Abstract：
:Mitochondrial damage and declines in ATP levels have been recently attributed to sertraline. The effects of sertraline on different parameters were investigated in washed platelets from 18 healthy male volunteers, after 24h of drug exposure. Sertraline toxicity was observed only at the highest concentrations, 30 and 100 μM, which significantly reduced platelet viability to 76 ± 3% and 20 ± 2%, respectively. The same concentrations significantly decreased total ATP to 73 ± 3% and 13 ± 2%, respectively. Basal values of glycogen were not significantly affected by sertraline treatment. Glutamate uptake was significantly reduced after treatment with 3, 30 and 100 μM, by 28 ± 6%, 32 ± 5% and 54 ± 4%, respectively. Our data showed that sertraline at therapeutic concentrations does not compromise platelet viability and ATP levels, but they suggest that in a situation where extracellular glutamate levels are potentially increased, sertraline might aggravate an excitotoxic condition.
journal_name
Neurotoxicologyjournal_title
Neurotoxicologyauthors
Rodrigues DO,Bristot IJ,Klamt F,Frizzo MEdoi
10.1016/j.neuro.2015.10.014subject
Has Abstractpub_date
2015-12-01 00:00:00pages
192-7eissn
0161-813Xissn
1872-9711pii
S0161-813X(15)30014-0journal_volume
51pub_type
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