Abstract:
:Bismuth levels in blood and brain of rats have been measured following acute or subchronic administration of tri-potassium-dicitrato bismuthate (TDB) by intraperitoneal injection or by gavage. After parenteral administration, the presence of bismuth in blood was associated with appreciable bismuth concentrations in brain of treated animals (approximately equal to 10-30% of blood levels). In contrast, following oral treatment, no bismuth was detected in brain of animals, even at doses of TDB able to produce blood bismuth concentrations comparable with those obtained after intraperitoneal administration. The formation of different bismuth species in blood of treated animals depending upon the route of administration of TDB is suggested.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Abbracchio MP,Balduini W,Cavallaro A,Adamoli P,Fittipaldi M,Muzio F,Malandrino S,Cattabeni Fsubject
Has Abstractpub_date
1985-10-01 00:00:00pages
139-43issue
3eissn
0161-813Xissn
1872-9711journal_volume
6pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities. We have developed a rodent survival model of POX toxicity that is being used to evaluate chronic morbidity and to screen...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.08.008
更新日期:2014-09-01 00:00:00
abstract::Zinc is the second abundant trace element in the human central nervous system (CNS). Zinc homeostasis is impaired in the elderly population and Alzheimer's disease (AD) patients. Due to the failures of β-amyloid (Aβ)- and microtubule-associated protein tau (MAP-tau, tau)-targeting drugs, many researchers consider AD a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.07.003
更新日期:2020-09-01 00:00:00
abstract::The present studies were conducted to changes arising from mercury poisoning in the central nervous system (CNS), with a focus on determining the receptors and neurotransmitters involved. Currently, little is known regarding the neurological basis of the cardiopulmonary effects of mercury poisoning. We evaluated chang...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.02.006
更新日期:2011-06-01 00:00:00
abstract::Mining the brain metabolome to understand behavioural disruptions induced in mouse fed Hypochoeris radicata (L.), a neurotoxic plant for horse. C57BL/6J mice orally exposed to 9% H. radicata (HR) are metabolically competent laboratory animals which can be used as model of Australian stringhalt, a neurological horse di...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.06.005
更新日期:2013-09-01 00:00:00
abstract::Chlorpyrifos (CPF) is an organophosphorus pesticide that can damage the central nervous system in children upon exposure. Taxifolin (Tax) exerts protective effects against neurotoxins; however, the mechanism has not yet been illustrated. The current study used BV2 cells to investigate the protective mechanism underlyi...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.05.010
更新日期:2019-09-01 00:00:00
abstract::Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Previous investigations have presented evidence for an increased prevalence of late cognitive effects in dental personnel exposed to metallic mercury. We wanted to examine if there was a correlation between mercury exposure and cognitive effects in a Norwegian population of dental workers, and if so, to quantify the o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.04.012
更新日期:2009-11-01 00:00:00
abstract::Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environme...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
abstract::Methylmercury (MeHg) toxicity in humans manifests deficits in neurological function. Cases of prenatal exposure to mercury have established that the developing nervous system is most highly susceptible to perturbation by MeHg. At a cellular level, MeHg-induced defects result from altered neuronal proliferation, migrat...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.04.005
更新日期:2006-12-01 00:00:00
abstract::Epilepsy or seizure disorder is one of the most common neurological diseases in humans. Although genetic mutations in ion channels and receptors and some other risk factors such as brain injury are linked to epileptogenesis, the underlying cause for the majority of epilepsy cases remains unknown. Gene-environment inte...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2011.12.014
更新日期:2012-01-01 00:00:00
abstract::Approximately half of those who survive severe carbon monoxide (CO) poisoning develop delayed neurologic sequelae. Growing evidence supports the crucial role of free radicals in delayed brain injury associated with CO toxicity. Xanthine oxidase (XO) has been reported to play a pivotal role in the generation of reactiv...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.03.015
更新日期:2015-05-01 00:00:00
abstract::The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids through the inhibition of fatty acid amide hydrolase (FAAH) and decr...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.002
更新日期:2020-03-01 00:00:00
abstract::The Inuit from Nunavik (Northern Québec) are one of the most highly exposed populations to environmental contaminants in North America mainly due to the bioaccumulation of contaminants in fish and marine mammals that constitute an important part of their diet. This follow-up study aimed to assess the impact of exposur...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.05.010
更新日期:2012-10-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway. In humans, perinatal exposure to dioxin-like PCBs is associated with neurodevelopmental toxicity in child...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.11.012
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To investigate the nature of parkinsonism associated with liver cirrhosis, which entails examination of the integrity of the nigrostriatal dopaminergic system. METHODS:Consecutive patients who had concurrent liver cirrhosis and parkinsonism were investigated with MRI and dopamine transporter (DAT) single-pho...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the p...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.11.008
更新日期:2018-03-01 00:00:00
abstract::Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.05.007
更新日期:2020-07-01 00:00:00
abstract::Paclitaxel (Taxol), a chemotherapeutic agent used to treat breast and ovarian tumors, has been reported to induce a predominantly sensory neuropathy. Co-treatment with neurotrophic factors and paclitaxel has been proposed for preventing or reversing paclitaxel-induced peripheral neuropathy. Prosaposin, the precursor o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract::Low-to-moderate level developmental and adult lead exposure produces retinal dysfunction and/or degeneration in humans and experimental animals. Although high level in vivo or in vitro lead disrupts blood-brain-barrier tight junctions and increases its permeability, the blood-retinal-barrier (BRB) has not been examine...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.09.013
更新日期:2016-12-01 00:00:00
abstract::Male and female rat pups were exposed to a single dose of triethyl tin (TET) or ethanol vehicle on day 5 postnatally and tested for responsiveness to apomorphine as adults. TET-exposed animals displayed an increased response to the stereotypic effects of 1 mg/kg of apomorphine. Female rats exposed neonatally to TET ha...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1982-07-01 00:00:00
abstract::To evaluate the role of diet composition on nerve agent toxicity, rats were fed four distinct diets ad libitum for 28 d prior to challenge with 110 μg/kg (1.0 LD(50), sc) soman. The four diets used were a standard rodent diet, a choline-enriched diet, a glucose-enriched diet, and a ketogenic diet. Body weight was reco...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.03.001
更新日期:2011-06-01 00:00:00
abstract::Nerve conduction velocities (NCV) of the median motor, median sensory, peroneal motor, and sural nerves were measured on 40 lead-exposed automobile production workers as part of a comprehensive health survey. Blood lead (Pb-B) and blood zinc protoporphyrin (ZPP) were measured. The control group (N = 31) consisted of w...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1983-07-01 00:00:00
abstract::Heavy metal toxicity has been implicated in the pathogenesis of motor neuron diseases. In an attempt to assess the efficacy of chelating agents to remove mercury from motor neurons, we quantitated the effect of the chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3- dimercaptopropane -1-sulphonate (DMPS)...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::A variety of neurological disorders are associated with the loss of specific populations of neurons. Alzheimer's, Parkinson's, and Huntington's diseases present unique constellations of behavioral and neurological abnormalities which result from the degeneration of neurons in specific regions of the brain. Approaches ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1992-04-01 00:00:00
abstract::Several studies have demonstrated neurobehavioral impairment related to manganese (Mn) exposure in the workplace. Exposure to high doses of manganese is associated with irreversible neurodegenerative disorders resembling idiopathic Parkinson disease. Although there is a risk of Mn accumulation in the foetus during pre...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/S0161-813X(03)00058-5
更新日期:2003-08-01 00:00:00
abstract::Snake venom group IA secretory phospholipase A2 (sPLA2-IA) is known as a neurotoxin. Snake venom sPLA2s are neurotoxic in vivo and in vitro, causing synergistic neurotoxicity to cortical cultures when applied with toxic concentrations of glutamate. However, it has not yet been cleared sufficiently how sPLA2-IA exerts ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.12.009
更新日期:2013-03-01 00:00:00
abstract::The estimation of risk for health effects due to chemical exposure is important to the development of standards for regulating the manufacture, use and release of chemicals into the environment. The quantitative data used to develop risk estimates usually come from laboratory animal studies employing relatively high d...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1990-07-01 00:00:00
abstract::The Serotonin/Norepinephrine Reuptake Inhibitor (SNRI) antidepressant venlafaxine (VEN, Effexor(®)) has become one of the most common antidepressants detected in North American and European streams. Mammalian research has established that VEN exposure is associated with a range of structural, neurochemical, and functi...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.05.023
更新日期:2016-07-01 00:00:00
abstract::Skeletal muscle and peripheral nerve of mice exposed to subacute doses of chlordecone were examined by electron microscopy to characterize the induced pathology. Adult mice were given daily ip doses of chlordecone for 8 days, then sacrificed on days 8, 15, and 35 of the experiment. Sciatic nerve and gluteal muscle wer...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1985-04-01 00:00:00
abstract::The developing female brain represents a potential target for estrogenic environmental chemicals because it depends on estrogen but is exposed to low endogenous estrogen levels, thus facilitating competition by exogenous estrogen receptor (ER) agonists. We investigated effects of two estrogenic UV filters, 4-methylben...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2008.12.008
更新日期:2009-03-01 00:00:00