Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.


:Circular RNAs (circRNAs), a novel class of endogenous long non-coding RNAs, have attracted considerable attention due to their closed continuous loop structure and potential clinical value. In this study, we investigated the function of circFASTKD1 in vascular endothelial cells. CircFASTKD1 bound directly to miR-106a and relieved its inhibition of Large Tumor Suppressor Kinases 1 and 2, thereby suppressing the Yes-Associated Protein signaling pathway. Under both normal and hypoxic conditions, the ectopic expression of circFASTKD1 reduced the viability, migration, mobility and tube formation of vascular endothelial cells, whereas the downregulation of circFASTKD1 induced angiogenesis by promoting these processes. Moreover, downregulation of circFASTKD1 in mice improved cardiac function and repair after myocardial infarction. These findings indicate that circFASTKD1 is a potent inhibitor of angiogenesis after myocardial infarction and that silencing circFASTKD1 exerts therapeutic effects during hypoxia by stimulating angiogenesis in vitro and in vivo.


Aging (Albany NY)




Gao WQ,Hu XM,Zhang Q,Yang L,Lv XZ,Chen S,Wu P,Duan DW,Lang YH,Ning M,Lai KG,Zhang ZY,Liang B,Bao JY,Wu HD,Li T




Has Abstract


2020-12-19 00:00:00










  • Calreticulin increases growth and progression of natural killer/T-cell lymphoma.

    abstract::In this study, we investigated the role of calreticulin (CALR) in the pathogenesis of natural killer/T-cell lymphoma (NKTCL). CALR expression was significantly higher in the NKTCL tissues than normal control tissues in the GSE80632 dataset. High CALR expression correlated with poorer overall survival of NKTCL patients...


    pub_type: 杂志文章


    authors: Zheng Y,Li C,Xin P,Peng Q,Zhang W,Liu S,Zhu X

    更新日期:2020-11-18 00:00:00

  • Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.

    abstract::Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...


    pub_type: 杂志文章


    authors: Bartley JM,Pan SJ,Keilich SR,Hopkins JW,Al-Naggar IM,Kuchel GA,Haynes L

    更新日期:2016-04-01 00:00:00

  • Implications of maraviroc and/or rapamycin in a mouse model of fragility.

    abstract:BACKGROUND:As age increases, the risk of developing fragility also increases. Improving the knowledge of frailty could contribute to maintaining the functional ability of elderly people. Interleukin (IL)-10 homozygous knockout mice (IL-10tm/tm [IL10KO]) constitute an excellent tool for the study of frailty. Because pat...


    pub_type: 杂志文章


    authors: Pérez-Martínez L,Romero L,Muñoz-Galván S,Verdugo-Sivianes EM,Rubio-Mediavilla S,Oteo JA,Carnero A,Blanco JR

    更新日期:2020-04-30 00:00:00

  • Prognostic roles of metabolic reprogramming-associated genes in patients with hepatocellular carcinoma.

    abstract::Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...


    pub_type: 杂志文章


    authors: Cui L,Xue H,Wen Z,Lu Z,Liu Y,Zhang Y

    更新日期:2020-11-12 00:00:00

  • Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity.

    abstract::New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1) are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse metabolism-targeting drugs, exposure to the dietary polyphenol resveratrol (RSV) revealed its differential capacity to generate a distinct P...


    pub_type: 杂志文章


    authors: Verdura S,Cuyàs E,Cortada E,Brunet J,Lopez-Bonet E,Martin-Castillo B,Bosch-Barrera J,Encinar JA,Menendez JA

    更新日期:2020-01-04 00:00:00

  • Ovulation and ovarian wound healing are impaired with advanced reproductive age.

    abstract::Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...


    pub_type: 杂志文章


    authors: Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

    更新日期:2020-05-14 00:00:00

  • Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation.

    abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...


    pub_type: 杂志文章


    authors: Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

    更新日期:2019-10-06 00:00:00

  • Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration.

    abstract::Skeletal muscle mass and power decrease with age, leading to impairment of mobility and metabolism in the elderly. Ca2+ signaling is crucial for myoblast differentiation as well as muscle contraction through activation of transcription factors and Ca2+-dependent kinases and phosphatases. Ca2+ channels, such as dihydro...


    pub_type: 杂志文章


    authors: Choi JY,Hwang CY,Lee B,Lee SM,Bahn YJ,Lee KP,Kang M,Kim YS,Woo SH,Lim JY,Kim E,Kwon KS

    更新日期:2016-09-21 00:00:00

  • Complete cardiac regeneration in a mouse model of myocardial infarction.

    abstract::Cardiac remodeling and subsequent heart failure remain critical issues after myocardial infarction despite improved treatment and reperfusion strategies. Recently, complete cardiac regeneration has been demonstrated in fish and newborn mice following resection of the cardiac apex. However, it remained entirely unclear...


    pub_type: 杂志文章


    authors: Haubner BJ,Adamowicz-Brice M,Khadayate S,Tiefenthaler V,Metzler B,Aitman T,Penninger JM

    更新日期:2012-12-01 00:00:00

  • Inducing cellular senescence in vitro by using genetically encoded photosensitizers.

    abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...


    pub_type: 杂志文章


    authors: Petrova NV,Luzhin AV,Serebrovskaya EO,Ryumina AP,Velichko AK,Razin SV,Kantidze OL

    更新日期:2016-10-14 00:00:00

  • Association between ageing population, median age, life expectancy and mortality in coronavirus disease (COVID-19).

    abstract::As of May 5, 2020, the number of confirmed coronavirus disease (COVID-19) cases has been more than 3.5 million with 243,540 deaths. We aimed to determine the associations between ageing population, median age, life expectancy at birth and COVID-19 mortality. The numbers of COVID-19 cases and deaths in the European reg...


    pub_type: 杂志文章


    authors: Wang XQ,Song G,Yang Z,Chen RJ,Zheng YL,Hu HY,Su X,Chen PJ

    更新日期:2020-11-24 00:00:00

  • SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...


    pub_type: 杂志文章


    authors: Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

    更新日期:2020-12-03 00:00:00

  • Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects.

    abstract::Telomeres are short segments in chromosome ends, the length of which is reduced during cell lifecycles. We examined the association of mean leukocyte telomere length (LTL) and short telomere proportion (STP) with hemodynamic variables in normotensive and never-treated hypertensive volunteers (n=566, 19-72 years). STP ...


    pub_type: 杂志文章


    authors: Honkonen M,Vääräniemi K,Saijonmaa O,Nyman A,Tikkakoski AJ,Koskela J,Lehtimäki T,Kähönen M,Mustonen J,Fyhrquist F,Pörsti I

    更新日期:2020-06-23 00:00:00

  • Expression and significance of miR - 20b in retinal photoreceptor cells exposed to PCB1254.

    abstract::Previous studies have shown that PCB1254 has an adverse effect on zebrafish retinal development, but the basic mechanism behind it is not clear. The purpose of this study was to investigate the molecular mechanisms of PCB-induced retinal dysplasia. RT-qPCR, immunoblotting, HE staining and immunofluorescence were adopt...


    pub_type: 杂志文章


    authors: Zhang X,Zhang Q,Jiang Y,Zhang S,Hong Q,Guo X,Chi X,Tong M

    更新日期:2019-10-16 00:00:00

  • Meta‐analysis of genetic variants associated with human exceptional longevity.

    abstract::Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, ...


    pub_type: 杂志文章,meta分析


    authors: Sebastiani P,Bae H,Sun FX,Andersen SL,Daw EW,Malovini A,Kojima T,Hirose N,Schupf N,Puca A,Perls TT

    更新日期:2013-09-01 00:00:00

  • The IL1β-HER2-CLDN18/CLDN4 axis mediates lung barrier damage in ARDS.

    abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...


    pub_type: 杂志文章


    authors: Ma X,Yu X,Zhou Q

    更新日期:2020-02-15 00:00:00

  • Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.

    abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...


    pub_type: 杂志文章


    authors: Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

    更新日期:2021-02-01 00:00:00

  • Long-term environmental enrichment affects microglial morphology in middle age mice.

    abstract::Aging is associated with increased central nervous system inflammation, in large part due to dysfunctional microglia. Environmental enrichment (EE) provides a model for studying the dynamics of lifestyle factors in the development of age-related neuroinflammation and microglial dysfunction. EE results in improvements ...


    pub_type: 杂志文章


    authors: Ali S,Liu X,Queen NJ,Patel RS,Wilkins RK,Mo X,Cao L

    更新日期:2019-04-29 00:00:00

  • Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p.

    abstract::Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...


    pub_type: 杂志文章


    authors: Song P,Yin SC

    更新日期:2016-11-03 00:00:00

  • Association of KRAS and NRAS gene polymorphisms with Wilms tumor risk: a four-center case-control study.

    abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...


    pub_type: 杂志文章,多中心研究


    authors: Fu W,Zhuo Z,Hua RX,Fu K,Jia W,Zhu J,Zhang J,Cheng J,Zhou H,Xia H,He J,Liu G

    更新日期:2019-03-12 00:00:00

  • PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation.

    abstract::Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...


    pub_type: 杂志文章


    authors: Rajapakse D,Chen M,Curtis TM,Xu H

    更新日期:2017-10-09 00:00:00

  • Urinary metabolite signature in bipolar disorder patients during depressive episode.

    abstract::The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...


    pub_type: 杂志文章


    authors: Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

    更新日期:2019-02-05 00:00:00

  • TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling.

    abstract::Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was si...


    pub_type: 杂志文章


    authors: Yin L,Gao S,Shi H,Wang K,Yang H,Peng B

    更新日期:2019-09-27 00:00:00

  • Transcriptional regulation of miR-483-3p mediated by IL-6/STAT3 axis promoted epithelial-mesenchymal transition and tumor stemness in glioma.

    abstract:BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...


    pub_type: 杂志文章


    authors: Xu D,Chi G,Xu D

    更新日期:2020-11-04 00:00:00

  • Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

    abstract::Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...


    pub_type: 杂志文章


    authors: Jin D,Zhang R,Chen H,Li C

    更新日期:2020-06-13 00:00:00

  • Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells.

    abstract::Human tumors and cultured cells contain elevated levels of endogenous DNA damage resulting from telomere dysfunction, replication and transcription errors, reactive oxygen species, and genome instability. However, the contribution of telomere-associated versus telomere-independent endogenous DNA lesions to this damage...


    pub_type: 杂志文章


    authors: Nakamura AJ,Redon CE,Bonner WM,Sedelnikova OA

    更新日期:2009-02-04 00:00:00

  • Survival of irradiated recipient mice after transplantation of bone marrow from young, old and "early aging" mice.

    abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...


    pub_type: 杂志文章


    authors: Guest I,Ilic Z,Scrable H,Sell S

    更新日期:2015-12-01 00:00:00

  • Subgroup analysis of proinsulin and insulin levels reveals novel correlations to metabolic indicators of type 2 diabetes.

    abstract::Proinsulin, insulin and proinsulin/insulin (P/I) ratio have been reported to be correlated with fasting plasma glucose (FPG) and Hemoglobin A1c (HbA1c) in whole population study therefore sensitive predictors of T2D progression. However, by analyzing data collected from 2018-2019 from a cohort of 1579 East Asian indiv...


    pub_type: 杂志文章


    authors: Li T,Quan H,Zhang H,Lin L,Lin L,Ou Q,Chen K

    更新日期:2020-06-12 00:00:00

  • Beyond the social gradient: the role of lifelong socioeconomic status in older adults' health trajectories.

    abstract::Inequalities in older adults' health rarely consider life-course aspects of socioeconomic status (SES). We examined the association between lifelong SES and old-age health trajectories, and explored the role of lifestyle factors and depressive symptoms in this association. We followed 2760 adults aged 60+ from the Swe...


    pub_type: 杂志文章


    authors: Harber-Aschan L,Calderón-Larrañaga A,Darin-Mattson A,Hu X,Fratiglioni L,Dekhtyar S

    更新日期:2020-12-21 00:00:00

  • Risk factors and prediction of second primary cancer in primary female non-metastatic breast cancer survivors.

    abstract::This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...


    pub_type: 杂志文章


    authors: Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

    更新日期:2020-10-13 00:00:00