Abstract：
:Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the present study, we tested if E2 and TX attenuate Mn-induced neurotoxicity in mice, assessing motor deficit and dopaminergic neurodegeneration. We implanted E2 and TX pellets in the back of the neck of ovariectomized C57BL/6 mice two weeks prior to a single injection of Mn into the striatum. One week later, we assessed locomotor activity and molecular mechanisms by immunohistochemistry, real-time quantitative PCR, western blot and enzymatic biochemical analyses. The results showed that both E2 and TX attenuated Mn-induced motor deficits and reversed the Mn-induced loss of dopaminergic neurons in the substantia nigra. At the molecular level, E2 and TX reversed the Mn-induced decrease of (1) glutamate aspartate transporter (GLAST) and glutamate transporter 1 (GLT-1) mRNA and protein levels; (2) transforming growth factor-α (TGF-α) and estrogen receptor-α (ER-α) protein levels; and (3) catalase (CAT) activity and glutathione (GSH) levels, and Mn-increased (1) malondialdehyde (MDA) levels and (2) the Bax/Bcl-2 ratio. These results indicate that E2 and TX afford protection against Mn-induced neurotoxicity by reversing Mn-reduced GLT1/GLAST as well as Mn-induced oxidative stress. Our findings may offer estrogenic agents as potential candidates for the development of therapeutics to treat Mn-induced neurotoxicity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Pajarillo E,Johnson J Jr,Kim J,Karki P,Son DS,Aschner M,Lee Edoi
10.1016/j.neuro.2017.11.008subject
Has Abstractpub_date
2018-03-01 00:00:00pages
280-288eissn
0161-813Xissn
1872-9711pii
S0161-813X(17)30231-0journal_volume
65pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Tolerance to the toxic effects of exposure to the organophosphate acetylcholinesterase inhibitor, disulfoton, was induced by giving multiple, sublethal doses of the compound to male rats. Tolerance was judged to have been induced when toxic signs of exposure, including weight loss, were reversed or diminished. Binding...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1981-12-01 00:00:00
abstract：:Development of the mammalian central nervous system is a complex process whose disruption may have severe and long-lasting consequences upon brain structure and function, potentially resulting in a neurodevelopmental disorder (NDD). Many NDDs are known to be genetic in origin, with symptom onset and their underlying m...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2016.10.017
更新日期：2017-01-01 00:00:00
abstract：:Neuroinflammation and microglia as the resident immune cells of the brain has garnered a significant amount of interest with regards to brain injury and neurotoxicology. Much of this interest and research has been focused on responses in the adult brain with little attention paid to the role of these cells during deve...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.03.013
更新日期：2012-06-01 00:00:00
abstract：:Recent findings derived from large-scale datasets and biobanks link multiple genes to autism spectrum disorders. Consequently, novel rodent mutants with deletions, truncations and in some cases, overexpression of these candidate genes have been developed and studied both behaviorally and biologically. At the Annual Ne...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.07.002
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiol...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.04.003
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. OBJECTIVES:To examine whether exposure to resin-based composite restorations is associated with neuropsychological de...
journal_title：Neurotoxicology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neuro.2012.08.001
更新日期：2012-10-01 00:00:00
abstract：:Nerve conduction velocities (NCV) of the median motor, median sensory, peroneal motor, and sural nerves were measured on 40 lead-exposed automobile production workers as part of a comprehensive health survey. Blood lead (Pb-B) and blood zinc protoporphyrin (ZPP) were measured. The control group (N = 31) consisted of w...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.04.009
更新日期：2009-07-01 00:00:00
abstract：:Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Bisphenol A (BPA) is a high volume endocrine disrupting chemical found in a wide variety of products including plastics and epoxy resins. Human exposure is nearly ubiquitous, and higher in children than adults. Because BPA has been reported to interfere with sex steroid hormone signaling, there is concern that develop...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.09.002
更新日期：2017-12-01 00:00:00
abstract：:The present studies were conducted to changes arising from mercury poisoning in the central nervous system (CNS), with a focus on determining the receptors and neurotransmitters involved. Currently, little is known regarding the neurological basis of the cardiopulmonary effects of mercury poisoning. We evaluated chang...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.02.006
更新日期：2011-06-01 00:00:00
abstract：:Lead (Pb) exposure has long been recognized to cause neurological alterations in both adults and children. While most of the studies in adults are related to higher dose exposure, epidemiological studies indicate cognitive decline and neurobehavioral alterations in children associated with lower dose environmental Pb ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2014.03.008
更新日期：2014-07-01 00:00:00
abstract：:Administration of 0.3% aluminum in drinking water elevated serum aluminum concentrations 8-fold in rats. Further, chronic treatment with aluminum for 2-3 mon, in both developing and adult rats, significantly decreased the levels of MAP-2 in brain, as determined by quantitative immunoblot analysis. Aluminum treatment a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：:Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the neurobehavioral effects produced by low levels of lead in wild animals. Herein we describe the neurobehavioral effects of lead on learning using herring gulls (Larus arge...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.01.005
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Bisphenol A (BPA) has been associated with impairments in children's behavior, but few studies have investigated its relationship with cognitive function. OBJECTIVE:To investigate the association of urinary BPA concentrations with cognitive domains and intelligence quotient (IQ) in Spanish boys. METHODS:BP...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.06.006
更新日期：2019-09-01 00:00:00
abstract：:Gulf War Illness (GWI) manifests a multitude of symptoms, including neurological and immunological, and approximately a third of the 1990-1991 Gulf War (GW) veterans suffer from it. This study sought to characterize the acute neurochemical (monoamine) and neuroinflammatory profiles of two established GWI animal models...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.12.012
更新日期：2020-03-01 00:00:00
abstract：:Environmental exposure to methylmercury (MeHg) during development is of concern because it is easily incorporated in children's body both pre- and post-natal, it acts at several levels of neural pathways (mitochondria, cytoskeleton, neurotransmission) and it causes behavioral impairment in child. We evaluated the effe...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.05.018
更新日期：2017-03-01 00:00:00
abstract：:In this study, we report initial results concerning the effects of elevated dietary trace metals upon delayed relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. Animals were assigned to a control diet as well as to diets with increased content of NiS0(4) and ZnS0(4) prior to immunization for EAE. Dur...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse di...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.06.005
更新日期：2013-09-01 00:00:00
abstract：:Sodium metavanadate (2.5, 3.5 or 5.0 mg/kg) administration to rats, intraperitoneally, for 7, 3 or 2 consecutive days was found to enhance lipid peroxidation in various rat brain fractions. However, administration of alpha-tocopherol (335 or 585 mg/kg) in combination with sodium metavanadate decreased the vanadium-sti...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1991-04-01 00:00:00
abstract：BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.06.013
更新日期：2016-09-01 00:00:00
abstract：:Manganese-deficient individuals have decreased manganese elimination. This observation has prompted suggestions that relative manganese deficiency may increase the risk for manganese neurotoxicity following inhalation exposure. The objective of this study was to determine whether dietary manganese intake influences th...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(01)00075-4
更新日期：2002-07-01 00:00:00
abstract：:Protein phosphorylation represents a major post-translational mechanism through which numerous physiological processes are regulated. In the central nervous system, many extracellular messengers appear to exert their effects by regulating the intracellular concentration of specific second messengers which in turn acti...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-04-01 00:00:00
abstract：:Mortality and morbidity by toxic metals is an important issue of occupational health. Lead is an ubiquitous heavy metal in our environment despite having no physiological role in biological systems. Being an homeostatic controller is expected that the autonomic nervous system would show a degree of impairment in lead ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.04.016
更新日期：2016-05-01 00:00:00
abstract：:Ethanol is one of the most widely consumed drugs in the world, and the effects of ethanol during early development include morphological and cognitive problems. The regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate and dopamine; t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.08.012
更新日期：2018-12-01 00:00:00
abstract：:Exposure to soman, a toxic organophosphate nerve agent, causes severe adverse effects and long term changes in the peripheral and central nervous systems. The goal of this study was to evaluate the ability of prophylactic treatments to block the deleterious effects associated with soman poisoning. scopolamine, a class...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章
doi：10.1016/s0161-813x(02)00005-0
更新日期：2002-05-01 00:00:00
abstract：:While hippocampus is a brain region particularly susceptible to the effects of MDMA, the cellular and molecular changes induced by MDMA are still to be fully elucidated, being the dosage regimen, the species and the developmental stage under study great variables. This study compared the effects of one and four days o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.06.001
更新日期：2015-07-01 00:00:00
abstract：:Cytoskeletal alteration is a key factor in neurodegenerative processes like Alzheimer's or Parkinson's disease. Colchicine is a microtubule-disrupting agent that binds to tubuline, inhibiting microtubule assembly, and which triggers apoptosis. The present research describes the transcriptional activation of molecules ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2007.11.007
更新日期：2008-03-01 00:00:00
abstract：:Lead is one of the major pollutants of environment and is highly toxic to the functioning of central nervous system (CNS). The chronic exposure of this heavy metal is debilitating to the functional behavior of an organism. Studies have shown that acute exposure to Pb can lead to glial activation and secretion of cyto-...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.02.002
更新日期：2014-03-01 00:00:00
