听力与言语-语言病理学

行为科学

医学伦理学

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  • Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.

    abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202445

    authors: Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

    更新日期:2021-02-01 00:00:00

  • Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers.

    abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202388

    authors: Liu D,Li B,Shi X,Zhang J,Chen AM,Xu J,Wang W,Huang K,Gao J,Zheng Z,Liu D,Wang H,Shi W,Chen L,Xu J

    更新日期:2021-01-20 00:00:00

  • RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.

    abstract::Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202385

    authors: Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

    更新日期:2021-01-20 00:00:00

  • Sulforaphane promotes C. elegans longevity and healthspan via DAF-16/DAF-2 insulin/IGF-1 signaling.

    abstract::The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin a...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202512

    authors: Qi Z,Ji H,Le M,Li H,Wieland A,Bauer S,Liu L,Wink M,Herr I

    更新日期:2021-01-20 00:00:00

  • Histological characteristics of bone in-growth of proximal humeral implants with different spatial structures.

    abstract::This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202391

    authors: Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

    更新日期:2021-01-20 00:00:00

  • Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling.

    abstract::Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202415

    authors: Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

    更新日期:2021-01-20 00:00:00

  • Fighting the storm: could novel anti-TNFα and anti-IL-6 C. sativa cultivars tame cytokine storm in COVID-19?

    abstract::The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202500

    authors: Kovalchuk A,Wang B,Li D,Rodriguez-Juarez R,Ilnytskyy S,Kovalchuk I,Kovalchuk O

    更新日期:2021-01-19 00:00:00

  • DNA methylation perturbations may link altered development and aging in the lung.

    abstract::Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 expose...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202544

    authors: Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

    更新日期:2021-01-19 00:00:00

  • Combined transplantation of neural stem cells and bone marrow mesenchymal stem cells promotes neuronal cell survival to alleviate brain damage after cardiac arrest via microRNA-133b incorporated in extracellular vesicles.

    abstract::Neural stem cell (NSC) transplantation has prevailed as a promising protective strategy for cardiac arrest (CA)-induced brain damage. Surprisingly, the poor survival of neuronal cells in severe hypoxic condition restricts the utilization of this cell-based therapy. Extracellular vesicles (EVs) transfer microRNAs (miRN...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103920

    authors: Li F,Zhang J,Chen A,Liao R,Duan Y,Xu Y,Tao L

    更新日期:2021-01-12 00:00:00

  • Correlates of change in accelerometer-assessed total sedentary time and prolonged sedentary bouts among older English adults: results from five-year follow-up in the EPIC-Norfolk cohort.

    abstract:BACKGROUND:Development of effective strategies to reduce sedentary time among older adults necessitates understanding of its determinants but longitudinal studies of this utilising objective measures are scarce. METHODS:Among 1536 older adults (≥60 years) in the EPIC-Norfolk study, sedentary time was assessed for seve...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202497

    authors: Yerrakalva D,Hajna S,Wijndaele K,Westgate K,Khaw KT,Wareham N,Griffin SJ,Brage S

    更新日期:2021-01-11 00:00:00

  • CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer.

    abstract::According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202382

    authors: Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

    更新日期:2021-01-10 00:00:00

  • Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages.

    abstract::Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is kn...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202273

    authors: Yin M,Lu J,Guo Z,Zhang Y,Liu J,Wu T,Guo K,Luo T,Guo Z

    更新日期:2021-01-10 00:00:00

  • Knockdown of CENPF inhibits the progression of lung adenocarcinoma mediated by ERβ2/5 pathway.

    abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202303

    authors: Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

    更新日期:2021-01-10 00:00:00

  • Downregulation of miR-155-5p enhances the anti-tumor effect of cetuximab on triple-negative breast cancer cells via inducing cell apoptosis and pyroptosis.

    abstract::Cetuximab resistance is the main obstacle for the treatment of EGFR overexpression cancer, including triple-negative breast cancer (TNBC). MicroRNA (miRNA)-155-5p is upregulated in TNBC cells; thus, the present study explored whether the downregulation of miR-155-5p enhanced the anti-tumor effect of cetuximab in TNBC ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103669

    authors: Xu W,Song C,Wang X,Li Y,Bai X,Liang X,Wu J,Liu J

    更新日期:2021-01-05 00:00:00

  • Dexrazoxane ameliorates radiation-induced heart disease in a rat model.

    abstract::Treatment of thoracic tumors with radiotherapy can lead to severe cardiac injury. We investigated the effects of dexrazoxane, a USFDA-approved cardioprotective drug administered with chemotherapy, on radiation-induced heart disease (RIHD) in a rat model. Male Sprague-Dawley rats were irradiated with a single dose of 2...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202332

    authors: Li L,Nie X,Zhang P,Huang Y,Ma L,Li F,Yi M,Qin W,Yuan X

    更新日期:2021-01-02 00:00:00

  • Prognostic relevance of SMC family gene expression in human sarcoma.

    abstract:OBJECTIVE:To explore the prognostic value of the expression of genes encoding structural maintenance of chromosomes (SMCs) in human sarcoma. RESULTS:We found that the levels of SMC1A, SMC2, SMC3, SMC4, SMC5 and SMC6 mRNA were all higher in most tumors compared to normal tissues, and especially in sarcoma. According to...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202455

    authors: Zhou J,Wu G,Tong Z,Sun J,Su J,Cao Z,Luo Y,Wang W

    更新日期:2020-12-30 00:00:00

  • Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.

    abstract::Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a re...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202453

    authors: Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG

    更新日期:2020-12-29 00:00:00

  • Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection.

    abstract::DNA repair mechanisms play a crucial role in maintaining genome integrity. However, the increased frequency of DNA double-strand breaks (DSBs) and genome rearrangements in aged individuals suggests an age-associated DNA repair deficiency. Previous work from our group revealed a delayed firing of the DNA damage respons...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202419

    authors: Anglada T,Genescà A,Martín M

    更新日期:2020-12-27 00:00:00

  • Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure.

    abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202405

    authors: Tian Y,Yang J,Lan M,Zou T

    更新日期:2020-12-26 00:00:00

  • Beyond the social gradient: the role of lifelong socioeconomic status in older adults' health trajectories.

    abstract::Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swe...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202342

    authors: Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar S

    更新日期:2020-12-21 00:00:00

  • Overexpression of long noncoding RNA ANRIL inhibits phenotypic switching of vascular smooth muscle cells to prevent atherosclerotic plaque development in vivo.

    abstract:BACKGROUND:Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Long noncoding RNA ANRIL (lncRNA-ANRIL) is critical in vascular homeostasis. Metformin produces multiple beneficial effects in atherosclerosis. However, the underlying mechanisms need to be elucidated. METHODS ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202392

    authors: Hu DJ,Li ZY,Zhu YT,Li CC

    更新日期:2020-12-19 00:00:00

  • Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.

    abstract::Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202305

    authors: Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T

    更新日期:2020-12-19 00:00:00

  • Safety and efficacy of convalescent plasma therapy in severely and critically ill patients with COVID-19: a systematic review with meta-analysis.

    abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...

    journal_title:Aging

    pub_type: 杂志文章,meta分析

    doi:10.18632/aging.202195

    authors: Wenjing L,Yuanzheng F,Li JY,Tang LV,Yu H

    更新日期:2020-12-15 00:00:00

  • Role of FUT8 expression in clinicopathology and patient survival for various malignant tumor types: A systematic review and meta-analysis.

    abstract::Dysregulation of α(1,6)-fucosyltransferase (FUT8) plays significant roles in development of a variety of malignant tumor types. We collected as many relevant articles and microarray datasets as possible to assess the prognostic value of FUT8 expression in malignant tumors. For this purpose, we systematically searched ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202239

    authors: Ma M,Han G,Wang Y,Zhao Z,Guan F,Li X

    更新日期:2020-12-11 00:00:00

  • FX5 as a non-steroidal GR antagonist improved glucose homeostasis in type 2 diabetic mice via GR/HNF4α/miR-122-5p pathway.

    abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202275

    authors: Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

    更新日期:2020-12-09 00:00:00

  • Immune profile of the tumor microenvironment and the identification of a four-gene signature for lung adenocarcinoma.

    abstract::The composition and relative abundances of immune cells in the tumor microenvironment are key factors affecting the progression of lung adenocarcinomas (LUADs) and the efficacy of immunotherapy. Using the cancer gene expression dataset from The Cancer Genome Atlas (TCGA) program, we scored stromal and immune cells for...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202269

    authors: Fan T,Zhu M,Wang L,Liu Y,Tian H,Zheng Y,Tan F,Sun N,Li C,He J

    更新日期:2020-12-09 00:00:00

  • Matrix stiffness regulates myocardial differentiation of human umbilical cord mesenchymal stem cells.

    abstract::Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202244

    authors: Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

    更新日期:2020-12-09 00:00:00

  • SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202164

    authors: Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

    更新日期:2020-12-03 00:00:00

  • Assessment of real-time three-dimensional echocardiography as a tool for evaluating left atrial volume and function in patients with type 2 diabetes mellitus.

    abstract:OBJECTIVE:To assess the value of real-time three-dimensional echocardiography (RT-3DE) in evaluating changes in left atrial volume and function in type 2 diabetes mellitus (DM) and type 2 diabetic nephropathy (DN) patients. METHOD:104 control subjects, 109 DN patients, and 111 DM patients were recruited and underwent ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202218

    authors: Li X,Dong Y,Zheng C,Wang P,Xu M,Zou C,Wang L

    更新日期:2020-12-03 00:00:00

  • A model integrating donor gene polymorphisms predicts fibrosis after liver transplantation.

    abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202302

    authors: Wang C,Zhang X,Ling Q,Zheng S,Xu X

    更新日期:2020-12-03 00:00:00

  • E3 ligase FBXW7 restricts M2-like tumor-associated macrophage polarization by targeting c-Myc.

    abstract::FBXW7 functions as an E3 ubiquitin ligase to mediate oncoprotein degradation via the ubiquitin-proteasome system in cancer cells, effectively inhibiting the growth and survival of tumor cells. However, little is known about the functions of FBXW7 in macrophages and the tumor immune microenvironment. In this study, we ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202293

    authors: Zhong L,Zhang Y,Li M,Song Y,Liu D,Yang X,Yang D,Qu H,Lai L,Wang Q,Chen Z

    更新日期:2020-12-01 00:00:00

  • Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats.

    abstract::The incidence of subarachnoid hemorrhage (SAH) and hazard ratio of death increase with age. Overactivation of microglia contributes to brain damage. This study aimed to investigate the effects of A3 adenosine receptors (A3R) activation on neurofunction and microglial phenotype polarization in the context of SAH in age...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202178

    authors: Li P,Li X,Deng P,Wang D,Bai X,Li Y,Luo C,Belguise K,Wang X,Wei X,Xia Z,Yi B

    更新日期:2020-11-30 00:00:00

  • Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice.

    abstract::Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202200

    authors: Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

    更新日期:2020-11-26 00:00:00

  • Periodontitis in elderly patients with type 2 diabetes mellitus: impact on gut microbiota and systemic inflammation.

    abstract::Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202174

    authors: Li J,Lu H,Wu H,Huang S,Chen L,Gui Q,Zhou W,Yang Y,Wu Y,Zhang H,Zhang Q,Yang Y

    更新日期:2020-11-25 00:00:00

  • Association between ageing population, median age, life expectancy and mortality in coronavirus disease (COVID-19).

    abstract::As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104193

    authors: Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

    更新日期:2020-11-24 00:00:00

  • Loss of Atg7 causes chaotic nucleosome assembly of mouse bone marrow CD11b+Ly6G- myeloid cells.

    abstract::Atg7, a critical component of autophagy machinery, is essential for counteracting hematopoietic aging. However, the non-autophagic role of Atg7 on hematopoietic cells remains fundamentally unclear. In this study, we found that loss of Atg7, but not Atg5, another autophagy-essential gene, in the hematopoietic system re...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104176

    authors: Fang Y,Gu Y,Li L,Zhu L,Qian J,Zhao C,Xu L,Wei W,Du Y,Yuan N,Zhang S,Yuan Y,Xu Y,Jiang C,Wang J

    更新日期:2020-11-24 00:00:00

  • Silencing hTERT attenuates cancer stem cell-like characteristics and radioresistance in the radioresistant nasopharyngeal carcinoma cell line CNE-2R.

    abstract:OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104167

    authors: Chen K,Li L,Qu S,Pan X,Sun Y,Wan F,Yu B,Zhou L,Zhu X

    更新日期:2020-11-24 00:00:00

  • Impairment of Pol β-related DNA base-excision repair leads to ovarian aging in mice.

    abstract::The mechanism underlying the association between age and depletion of the human ovarian follicle reserves remains uncertain. Many identified that impaired DNA polymerase β (Pol β)-mediated DNA base-excision repair (BER) drives to mouse oocyte aging. With aging, DNA lesions accumulate in primordial follicles. However, ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104123

    authors: Hua K,Wang L,Sun J,Zhou N,Zhang Y,Ji F,Jing L,Yang Y,Xia W,Hu Z,Pan F,Chen X,Yao B,Guo Z

    更新日期:2020-11-20 00:00:00

  • A systematic review and network meta-analysis of single nucleotide polymorphisms associated with pancreatic cancer risk.

    abstract::In this meta-analysis, we systematically investigated the correlation between single nucleotide polymorphisms (SNPs) and pancreatic cancer (PC) risk. We searched PubMed, Network Science, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science and Technology Periodical Database (VIP), an...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104128

    authors: Ye ZM,Li LJ,Luo MB,Qing HY,Zheng JH,Zhang C,Lu YX,Tang YM

    更新日期:2020-11-20 00:00:00

  • TNFAIP3 ameliorates the degeneration of inflammatory human nucleus pulposus cells by inhibiting mTOR signaling and promoting autophagy.

    abstract::Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degenerat...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104160

    authors: Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu B

    更新日期:2020-11-20 00:00:00

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