RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.

Abstract:

:Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA pairs that regulate related molecular signaling networks. We established an RV dysfunction-induced type II CRS mouse model by pulmonary artery constriction (PAC). PAC mice developed severe RV hypertrophy and fibrosis; renal atrophy and dysfunction with elevated creatinine were subsequently observed. Expression profiles in RV and kidney tissues were obtained by whole transcriptome sequencing, revealing a total of 741 and 86 differentially expressed (DE) mRNAs, 159 and 29 DEmiRNAs and 233 and 104 DEcircRNAs between RV and kidney tissue, respectively. Competing endogenous RNA (ceRNA) networks were established. A significant alteration in proliferative, fibrotic and metabolic pathways was found based on GO and KEGG analyses, and the network revealed key ceRNA pairs, such as novel_circ_002631/miR-181a-5p/Creb1 and novel_circ_002631/miR-33-y/Kpan6. These findings indicate that significantly dysregulated pathways in RV dysfunction induced type II CRS include Ras, PI3K/Akt, cGMP-PKG pathways, and thyroid metabolic pathways. These ceRNA pairs can be considered potential targets for the treatment of type II CRS.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Chen K,Huang X,Xie D,Shen M,Lin H,Zhu Y,Ma S,Zheng C,Chen L,Liu Y,Liao W,Bin J,Liao Y

doi

10.18632/aging.202385

subject

Has Abstract

pub_date

2021-01-20 00:00:00

issn

1945-4589

pii

202385

journal_volume

12

pub_type

杂志文章

相关文献

Aging-US文献大全
  • Increased expression of connexin 43 in a mouse model of spinal motoneuronal loss.

    abstract::Amyotrophic lateral sclerosis (ALS) is one of the most common motoneuronal disease, characterized by motoneuronal loss and progressive paralysis. Despite research efforts, ALS remains a fatal disease, with a survival of 2-5 years after disease onset. Numerous gene mutations have been correlated with both sporadic (sAL...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103561

    authors: Spitale FM,Vicario N,Rosa MD,Tibullo D,Vecchio M,Gulino R,Parenti R

    更新日期:2020-06-24 00:00:00

  • LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules.

    abstract::Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103171

    authors: Annis S,Fleischmann Z,Logan R,Mullin-Bernstein Z,Franco M,Saürich J,Tilly JL,Woods DC,Khrapko K

    更新日期:2020-04-28 00:00:00

  • The diagnostic and prognostic role of RhoA in hepatocellular carcinoma.

    abstract::The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102110

    authors: Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

    更新日期:2019-07-22 00:00:00

  • DNA methylation perturbations may link altered development and aging in the lung.

    abstract::Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 expose...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202544

    authors: Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

    更新日期:2021-01-19 00:00:00

  • SNRPB-mediated RNA splicing drives tumor cell proliferation and stemness in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading malignant diseases worldwide, but therapeutic targets for HCC are lacking. Here, we characterized a significant upregulation of Small Nuclear Ribonucleoprotein Polypeptides B and B1 (SNRPB) in HCC via qRT-PCR, western blotting, tissue microarray and public database ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202164

    authors: Zhan YT,Li L,Zeng TT,Zhou NN,Guan XY,Li Y

    更新日期:2020-12-03 00:00:00

  • High expression of the breast cancer susceptibility gene BRCA1 in long-lived termite kings.

    abstract::Aging is associated with the accumulation of DNA damage. High expression of DNA repair genes has been suggested to contribute to prolonged lifespan in several organisms. However, the crucial DNA repair genes contributing to longevity remain unknown. Termite kings have an extraordinary long lifespan compared with that ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101578

    authors: Tasaki E,Mitaka Y,Nozaki T,Kobayashi K,Matsuura K,Iuchi Y

    更新日期:2018-10-11 00:00:00

  • Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2.

    abstract::Morbidity and mortality of coronavirus disease 2019 (COVID-19) is age-dependent. It remains unclear whether vertical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs during pregnancy and how such infection will affect fetal development. Here, we performed single-cell transcriptomic analysis of place...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.104015

    authors: Lü M,Qiu L,Jia G,Guo R,Leng Q

    更新日期:2020-10-26 00:00:00

  • Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults.

    abstract::Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102678

    authors: Fujie S,Hasegawa N,Sanada K,Hamaoka T,Maeda S,Padilla J,Martinez-Lemus LA,Iemitsu M

    更新日期:2020-01-09 00:00:00

  • HPV-18 E2 protein downregulates antisense noncoding mitochondrial RNA-2, delaying replicative senescence of human keratinocytes.

    abstract::Human and mouse cells display a differential expression pattern of a family of mitochondrial noncoding RNAs (ncmtRNAs), according to proliferative status. Normal proliferating and cancer cells express a sense ncmtRNA (SncmtRNA), which seems to be required for cell proliferation, and two antisense transcripts referred ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101711

    authors: Villota C,Varas-Godoy M,Jeldes E,Campos A,Villegas J,Borgna V,Burzio LO,Burzio VA

    更新日期:2018-12-30 00:00:00

  • Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan.

    abstract::Differences in the way human and mouse fibroblasts experience senescence in culture had long puzzled researchers. While senescence of human cells is mediated by telomere shortening, Parrinello et al. demonstrated that senescence of mouse cells is caused by extreme oxygen sensitivity. It was hypothesized that the strik...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100958

    authors: Patrick A,Seluanov M,Hwang C,Tam J,Khan T,Morgenstern A,Wiener L,Vazquez JM,Zafar H,Wen R,Muratkalyeva M,Doerig K,Zagorulya M,Cole L,Catalano S,Lobo Ladd AA,Coppi AA,Coşkun Y,Tian X,Ablaeva J,Nevo E,Gladyshev VN

    更新日期:2016-05-01 00:00:00

  • Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.

    abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202445

    authors: Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

    更新日期:2021-02-01 00:00:00

  • Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5).

    abstract::Reducing the expression of the Indy (I'm Not Dead Yet) gene in lower organisms extends life span by mechanisms resembling caloric restriction. Similarly, deletion of the mammalian homolog, mIndy (Slc13a5), encoding for a plasma membrane tricarboxylate transporter, protects from aging- and diet-induced adiposity and in...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100854

    authors: Pesta DH,Perry RJ,Guebre-Egziabher F,Zhang D,Jurczak M,Fischer-Rosinsky A,Daniels MA,Willmes DM,Bhanot S,Bornstein SR,Knauf F,Samuel VT,Shulman GI,Birkenfeld AL

    更新日期:2015-12-01 00:00:00

  • Transcriptional regulation of miR-483-3p mediated by IL-6/STAT3 axis promoted epithelial-mesenchymal transition and tumor stemness in glioma.

    abstract:BACKGROUND:MiRNA can be involved in regulating tumor genesis and development through regulating the major genes expression and regulating corresponding pathways. Here, we investigated the function and mechanisms of miR-483-3p in glioma progression. RESULTS:We found that miR-483-3p was increased in glioma cells and tis...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103761

    authors: Xu D,Chi G,Xu D

    更新日期:2020-11-04 00:00:00

  • S-allyl cysteine reduces osteoarthritis pathology in the tert-butyl hydroperoxide-treated chondrocytes and the destabilization of the medial meniscus model mice via the Nrf2 signaling pathway.

    abstract::In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeo...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103757

    authors: Shao Z,Pan Z,Lin J,Zhao Q,Wang Y,Ni L,Feng S,Tian N,Wu Y,Sun L,Gao W,Zhou Y,Zhang X,Wang X

    更新日期:2020-10-07 00:00:00

  • Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway.

    abstract::Cerebral hypometabolism is a pathophysiological hallmark of Alzheimer's disease (AD). Our previous studies found that a mitochondrial protein, sirtuin3 (Sirt3), was down-regulated in human AD postmortem brains. Sirt3 protected neurons against oligo-amyloid β-42 induced hypometabolism in human Apolipoprotein E4 (ApoE4)...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102516

    authors: Yin J,Nielsen M,Carcione T,Li S,Shi J

    更新日期:2019-12-06 00:00:00

  • Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.

    abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101908

    authors: Ren W,Guan W,Zhang J,Wang F,Xu G

    更新日期:2019-04-14 00:00:00

  • Effects of N-acetyl-L-cysteine on lifespan, locomotor activity and stress-resistance of 3 Drosophila species with different lifespans.

    abstract::N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101561

    authors: Shaposhnikov MV,Zemskaya NV,Koval LA,Schegoleva EV,Zhavoronkov A,Moskalev AA

    更新日期:2018-09-20 00:00:00

  • MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

    abstract::Acute ischemic stroke (AIS) is a major public health problem in China. Impaired angiogenesis plays crucial roles in the development of ischemic cerebral injury. Recent studies have identified that microRNAs (miRNAs) are important regulators of angiogenesis, but little is known the exact effects of angiogenesis-associa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101948

    authors: Du K,Zhao C,Wang L,Wang Y,Zhang KZ,Shen XY,Sun HX,Gao W,Lu X

    更新日期:2019-05-07 00:00:00

  • Efficacy and safety of tocilizumab in COVID-19 patients.

    abstract::In this retrospective study we assessed the efficacy and safety of tocilizumab in patients with critical or severe coronavirus disease 2019 (COVID-19). We enrolled 181 patients admitted to Huoshenshan Hospital (Wuhan, China) with confirmed COVID-19 between January 2020 and February 2020. Ninety-two patients were treat...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103988

    authors: Zheng KL,Xu Y,Guo YF,Diao L,Kong XY,Wan XJ,Zhao F,Ning FZ,Wang LB,Qiao F,Zhao JM,Zhou JH,Zhong YQ,Wu SX,Chen Y,Jin G,Dong YC

    更新日期:2020-10-08 00:00:00

  • Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.

    abstract::Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102181

    authors: Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

    更新日期:2019-08-30 00:00:00

  • Cystathionine beta synthase modulates senescence of human endothelial cells.

    abstract::Availability of methionine is known to modulate the rate of aging in model organisms, best illustrated by the observation that dietary methionine restriction extends the lifespan of rodents. However, the underlying mechanisms are incompletely understood. In eukaryotic cells, methionine can be converted to cysteine thr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100491

    authors: Albertini E,Kozieł R,Dürr A,Neuhaus M,Jansen-Dürr P

    更新日期:2012-10-01 00:00:00

  • Methionine abrogates the renoprotective effect of a low-protein diet against diabetic kidney disease in obese rats with type 2 diabetes.

    abstract::Dietary interventions, including a low-protein diet (LPD) and methionine (Met) restriction, have shown longevity, anti-aging and metabolic health effects. We previously reported that the LPD has a renoprotective effect against diabetic kidney disease (DKD) in rats with type 2 diabetes and obesity. However, it is uncle...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102902

    authors: Kitada M,Ogura Y,Monno I,Xu J,Koya D

    更新日期:2020-03-06 00:00:00

  • Association between serum levels of Klotho and inflammatory cytokines in cardiovascular disease: a case-control study.

    abstract::Decrease in soluble anti-aging Klotho protein levels is associated to cardiovascular disease (CVD). Diverse studies have shown a bidirectional relationship between Klotho and inflammation, a risk factor for the development of CVD. In this work we aimed to evaluate the association between Klotho and inflammatory cytoki...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102734

    authors: Martín-Núñez E,Donate-Correa J,Ferri C,López-Castillo Á,Delgado-Molinos A,Hernández-Carballo C,Pérez-Delgado N,Rodríguez-Ramos S,Cerro-López P,Tagua VG,Mora-Fernández C,Navarro-González JF

    更新日期:2020-01-27 00:00:00

  • DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells.

    abstract::Supporting cells (SCs) of the cochlear (auditory) and vestibular (balance) organs hold promise as a platform for therapeutic regeneration of the sensory hair cells. Prior data have shown proliferative restrictions of adult SCs forced to re-enter the cell cycle. By comparing juvenile and adult SCs in explant cultures, ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100668

    authors: Laos M,Anttonen T,Kirjavainen A,af Hällström T,Laiho M,Pirvola U

    更新日期:2014-06-01 00:00:00

  • Association between immune-related adverse events and efficacy of PD-1 inhibitors in Chinese patients with advanced melanoma.

    abstract::Programmed cell death 1 (PD-1) checkpoint inhibitor therapy leads to immune-related adverse events (irAEs). We sought to evaluate whether the development of irAEs correlates with the treatment response in Chinese patients with advanced melanoma. In this study, we conducted a retrospective study of advanced melanoma pa...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103285

    authors: Zhao JJ,Wen XZ,Ding Y,Li DD,Zhu BY,Li JJ,Weng DS,Zhang X,Zhang XS

    更新日期:2020-06-08 00:00:00

  • Telomere sister chromatid exchange and the process of aging.

    abstract::Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100206

    authors: Blagoev KB,Goodwin EH,Bailey SM

    更新日期:2010-10-01 00:00:00

  • Pharmacological blockade of TNFα prevents sarcopenia and prolongs survival in aging mice.

    abstract::Sarcopenia is a hallmark of aging. Inflammation due to increased generation of cytokines such as TNFα, IL-1β and IL-6 has been implicated in the pathogenesis of sarcopenia. In skeletal muscle of C57BL/6 mice from 12 until 28 months of age, we observed a progressive reduction of myofiber cross sectional area, loss of t...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202200

    authors: Sciorati C,Gamberale R,Monno A,Citterio L,Lanzani C,De Lorenzo R,Ramirez GA,Esposito A,Manunta P,Manfredi AA,Rovere-Querini P

    更新日期:2020-11-26 00:00:00

  • Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis.

    abstract::Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103140

    authors: Ou M,Hao S,Chen J,Zhao S,Cui S,Tu J

    更新日期:2020-11-14 00:00:00

  • Overexpression of long noncoding RNA ANRIL inhibits phenotypic switching of vascular smooth muscle cells to prevent atherosclerotic plaque development in vivo.

    abstract:BACKGROUND:Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Long noncoding RNA ANRIL (lncRNA-ANRIL) is critical in vascular homeostasis. Metformin produces multiple beneficial effects in atherosclerosis. However, the underlying mechanisms need to be elucidated. METHODS ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202392

    authors: Hu DJ,Li ZY,Zhu YT,Li CC

    更新日期:2020-12-19 00:00:00

  • Brain ageing changes proteoglycan sulfation, rendering perineuronal nets more inhibitory.

    abstract::Chondroitin sulfate (CS) proteoglycans in perineuronal nets (PNNs) from the central nervous system (CNS) are involved in the control of plasticity and memory. Removing PNNs reactivates plasticity and restores memory in models of Alzheimer's disease and ageing. Their actions depend on the glycosaminoglycan (GAG) chains...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101256

    authors: Foscarin S,Raha-Chowdhury R,Fawcett JW,Kwok JCF

    更新日期:2017-06-28 00:00:00