Abstract:
:Atherosclerosis is a lipid-driven chronic inflammatory disease in which lipid-laden macrophage foam cells lead to inflamed lesions in arteries. Previous studies have proven that sulfotransferase 2B1b (SULT2B1b) has several roles in the regulation of lipid metabolism and the inflammatory response. However, little is known about the functions of SULT2B1b in ox-LDL-induced inflammation in macrophages. In this study, after treatment with either ox-LDL alone or combined with transfection of siRNAs targeting SULT2B1b, IL-6, TNF-α, NF-κB, IKKβ and IκB mRNA and protein expression were determined in Raw264.7 cells by real-time PCR and Western blot, respectively. The proliferative capacity was determined by EdU staining and Cell Counting Kit-8. Our data demonstrated that SULT2B1b knockdown could reduce phosphorylated NF-κB levels and downregulate IKKβ protein levels. Additionally, IκB levels were increased and the proliferation of ox-LDL stimulated cells was inhibited after SULT2B1b silencing. Downregulation of SULT2B1b expression was found to upregulate miR-148a-3p expression by microarray assay, while IKKβ was a miR-148a-3p target gene. Our study suggests that SULT2B1b knockdown could promote miR148a-3p expression and inhibit activation of the IKKβ/NF-κB signalling pathway, which suppressed the inflammatory response in macrophages. Therefore, targeting the SULT2B1b gene might be potentially beneficial for atherosclerosis prevention by decreasing the inflammatory response.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Yin M,Lu J,Guo Z,Zhang Y,Liu J,Wu T,Guo K,Luo T,Guo Zdoi
10.18632/aging.202273subject
Has Abstractpub_date
2021-01-10 00:00:00issn
1945-4589pii
202273journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103171
更新日期:2020-04-28 00:00:00
abstract::Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks of aging. However, the underlying mechanisms are not well understood. Age-associated alterations in the DNA either due to oxidative damage, defects in DNA repair or epigenetic modifications such as methylation that lead ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100121
更新日期:2010-03-20 00:00:00
abstract::Spinal cord injury (SCI) causes long-term and severe disability, influencing the quality of life and triggering serious socioeconomic consequences. Lack of effective pharmacotherapies for SCI is largely attributable to an incomplete understanding of its pathogenesis. Caspase recruitment domain family member 6 (CARD6) ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102561
更新日期:2019-12-16 00:00:00
abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101305
更新日期:2017-10-20 00:00:00
abstract::Most muscle pathologies are characterized by the progressive loss of muscle tissue due to chronic degeneration combined with the inability of regeneration machinery to replace the damaged muscle. These pathological changes, known as muscle wasting, can be attributed to the activation of several proteolytic systems, su...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100050
更新日期:2009-05-13 00:00:00
abstract::In this study, we used murine chondrocytes as an in vitro model and mice exhibiting destabilization of the medial meniscus (DMM) as an in vivo model to investigate the mechanisms through which S-allyl cysteine (SAC) alleviates osteoarthritis (OA). SAC significantly reduced apoptosis and senescence and maintained homeo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103757
更新日期:2020-10-07 00:00:00
abstract::Combination treatment is a promising strategy to improve prognosis of hepatocellular carcinoma (HCC). Sorafenib is a traditional first-line agent approved for the treatment of advanced HCC, though with limited efficacy. Previously, we reported that lonafarnib, an orally bioavailable non-peptide inhibitor targeting far...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102165
更新日期:2019-08-13 00:00:00
abstract::The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100967
更新日期:2016-06-01 00:00:00
abstract::As an emerging technology, artificial intelligence has been applied to identify various physical disorders. Here, we developed a three-layer diagnosis system for lung cancer, in which three machine learning approaches including decision tree C5.0, artificial neural network (ANN) and support vector machine (SVM) were i...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103249
更新日期:2020-05-23 00:00:00
abstract:BACKGROUND:The rapidly evolving coronavirus disease 2019 (COVID-19) has resulted in more than 24 million infections and 821 thousand deaths. However, a vaccine or specific drug is absent up to this date and more attention has been focused on the use of convalescent plasma (CP). Several articles have described the CP tr...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.202195
更新日期:2020-12-15 00:00:00
abstract::Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101193
更新日期:2017-03-12 00:00:00
abstract::Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the g-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100927
更新日期:2016-04-01 00:00:00
abstract::Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102430
更新日期:2019-11-15 00:00:00
abstract::Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101671
更新日期:2018-12-06 00:00:00
abstract::In this study, we investigated brain morphological changes in adults with non-syndromic cleft lip and palate (NSCLP) after articulation rehabilitation (AR). High-resolution T1 weighted brain magnetic resonance imaging data were analyzed from 45 adults with NSCLP after palatoplasty: 24 subjects were assessed before AR ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103402
更新日期:2020-07-03 00:00:00
abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202405
更新日期:2020-12-26 00:00:00
abstract::The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100319
更新日期:2011-04-01 00:00:00
abstract::Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103363
更新日期:2020-06-19 00:00:00
abstract::Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100492
更新日期:2012-10-01 00:00:00
abstract::Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular en...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101225
更新日期:2017-04-01 00:00:00
abstract::Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.100459
更新日期:2012-05-01 00:00:00
abstract::One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101146
更新日期:2016-12-28 00:00:00
abstract:PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103111
更新日期:2020-04-22 00:00:00
abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101601
更新日期:2018-10-25 00:00:00
abstract::N-acetyl-L-cysteine (NAC) is a derivative of the sulphur-containing amino acid L-cysteine with potential anti-aging properties. We studied 3 Drosophila species with contrast longevity differences (D. virilis is longest-lived, D. kikkawai is shortest-lived and D. melanogaster has moderate lifespan) to test the effects ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101561
更新日期:2018-09-20 00:00:00
abstract::Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101145
更新日期:2016-12-20 00:00:00
abstract::Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103005
更新日期:2020-05-21 00:00:00
abstract::The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103032
更新日期:2020-05-05 00:00:00
abstract::The broccoli-derived isothiocyanate sulforaphane inhibits inflammation, oxidative stress and cancer, but its effect on healthspan and longevity are unclear. We used the C. elegans nematode model and fed the wildtype and 9 mutant strains ±sulforaphane. The lifespan, phenotype, pharyngeal pumping, mobility, lipofuscin a...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202512
更新日期:2021-01-20 00:00:00
abstract::Age-associated cognitive impairment is a major health and social issue because of increasing aged population. Cognitive decline is not homogeneous in humans and the determinants leading to differences between subjects are not fully understood. In middle-aged healthy humans, fasting blood glucose levels in the upper no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101148
更新日期:2016-12-28 00:00:00