Abstract:
:Developmental exposure to polychlorinated biphenyls (PCBs) has been associated with cognitive deficits in humans and laboratory animals. Previous work has demonstrated a reduced capacity to support long-term potentiation (LTP) in animals exposed to a PCB mixture, Aroclor 1254 (A1254) via the dam in utero and throughout the preweaning period [Brain Res. 850;1999:87-95; Toxicol. Sci. 57;2000:102-11]. Assessment of normalized input/output (I/O) functions collected prior to LTP induction failed to reveal consistent differences in baseline synaptic transmission between control and PCB-exposed groups. The present study was designed to systematically evaluate excitatory and inhibitory synaptic transmission using a more extensive I/O analysis and paired pulse functions to assess short-term plasticity. Pregnant Long-Evans rats were administered either corn oil (control) or 6 mg/kg per day of A1254 by gavage from gestational day (GD) 6 until pups were weaned on postnatal day (PND) 21. In adult male offspring (5-11 months of age), field potentials evoked by perforant path stimulation were recorded in the dentate gyrus under urethane anesthesia. Detailed I/O functions were assessed by averaging the responses evoked in the dentate gyrus to stimulus pulses delivered to the perforant path in an extensive ascending intensity series. Population spike (PS) and postsynaptic potential (PSP) amplitudes recorded in the dentate gyrus were significantly enhanced in PCB-exposed animals relative to controls at midrange intensities. No group differences were observed in EPSP slope amplitudes. Short-term plasticity was assessed by delivering pairs of stimulus pulses at interpulse intervals (IPIs) ranging from 10 to 70 ms. In the dentate gyrus this range of intervals activates both inhibitory and excitatory mechanisms leading to a pattern of depression at brief intervals (<30 ms) followed by facilitation as the interval between pulses is extended. Paired pulse depression was decreased at an intermediate IPI (30 ms) with submaximal stimulus intensities. These data augment previous work demonstrating persistent changes in hippocampal plasticity as a result of exposure to PCBs during development. Furthermore, as increases in field potential amplitudes were observed, these findings support previous conclusions that A1254-induced LTP deficits are not readily attributable to reductions in synaptic excitability. Thus, in addition to impairment in use-dependent synaptic plasticity reported previously, the present report reveals that basic components of information processing within the hippocampus are permanently altered as a result of perinatal exposure to PCBs.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Gilbert MEdoi
10.1016/S0161-813X(03)00073-1subject
Has Abstractpub_date
2003-12-01 00:00:00pages
851-60issue
6eissn
0161-813Xissn
1872-9711pii
S0161-813X(03)00073-1journal_volume
24pub_type
杂志文章相关文献
NEUROTOXICOLOGY文献大全abstract::Neuroimaging such as magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have been used in the last decade for investigating the neurotoxicolgy of manganese (Mn). Increased signal intensities on a T1-weighted image may reflect increased Mn deposi...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/j.neuro.2005.12.002
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2016.06.013
更新日期:2016-09-01 00:00:00
abstract::Intracerebral injection of methylmercury (CH3Hg) into the mouse brain resulted in significant weight loss and the appearance of characteristic neurological disturbances associated with CH3Hg intoxication. Neurological effects appeared dependent upon a minimum injected dose of 16 micrograms of CH3Hg corresponding to a ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1987-07-01 00:00:00
abstract::The subchronic neurotoxic effects of isobutanol were studied by exposing Sprague-Dawley rats to isobutanol vapor concentrations of 0, 250, 1000, and 2500 ppm for 6 hrs/day, 5 days/wk, for 3 months. A comprehensive set of neurotoxicity tests (functional observational battery, motor activity, perfusion fixation neuropat...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::The recently published crystal structure of monoamine oxidase (MAO) B was a major breakthrough for structural and functional understanding of flavin containing amine oxidases: it opens a new era of research and provides new opportunities to those interested in the biochemistry and pharmacology of those important drug ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:10.1016/S0161-813X(03)00088-3
更新日期:2004-01-01 00:00:00
abstract::Long-term exposure to high manganese (Mn) levels can lead to Parkinson-like neurological disorders. Molecular mechanisms underlying Mn cytotoxicity have been not defined. It is known that Mn induces apoptosis in PC12 cells and that this involves the activation of some signal transduction pathways. Although the role of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.07.006
更新日期:2013-12-01 00:00:00
abstract::Methylmercury has been designated a "behavioral teratogen" because of its ability to evoke abnormalities in the absence of gross morphological damage to the developing brain. Recent work indicates that exposure to doses of methylmercury associated with neurobehavioral actions causes early alterations in brain ornithin...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1987-04-01 00:00:00
abstract::Application of the widely used immunosuppressant (ISS) cyclosporine (CsA) is severely limited by a number of serious side-effects such as kidney and neurotoxicity. As we have shown before, CsA exhibits metabolic toxicity in brain-models. The macrolide ISSs sirolimus (SRL) and everolimus (RAD) are capable of modulating...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2010.10.006
更新日期:2011-01-01 00:00:00
abstract::MPP(+) (1-methyl-4-phenylpyridinium; the active metabolite of the neurotoxin MPTP (1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine)) depletes dopamine (DA) content and elicits cell death in PC12 cells. However, the mechanism of MPP(+)-induced neurotoxicity is still unclear. In this study, the dose response and time-cours...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.12.008
更新日期:2005-08-01 00:00:00
abstract::Gadolinium is a rare-earth lanthanide metal ion and is used as organic gadolinium complexes in magnetic resonance imaging (MRI). Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2008.10.003
更新日期:2009-01-01 00:00:00
abstract::This study examined the significance of nerve microviscosity changes which occur in 2,5-hexanedione (2,5-HD) neurotoxicity. To establish a correlation between microviscosity changes and neuronal damage, a standard axonal neuropathy (nerve section) was employed. Electrophysiological studies of the sciatic-tibial nerve ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1981-11-01 00:00:00
abstract::The in vitro and vivo effects of lead on the NMDA-receptors in adult and juvenile mice were studied by means of receptor binding assays. Adult female NMRI-mice received 100 and 1,000 ppm lead as nitrate in their drinking water for 30 and 90 days. Perinatal exposure was achieved by treating gestating mice from the 5th ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Neurotoxicology integrates the best aspects of pharmacology, neuroscience, and toxicology and has established unique approaches, questions, and model systems. It has contributed to (i) isolating the multitude of environmental factors that damage the nervous system, (ii) characterizing the nature of the insult in both ...
journal_title:Neurotoxicology
pub_type: 杂志文章,评审
doi:
更新日期:1994-10-01 00:00:00
abstract::The purpose of this study was to determine whether the regional brain biogenic amine levels in adult rats were altered by pre- and post-natal exposure to 2,4-dichlorophenoxyacetic acid (2,4-D). Pregnant rats were daily orally exposed to 70 mg/kg per day of 2,4-D from gestation day (GD) 16 to post-partum day (PPD) 23. ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/s0161-813x(02)00156-0
更新日期:2003-01-01 00:00:00
abstract::Currently, 26 mineral elements are considered important for humans; these include essential trace and macro elements, two that may be required, and others of concern solely for their toxic properties. Almost all elements are toxic at high intakes, and excessive consumption of dietary mineral supplements is a source of...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1983-10-01 00:00:00
abstract::Identification of critical receptors in seizure controlling brain regions may facilitate the development of more efficacious pharmacological therapies against nerve agent intoxication. In the present study, a number of drugs with anticonvulsant potency were microinfused into the perirhinal cortex (PRC) or posterior pi...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.10.002
更新日期:2010-01-01 00:00:00
abstract::Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson's disease (PD). In the p...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2017.11.008
更新日期:2018-03-01 00:00:00
abstract::Phosphoinositide (PtdIns) metabolism activated by cholinergic muscarinic receptors appears to play a role in brain development and has been recently suggested as a possible biochemical target for the developmental neurotoxicity of ethanol (EtOH). Recent experimental evidence indicates that, in rat brain, muscarinic re...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::For the diagnosis of patients suspected of chronic solvent-induced encephalopathy (CSE), it would be helpful if the applied cognitive tests show a characteristic profile of impairment in this disease. We investigated the existence of such a profile. In 1997-2006 two expert teams in The Netherlands systematically exami...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2012.06.005
更新日期:2012-08-01 00:00:00
abstract::The contribution of environmental toxicants to the etiology and risk of Parkinson's disease (PD) has been clearly established, with organochlorine insecticides routinely shown to damage the nigrostriatal dopamine pathway. Although PD is generally considered an adult onset disease, it has been postulated that exposure ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2014.07.008
更新日期:2014-09-01 00:00:00
abstract::Knowledge on the impact of the exposure to indoor ultrafine particles (UFPs) on the human brain is restricted. Twelve non-atopic, non-smoking, and healthy adults (10 female and 7 male, in average 22 years old) were monitored for brain physiological responses via electroencephalographs (EEGs) during cooking. Frying gro...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2019.06.008
更新日期:2019-09-01 00:00:00
abstract::In 1983, Roels et al. (1987a, b) collected blood and urine samples and conducted neurological testing of workers at a manganese oxide and salt producing plant in Belgium, and at a nearby chemical plant. Workers from the manganese plant performed significantly worse than workers from the chemical plant on tests of shor...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1999-04-01 00:00:00
abstract::The normalization of certain behavioral functions after a trimethyltin (TMT) insult indicates that compensatory processes may occur (Paule and McMillan, 1986; Bushnell and Angell, 1992). The monoamine (MA) neurons are known to be sensitive to TMT, however, a detailed temporal description of the effects is lacking. One...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1995-07-01 00:00:00
abstract::Chlordecone is a persistent organochlorine pesticide that was used in the French West Indies until the early 1990s for banana weevil borer control. Human exposure to this chemical in this area still occurs nowadays due to consumption of contaminated food. Although adverse effects on neurodevelopment, including tremors...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2013.01.007
更新日期:2013-03-01 00:00:00
abstract::Four elements that have been implicated in free-radical-induced oxidative stress in Alzheimer's disease (AD) were measured by instrumental neutron activation analysis (INAA) in seven brain regions from 58 AD patients and 21 control subjects. A statistically significant elevation of iron and zinc was observed in multip...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::The herbicide cycloate (carbamothioic acid, ethyl(cyclohexyl)-S-ethyl ester) given as a single oral dose to rats, caused selective neuronal cell death in two regions in the rat forebrain, the pyramidal neurons of layers II-III throughout the pyriform cortex and in granule cells of the caudal ventro-lateral dentate gyr...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2004.07.006
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2009.04.009
更新日期:2009-07-01 00:00:00
abstract::On the basis of the evidence that extracellular Zn2+ influx induced with AMPA causes Parkinson's syndrome in rats that apomorphine-induced movement disorder emerges, here we used a low dose of AMPA, which does not increase intracellular Zn2+ level in the substantia nigra pars compacta (SNpc) of young adult rats, and t...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2020.12.014
更新日期:2021-01-02 00:00:00
abstract::This paper deals with the assumption that young adults with self-reported multiple chemical sensitivity (sMCS) show a heightened sensitivity of autonomic functions during experimental solvent exposure. Male sMCS-subjects were selected (out of n=274) on the base of a German questionnaire on chemical and environmental s...
journal_title:Neurotoxicology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/S0161-813X(02)00213-9
更新日期:2003-03-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants. The most toxic PCBs are the non-ortho-substituted ("dioxin-like") congeners that act through the aryl hydrocarbon receptor (AHR) pathway. In humans, perinatal exposure to dioxin-like PCBs is associated with neurodevelopmental toxicity in child...
journal_title:Neurotoxicology
pub_type: 杂志文章
doi:10.1016/j.neuro.2015.11.012
更新日期:2016-01-01 00:00:00