The neurotoxicology of lead.

Abstract:

:In the past six years, our research group has investigated the relationship between lead exposure and mental and behavioural development. This has been carried out through studies in children and animals. Earlier studies in children have shown that associations might be expected between environmental exposure to lead and various aspects of cognitive and behavioural development. Our study has examined and continues to examine, a cohort of children sub-divided into three groups according to the level of lead exposure during early 'in utero' development. Data amassed to date includes measurement of psychometric function and post natal development, together with biochemical measures of lead exposure. Assessment will continue through to early scholastic performance and will include measurement of deciduous tooth lead concentration as an integrated measure of long term exposure. In addition to these studies in children, a series of neurochemical studies have been carried out using a rat model of lead exposure. Data obtained from both our own neurochemical experiments and those of other groups indicate an extremely complex plethora of neurotoxic actions of lead.

journal_name

Neurotoxicology

journal_title

Neurotoxicology

authors

Moore MR,McIntosh MJ,Bushnell IW

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

541-56

issue

2

eissn

0161-813X

issn

1872-9711

journal_volume

7

pub_type

杂志文章,评审
  • The association between neurobehavioral performance and lung function.

    abstract::This study investigated the relationship between neurobehavioral performance and pulmonary function in young and middle adults. Data were collected from 178 subjects (88 male, 90 female) aged 20-50 years. Neurobehavioral performance was assessed by the Korean version of The Swedish Performance Evaluation System (SPES-...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2006.03.019

    authors: Min JY,Min KB,Paek D,Sakong J,Cho SI

    更新日期:2007-03-01 00:00:00

  • Increased inorganic mercury in spinal motor neurons following chelating agents.

    abstract::Heavy metal toxicity has been implicated in the pathogenesis of motor neuron diseases. In an attempt to assess the efficacy of chelating agents to remove mercury from motor neurons, we quantitated the effect of the chelating agents meso-2,3-dimercaptosuccinic acid (DMSA) and 2,3- dimercaptopropane -1-sulphonate (DMPS)...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Ewan KB,Pamphlett R

    更新日期:1996-07-01 00:00:00

  • Oxaliplatin treatment impairs extension of sensory neuron neurites in vitro through miR-204 overexpression.

    abstract::Oxaliplatin is a platinum-based drug used in the treatment of gastric cancers. Oxaliplatin treatment induces sensory neuropathy characterized by cold hypersensibility in the acute phase and sensory impairment when the neuropathy becomes chronic. In order to determine the effect of oxaliplatin on sensory neurons, we us...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2018.07.009

    authors: López-González MJ,Soula A,Landry M,Favereaux A

    更新日期:2018-09-01 00:00:00

  • Vinblastine and doxorubicin administration to pregnant mice affects brain development and behaviour in the offspring.

    abstract:BACKGROUND:Administration of chemotherapy during the fetal phase of pregnancy may put late-developing organs like the central nervous system at risk. METHODS:Transplacental transfer of doxorubicin and vinblastine was measured in C57/BJ mice by high-performance liquid chromatographic detection of the drugs in maternal ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2009.04.009

    authors: Van Calsteren K,Hartmann D,Van Aerschot L,Verbesselt R,Van Bree R,D'Hooge R,Amant F

    更新日期:2009-07-01 00:00:00

  • Data relating to prenatal lead exposure and child IQ at 4 and 8 years old in the Avon Longitudinal Study of Parents and Children.

    abstract::As part of the Avon Longitudinal Study of Parents and Children (ALSPAC), measures of child IQ were collected by trained psychologists. The Wechsler Pre-school and Primary Scale of Intelligence - Revised UK edition (WPPSI) was used at age 4 years in a subsample of children enrolled in ALSPAC (the Children in Focus coho...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2017.07.025

    authors: Taylor CM,Kordas K,Golding J,Emond AM

    更新日期:2017-09-01 00:00:00

  • Mother's environmental tobacco smoke exposure during pregnancy and externalizing behavior problems in children.

    abstract:BACKGROUND:While the impact of active maternal smoking during pregnancy on child health has been well investigated, the association between maternal passive smoking, or environmental tobacco smoke (ETS), or second-hand smoke, and behavioral development of offspring is less clear. This study examines the association bet...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2012.11.005

    authors: Liu J,Leung PW,McCauley L,Ai Y,Pinto-Martin J

    更新日期:2013-01-01 00:00:00

  • Breathing and heart rate during experimental solvent exposure of young adults with self-reported multiple chemical sensitivity (sMCS).

    abstract::This paper deals with the assumption that young adults with self-reported multiple chemical sensitivity (sMCS) show a heightened sensitivity of autonomic functions during experimental solvent exposure. Male sMCS-subjects were selected (out of n=274) on the base of a German questionnaire on chemical and environmental s...

    journal_title:Neurotoxicology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/S0161-813X(02)00213-9

    authors: Haumann K,Kiesswetter E,van Thriel C,Blaszkewicz M,Golka K,Seeber A

    更新日期:2003-03-01 00:00:00

  • A rapid and sensitive high throughput reporter gene assay for estrogenic effects of environmental contaminants.

    abstract::We have developed an estrogen sensitive reporter gene assay and report here on its responsiveness to steroid hormones and several estrogenic contaminants, including pesticides and polychlorinated biphenyls (PCBs), GH4C1 rat pituitary cells were stably transfected with the reported gene ERE-TK-Luc which contains a luci...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Edmunds JS,Fairey ER,Ramsdell JS

    更新日期:1997-01-01 00:00:00

  • A pilot study of occupational and environmental risk factors for Parkinson's disease.

    abstract::Increasingly, the etiology of Parkinson's disease (PD) has been linked to exposures to environmental toxicants. This epidemiologic pilot study used a self-administered questionnaire among 34 PD cases and 22 other neurology clinic control patients. All subjects were at least 40 years old. Risk factors investigated incl...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Wechsler LS,Checkoway H,Franklin GM,Costa LG

    更新日期:1991-10-01 00:00:00

  • Neurobehavioral and neurophysiological observations in six year old children with low lead levels in East and West Germany.

    abstract::Within a larger comparative environmental health screening program in East and West Germany neurobehavioral and neurophysiological measures were taken in 367 six year old children in Leipzig (N = 179), Gardelegen (N = 68), and Duisburg (N = 120). Lead concentrations from venous blood samples (PbB) and from deciduous t...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Winneke G,Altmann L,Krämer U,Turfeld M,Behler R,Gutsmuths FJ,Mangold M

    更新日期:1994-10-01 00:00:00

  • Neurobehavioral effects of exposure to organophosphates and pyrethroid pesticides among Thai children.

    abstract::The use of pesticides for crop production has grown rapidly in Thailand during the last decade, resulting in significantly greater potential for exposure among children living on farms. Although some previous studies assessed exposures to pesticides in this population, no studies have been conducted to evaluate corres...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.02.003

    authors: Fiedler N,Rohitrattana J,Siriwong W,Suttiwan P,Ohman Strickland P,Ryan PB,Rohlman DS,Panuwet P,Barr DB,Robson MG

    更新日期:2015-05-01 00:00:00

  • Anti-epileptic activity of daidzin in PTZ-induced mice model by targeting oxidative stress and BDNF/VEGF signaling.

    abstract::Epilepsy is a complex and multifactorial neurodegenerative disease described by recurrent seizures. Oxidative stress and dysregulation of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) are critical factors for the development of epilepsy. Daidzin is well-known for its effective ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2020.05.005

    authors: Kazmi Z,Zeeshan S,Khan A,Malik S,Shehzad A,Seo EK,Khan S

    更新日期:2020-07-01 00:00:00

  • Pharmacokinetic data needs to support risk assessments for inhaled and ingested manganese.

    abstract::Manganese (Mn)-deficiency or Mn-excess can lead to adverse biological consequences. Central nervous system tissues, rich in dopaminergic neurons, are the targets whether the Mn gains entrance by inhalation, oral ingestion, or intravenous administration. Risk assessments with Mn need to ensure that brain concentrations...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Andersen ME,Gearhart JM,Clewell HJ 3rd

    更新日期:1999-04-01 00:00:00

  • Chronic low-level lead exposure in monkeys does not affect simple reaction time.

    abstract::Simple visual reaction time was measured in a group of adult monkeys (Macaca fascicularis) dosed continuously with lead from birth onward, and in matched controls. Blood lead concentrations had been stable for 6 years at 33 micrograms/dl at the time of testing. The monkey was required to make contact with a stainless ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Rice DC

    更新日期:1988-04-01 00:00:00

  • Quantitative approaches to human risk assessment for noncancer health effects.

    abstract::The estimation of risk for health effects due to chemical exposure is important to the development of standards for regulating the manufacture, use and release of chemicals into the environment. The quantitative data used to develop risk estimates usually come from laboratory animal studies employing relatively high d...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:

    authors: Kimmel CA

    更新日期:1990-07-01 00:00:00

  • Effects of chronic lead exposure on the neuromuscular junction in Drosophila larvae.

    abstract::Long term or chronic exposure to lead is associated with cognitive and other deficits in humans, which may reflect lead-induced changes in synaptic development and function. We believe that Drosophila has great potential as a model system for studying such changes. To test this, we compared the structure of single, id...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/s0161-813x(02)00095-5

    authors: Morley EJ,Hirsch HV,Hollocher K,Lnenicka GA

    更新日期:2003-01-01 00:00:00

  • Re-evaluation of archival material for neuronal cell injury produced by L-2-chloropropionic acid in the rat brain.

    abstract::Previous studies have shown that L-2-chloropropionic acid (L-CPA) produces necrosis to cerebellar granule cells with some associated Purkinje cell damage in the rat. We have re-evaluated the neuropathology using the original sections and fresh sections from archived brain material from rats treated with L-CPA at diffe...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2004.01.009

    authors: Duffell S,Lock EA

    更新日期:2004-12-01 00:00:00

  • Brain and blood levels of bismuth after oral or parenteral administration of tripotassium-dicitrato bismuthate to rats.

    abstract::Bismuth levels in blood and brain of rats have been measured following acute or subchronic administration of tri-potassium-dicitrato bismuthate (TDB) by intraperitoneal injection or by gavage. After parenteral administration, the presence of bismuth in blood was associated with appreciable bismuth concentrations in br...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Abbracchio MP,Balduini W,Cavallaro A,Adamoli P,Fittipaldi M,Muzio F,Malandrino S,Cattabeni F

    更新日期:1985-10-01 00:00:00

  • Excess amounts of 3-iodo-l-tyrosine induce Parkinson-like features in experimental approaches of Parkinsonism.

    abstract::3-iodo-l-tyrosine might play a role in Parkinson's disease since this molecule is able, at high concentration, to inhibit tyrosine-hydroxylase activity, the rate-limiting enzyme in dopamine biosynthesis. The possible Parkinson-like effects of 3-iodo-l-tyrosine were tested on three experimental approaches in mice: cult...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2018.06.002

    authors: Fernández-Espejo E,Bis-Humbert C

    更新日期:2018-07-01 00:00:00

  • Chronic exposure to anesthetic gases affects balance control in operating room personnel.

    abstract::Exposure to anesthetic gases is known to alter certain structures and functions of the central nervous system. As the effects of long-term exposure on balance control mechanisms have been the subject of few investigations, these were evaluated in 53 operating room personnel exposed to anesthetic gases and in 53 non-ex...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2004.11.002

    authors: Vouriot A,Gauchard GC,Chau N,Nadif R,Mur JM,Perrin PP

    更新日期:2005-03-01 00:00:00

  • Electrophysiological investigation of IDPN neuropathy--initial studies.

    abstract::beta,beta'-iminodipropionitrile (IDPN) causes giant axon swellings in proximal internodes of spinal motor axons and in stem processes of dorsal root ganglia neurons. The electrophysiological consequences of the swellings were investigated in cats given IDPN (50 mg/kg i.p.) weekly for 0 (control), 1 (7 days), 2 (14 day...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Lowndes HE,Delio DA,Gold BG

    更新日期:1985-01-01 00:00:00

  • Modeling of human monoamine oxidase A: from low resolution threading models to accurate comparative models based on crystal structures.

    abstract::The recently published crystal structure of monoamine oxidase (MAO) B was a major breakthrough for structural and functional understanding of flavin containing amine oxidases: it opens a new era of research and provides new opportunities to those interested in the biochemistry and pharmacology of those important drug ...

    journal_title:Neurotoxicology

    pub_type: 杂志文章,评审

    doi:10.1016/S0161-813X(03)00088-3

    authors: Léonard N,Lambert C,Depiereux E,Wouters J

    更新日期:2004-01-01 00:00:00

  • Ethanol and acetaldehyde differentially alter extracellular dopamine and serotonin in Aldh2-knockout mouse dorsal striatum: A reverse microdialysis study.

    abstract::Dopamine (DA) and serotonin (5-HT) seem to be involved in several of the effects of ethanol (EtOH). Acetaldehyde (AcH), especially in the brain, induces effects that mimic those of EtOH. The purpose of this study was to investigate the effects of local perfusion of EtOH and AcH on extracellular DA and 5-HT in the dors...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2015.12.011

    authors: Jamal M,Ameno K,Miki T,Tanaka N,Ito A,Ono J,Takakura A,Kumihashi M,Kinoshita H

    更新日期:2016-01-01 00:00:00

  • The effect of acute severe monocrotophos poisoning on inhibition, expression and activity of acetylcholinesterase in different rat brain regions.

    abstract:AIM:This study examined the acute effects of severe monocrotophos (MCP) poisoning on AChE inhibition, mRNA expression and recovery of acetylcholinesterase activity in different regions of the rat brain. STUDY:Wistar rats were administered monocrotophos (0.8LD(50)) by oral gavage to elicit severe effects of acute poiso...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2012.07.010

    authors: Kazi AI,Oommen A

    更新日期:2012-10-01 00:00:00

  • Novel in vitro assay to investigate radiation induced changes in the functionality of human embryonic stem cell-derived neurospheres.

    abstract::Ionizing radiation (IR) is increasingly used for diagnostics and therapy of severe brain diseases. However, IR also has adverse effects on the healthy brain tissue, particularly on the neuronal network. This is true for adults but even more pronounced in the developing brain of unborn and pediatric patients. Epidemiol...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2020.04.003

    authors: Mayer M,Arrizabalaga O,Ciba M,Schroeder IS,Ritter S,Thielemann C

    更新日期:2020-07-01 00:00:00

  • Absence of a protective effect of corticosterone on 0-0-diisopropyl phosphorofluoridate (DFP) induced delayed neurotoxicity in chickens.

    abstract::Chickens given 15 to 45 ppm dietary corticosterone 1 day prior to and 5 days following subcutaneous administration of 1 mg/kg 0,0-diisopropyl phosphorofluoridate (DFP) were not protected from either clinical delayed neuropathy, depression of neurotoxic esterase activity or advanced degenerative peripheral nerve myelin...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: Ehrich M,Jortner BS,Gross WB

    更新日期:1985-04-01 00:00:00

  • Neurotoxicity of manganese: Indications for future research and public health intervention from the Manganese 2016 conference.

    abstract::Manganese is an essential trace element, but also at high levels a neurotoxicant. Manganese neurotoxicity has been extensively studied since its discovery in highly exposed workers. The International conference MANGANESE2016 held at the Icahn School of Medicine at Mount Sinai in New York provided relevant updates on m...

    journal_title:Neurotoxicology

    pub_type: 社论

    doi:10.1016/j.neuro.2018.01.002

    authors: Lucchini RG,Aschner M,Landrigan PJ,Cranmer JM

    更新日期:2018-01-01 00:00:00

  • Acute exposure to lead acetate activates microglia and induces subsequent bystander neuronal death via caspase-3 activation.

    abstract::Lead is one of the major pollutants of environment and is highly toxic to the functioning of central nervous system (CNS). The chronic exposure of this heavy metal is debilitating to the functional behavior of an organism. Studies have shown that acute exposure to Pb can lead to glial activation and secretion of cyto-...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2014.02.002

    authors: Kumawat KL,Kaushik DK,Goswami P,Basu A

    更新日期:2014-03-01 00:00:00

  • Damage induced by systemic kainic acid in rats is dependent upon seizure activity--a behavioral and morphological study.

    abstract::Kainic acid (KA) was injected intraperitoneally into rats at a dose (9 mg/kg) which produced status epilepticus in approximately 50% of the animals. Rats were categorized into groups that displayed status epilepticus, partial seizures or no effect in the 4 hr following kainic acid injection. Behavioral and morphologic...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:

    authors: O'Shaughnessy D,Gerber GJ

    更新日期:1986-10-01 00:00:00

  • Alpha-synuclein-glucocerebrosidase interactions in pharmacological Gaucher models: a biological link between Gaucher disease and parkinsonism.

    abstract::A growing body of experimental and clinical literature indicates an association between Gaucher disease and parkinsonism, raising the possibility that convergent mechanisms may contribute to neurodegeneration in these disorders. The aim of this study was to determine whether there is a relationship between alpha-synuc...

    journal_title:Neurotoxicology

    pub_type: 杂志文章

    doi:10.1016/j.neuro.2009.06.009

    authors: Manning-Boğ AB,Schüle B,Langston JW

    更新日期:2009-11-01 00:00:00