Abstract:
:Autophagy is involved in degenerative diseases such as osteoarthritis and disc degeneration. Although, tumor necrosis factor α-induced protein 3 (TNFAIP3) is well-known as a key regulator of inflammation and autophagy, it is still not clear whether TNFAIP3 regulates autophagy to protect from human disc cells degeneration. We hypothesize that TNFAIP3 may also regulate autophagy to inhibit pro-inflammatory cytokines expression in human nucleus pulposus cells (NPCs). In this study, TNFAIP3 expression was increased in degenerative disc tissue as well as LPS-stimulated human NPCs, and the effect of TNFAIP3 in LPS-induced NPCs was further explored. The results demonstrated that pro-inflammatory cytokines expression in TNFAIP3-His cells was decreased, while it was increased in TNFAIP3-siRNA cells. Further molecular mechanism research showed that TNFAIP3-siRNA cells enhanced the phosphorylation of mammalian target of rapamycin (mTOR) and inhibited autophagy. Meanwhile, after treatment of TNFAIP3-siRNA cells with the mTOR inhibitor Torin1, the level of autophagy increased and the decrease of extracellular matrix was reversed. In summary, overexpressed TNFAIP3 can promote autophagy and reduce inflammation in LPS-induced human NPCs. Moreover, autophagy triggered by TNFAIP3 can ameliorate the degeneration of inflammatory human NPCs, providing a potential and an attractive therapeutic strategy for degenerative disease.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Chen J,Ma Y,Yang Z,Lan H,Liu G,Zhang Y,Xia H,Wang X,Han F,Tu X,Liu Bdoi
10.18632/aging.104160subject
Has Abstractpub_date
2020-11-20 00:00:00pages
24242-24254issue
23issn
1945-4589pii
104160journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101855
更新日期:2019-03-12 00:00:00
abstract::There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101496
更新日期:2018-07-18 00:00:00
abstract::Docetaxel is a first-line anticancer drug widely used in the treatment of advanced prostate cancer. However, its therapeutic efficacy is limited by its side effects and the development of chemoresistance by the tumor. Using a gene differential expression microarray, we identified 449 genes differentially expressed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102600
更新日期:2019-12-29 00:00:00
abstract::Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103297
更新日期:2020-06-13 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract::Despite improvements in surgical procedures and comprehensive therapies, pancreatic cancer remains one of the most aggressive and deadly human malignancies. It is therefore necessary to determine which cellular mediators associate with prognosis in pancreatic cancer so as to improve the treatment of this disease. In t...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102096
更新日期:2019-07-21 00:00:00
abstract::Genome stability of human embryonic stem cells (hESC) is an important issue because even minor genetic alterations can negatively impact cell functionality and safety. The incorrect repair of DNA double-stranded breaks (DSBs) is the ultimate cause of the formation of chromosomal aberrations. Using G2 radiosensitivity ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100336
更新日期:2011-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a common cancer with very poor survival due to lack of reliable biomarker for early diagnosis. In this study, we investigated microRNA (miRNA) profile of whole blood with a custom microarray containing probes for 1849 miRNA species in a total 213 successive subjects who were divided i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101253
更新日期:2017-06-27 00:00:00
abstract::Dysregulation of α(1,6)-fucosyltransferase (FUT8) plays significant roles in development of a variety of malignant tumor types. We collected as many relevant articles and microarray datasets as possible to assess the prognostic value of FUT8 expression in malignant tumors. For this purpose, we systematically searched ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202239
更新日期:2020-12-11 00:00:00
abstract::Recent studies have demonstrated circular RNAs (circRNAs) to be widely expressed and to have important physiological functions. However, the expression, regulation, and function of circRNAs in neuroglial cells are unknown. Herein, we characterized the expression, regulation, and function of circRNAs in astrocytes. Ast...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102529
更新日期:2019-12-20 00:00:00
abstract::Treatment of thoracic tumors with radiotherapy can lead to severe cardiac injury. We investigated the effects of dexrazoxane, a USFDA-approved cardioprotective drug administered with chemotherapy, on radiation-induced heart disease (RIHD) in a rat model. Male Sprague-Dawley rats were irradiated with a single dose of 2...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202332
更新日期:2021-01-02 00:00:00
abstract:BACKGROUND:Hepatocellular carcinomas (HCC) constantly rank among the malignancies with the highest death tolls on the global scale. Moreover, HCC are associated with a limited set of therapeutic options. This is particularly true in the case of advanced stage cancers, where long-term survival is uncommon. For the inope...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102292
更新日期:2019-10-25 00:00:00
abstract::Emerging evidence suggests that the dysregulation of autophagy-related genes (ARGs) is coupled with the carcinogenesis and progression of breast cancer (BRCA). We constructed three subtype-specific risk models using differentially expressed ARGs. In Luminal, Her-2, and Basal-like BRCA, four- (BIRC5, PARP1, ATG9B, and ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103437
更新日期:2020-07-10 00:00:00
abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103459
更新日期:2020-06-23 00:00:00
abstract::Exosomes play important roles in proliferation and microenvironment modulation of many types of cancers, including colorectal cancer (CRC). However, the inhibitory effect of CRC cells-derived exosomes in angiogenesis has not been fully discussed. In this study, the roles of microRNA-183-5p (miR-183-5p) in abundant in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103145
更新日期:2020-05-03 00:00:00
abstract::Evidence has shown that microRNAs (miRNAs) participate in the progression of CRC. Previous studies have indicated that miR-214-3p is abnormally expressed in various malignant tumors. However, the biological function it plays in CRC and the potential mechanism are unclear. Here, we demonstrated that miR-214-3p was obvi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103233
更新日期:2020-05-15 00:00:00
abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103465
更新日期:2020-08-05 00:00:00
abstract::Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101837
更新日期:2019-02-24 00:00:00
abstract::A recently discovered satiety molecule, nesfatin-1, is localized in neurons of the hypothalamus and brain stem and colocalized with stress-related substances, corticotropin-releasing hormone (CRH), oxytocin, proopiomelanocortin, noradrenaline (NA) and 5-hydroxytryptamine (5-HT). Intracerebroventricular (icv) administr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100207
更新日期:2010-11-01 00:00:00
abstract::Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, ...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.100594
更新日期:2013-09-01 00:00:00
abstract::Caveolae are vesicular invaginations of the plasma membrane. Caveolin-1 is the structural protein component of caveolae. Caveolin-1 participates in signal transduction processes by acting as a scaffolding protein that concentrates, organizes and functional regulates signaling molecules within caveolar membranes. Cigar...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100079
更新日期:2009-08-10 00:00:00
abstract:OBJECTIVE:This study aimed to explore the effect of silencing hTERT on the CSC-like characteristics and radioresistance of CNE-2R cells. RESULTS:Silencing hTERT suppressed CNE-2R cell proliferation and increased the cell apoptosis rate and radiosensitivity in vitro. Moreover, it could also inhibit the growth of xenogr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104167
更新日期:2020-11-24 00:00:00
abstract::Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202302
更新日期:2020-12-03 00:00:00
abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104028
更新日期:2020-11-16 00:00:00
abstract::The carbon dioxide (CO2) lattice laser has been successfully used to treat facial skin photoaging induced by UV light. In this study, we analyzed the effect of CO2 lattice laser irradiation on skin photoaging, and investigated the underlying mechanisms. Our results demonstrate that the laser promoted collagen synthesi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103063
更新日期:2020-04-20 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202275
更新日期:2020-12-09 00:00:00
abstract::We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specifically, we pursued the simultaneous youthful in vivo calibration of two determinan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102148
更新日期:2019-08-15 00:00:00
abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101711
更新日期:2018-12-30 00:00:00
abstract::Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100548
更新日期:2013-04-01 00:00:00
abstract::The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103931
更新日期:2020-10-14 00:00:00