Abstract:
:Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI and its metabolites. Recordings from the 350 ppm group showed a significant (p less than 0.001) decrease in the amplitude of VEPs, while a significant (p less than 0.001) increase was observed in the 700 ppm group. Both effects were reversed to baseline values within six weeks after the last exposure. The observed modifications in VEP amplitudes were related to blood level of trichloroethanol. These results thus confirm the neuro-ophthalmotoxicity of TRI and support the hypothesis that trichloroethanol is a reliable marker of the effective neurotoxic dose of this organic solvent.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Blain L,Lachapelle P,Molotchnikoff Ssubject
Has Abstractpub_date
1992-04-01 00:00:00pages
203-6issue
1eissn
0161-813Xissn
1872-9711journal_volume
13pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::The neurobehavioral consequences of inhalational exposure to carbon disulfide (CS2) were evaluated as part of a joint project between the National Institute of Environmental Health Sciences and the U.S. Environmental Protection Agency. Behavioral changes in rats were measured using a functional observational battery (...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1998-02-01 00:00:00
abstract::The authors carried out neurological examination, visual evoked potentials (VEP) examination, and electromyography (EMG) on 77 workers, aged 21-61 yrs, who were exposed occupationally to Hgo vapors for 1-20 yrs (mean 9 yrs). The mean air-borne concentration of Hgo was 0.25 mg/m3 (range 0.02-1.00 mg m3), and the mean H...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::A pathological hallmark of Alzheimer's disease (AD), aggregation and deposition of amyloid-β peptides, has been recognized as a potent activator of microglia-mediated neuroinflammation and neuronal dysfunction. Therefore, downregulation of microglial activation has a significant therapeutic demand. In this study, focu...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.12.004
更新日期:2013-03-01 00:00:00
abstract::1-Methyl-4-phenylpyridinium ion (MPP+)-induced neurotoxicity produces cellular damage resembling that encountered in Parkinson's disease. The mechanisms of cellular death after MPP+ include the participation of oxidative stress in the loss of dopaminergic neurons. Among the mechanisms of defense against oxidative stre...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.10.011
更新日期:2021-01-01 00:00:00
abstract::Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.10.002
更新日期:2007-05-01 00:00:00
abstract::Inorganic mercury salts administered systemically at low mg/ml doses produce neurotoxic effects without penetrating the cerebral microvascular endothelial cells which form the blood-brain barrier (BBB). This phenomenon promoted investigations testing a hypothesis relating inorganic mercury-induced brain dysfunction to...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1994-01-01 00:00:00
abstract::Mouse embryonic stem cells (mESCs) represent an attractive cellular system for in vitro studies in developmental biology as well as toxicology because of their potential to differentiate into all fetal cell lineages. The present study aims to establish an in vitro system for developmental neurotoxicity testing employi...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.06.006
更新日期:2012-10-01 00:00:00
abstract::Free radical-induced brain oxidative injury is thought to play a role in the etiology and pathogenesis of neurodegenerative disorders. Iron (Fe) can catalyze the Fenton reaction and mediate hydroxyl radical (HO.) generation to initiate lipid peroxidation (LP). The neurotoxin aluminum (Al) can facilitate Fe-mediated LP...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::The development of new antiepileptic drugs is a high-risk/high-cost research field, which is made even riskier if the behavioral epileptic seizure profile is the unique approach on which the development is based. In order to increase the effectiveness of the screening conducted in the zebrafish model of status epilept...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.04.007
更新日期:2018-07-01 00:00:00
abstract::The organophosphorus insecticide chlorpyrifos (CPF) is suspected to cause developmental neurotoxicity in children leading to long term effects. Developmental exposure of rat pups to CPF at low levels disrupts degradation of the brain endocannabinoids through the inhibition of fatty acid amide hydrolase (FAAH) and decr...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.01.002
更新日期:2020-03-01 00:00:00
abstract::Pollution of hydrographic basins has affected the flora and fauna that thrive in these aquatic ecosystems, and fish, which constitute an important food resource, often contain a plethora of potentially toxic chemicals. In a major research project on early neurotoxic effects of environmental exposure to manganese among...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract:BACKGROUND:Prenatal exposure to p,p'-DDE is associated with impairments in motor development during the first year of life, with no related repercussions on mental or motor development at 12-30 months and with impairments in cognitive areas, but not in perceptual and motor areas at preschool age. However, its associati...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.12.011
更新日期:2015-03-01 00:00:00
abstract::The contribution of environmental toxicants to the etiology and risk of Parkinson's disease (PD) has been clearly established, with organochlorine insecticides routinely shown to damage the nigrostriatal dopamine pathway. Although PD is generally considered an adult onset disease, it has been postulated that exposure ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.07.008
更新日期:2014-09-01 00:00:00
abstract::The acute biocidal effects of organophosphorus pesticides are a central feature of modern agricultural chemistry, and also define the concerns of regulatory toxicology. Less well known, but more complex and idiosyncratic, is the potential for some agents to produce a delayed and progressive polyneuropathy--Organophosp...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1988-07-01 00:00:00
abstract::Both acute and chronic lead exposure have been found to inhibit transmission at chemical synapses, possibly by interfering with inward calcium current. We have found that chronic lead exposure slightly reduces input resistance and greatly reduces the junctional resistance between two strongly electrically coupled neur...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1984-01-01 00:00:00
abstract::Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.09.013
更新日期:2017-12-01 00:00:00
abstract:AIMS:The aim of the present study was to evaluate the toxicity of magnetic iron oxide nanoparticles (MIONs) which were synthesized using carob leaf extract on various brain areas of Wistar rats. MAIN METHODS:Carob leaf synthesized-MIONs were characterized using different techniques: Dynamic Light Scattering (DLS), Tra...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.12.014
更新日期:2020-03-01 00:00:00
abstract::The concentrations of 17 elements in the hair and nails of 180 Alzheimer's disease (AD) and control subjects have been determined by instrumental neutron activation analysis (INAA). Comparisons of trace element levels of properly matched AD and control groups revealed significant imbalances in the concentrations of si...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1988-07-01 00:00:00
abstract::Oxidative stress has been implicated in the pathogenesis of methylmercury (MeHg) neurotoxicity. Studies of mature neurons suggest that the mitochondrion may be a major source of MeHg-induced reactive oxygen species and a critical mediator of MeHg-induced neuronal death, likely by activation of apoptotic pathways. It i...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.07.006
更新日期:2011-10-01 00:00:00
abstract::Numerous specific genetic polymorphisms (PM) in the multi-gene families of cytochromes P450 (CYPs) and glutathione S-transferases (GSTs) have been described in the human population in the past decade. For example, one or more PM have been identified in human CYP1A1, CYP1B1, CYP2C9, CYP2C18, CYP2D6, and CYP2E1. Recent ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-01 00:00:00
abstract::The purpose the present study was to determine if tolerance is developed to all behavioural effects produced by a single high dose of chlorpyrifos (CPF). For this, the study was divided in two phases; in the first phase, we studied the time course of the effects produced by treatment with a high dose of CPF (250 mg/kg...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2007.01.013
更新日期:2007-05-01 00:00:00
abstract::Neuroimaging such as magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have been used in the last decade for investigating the neurotoxicolgy of manganese (Mn). Increased signal intensities on a T1-weighted image may reflect increased Mn deposi...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2005.12.002
更新日期:2006-05-01 00:00:00
abstract::Approximately half of those who survive severe carbon monoxide (CO) poisoning develop delayed neurologic sequelae. Growing evidence supports the crucial role of free radicals in delayed brain injury associated with CO toxicity. Xanthine oxidase (XO) has been reported to play a pivotal role in the generation of reactiv...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.03.015
更新日期:2015-05-01 00:00:00
abstract::Increasingly, the etiology of Parkinson's disease (PD) has been linked to exposures to environmental toxicants. This epidemiologic pilot study used a self-administered questionnaire among 34 PD cases and 22 other neurology clinic control patients. All subjects were at least 40 years old. Risk factors investigated incl...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1991-10-01 00:00:00
abstract::The effect of systemically administered diisopropylfluorophosphate (DFP) on the spontaneous firing rate and light-evoked responses of rat superior colliculus neurons was determined from average histograms of single unit and multiunit activity. DFP produced a dose-dependent increase in superior colliculus spontaneous a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Nerve agents (NAs) are potent organophosphorus (OP) compounds with applications in chemical warfare. OP compounds act by inhibiting acetylcholinesterase (AChE). Soman (O-pinacolyl methylphosphonofluoridate) is one of the most potent NAs. It is well known that small doses of NAs can be lethal, and that even non-lethal ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.01.007
更新日期:2018-03-01 00:00:00
abstract::To evaluate the role of diet composition on nerve agent toxicity, rats were fed four distinct diets ad libitum for 28 d prior to challenge with 110 μg/kg (1.0 LD(50), sc) soman. The four diets used were a standard rodent diet, a choline-enriched diet, a glucose-enriched diet, and a ketogenic diet. Body weight was reco...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.03.001
更新日期:2011-06-01 00:00:00
abstract::Organophosphate poisonings are not uncommon, and are the leading cause of death in suicide patients in Taiwan. Acute cholinergic crisis caused by the inhibition of synaptic acetylcholinesterase is the major manifestation of organophosphate poisoning and may cause death within minutes. Delayed neurotoxicities include i...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/s0161-813x(01)00044-4
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:To investigate the nature of parkinsonism associated with liver cirrhosis, which entails examination of the integrity of the nigrostriatal dopaminergic system. METHODS:Consecutive patients who had concurrent liver cirrhosis and parkinsonism were investigated with MRI and dopamine transporter (DAT) single-pho...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2010.05.002
更新日期:2010-08-01 00:00:00
abstract::Chronic exposure to Mn results in the development of a neurological disorder known as manganism characterized by neurological deficits resembling that seen in Parkinsonism. Although dopaminergic neurons within the nigrostriatal pathway appear intact, Mn-induced irregularities in DA transmission have been observed incl...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.01.002
更新日期:2013-03-01 00:00:00