Abstract：
:Inorganic arsenic (iAs) is an important natural pollutant. Millions of individuals worldwide drink water with high levels of iAs. Arsenic exposure has been associated to cognitive deficits. However, the underlying mechanisms remain unknown. In the present work we investigated in female adult offspring the effect of the exposure to low arsenite sodium levels through drinking water during pregnancy and lactation on short- and long-term memory. We also considered a possible underlying neurotoxic mechanism. Pregnant rats were exposed during pregnancy and lactation to environmentally relevant iAs concentrations (0.05 and 0.10 mg/L). In 90-day-old female offspring, short-term memory (STM) and long-term memory (LTM) were evaluated using a step-down inhibitory avoidance task. In addition, we evaluated the α7 nicotinic receptor (α7-nAChR) expression, the transaminases and the oxidative stress levels in hippocampus. The results showed that the exposure to 0.10 mg/L iAs in this critical period produced a significant impairment in the LTM retention. This behavioral alteration might be associated with several events that occur in the hippocampus: decrease in α7-nAChR expression, an increase of glutamate levels that may produce excitotoxicity, and a decrease in the antioxidant enzyme catalase (CAT) activity.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Mónaco NM,Bartos M,Dominguez S,Gallegos C,Bras C,Esandi MDC,Bouzat C,Giannuzzi L,Minetti A,Gumilar Fdoi
10.1016/j.neuro.2018.04.011subject
Has Abstractpub_date
2018-07-01 00:00:00pages
37-45eissn
0161-813Xissn
1872-9711pii
S0161-813X(18)30125-6journal_volume
67pub_type
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