Abstract：
:In this study, we report initial results concerning the effects of elevated dietary trace metals upon delayed relapsing experimental allergic encephalomyelitis (EAE) in SJL mice. Animals were assigned to a control diet as well as to diets with increased content of NiS0(4) and ZnS0(4) prior to immunization for EAE. During a six month follow-up period, trends appeared which indicated that the incidence of EAE might be lower in the nickel-fed animals than in the comparison groups. EAE onset also seemed to occur later in the nickel group. Histopathologic ratings of standardized tissue sections suggested more widespread inflammatory disease of the central nervous system in the high zinc group.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Schiffer RB,Herndon RM,Eskin Tsubject
Has Abstractpub_date
1990-10-01 00:00:00pages
443-50issue
3eissn
0161-813Xissn
1872-9711journal_volume
11pub_type
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