathway leading to cell death. ROS production resulting in oxidative stress and disruption of calcium homeostasis leading to increases in [Ca2+]i have been described as ear...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Mundy WR,Freudenrich TM

    更新日期：2000-12-01 00:00:00

  • Evoked potentials are modified by long term exposure to trichloroethylene.

    abstract：:Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：

    authors： Blain L,Lachapelle P,Molotchnikoff S

    更新日期：1992-04-01 00:00:00

  • Hyperglycemia exacerbates antiretroviral drug combination induced blood-brain barrier endothelial toxicity.

    abstract：:In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB) endothelial function. Immortalized human brain microvascular endothelial cell line (hCMEC/D3) was exposed to azidothymidine (AZT; a nucleoside reverse transcrip...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2016.06.011

    authors： Prasad S,Sajja RK,Kaisar MA,Cucullo L

    更新日期：2016-09-01 00:00:00

  • Thyroid hormone treatment alleviates the impairments of neurogenesis, mitochondrial biogenesis and memory performance induced by methamphetamine.

    abstract：:Chronic use of methamphetamine (MA), a neurotoxic psychostimulant, leads to long-lasting cognitive dysfunctions in humans and animal models. Thyroid hormones (THs) have several physiological actions and are crucial for normal behavioral, intellectual and neurological development. Considering the importance of THs in t...

    journal_title：Neurotoxicology

    pub_type： 杂志文章

    doi：10.1016/j.neuro.2019.05.003

    authors： Seyedhosseini Tamijani SM,Beirami E,Ahmadiani A,Dargahi L

    更新日期：2019-09-01 00:00:00

  • Prenatal bisphenol A (BPA) exposure alters the transcriptome of the neonate rat amygdala in a sex-specific manner: a CLARITY-BPA consortium study.

    abstract：:Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/...

    journal_title：Neurotoxicology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.neuro.2017.10.005

    authors： Arambula SE,Jima D,Patisaul HB

    更新日期：2018-03-01 00:00:00