Abstract：
:Neurotransmitter amino acid levels were measured in select brain regions of rats and mice after chronic treatment with sublethal doses of sodium hydrosulfide (NaHS). Brainstem aspartate, glutamate, glutamine, taurine and GABA levels increased in chronically but not acutely saline-treated rats. These increases may have been due to stress from frequent handling, and were prevented by chronic NaHS treatment (7.5 mg/kg ip every 8 hr for 3 consecutive days). In contrast, aspartate, glutamate and glutamine increased in female but not in male ICR mouse brainstems after once daily treatment with 7.0 mg/kg NaHS for 5 consecutive days. These effects of NaHS may indicate chronic low level H2S neurotoxicity. Differences between chronic and acute treatments, female and male responses, and treatment paradigms may complicate interpretations of such toxicity studies.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Warenycia MW,Kombian SB,Reiffenstein RJsubject
Has Abstractpub_date
1990-04-01 00:00:00pages
93-7issue
1eissn
0161-813Xissn
1872-9711journal_volume
11pub_type
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