Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment.


:Currently, no pharmacotherapy has been proven effective in treating photoreceptor degeneration in patients. Discovering readily available and safe neuroprotectants is therefore highly sought after. Here, we investigated nicotinamide mononucleotide (NMN), a precursor of nicotinamide adenine dinucleotide (NAD+), in a retinal detachment (RD) induced photoreceptor degeneration. NMN administration after RD resulted in a significant reduction of TUNEL+ photoreceptors, CD11b+ macrophages, and GFAP labeled glial activation; a normalization of protein carbonyl content (PCC), and a preservation of the outer nuclear layer (ONL) thickness. NMN administration significantly increased NAD+ levels, SIRT1 protein expression, and heme oxygenase-1 (HO-1) expression. Delayed NMN administration still exerted protective effects after RD. Mechanistic in vitro studies using 661W cells revealed a SIRT1/HO-1 signaling as a downstream effector of NMN-mediated protection under oxidative stress and LPS stimulation. In conclusion, NMN administration exerts neuroprotective effects on photoreceptors after RD and oxidative injury, suggesting a therapeutic avenue to treating photoreceptor degeneration.


Aging (Albany NY)




Chen X,Amorim JA,Moustafa GA,Lee JJ,Yu Z,Ishihara K,Iesato Y,Barbisan P,Ueta T,Togka KA,Lu L,Sinclair DA,Vavvas DG




Has Abstract


2020-12-29 00:00:00














  • Dopamine suppresses octopamine signaling in C. elegans: possible involvement of dopamine in the regulation of lifespan.

    abstract::Amine neurotransmitters, such as dopamine, serotonin, and noradrenaline, play important roles in the modulation of behaviors and metabolism of animals. InC. elegans, it has been shown that serotonin and octopamine, an invertebrate equivalent of noradrenaline, also regulate lifespan through a mechanism related to food ...


    pub_type: 杂志文章


    authors: Suo S,Culotti JG,Van Tol HH

    更新日期:2009-10-21 00:00:00

  • KCNQ1OT1 promotes melanoma growth and metastasis.

    abstract::Melanoma is the deadliest cutaneous neoplasm. To prevent metastasis, early diagnosis and surgical treatment is vital. Long non-coding RNAs (lncRNAs) may serve as biomarkers and therapeutic targets in tumors. We investigated the molecular mechanisms of lncRNA KCNQ1OT1 in melanoma. Real time PCR demonstrated that KCNQ1O...


    pub_type: 杂志文章


    authors: Guo B,Zhang Q,Wang H,Chang P,Tao K

    更新日期:2018-04-17 00:00:00

  • Fish oil supplements, longevity and aging.

    abstract::Fish oil supplementation is of great medical and public interest with epidemiological evidence of health benefits in humans, in particular by conferring protection against heart diseases. Its anti-inflammatory properties have also been reported. Initial results from short-lived mouse strains showed that fish oil can i...


    pub_type: 评论,杂志文章


    authors: de Magalhães JP,Müller M,Rainger GE,Steegenga W

    更新日期:2016-08-01 00:00:00

  • Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice.

    abstract::Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. In this study, taking advantage o...


    pub_type: 杂志文章


    authors: Qian L,Zhang H,Gu Y,Li D,He S,Wang H,Cheng Y,Yang W,Yu H,Zhao X,Cai W,Meng L,Jin M,Wang Y,Zhang Y

    更新日期:2018-12-04 00:00:00

  • The diagnostic and prognostic role of RhoA in hepatocellular carcinoma.

    abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...


    pub_type: 杂志文章


    authors: Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

    更新日期:2019-07-22 00:00:00

  • The protective effects of dehydrocostus lactone against TNF-α-induced degeneration of extracellular matrix (ECM) in SW1353 cells.

    abstract::Osteoarthritis is a common joint disease that disrupts the lives of millions of people worldwide. To date, a safe and reliable treatment has not yet been announced. Excessive production of pro-inflammatory cytokines such as TNF-α plays an important role in the pathological development of OA. Dehydrocostus lactone (DHC...


    pub_type: 杂志文章


    authors: Wang L,Yang M,Zhang C,Huang F

    更新日期:2020-09-14 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...


    pub_type: 杂志文章


    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00

  • Loss of macroH2A1 decreases mitochondrial metabolism and reduces the aggressiveness of uveal melanoma cells.

    abstract::Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...


    pub_type: 杂志文章


    authors: Giallongo S,Di Rosa M,Caltabiano R,Longhitano L,Reibaldi M,Distefano A,Lo Re O,Amorini AM,Puzzo L,Salvatorelli L,Palmucci S,Tibullo D,Russo A,Longo A,Lazzarino G,Li Volti G,Vinciguerra M

    更新日期:2020-05-12 00:00:00

  • Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

    abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...


    pub_type: 杂志文章


    authors: Honkonen M,Vääräniemi K,Saijonmaa O,Nyman A,Tikkakoski AJ,Koskela J,Lehtimäki T,Kähönen M,Mustonen J,Fyhrquist F,Pörsti I

    更新日期:2020-06-23 00:00:00

  • Prognostic value of immune-related genes in clear cell renal cell carcinoma.

    abstract::Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the...


    pub_type: 杂志文章


    authors: Wan B,Liu B,Huang Y,Yu G,Lv C

    更新日期:2019-12-10 00:00:00

  • Modelling biological age based on plasma peptides in Han Chinese adults.

    abstract::Age-related disease burdens increased over time, and whether plasma peptides can be used to accurately predict age in order to explain the variation in biological indicators remains inadequately understood. Here we first developed a biological age model based on plasma peptides in 1890 Chinese Han adults. Based on mas...


    pub_type: 杂志文章


    authors: Cao W,Zheng D,Wang G,Zhang J,Ge S,Singh M,Wang H,Song M,Li D,Wang W,Xu X,Wang Y

    更新日期:2020-06-05 00:00:00

  • Age-related hearing loss accelerates cerebrospinal fluid tau levels and brain atrophy: a longitudinal study.

    abstract::Age-related hearing loss (ARHL) has been considered as a promising modifiable risk factor for cognitive impairment and dementia. Nonetheless, it is still unclear whether age-related hearing loss associates with neurodegenerative biomarkers of Alzheimer's disease (AD). Participants with ARHL were selected from the esta...


    pub_type: 杂志文章


    authors: Xu W,Zhang C,Li JQ,Tan CC,Cao XP,Tan L,Yu JT,Alzheimer’s Disease Neuroimaging Initiative.

    更新日期:2019-05-22 00:00:00

  • Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer.

    abstract::To identify an immune-related prognostic signature based on long non-coding RNAs (lncRNAs) and find immunotherapeutic targets for bladder urothelial carcinoma, we downloaded RNA-sequencing data from The Cancer Genome Atlas (TCGA) dataset. Functional enrichment analysis demonstrated bladder urothelial carcinoma was rel...


    pub_type: 杂志文章


    authors: Song Y,Jin D,Chen J,Luo Z,Chen G,Yang Y,Liu X

    更新日期:2020-06-24 00:00:00

  • lncRNA OGFRP1 functions as a ceRNA to promote the progression of prostate cancer by regulating SARM1 level via miR-124-3p.

    abstract::lncRNA can interact with miRNA as a ceRNA to participate in the regulation of target gene expression, thus playing an important role in the development of malignant tumors. In this research, we found that OGFRP1 was up-regulated in prostate cancer (PCa) clinical samples and cell lines. Additionally, OGFRP1 is signific...


    pub_type: 杂志文章


    authors: Yan K,Hou L,Liu T,Jiao W,Ma Q,Fang Z,Zhang S,Song D,Liu J,Gao X,Fan Y

    更新日期:2020-05-19 00:00:00

  • Identification of a hippocampal lncRNA-regulating network in cognitive dysfunction caused by chronic cerebral hypoperfusion.

    abstract::Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...


    pub_type: 杂志文章


    authors: Yao ZH,Wang J,Shen BZ,Li YT,Yao XL,Zhang SF,Zhang Y,Hu JC,Xie YC

    更新日期:2020-10-11 00:00:00

  • LINC01419 facilitates hepatocellular carcinoma growth and metastasis through targeting EZH2-regulated RECK.

    abstract::Long non-coding RNAs (lncRNAs) have been reported to play significant roles in human tumorigenesis, for example, in hepatocellular carcinoma (HCC). This study explored the role of LINC01419, a new lncRNA, in HCC. In vitro study revealed that LINC01419 promotes growth and migration of HCC cells. Genes that affected cel...


    pub_type: 杂志文章


    authors: Zhang G,Chen X,Ma L,Ding R,Zhao L,Ma F,Deng X

    更新日期:2020-06-10 00:00:00

  • Immune senescence and immune activation in elderly colorectal cancer patients.

    abstract::In our previous study, we found that low thymic output and short telomere length were associated with a higher risk of tumor in elderly cancer patients. Here, we aimed to examine in depth the impact of immunological and biological senescence and immune activation on disease outcome in elderly patients with colorectal ...


    pub_type: 杂志文章


    authors: Giunco S,Petrara MR,Bergamo F,Del Bianco P,Zanchetta M,Carmona F,Zagonel V,De Rossi A,Lonardi S

    更新日期:2019-06-13 00:00:00

  • Role of FUT8 expression in clinicopathology and patient survival for various malignant tumor types: A systematic review and meta-analysis.

    abstract::Dysregulation of α(1,6)-fucosyltransferase (FUT8) plays significant roles in development of a variety of malignant tumor types. We collected as many relevant articles and microarray datasets as possible to assess the prognostic value of FUT8 expression in malignant tumors. For this purpose, we systematically searched ...


    pub_type: 杂志文章


    authors: Ma M,Han G,Wang Y,Zhao Z,Guan F,Li X

    更新日期:2020-12-11 00:00:00

  • The transcription factor CREB acts as an important regulator mediating oxidative stress-induced apoptosis by suppressing αB-crystallin expression.

    abstract::The general transcription factor, CREB has been shown to play an essential role in promoting cell proliferation, neuronal survival and synaptic plasticity in the nervous system. However, its function in stress response remains to be elusive. In the present study, we demonstrated that CREB plays a major role in mediati...


    pub_type: 杂志文章


    authors: Wang L,Nie Q,Gao M,Yang L,Xiang JW,Xiao Y,Liu FY,Gong XD,Fu JL,Wang Y,Nguyen QD,Liu Y,Liu M,Li DW

    更新日期:2020-06-17 00:00:00

  • Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

    abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...


    pub_type: 杂志文章


    authors: Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

    更新日期:2020-08-05 00:00:00

  • Rapamycin-induced metabolic defects are reversible in both lean and obese mice.

    abstract::The inhibition of mTOR (mechanistic target of rapamycin) by the macrolide rapamycin has many beneficial effects in mice, including extension of lifespan and reduction or prevention of several age-related diseases. At the same time, chronic rapamycin treatment causes impairments in glucose metabolism including hypergly...


    pub_type: 杂志文章


    authors: Liu Y,Diaz V,Fernandez E,Strong R,Ye L,Baur JA,Lamming DW,Richardson A,Salmon AB

    更新日期:2014-09-01 00:00:00

  • A CREB1/miR-433 reciprocal feedback loop modulates proliferation and metastasis in colorectal cancer.

    abstract::Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...


    pub_type: 杂志文章


    authors: Yan L,You WQ,Sheng NQ,Gong JF,Hu LD,Tan GW,Chen HQ,Wang ZG

    更新日期:2018-12-06 00:00:00

  • Age-related micro-RNA abundance in individual C. elegans.

    abstract::Non-coding small RNAs of the micro-RNA class (miRNA) are conserved regulators of gene function with a broad impact on biological processes. We screened miRNA levels for age-related changes in individual worms and investigated their influence on the lifespan of the nematode C. elegans. We measured the abundance of 69 m...


    pub_type: 杂志文章


    authors: Lucanic M,Graham J,Scott G,Bhaumik D,Benz CC,Hubbard A,Lithgow GJ,Melov S

    更新日期:2013-06-01 00:00:00

  • Hypoxia induces pulmonary artery smooth muscle dysfunction through mitochondrial fragmentation-mediated endoplasmic reticulum stress.

    abstract::Pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) dysfunction. However, the underlying mechanisms of PASMC dysfunction remain largely unknown. Here, we show that mitochondrial fragmentation contributes to PASMC dysfunction through enhancement of endoplasmic reticulum...


    pub_type: 杂志文章


    authors: Zhuan B,Wang X,Wang MD,Li ZC,Yuan Q,Xie J,Yang Z

    更新日期:2020-11-18 00:00:00

  • Biomarkers of aging and lung function in the normative aging study.

    abstract::Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...


    pub_type: 杂志文章


    authors: Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

    更新日期:2020-06-19 00:00:00

  • Novel cellular evidence of lipophagy within the Sertoli cells during spermatogenesis in the turtle.

    abstract::Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...


    pub_type: 杂志文章


    authors: Ahmed N,Liu Y,Chen H,Yang P,Waqas Y,Liu T,Gandahi JA,Huang Y,Wang L,Song X,Rajput IR,Wang T,Chen Q

    更新日期:2016-10-16 00:00:00

  • A predictive model for the severity of COVID-19 in elderly patients.

    abstract::Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, with a high fatality rate. To date, there is no model to predict the severity of COVID-19 in elderly patients. In this study, patients who maintained a non-severe condition and patients who progressed to ...


    pub_type: 杂志文章


    authors: Zeng F,Deng G,Cui Y,Zhang Y,Dai M,Chen L,Han D,Li W,Guo K,Chen X,Shen M,Pan P

    更新日期:2020-11-10 00:00:00

  • Probucol, a "non-statin" cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice.

    abstract::Oxidative stress plays a vital role in the initiation and progression of age-related neurodegenerative diseases. Ameliorating oxidative damage is therefore considered as a beneficial strategy for the treatment of age-related neurodegenerative disorders. Probucol (Prob), a lipid-lowering prototype agent, was reported t...


    pub_type: 杂志文章


    authors: Huang JL,Yu C,Su M,Yang SM,Zhang F,Chen YY,Liu JY,Jiang YF,Zhong ZG,Wu DP

    更新日期:2019-10-07 00:00:00

  • LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma.

    abstract::Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, W...


    pub_type: 杂志文章


    authors: Su W,Wang L,Niu F,Zou L,Guo C,Wang Z,Yang X,Wu J,Lu Y,Zhang J,Beer DG,Yang Z,Chen G

    更新日期:2019-05-13 00:00:00

  • Calreticulin increases growth and progression of natural killer/T-cell lymphoma.

    abstract::In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with poorer overall survival of NKTCL patients...


    pub_type: 杂志文章


    authors: Zheng Y,Li C,Xin P,Peng Q,Zhang W,Liu S,Zhu X

    更新日期:2020-11-18 00:00:00