Abstract：
:Approximately half of those who survive severe carbon monoxide (CO) poisoning develop delayed neurologic sequelae. Growing evidence supports the crucial role of free radicals in delayed brain injury associated with CO toxicity. Xanthine oxidase (XO) has been reported to play a pivotal role in the generation of reactive oxygen species (ROS) in CO poisoning. A recent report indicates that allopurinol both attenuated oxidative stress and possessed anti-inflammatory properties in an animal model of acute liver failure. In this study, we aimed to explore the potential of allopurinol to reduce the severity of delayed neurologic sequelae. The rats were first exposed to 1000 ppm CO for 40 min and then to 3000 ppm CO for another 20 min. Following CO poisoning, the rats were injected with allopurinol (50 mg/kg, i.p.) six times. Results showed that allopurinol significantly reduced neuronal death and suppressed expression of pro-inflammatory factors, including tumor necrosis factor-α, intercellular adhesion molecule-1, ionized calcium-binding adapter molecule 1, and degraded myelin basic protein. Furthermore, behavioral studies revealed an improved performance in the Morris water maze test. Our findings indicated that allopurinol may have protective effects against delayed neurologic sequelae caused by CO toxicity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Dong G,Ren M,Wang X,Jiang H,Yin X,Wang S,Wang X,Feng Hdoi
10.1016/j.neuro.2015.03.015subject
Has Abstractpub_date
2015-05-01 00:00:00pages
171-9eissn
0161-813Xissn
1872-9711pii
S0161-813X(15)00055-8journal_volume
48pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract：:Selenium (Se) supplementation in the nutritionally relevant range counteracts methylmercury (MeHg) toxicity. Since Se tends to be abundant in fish, MeHg exposures alone may not provide an accurate index of risk from fish consumption. Molar ratios of MeHg:Se in the diets and Hg:Se in tissues of exposed individuals may ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.07.007
更新日期：2008-09-01 00:00:00
abstract：:The chelating agent, CaNa2EDTA, has proven useful for both the diagnosis and treatment of lead poisoning. The EDTA lead-mobilization test has demonstrated the presence of excessive body lead stores when blood concentrations were "normal." The EDTA lead-mobilization test is, however, impractical because it requires inj...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1992-01-01 00:00:00
abstract：:Phthalates are synthetically derived chemicals used as plasticizers in a variety of common household products. They are not chemically bound to plastic polymers and over time, easily migrate out of these products and into the environment. Experimental investigations evaluating the biological impact of phthalate exposu...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2015.02.008
更新日期：2015-05-01 00:00:00
abstract：:The acute biocidal effects of organophosphorus pesticides are a central feature of modern agricultural chemistry, and also define the concerns of regulatory toxicology. Less well known, but more complex and idiosyncratic, is the potential for some agents to produce a delayed and progressive polyneuropathy--Organophosp...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1988-07-01 00:00:00
abstract：:Groups of rats received single subcutaneous injections of the highly toxic organophosphate compound, soman, in doses of 106, 133 or 165 micrograms/kg and were observed during the acute phase of intoxication. Survivors were killed at intervals up to fourteen days after exposure, and brain sections were examined by ligh...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1984-07-01 00:00:00
abstract：:During early pregnancy, iodine deficiency (ID) is linked to adverse effects on child motor and psychomotor function. Maternal marginal ID has become a common public health problem. It is unclear whether marginal ID influences the development of the cerebellum or its underlying mechanisms. Thus, the purpose of this stu...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.08.004
更新日期：2018-09-01 00:00:00
abstract：:Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of th...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.04.011
更新日期：2018-07-01 00:00:00
abstract：:Several striatal toxins can be used to induce motor disruption. One example is MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), whose toxicity is accepted as a murine model of parkinsonism. Recently, 3-Thienylboronic acid (3TB) was found to produce motor disruption and biased neuronal damage to basal ganglia in mi...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.06.004
更新日期：2017-09-01 00:00:00
abstract：:Inorganic mercury salts administered systemically at low mg/ml doses produce neurotoxic effects without penetrating the cerebral microvascular endothelial cells which form the blood-brain barrier (BBB). This phenomenon promoted investigations testing a hypothesis relating inorganic mercury-induced brain dysfunction to...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：:In this study, we sought to investigate how concomitant hyperglycemia influences the impact of combination antiretroviral therapy on blood-brain barrier (BBB) endothelial function. Immortalized human brain microvascular endothelial cell line (hCMEC/D3) was exposed to azidothymidine (AZT; a nucleoside reverse transcrip...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.06.011
更新日期：2016-09-01 00:00:00
abstract：:In aquatic ecosystems, mercury can become methylated and act as a potent environmental toxin, producing developmental and neurotoxic effects in a variety of species, including frogs. Molecular indicators provide a means of assessing exposure to methylmercury and for understanding how it and other environmental toxins ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:As obvious from the basic prerequisite of any particle in nanoscale, Zinc oxide nanoparticles (ZnO NPs) possess numerous tunable properties distinct from their bulk formulations. Emerging innovations in various sectors of nanotechnology are exploiting ZnO NPs largely. This inturn picks up the occasions of human exposu...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.04.008
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:Prenatal exposure to p,p'-DDE is associated with impairments in motor development during the first year of life, with no related repercussions on mental or motor development at 12-30 months and with impairments in cognitive areas, but not in perceptual and motor areas at preschool age. However, its associati...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.12.011
更新日期：2015-03-01 00:00:00
abstract：:Galantamine, a drug currently approved for the treatment of Alzheimer's disease, has recently emerged as an effective pretreatment against the acute toxicity and delayed cognitive deficits induced by organophosphorus (OP) nerve agents, including soman. Since cognitive deficits can result from impaired glutamatergic tr...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.07.005
更新日期：2014-09-01 00:00:00
abstract：:The neurophysiologic effects of chemical agent hydrolysis products were examined on cultured cortical neurons using multielectrode array (MEA) recording and the whole-cell patch clamp technique. Measurement of neuronal network extracellular potentials showed that the primary hydrolysis product of soman, pinacolyl meth...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(01)00028-6
更新日期：2001-06-01 00:00:00
abstract：:Perfluoroalkyl and polyfluoroalkyl substances are used in commercial applications and developmental exposure has been implicated in alterations in neurobehavioral functioning. While associations between developmental perfluorooctanoic acid (PFOA) exposure and human outcomes have been inconsistent, studies in experimen...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.11.008
更新日期：2017-01-01 00:00:00
abstract：:Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were expos...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:The current study was aimed to characterize for the first time the alterations in the characteristic neuro-inflammatory markers triggered by sarin exposure in the rat's brain, and to investigate its dependency on seizure duration. Centrally mediated seizures are a common consequence of exposure to organophosphates (OP...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.11.009
更新日期：2006-03-01 00:00:00
abstract：:The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.01.004
更新日期：2006-07-01 00:00:00
abstract：:Chronic use of methamphetamine (MA), a neurotoxic psychostimulant, leads to long-lasting cognitive dysfunctions in humans and animal models. Thyroid hormones (THs) have several physiological actions and are crucial for normal behavioral, intellectual and neurological development. Considering the importance of THs in t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.05.003
更新日期：2019-09-01 00:00:00
abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.05.007
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:Magnetic resonance spectroscopy (MRS) is a non-invasive method to quantify neurometabolite concentrations in the brain. Within the framework of the WELDOX II study, we investigated the association of exposure to manganese (Mn) and iron (Fe) with γ-aminobutyric acid (GABA) and other neurometabolites in the str...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.08.004
更新日期：2018-01-01 00:00:00
abstract：BACKGROUND:Methanol intoxication is an uncommon clinical problem leading to profound metabolic acidosis with serious neurological deterioration. We describe methanol induced brain lesions on diffusion-weighted MR images and discuss the pathophysiology of these lesions in light of diffusion changes. CASE REPORT:Brain i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:In normal cerebral development, language function typically becomes lateralized in the left hemisphere in most individuals. It is theorized that disturbances in the development of this cerebral asymmetry may result in language dysfunction such as dyslexia and dysphasia. Recently, it has been reported that language dis...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1988-10-01 00:00:00
abstract：:Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.01.011
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To investigate the nature of parkinsonism associated with liver cirrhosis, which entails examination of the integrity of the nigrostriatal dopaminergic system. METHODS:Consecutive patients who had concurrent liver cirrhosis and parkinsonism were investigated with MRI and dopamine transporter (DAT) single-pho...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2010.05.002
更新日期：2010-08-01 00:00:00
abstract：:Epigallocatechin gallate (EGCG) is one of most famous compounds of green tea. EGCG suppresses apoptosis induced by oxidative radical stress through several mechanisms. This study was designed to investigate whether EGCG plays a cytoprotective role by activating phosphatidylinositol-3 kinase (PI3K)/Akt-dependent anti-a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2004.02.001
更新日期：2004-09-01 00:00:00
abstract：:This evaluative review covers the neurotoxic effects of toluene. General health effects of toluene are also discussed in more limited detail. A brief description of chemical properties and environmental prevalence is given, followed by a review of pharmacokinetic data. General health effects include lethality, growth,...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1981-11-01 00:00:00
abstract：:Effects of d-amphetamine on the renal outer medullary potassium (ROMK1) channels were tested in the Xenopus oocytes expression system. Xenopus oocytes were injected with mRNA coding for wild-type or mutant ROMK1 channels. Giant inside-out patch-clamp recordings were performed. d-Amphetamine inhibited the activity of R...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.05.002
更新日期：2008-07-01 00:00:00
abstract：:Identification of critical receptors in seizure controlling brain regions may facilitate the development of more efficacious pharmacological therapies against nerve agent intoxication. In the present study, a number of drugs with anticonvulsant potency were microinfused into the perirhinal cortex (PRC) or posterior pi...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.10.002
更新日期：2010-01-01 00:00:00
