Abstract：
:Mice who were exposed to phenobarbital prenatally (B mice) had at adulthood deficits in the hippocampal eight-arm maze, spontaneous alternations, and water maze behaviors. Morphological studies revealed neuronal losses in the hippocampus. The surviving neurons had reductions from control in the number of dendritic branches, area and spine density, but wider fission angle than control. Neurochemical studies on the hippocampus revealed the following alterations: (a) decrease in NE level and the number of the NE cell bodies (b) no change in the serotonergic system (c) an increase in muscarinic receptors Bmax in the hippocampus; (d) no changes in GABA and benzodiazepine receptors. However, neonatal phenobarbital exposure caused an increase in the Bmax of GABA and benzodiazepine receptors. Transplantation of fetal septal cholinergic neurons into the hippocampus of B mice reversed most of the deficits in eight-arm maze behavior, while transplantation of noradrenergic cells did not affect the performance of B mice. In further studies on cholinergic mechanisms, the dopaminergic innervations in the septum (originating from A10), which are known to indirectly inhibit the activity of the septohippocampal cholinergic pathways, were destroyed by 6-OHDA. B mice treated with 6-OHDA had an increase in hippocampal ChAT activity and improved their eight-arm maze performance. Thus, understanding of the mechanism of a particular behavioral deficit enables one to correct it despite the nonspecific action of the neuroteratogen.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Yanai J,Fares F,Gavish M,Greenfeld Z,Katz Y,Marcovici G,Pick CG,Rogel-Fuchs Y,Weizman Asubject
Has Abstractpub_date
1989-10-01 00:00:00pages
543-54issue
3eissn
0161-813Xissn
1872-9711journal_volume
10pub_type
杂志文章,评审相关文献
NEUROTOXICOLOGY文献大全abstract：:Neurotoxicology integrates the best aspects of pharmacology, neuroscience, and toxicology and has established unique approaches, questions, and model systems. It has contributed to (i) isolating the multitude of environmental factors that damage the nervous system, (ii) characterizing the nature of the insult in both ...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1994-10-01 00:00:00
abstract：:Given the well-known antioxidant and neuroprotective properties of quercetin, the aim of this work was to evaluate the effects of quercetin stabilized by microencapsulation at two doses (10 mg kg-1 and 100 mg kg-1) on the oxidative/antioxidant status, number and morphological features of ICC, nitrergic neurons and M2-...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2020.01.011
更新日期：2020-03-01 00:00:00
abstract：:It has been suggested that childhood exposure to neurotoxicants may increase the risk of Parkinson's disease (PD) or other neurodegenerative disease in adults. Some recessive forms of PD have been linked to loss-of-function mutations in the Park2 gene that encodes for parkin. The purpose of this pilot study was to eva...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.10.002
更新日期：2018-01-01 00:00:00
abstract：:This paper describes the development of the protocol for the International Programme on Chemical Safety (IPCS)-sponsored Collaborative Study on Neurobehavioral Screening Methods, including background on the methods and chemicals selected, as well as details concerning the conduct of the collaborative study, including ...
journal_title：Neurotoxicology
pub_type： 杂志文章,多中心研究
doi：
更新日期：1997-01-01 00:00:00
abstract：:Many inhibitors of monoamine oxidase, particularly those developed during the past three decades, are often referred to as being "selective" for one or other isoform of the enzyme. However true this may be, selectivity within the EC 1.4.3.4 family does not preclude the possibility of interactions of these drugs with o...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/S0161-813X(03)00104-9
更新日期：2004-01-01 00:00:00
abstract：:Throughout the world, alum (aluminum sulfate) is used in municipal water treatment plants to clarify water. Alum treatment usually removes aluminosilicate particles from drinking water but can substantially increase its soluble aluminum content (Zhang et al., 1994; Tran et al., 1993; Kopp, 1970). Soluble aluminum is t...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1995-04-01 00:00:00
abstract：:Chaperones in the endoplasmic reticulum play vital roles in the folding, assembly, and post-translational modification of secretory proteins and also recycle, refold, or initiate degradation of misfolded proteins. Chaperone deficiencies in either amount or function are implicated in the etiology or pathogenesis of Alz...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：10.1016/j.neuro.2012.02.007
更新日期：2012-06-01 00:00:00
abstract：:It is still being debated whether neurogenesis in the subventricular zone (SVZ) is enhanced in response to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) injury in the adult mouse brain. Our previous studies provided evidence that MPTP induces apoptosis of migrating neuroblasts (neural progenitor cells, A cells) ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2015.07.007
更新日期：2015-09-01 00:00:00
abstract：:The present study investigates the effects of 1-bromopropane (1BP) on animal behavior to determine the extent of toxicity to the central nervous system (CNS). We measured the spontaneous locomotor activity (SLA) of rats before and after 3 weeks of exposure to 1BP for 8 h per day. In control and 10 ppm groups, the SLA ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/S0161-813X(03)00049-4
更新日期：2003-08-01 00:00:00
abstract：:Clinical use of vincristine (VCR), an effective chemotherapeutic agent, has been limited due to its peripheral neuropathy toxicity. Sumatriptan, which is an anti-migraine agent is a specific agonist for 5-hydroxytryptamine 1B, 1D (5HT1B, 1D) receptors. Several studies have shown that sumatriptan exerts anti-inflammato...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2018.06.012
更新日期：2018-07-01 00:00:00
abstract：:Nerve conduction velocities (NCV) of the median motor, median sensory, peroneal motor, and sural nerves were measured on 40 lead-exposed automobile production workers as part of a comprehensive health survey. Blood lead (Pb-B) and blood zinc protoporphyrin (ZPP) were measured. The control group (N = 31) consisted of w...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1983-07-01 00:00:00
abstract：:The ubiquitous functional roles of brain catecholamines have led to the notion that in vitro neurochemical changes in these systems may predict neurotoxicity. Conversely, others have argued that the appropriate use of neurochemical methods is for testing specific hypotheses that are developed based on observed phenome...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1987-04-01 00:00:00
abstract：:A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2009.06.009
更新日期：2009-11-01 00:00:00
abstract：:Traditionally, gamma-diketone neuropathy is classified as a distal axonopathy and has been characterized by giant axonal swellings in CNS and PNS tissues. These swellings contain neurofilamentous masses and are associated with thinning and retraction of the myelin sheath. It has been proposed that this axonopathy is c...
journal_title：Neurotoxicology
pub_type： 评论,杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
abstract：:Organophosphate (OP) compounds, including paraoxon (POX), are similar to nerve agents such as sarin. There is a growing concern that OP agents could be weaponized to cause mass civilian causalities. We have developed a rodent survival model of POX toxicity that is being used to evaluate chronic morbidity and to screen...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2014.08.008
更新日期：2014-09-01 00:00:00
abstract：:To study the effects from low level exposure to manganese, 30 men at steel smelting works and 60 nonexposed reference subjects, were neurophysiologically examined using: (i) Electroencephalogram (EEG), Event related auditory evoked potential (AEP/P300), Brain stem auditory evoked potential (BAEP) and diadochokinesomet...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1992-04-01 00:00:00
abstract：:Several organolead compounds have been shown to inhibit both the basal and dopamine-sensitive forms of adenylate cyclase obtained from rat caudate nucleus. The mode of action of the trisubstituted lead compounds is shown to depend upon the form of adenylate cyclase studied. The dopamine-sensitive form of adenylate cyc...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/0191-8869(82)90087-3
更新日期：1982-07-01 00:00:00
abstract：:The Faroe Islands study is a prospective study designed to assess the neurological and behavioral consequences of in utero exposure to methylmercury (meHg). Maternal exposure to meHg was through consumption of fish and intermittent higher-level exposure through pilot whale meat, while consumption of pilot whale blubbe...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：2000-12-01 00:00:00
abstract：:This paper deals with the assumption that young adults with self-reported multiple chemical sensitivity (sMCS) show a heightened sensitivity of autonomic functions during experimental solvent exposure. Male sMCS-subjects were selected (out of n=274) on the base of a German questionnaire on chemical and environmental s...
journal_title：Neurotoxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/S0161-813X(02)00213-9
更新日期：2003-03-01 00:00:00
abstract：:Developmentally-lead (Pb)-exposed rats showed an enhanced vulnerability to the stimulating and motivational effects of ethanol (EtOH). This is accompanied by differential activity of the brain EtOH-metabolizing enzymes catalase (CAT) and mitochondrial aldehyde dehydrogenase (ALDH2). Based on the theory that brain acet...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2019.09.011
更新日期：2019-12-01 00:00:00
abstract：:Betulin is extracted from birch tree bark and exerts diverse pharmacological activities. The present study was designed to investigate the protective effect of betulin (BE) on cognitive decline in streptozotocin (STZ)-induced diabetic rats. The diabetic model was built by streptozotocin (STZ) (30mg/kg, ip). After 4 we...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2016.09.009
更新日期：2016-12-01 00:00:00
abstract：:Pyrethroids, including permethrin and deltamethrin (DLM), are very widely used of insecticides. It was hypothesized that lower plasma binding and increased blood-brain barrier (BBB) penetration of DLM in immature rats contribute to the higher brain concentrations of DLM and more pronounced neurotoxicity reported in th...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2017.04.009
更新日期：2017-09-01 00:00:00
abstract：:Mitoxantrone is an antineoplastic agent considered a potential human teratogen because of its mechanism of action and is classified by the US Food and Drug Administration in pregnancy category risk D. In the literature there are only four cases of women exposed to the drug in late pregnancy. We report the first case o...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2006.10.002
更新日期：2007-05-01 00:00:00
abstract：:Gadolinium is a rare-earth lanthanide metal ion and is used as organic gadolinium complexes in magnetic resonance imaging (MRI). Although gadolinium-based MRI agents are thought to be safe in clinical use, the in vivo release of the toxic free inorganic gadolinium (Gd3+) has been reported in some patients with kidney ...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2008.10.003
更新日期：2009-01-01 00:00:00
abstract：:Many uncertainties remain today concerning effects of lead on the nervous system, particularly in regard to levels of lead exposure causing minimal brain dysfunction in children. Past studies in children have failed to define adequately the nature of the effect, the critical period and duration of exposure and the rol...
journal_title：Neurotoxicology
pub_type： 杂志文章,评审
doi：
更新日期：1984-10-01 00:00:00
abstract：:It has been hypothesised that some motor neuron diseases may result from lead (Pb) being retrogradely transported in axons from muscle to spinal cord. To test this hypothesis, we injected mice in the right hindlimb with 0.1 ml of 0.25% or 2.5% Pb. In some animals the sciatic nerve was cut before injection. Pb levels w...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1994-07-01 00:00:00
abstract：:ω-Agatoxin-IVA is a well known P/Q-type Ca(2+) channel blocker and has been shown to affect presynaptic Ca(2+) currents as well postsynaptic potentials. P/Q-type voltage gated Ca(2+) channels play a vital role in presynaptic neurotransmitter release and thus play a role in action potential generation. Monitoring spont...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2013.03.002
更新日期：2013-07-01 00:00:00
abstract：:Oxidative stress has been implicated in the pathogenesis of methylmercury (MeHg) neurotoxicity. Studies of mature neurons suggest that the mitochondrion may be a major source of MeHg-induced reactive oxygen species and a critical mediator of MeHg-induced neuronal death, likely by activation of apoptotic pathways. It i...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：10.1016/j.neuro.2011.07.006
更新日期：2011-10-01 00:00:00
abstract：:Pheochromocytoma (PC-12) cells synthesize, store, release and metabolize dopamine (DA) and norepinephrine (NE) in a manner analogous to that observed in the mammalian central nervous system. These cells were used to develop and validate an alternate method to animal testing to assess the effects of a complex environme...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:A 47 year old female dentist suffered from hemiparkinsonism which had started eighteen months earlier and was manifested mainly by resting tremor and cogwheel rigidity. A baseline quantitative urinary mercury excretion was 46 micrograms/day. The patient was treated with chelating agent d-penicillamine for a week. Chel...
journal_title：Neurotoxicology
pub_type： 杂志文章
doi：
更新日期：1996-04-01 00:00:00
