Abstract：
:It has been suggested that exposure to pesticides might be involved in the etiology of Parkinson's disease (PD). We conducted an updated systematic review of the epidemiologic literature over the past decade on the relationship between pesticide exposure and PD, using the MEDLINE database. Despite methodological differences, a significantly increased PD risk was observed in 13 out of 23 case-control studies that considered overall exposure to pesticides (risk estimates of 1.1-2.4) and in 10 out of 12 studies using other research designs (risk estimates of 2 or higher). Various studies found stronger associations in genetically susceptible individuals. Among a growing number of studies on the effects of exposure to specific pesticides (n=20), an increased PD risk has been associated with insecticides, especially chlorpyrifos and organochlorines, in six studies (odds ratios of 1.8-4.4), and with the herbicide paraquat, the fungicide maneb or the combination of both. Findings considerably strengthen the evidence that exposure to pesticides in well water may contribute to PD, whereas studies of farming and rural residence found inconsistent or little association with the disease. Taken together, this comprehensive set of results suggests that the hypothesis of an association between pesticide exposure and PD cannot be ruled out. However, inadequate data on consistent responses to exposure hinder the establishment of a causal relationship with PD. Given the extensive worldwide use of many pesticides, further studies are warranted in larger populations that include detailed quantitative data on exposure and determination of genetic polymorphisms.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Freire C,Koifman Sdoi
10.1016/j.neuro.2012.05.011subject
Has Abstractpub_date
2012-10-01 00:00:00pages
947-71issue
5eissn
0161-813Xissn
1872-9711pii
S0161-813X(12)00126-Xjournal_volume
33pub_type
杂志文章,评审相关文献
NEUROTOXICOLOGY文献大全abstract：:Male and female rat pups were exposed to a single dose of triethyl tin (TET) or ethanol vehicle on day 5 postnatally and tested for responsiveness to apomorphine as adults. TET-exposed animals displayed an increased response to the stereotypic effects of 1 mg/kg of apomorphine. Female rats exposed neonatally to TET ha...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1982-07-01 00:00:00
abstract：:Mouse embryonic stem cells (mESCs) represent an attractive cellular system for in vitro studies in developmental biology as well as toxicology because of their potential to differentiate into all fetal cell lineages. The present study aims to establish an in vitro system for developmental neurotoxicity testing employi...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.06.006
更新日期：2012-10-01 00:00:00
abstract：:Gulf War Illness (GWI) manifests a multitude of symptoms, including neurological and immunological, and approximately a third of the 1990-1991 Gulf War (GW) veterans suffer from it. This study sought to characterize the acute neurochemical (monoamine) and neuroinflammatory profiles of two established GWI animal models...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.12.012
更新日期：2020-03-01 00:00:00
abstract：:Prenatal ethanol exposure affects brain development and causes neural impairment, leading to both cognitive and behavioral consequences in the offspring. Therefore, the aim of this study was to investigate the impact of prenatal exposure to small amounts of alcohol on social play behavior in adolescent male offspring....
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.05.007
更新日期：2020-07-01 00:00:00
abstract：:Bisphenol A (BPA) is a widely recognized endocrine disruptor prevalent in many household items. Because experimental and epidemiological data suggest links between prenatal BPA exposure and altered affective behaviors in children, even at levels below the current US FDA No Observed Adverse Effect Level (NOAEL) of 5mg/...
journal_title：Neurotoxicology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.neuro.2017.10.005
更新日期：2018-03-01 00:00:00
abstract：:Two groups of New Zealand albino rabbits were respectively exposed to 350 and 700 ppm of trichloroethylene (TRI) 4 hrs/day, 4 days/week for 12 weeks. Weekly, visual evoked potentials (VEP) recordings were obtained under mesopic condition. Blood samples were also collected weekly to determine the concentration of TRI a...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Many uncertainties remain today concerning effects of lead on the nervous system, particularly in regard to levels of lead exposure causing minimal brain dysfunction in children. Past studies in children have failed to define adequately the nature of the effect, the critical period and duration of exposure and the rol...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1984-10-01 00:00:00
abstract：:Neurotoxicity in the mouse was produced following oral administration of chlordecone at 10, 25 and 50 mg/kg/day in corn oil vehicle. Hyperexcitability and tremors were observed on the 1st, 4th and 9th day after the administration of chlordecone at 50, 25 and 10 mg/kg/day, respectively, and mortality occurred on the 5t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：BACKGROUND:The organophosphate insecticide chlorpyrifos (CPF), widely used for agricultural purposes, has been linked to neurodevelopmental deficits. Possible motor effects at low to moderate levels of exposure have not been evaluated. METHODS:Prenatal exposure to CPF was measured in umbilical cord blood in a sample o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.09.004
更新日期：2015-12-01 00:00:00
abstract：:Effects of d-amphetamine on the renal outer medullary potassium (ROMK1) channels were tested in the Xenopus oocytes expression system. Xenopus oocytes were injected with mRNA coding for wild-type or mutant ROMK1 channels. Giant inside-out patch-clamp recordings were performed. d-Amphetamine inhibited the activity of R...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.05.002
更新日期：2008-07-01 00:00:00
abstract：:The present study investigated the neuroprotective effects of Forsythia suspense extract in a rotenone-induced neurotoxic model. FS8, one of the herbal extracts, markedly protected PC12 cells against rotenone toxicity and was selected for the in vivo study. Gavage administration of FS8 (50 and 200mg/kg, but not 10mg/k...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.09.009
更新日期：2016-01-01 00:00:00
abstract：:The synthesis of the NMDA receptor glycine site antagonist kynurenic acid (KYNA) from exogenously added kynurenine was measured in cultured cerebral cortical neurons, cortical astrocytes and an oligodendroglial cell line OLN-93, incubated for 2 h in the presence or absence of ammonium acetate ("ammonia") at 0.1-10 mM ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.01.004
更新日期：2006-07-01 00:00:00
abstract：:Manganese is an element which is required by the human body. However, as with most metals, in large amounts manganese can be toxic. People who suffer from severe manganese intoxication have symptoms similar to those of Parkinson's disease. Preclinical symptoms of manganese intoxication have recently been detected in i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:Despite the large body of experimental evidence demonstrating the neuroprotective properties of 17beta-estradiol (17beta-E2) both in vitro and in vivo experimental models of neuronal injury, the exact mechanisms implicated in neuroprotection have not been fully delineated. Some experimental evidence highlight a role f...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.01.009
更新日期：2005-10-01 00:00:00
abstract：:Peripheral neuropathy, a chronic complication of diabetes mellitus (DM), is often accompanied by the onset of severe pain symptoms that affect quality of life. However, the underlying mechanisms remain elusive. In the present study, we used Sprague-Dawley rats to establish a rodent model of the human type 1 DM by a si...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.12.006
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Cyclophosphamide chemotherapy is a mainstay of adjuvant breast cancer treatment. Unfortunately, this drug is associated with cognitive impairments in cancer patients that may accelerate cognitive aging. Memory is particularly affected in many patients. In order to better understand the precise cognitive impa...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.06.013
更新日期：2016-09-01 00:00:00
abstract：:Pollution of hydrographic basins has affected the flora and fauna that thrive in these aquatic ecosystems, and fish, which constitute an important food resource, often contain a plethora of potentially toxic chemicals. In a major research project on early neurotoxic effects of environmental exposure to manganese among...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章
doi：
更新日期：1998-08-01 00:00:00
abstract：:Four elements that have been implicated in free-radical-induced oxidative stress in Alzheimer's disease (AD) were measured by instrumental neutron activation analysis (INAA) in seven brain regions from 58 AD patients and 21 control subjects. A statistically significant elevation of iron and zinc was observed in multip...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Over the past decade people have been constantly exposed to microwave radiation mainly from wireless communication devices used in day to day life. Therefore, the concerns over potential adverse effects of microwave radiation on human health are increasing. Until now no study has been proposed to investigate the under...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.10.009
更新日期：2015-12-01 00:00:00
abstract：:Amyloid-beta, (Abeta) is a cytotoxic peptide implicated in the pathology of Alzheimers disease. The antioxidant enzyme catalase has been suggested to protect against Abeta cytotoxicity in both neuronal and non-neuronal cell types. Inhibition of endogenous catalase using 3-amino-1,2,4-triazole (3AT) in neuronal (NT-2) ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/s0161-813x(01)00064-x
更新日期：2001-12-01 00:00:00
abstract：:Chronic exposure to Mn results in the development of a neurological disorder known as manganism characterized by neurological deficits resembling that seen in Parkinsonism. Although dopaminergic neurons within the nigrostriatal pathway appear intact, Mn-induced irregularities in DA transmission have been observed incl...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.01.002
更新日期：2013-03-01 00:00:00
abstract：:There are no Food and Drug Administration approved pharmacotherapies for methamphetamine (METH) overdose, thus identifying novel drug targets to prevent this devastating adverse event is a public-health imperative. Previous research suggests that serotonin and sigma receptors may contribute to the adverse effects of M...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.05.011
更新日期：2019-09-01 00:00:00
abstract：:Neuron-specific in vitro screening strategies have the potential to accelerate the evaluation of chemicals for neurotoxicity. We examined neurite outgrowth as a measure of neuronal response with a commercially available rat cortex progenitor cell model, where cells were exposed to a chemical during a period of cell di...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2012.06.010
更新日期：2012-10-01 00:00:00
abstract：:The PCBs are members of the halogenated hydrocarbon class of environmental chemicals that includes the dibenzofurans and dioxins. The PCBs were used over a period of 40 years for number of industrial purposes. Their appearance in the ecosystem and biological samples from wildlife, as well as documented cases of accide...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Lead is one of the most common metals in contaminated ecosystems. Although lead poisoning and mortality have long been known, little is known of the neurobehavioral effects produced by low levels of lead in wild animals. Herein we describe the neurobehavioral effects of lead on learning using herring gulls (Larus arge...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2005.01.005
更新日期：2005-08-01 00:00:00
abstract：:Neuroimaging such as magnetic resonance imaging (MRI), positron emission tomography (PET), and single-photon emission computed tomography (SPECT) have been used in the last decade for investigating the neurotoxicolgy of manganese (Mn). Increased signal intensities on a T1-weighted image may reflect increased Mn deposi...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2005.12.002
更新日期：2006-05-01 00:00:00
abstract：:The field of neurotoxicology needs to satisfy two opposing demands: the testing of a growing list of chemicals, and resource limitations and ethical concerns associated with testing using traditional mammalian species. National and international government agencies have defined a need to reduce, refine or replace mamm...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2008.04.006
更新日期：2008-05-01 00:00:00
abstract：:Neural cell cultures were used to investigate the effects of acute and chronic ethanol exposure on electric membrane properties (EMP) of adult mouse dorsal root ganglion (DRG) neurons. These results in combination with results from additional experiments involving chronic exposure to hyposomotic medium provided furthe...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
abstract：:Although toxins exert their impact on a molecular level, they may yield molar effects by affecting areas large enough to be visualized by neuroimaging techniques. Therefore, neuroimaging of the brain may be used to render the macroscopic sequelae of neurotoxins visible. Toxic agents may induce brain edema or atrophy, ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-10-01 00:00:00
abstract：:Concern about lead as a significant public health problem has increased as epidemiological and experimental evidence has mounted regarding adverse health effects at successively lower levels of lead exposure. This concern has led to downward revision of criteria for acceptable blood lead concentrations to the 10 micro...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1993-07-01 00:00:00
