Abstract:
:Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammatory and immunomodulatory properties. This study aimed to investigate the effects of sumatriptan on VCR-induced peripheral neuropathy in a rat model. Male Wistar rats were intraperitoneally injected with VCR and normal saline four times per week for 2 weeks. In the treatment group, sumatriptan (1 mg/kg) was administered intraperitoneally 30 min prior to VCR injection every day. Mortality rate, weight variations and histopathological changes were monitored. Hot plate, tail flick and motor nerve conduction velocity (MNCV) tests were used to evaluate sensory and motor neuropathy. Levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β) and caspase-3 in the dorsal ganglion root were assessed by quantitative reverse transcription-PCR (qRT-PCR). Moreover, the protein levels of p65 nuclear factor kappa B (NF-
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Khalilzadeh M,Panahi G,Rashidian A,Hadian MR,Abdollahi A,Afshari K,Shakiba S,Norouzi-Javidan A,Rahimi N,Momeny M,Dehpour ARdoi
10.1016/j.neuro.2018.06.012subject
Has Abstractpub_date
2018-07-01 00:00:00pages
279-286eissn
0161-813Xissn
1872-9711pii
S0161-813X(18)30236-5journal_volume
67pub_type
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