Abstract:
:Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in gene sequencing technology in recent years, more heart failure-related genes have been identified. Using existing gene expression data in the Gene Expression Omnibus (GEO) database, we screened differentially expressed genes (DEGs) of heart failure and identified six key genes (HMOX2, SERPINA3, LCN6, CSDC2, FREM1, and ZMAT1) by random forest classifier. Of these genes, CSDC2, FREM1, and ZMAT1 have never been associated with heart failure. We also successfully constructed a new diagnostic model of heart failure using an artificial neural network and verified its diagnostic efficacy in public datasets.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Tian Y,Yang J,Lan M,Zou Tdoi
10.18632/aging.202405subject
Has Abstractpub_date
2020-12-26 00:00:00pages
26221-26235issue
24issn
1945-4589pii
202405journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::One of the most striking changes during mammal aging is a progressive involution of the thymus, associated with an increase in susceptibility to infections, autoimmune diseases and cancer. In order to delay age-related processes, we have developed mitochondria-targeted antioxidant plastoquinonyl decyltriphenyl phospho...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100043
更新日期:2009-04-22 00:00:00
abstract::Mounting studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development and occurrence of several human diseases. However, the role of LINC00461 in osteoarthritis (OA) remains obscure. A CCK-8 assay was performed to detect cell viability, and qRT-PCR analysis was used to measure mRNA exp...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102839
更新日期:2020-03-10 00:00:00
abstract:INTRODUCTION:Circulating non-coding RNA is an ideal source to discover novel biomarkers for non-invasive screening. However, studies for the discovery of universal miRNAs in serum and exosomes for breast cancer early diagnosis are limited. METHODS:Based on bioinformatic analysis, in vitro and in vivo studies were perf...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202388
更新日期:2021-01-20 00:00:00
abstract:BACKGROUND:Gastric cancer is a common malignancy and had poor response to treatment due to its strong heterogeneity. This study aimed to identify essential genes associated with diffuse type gastric cancer and construct a powerful prognostic model. RESULTS:We conducted a weighted gene co-expression network analysis (W...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103743
更新日期:2020-09-11 00:00:00
abstract::In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102481
更新日期:2019-11-22 00:00:00
abstract::Liver fibrosis biomarker, Type IV collagen, may function as hepatocarcinogenesis niche. However, among the six isoforms, the isoforms providing tumor microenvironment and their regulatory network are still unclarified. Based on bioinformatics analysis of hundreds of HCC transcriptome datasets from public databases, we...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102610
更新日期:2020-01-05 00:00:00
abstract::Genome stability of human embryonic stem cells (hESC) is an important issue because even minor genetic alterations can negatively impact cell functionality and safety. The incorrect repair of DNA double-stranded breaks (DSBs) is the ultimate cause of the formation of chromosomal aberrations. Using G2 radiosensitivity ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100336
更新日期:2011-06-01 00:00:00
abstract::Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101975
更新日期:2019-05-29 00:00:00
abstract::The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...
journal_title:Aging
pub_type: 社论
doi:10.18632/aging.100202
更新日期:2010-09-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have emerged as important regulators in the development and progression of gastric cancer (GC). ARHGAP27P1 is a pseudogene-derived lncRNA, and it has been found to be associated with GC in our preliminary study, but this association has not been studied further. Herein, we confirmed that ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102377
更新日期:2019-10-30 00:00:00
abstract:UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100484
更新日期:2012-09-01 00:00:00
abstract::Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102774
更新日期:2020-02-10 00:00:00
abstract:BACKGROUND:Nucleus accumbens-associated protein 1 (NAC1) has multifaceted roles in cancer pathogenesis and progression, including the development of drug resistance, promotion of cytokinesis, and maintenance of "stem cell-like" phenotypes. NAC1 is a transcriptional co-regulator belonging to the bric-a-brac tramtrack br...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103203
更新日期:2020-05-14 00:00:00
abstract::Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104078
更新日期:2020-11-18 00:00:00
abstract::Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103241
更新日期:2020-05-12 00:00:00
abstract::The frailty index (FI) is one of the most widespread tools used to predict poor, health-related outcomes in older persons. The selection of clinical and functional deficits to include in a FI is mostly based on the users' clinical experience. However, this approach may not be sufficiently accurate to predict health ou...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103118
更新日期:2020-04-28 00:00:00
abstract::Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103393
更新日期:2020-07-02 00:00:00
abstract::We examined the effects of coronary heart disease (CHD), hypertension and diabetes on the development of severe COVID-19. We performed a comprehensive, systematic literature search for studies published between December 2019 and July 5, 2020 in five databases. The prevalence of severe COVID-19 in patients with CHD, hy...
journal_title:Aging
pub_type: 杂志文章,meta分析
doi:10.18632/aging.103991
更新日期:2020-11-16 00:00:00
abstract::In this study, we investigated the functional and clinical significance of the long non-coding RNA (lncRNA) FAM181A-AS1 in human gliomas. TCGA, GTEx and CGGA database analyses showed that high FAM181A-AS1 expression correlates with advanced tumor stage and poor survival of glioma patients. FAM181A-AS1 expression is hi...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103391
更新日期:2020-10-20 00:00:00
abstract::Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202415
更新日期:2021-01-20 00:00:00
abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102035
更新日期:2019-06-19 00:00:00
abstract::The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103032
更新日期:2020-05-05 00:00:00
abstract::Aging is associated with impaired angiogenesis and lung alveolar regeneration, which contributes to the increased susceptibility to chronic lung diseases (CLD). We have reported that the Wnt ligand co-receptor, low-density lipoprotein receptor-related protein 5 (LRP5), stimulates angiogenesis and lung alveolar regener...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101722
更新日期:2019-01-05 00:00:00
abstract::Long noncoding RNAs (lncRNAs) have multiple regulatory roles and are involved in many human diseases. A potential therapeutic strategy based on targeting lncRNAs was recently developed. To gain insight into the global relationship between small molecule drugs and their affected lncRNAs, we constructed a small molecule...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102581
更新日期:2019-12-18 00:00:00
abstract::Circular RNAs (circRNAs) play important roles in cancer progression. hsa_circRNA6448-14 originates from exon 5 to exon 11 of the TGFBI gene. We investigated the roles of hsa_circRNA6448-14 in esophageal squamous cell carcinoma (ESCC) with microarrays and quantitative real-time polymerase chain reaction (qRT-PCR), Kapl...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103650
更新日期:2020-08-15 00:00:00
abstract::The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer mitochondrial Reactive Oxygen Species (mtROS) than short-lived individuals or specie...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100137
更新日期:2010-04-01 00:00:00
abstract::We explored whether acute atorvastatin treatment would improve clinical outcomes and reduce the incidence of cerebral vasospasm after aneurysmal subarachnoid hemorrhage in elderly Chinese adults. Patients (60 to 90 years old) were admitted to intensive care units after surgery to clip or embolize their aneurysms. We a...
journal_title:Aging
pub_type: 杂志文章,随机对照试验
doi:10.18632/aging.102788
更新日期:2020-02-07 00:00:00
abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103907
更新日期:2020-10-08 00:00:00
abstract::The gerosuppressant metformin operates as an efficient inhibitor of the mTOR/S6K1 gerogenic pathway due to its ability to ultimately activate the energy-sensor AMPK. If an aging-related decline in the AMPK sensitivity to cellular stress is a crucial event for mTOR-driven aging and aging-related diseases, including can...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100523
更新日期:2012-12-01 00:00:00
abstract::Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102577
更新日期:2019-12-08 00:00:00