Abstract:
:Since both Pb exposure and aging have been associated with alterations in memory functions, this study compared the effects of Pb exposure initiated at early, middle and later stages of the life cycle on delayed spatial alternation performance. Young (21 day old), adult (8 mon old) and old (16 mon old) rats were exposed for a total duration of 8.5 mon to 0, 2 or 10 mg Pb acetate/kg/day (young rats) or 0, 1.9 or 9.3 mg Pb acetate/kg/day (adult and old rats) in drinking water. These doses were designed to produce equivalent brain Pb concentrations across the three age groups. Behavioral testing began after 4 mon of exposure utilizing a standard delayed alternation paradigm with delay values of 0, 3, 6, 9 and 12 sec presented randomly during each experimental session for a total of 40 sessions. Aging, as expected, was associated with impairments of accuracy, but the disruption of accuracy at the 0 sec delay suggested that these were performance rather than memory deficits. Pb exposure actually improved delayed spatial alternation performance in both young and old animals: accuracy values were increased, while error frequencies declined in the two age groups. The increases in accuracy occurred primarily at the longest delay value in young rats, but were more prominent at short delay values in old rats. This difference may have been the result of a ceiling effect, since accuracy for young rats at short delay values was already quite high. Delayed spatial alternation performance of adult rats was generally unaffected by Pb exposure. A possible explanation of the improved performance of young and old Pb-exposed rats is one based on response perseveration, i.e., a facilitation of rote alternation behavior engendered by the cued alternation training program. The results of this study suggest that both early and late stages of the life cycle must be considered periods of enhanced vulnerability to Pb-induced behavioral changes.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Cory-Slechta DA,Pokora MJ,Widzowski DVsubject
Has Abstractpub_date
1991-01-01 00:00:00pages
761-76issue
4eissn
0161-813Xissn
1872-9711journal_volume
12pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Bismuth levels in blood and brain of rats have been measured following acute or subchronic administration of tri-potassium-dicitrato bismuthate (TDB) by intraperitoneal injection or by gavage. After parenteral administration, the presence of bismuth in blood was associated with appreciable bismuth concentrations in br...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1985-10-01 00:00:00
abstract::The authors carried out neurological examination, visual evoked potentials (VEP) examination, and electromyography (EMG) on 77 workers, aged 21-61 yrs, who were exposed occupationally to Hgo vapors for 1-20 yrs (mean 9 yrs). The mean air-borne concentration of Hgo was 0.25 mg/m3 (range 0.02-1.00 mg m3), and the mean H...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-04-01 00:00:00
abstract::Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case o...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.10.002
更新日期:2007-05-01 00:00:00
abstract::Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the neurobehavioral effects produced by low levels of lead in wild animals. Herein we describe the neurobehavioral effects of lead on learning using herring gulls (Larus arge...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2005.01.005
更新日期:2005-08-01 00:00:00
abstract::Drinking water manganese (WMn) is a potential threat to children's health due to its associations with a wide range of outcomes including cognitive, behavioral and neuropsychological effects. Although adverse effects of Mn on cognitive function of the children indicate possible impact on their academic achievement lit...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.12.002
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Resin-based dental restorations may intra-orally release their components and bisphenol A. Gestational bisphenol A exposure has been associated with poorer executive functioning in children. OBJECTIVES:To examine whether exposure to resin-based composite restorations is associated with neuropsychological de...
journal_title:Neurotoxicology
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neuro.2012.08.001
更新日期:2012-10-01 00:00:00
abstract::This study investigated the relationship between neurobehavioral performance and pulmonary function in young and middle adults. Data were collected from 178 subjects (88 male, 90 female) aged 20-50 years. Neurobehavioral performance was assessed by the Korean version of The Swedish Performance Evaluation System (SPES-...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.03.019
更新日期:2007-03-01 00:00:00
abstract::Despite the large body of experimental evidence demonstrating the neuroprotective properties of 17beta-estradiol (17beta-E2) both in vitro and in vivo experimental models of neuronal injury, the exact mechanisms implicated in neuroprotection have not been fully delineated. Some experimental evidence highlight a role f...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2005.01.009
更新日期:2005-10-01 00:00:00
abstract::Ethanol is one of the most widely consumed drugs in the world, and the effects of ethanol during early development include morphological and cognitive problems. The regulation of adenosine levels is essential for the proper function of major neurotransmitter systems in the brain, particularly glutamate and dopamine; t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2018.08.012
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.04.009
更新日期:2009-07-01 00:00:00
abstract::Chlorpyrifos (CPF) is an organophosphorus insecticide that elicits toxicity through inhibition of acetylcholinesterase (AChE). Young animals are markedly more sensitive than adults to the acute toxicity of CPF. We evaluated acetylcholine (ACh) release and its muscarinic receptor-mediated regulation (i.e. muscarinic au...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(00)00009-7
更新日期:2001-02-01 00:00:00
abstract::Protein phosphorylation represents a major post-translational mechanism through which numerous physiological processes are regulated. In the central nervous system, many extracellular messengers appear to exert their effects by regulating the intracellular concentration of specific second messengers which in turn acti...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1994-04-01 00:00:00
abstract::There are reports suggesting that some autistic children are unable to mount an adequate response following exposure to environmental toxins. This potential deficit, coupled with the similarity in clinical presentations of autism and some heavy metal toxicities, has led to the suggestion that heavy metal poisoning mig...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.06.003
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Visual functions are known to be sensitive to toxins such as mercury (Hg) and lead (Pb), while omega-3 fatty acids (FA) and selenium (Se) may be protective. In the Tapajós region of the Brazilian Amazon, all of these elements are present in the local diet. OBJECTIVE:Examine how near visual contrast sensitiv...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.04.010
更新日期:2013-07-01 00:00:00
abstract::Diethyldithiocarbamate (DDC) has been shown to enhance 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal dopamine depletion in mice. Surprisingly, although DDC is a prototypic member of a class of compounds called dithiocarbamates (DTCs) that are widely used in industry and agriculture, only one stu...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:2000-06-01 00:00:00
abstract::Approximately half of those who survive severe carbon monoxide (CO) poisoning develop delayed neurologic sequelae. Growing evidence supports the crucial role of free radicals in delayed brain injury associated with CO toxicity. Xanthine oxidase (XO) has been reported to play a pivotal role in the generation of reactiv...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.03.015
更新日期:2015-05-01 00:00:00
abstract::There is a wide variation in sensitivity to lead (Pb) exposure, which may be due to genetic susceptibility towards Pb. We investigated whether a polymorphism (rs1800435) in the δ-aminolevulinic acid dehydratase (ALAD) gene affected the toxicokinetics and toxicodynamics of Pb. Among 461 Chinese Pb-exposed storage batte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2011.03.006
更新日期:2011-08-01 00:00:00
abstract::Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Mercury (Hg) is considered one of the worlds most toxic metals. Current thinking suggests that exposure to mercury occurs primarily from seafood contamination and rare catastrophic events. Recently, another common source of exposure has been identified. Thimerosal (TMS), a preservative found in many infant vaccines, c...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(01)00067-5
更新日期:2001-10-01 00:00:00
abstract::For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.06.005
更新日期:2012-08-01 00:00:00
abstract::Exposure to anesthetic gases is known to alter certain structures and functions of the central nervous system. As the effects of long-term exposure on balance control mechanisms have been the subject of few investigations, these were evaluated in 53 operating room personnel exposed to anesthetic gases and in 53 non-ex...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.11.002
更新日期:2005-03-01 00:00:00
abstract::Glial cells and their interactions with neurons play vital roles during the ontogeny of the nervous system and in the adult brain. Alcohol intake during pregnancy can cause mental retardation and neurobehavioral disorders as well as fetal alcohol syndrome (FAS). Clinical and experimental evidence indicate that in uter...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/s0161-813x(01)00037-7
更新日期:2001-10-01 00:00:00
abstract:BACKGROUND:Prenatal chemical exposures may adversely affect neurodevelopment, but few studies have examined the persistence of these associations. We examined whether associations between prenatal bisphenol A (BPA) or polybrominated diphenyl ether (PBDE) exposures persist or resolve as children age. METHODS:We followe...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.07.027
更新日期:2017-09-01 00:00:00
abstract::In a pilot study, serum dopamine beta-hydroxylase (DBH), platelets monoamine oxidase type B (MAO B) activities and basal plasma prolactin (PRL) were measured, among 10 workers occupationally exposed to toluene and 10 control subjects, preceding and immediately following vacation. Six exposed subjects were employed in ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::Methyl mercury (MeHg) is highly toxic to the developing nervous system. Human exposure is mainly from fish consumption since small amounts are present in all fish. Findings of developmental neurotoxicity following high-level prenatal exposure to MeHg raised the question of whether children whose mothers consumed fish ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2006.05.016
更新日期:2006-09-01 00:00:00
abstract:BACKGROUND:Long-term exposure to organic solvents may lead to chronic solvent induced encephalopathy (CSE) in painters. In combination with reduction of exposure, a workers' health surveillance programme was developed, resulting in a three-stage CSE screening procedure for early neurobehavioural changes possibly predic...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.05.015
更新日期:2012-08-01 00:00:00
abstract::We have recently observed that DDT and a DDT metabolite, DDOH, conjugated to a fatty acid, palmitic acid, DDOH-PA, affects muscarinic cholinergic receptors (MAChR) in the neonatal mouse brain when given to suckling mice during rapid brain growth. This early exposure of the neonatal mouse also affects the behaviour of ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1990-07-01 00:00:00
abstract::Acrylonitrile (ACN) is a widely used chemical in the production of plastics, resin, nitrile, acrylic fibers, synthetic rubber, and acrylamide. ACN is considered a Group 2B possible carcinogen in humans and is known to cause gliomas in rats. These gliomas are predominantly composed of microglia and not astrocytes. Inte...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.09.013
更新日期:2017-12-01 00:00:00
abstract::The purpose of this study was to determine whether the regional brain biogenic amine levels in adult rats were altered by pre- and post-natal exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). Pregnant rats were daily orally exposed to 70 mg/kg per day of 2,4-D from gestation day (GD) 16 to post-partum day (PPD) 23. ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00156-0
更新日期:2003-01-01 00:00:00