Impact of cardiovascular and metabolic diseases on the severity of COVID-19: a systematic review and meta-analysis.

abstract：:Metabolic syndrome, a network of medical disorders that greatly increase the risk for developing metabolic and cardiovascular diseases, has reached epidemic levels in many areas of today's world. Despite this alarming medicare situation, scientific understandings on the root mechanisms of metabolic syndrome are still ...

journal_title：Aging

authors： Cai D,Liu T

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:Mitochondrial dysfunction and oxidative stress are closely associated with the pathogenesis of Parkinson's disease. Peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC-1α) is thought to play multiple roles in the regulation of mitochondrial biogenesis and cellular energy metabolism. We rece...

journal_title：Aging

authors： Wang Y,Chen C,Huang W,Huang M,Wang J,Chen X,Ye Q

更新日期：2019-10-21 00:00:00

abstract：:Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...

journal_title：Aging

authors： Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

更新日期：2020-06-19 00:00:00

abstract：BACKGROUND:Phenotypic switching of vascular smooth muscle cells (VSMCs) plays a key role in atherosclerosis. Long noncoding RNA ANRIL (lncRNA-ANRIL) is critical in vascular homeostasis. Metformin produces multiple beneficial effects in atherosclerosis. However, the underlying mechanisms need to be elucidated. METHODS ...

journal_title：Aging

authors： Hu DJ,Li ZY,Zhu YT,Li CC

更新日期：2020-12-19 00:00:00

abstract：:The full spectrum of activities of the tumor suppressor p53 (TP53) has not been completely elucidated yet. Recently, it was demonstrated that TP53 communicates with the metabolic regulator mechanistic target of rapamycin (MTOR) to determine whether stressed cells undergo cell death, reversible quiescence or irreversib...

journal_title：Aging

authors： Galluzzi L,Kepp O,Kroemer G

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVE:Genome-wide association studies (GWAS) and the candidate gene based association studies have identified a panel of variants associated with atrial fibrillation (AF), however, most of the identified single nucleotide polymorphisms (SNPs) were found located within intergenic or intronic genomic regions, and whe...

journal_title：Aging

authors： Xu C,Zhang R,Xia Y,Xiong L,Yang W,Wang P

更新日期：2020-09-09 00:00:00

abstract：:Skeletal muscle mass and power decrease with age, leading to impairment of mobility and metabolism in the elderly. Ca2+ signaling is crucial for myoblast differentiation as well as muscle contraction through activation of transcription factors and Ca2+-dependent kinases and phosphatases. Ca2+ channels, such as dihydro...

journal_title：Aging

authors： Choi JY,Hwang CY,Lee B,Lee SM,Bahn YJ,Lee KP,Kang M,Kim YS,Woo SH,Lim JY,Kim E,Kwon KS

更新日期：2016-09-21 00:00:00

abstract：:Although there is previous evidence showing an increase in various types of DNA damage with aging in mice and humans, a comparative study determining accumulation rates of DNA double strand breaks, as determined by presence of phosphorylated histone H2AX (γH2AX), in leukocytes of individuals of different ages from phy...

journal_title：Aging

authors： Whittemore K,Martínez-Nevado E,Blasco MA

更新日期：2019-11-15 00:00:00

abstract：:Stress responses are affected by aging. However, studies on stress-related changes in feeding patterns with aging subject are minimal. We investigated feeding patterns induced by two psychological stress models, revealing characteristics of stress-induced feeding patterns as "meal" and "bout" (defined as the minimum f...

journal_title：Aging

authors： Yamada C,Mogami S,Hattori T

更新日期：2017-11-09 00:00:00

abstract：:The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...

journal_title：Aging

authors： Liao Y,Feng Y,Wang B,Wang H,Huang J,Wu Y,Wu Z,Chen X,Yang C,Fu X,Sun H

更新日期：2020-10-14 00:00:00

abstract：:Cerebral hypometabolism is a pathophysiological hallmark of Alzheimer's disease (AD). Our previous studies found that a mitochondrial protein, sirtuin3 (Sirt3), was down-regulated in human AD postmortem brains. Sirt3 protected neurons against oligo-amyloid β-42 induced hypometabolism in human Apolipoprotein E4 (ApoE4)...

journal_title：Aging

authors： Yin J,Nielsen M,Carcione T,Li S,Shi J

更新日期：2019-12-06 00:00:00

abstract：:DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis. Although a few...

journal_title：Aging

authors： Zhang TJ,Zhang LC,Xu ZJ,Zhou JD

更新日期：2020-06-26 00:00:00

abstract：:Long non-coding RNA (lncRNA) Ewing sarcoma associated transcript 1 (EWSAT1) has been identified as an oncogene, and its dysregulation is closed corrected with tumor progression in Ewing sarcoma. Recently, high-through put analysis reveals that EWSAT1 is also highly expressed in human nasopharyngeal carcinoma (NPC). Ho...

journal_title：Aging

authors： Song P,Yin SC

更新日期：2016-11-03 00:00:00

abstract：:Elderly patients with coronavirus disease 2019 (COVID-19) are more likely to develop severe or critical pneumonia, with a high fatality rate. To date, there is no model to predict the severity of COVID-19 in elderly patients. In this study, patients who maintained a non-severe condition and patients who progressed to ...

journal_title：Aging

authors： Zeng F,Deng G,Cui Y,Zhang Y,Dai M,Chen L,Han D,Li W,Guo K,Chen X,Shen M,Pan P

更新日期：2020-11-10 00:00:00

abstract：:Long intergenic nonprotein-coding RNA 00514 (LINC00514) is upregulated in papillary thyroid cancer and contributes to its aggressiveness. In this study, we thoroughly explored the expression profile, specific functions, and relevant molecular mechanism of LINC00514 in osteosarcoma (OS). Herein, LINC00514 was significa...

journal_title：Aging

authors： Yu D,Xu X,Li S,Zhang K

更新日期：2020-04-23 00:00:00

abstract：:Telomeres are a hotspot for sister chromatid exchange (T-SCE). Any biological consequence of this form of instability remained obscure until quantitative modeling revealed a link between elevated T-SCE rates and accelerated cellular replicative senescence. This work strongly suggests that progressive telomere erosion ...

journal_title：Aging

authors： Blagoev KB,Goodwin EH,Bailey SM

更新日期：2010-10-01 00:00:00

abstract：PURPOSE:This study aimed to validate the newly proposed American Joint Committee on Cancer (AJCC) pathological prognostic staging system for young breast cancer patients (aged ≤40 years). RESULTS:We included 12811 women in this study. Overall, 52.8% of patients in the 7th AJCC stages were restaged to the 8th AJCC path...

journal_title：Aging

authors： Zhou J,Lei J,Wang J,Lian CL,Hua L,Yang LC,Wu SG

更新日期：2020-04-22 00:00:00

abstract：:Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...

journal_title：Aging

authors： Zhu L,Zhong Q,Yang T,Xiao X

更新日期：2019-12-21 00:00:00

abstract：:The global increase in neurodegenerative disorders is one of the most crucial public health issues. Oral polyamine intake was shown to improve memory performance which is thought to be mediated at least in part via increased autophagy induced in brain cells. In Alzheimer's Disease, T-cells were identified as important...

journal_title：Aging

authors： Fischer M,Ruhnau J,Schulze J,Obst D,Flöel A,Vogelgesang A

更新日期：2020-06-30 00:00:00

abstract：:PaMTH1 is an O-methyltransferase catalysing the methylation of vicinal hydroxyl groups of polyphenols. The protein accumulates during ageing of Podospora anserina in both the cytosol and in the mitochondrial matrix. The construction and characterisation of a PaMth1 deletion strain provided additional evidence about th...

journal_title：Aging

authors： Kunstmann B,Osiewacz HD

更新日期：2009-03-03 00:00:00

abstract：:In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...

journal_title：Aging

authors： Li M,Liu Y,Liu J,Li W,Li N,Xue D,Zhang X,Wang P

更新日期：2019-11-22 00:00:00

abstract：:Expansion of polyglutamine stretch in the huntingtin (HTT) protein is a major cause of Huntington's disease (HD). The polyglutamine part in HTT interacts with various proteins implicated in epigenetic regulation of genes, suggesting that mutant HTT may disturb the integrity of the epigenetic system. Here, we used a PC...

journal_title：Aging

authors： Park M,Min B,Jeon K,Cho S,Park JS,Kim J,Jeon J,Song J,Kim S,Jeong S,Seo H,Kang YK

更新日期：2017-03-12 00:00:00

abstract：:There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...

journal_title：Aging

authors： Hung PH,Lin CH,Hung KY,Muo CH,Chung MC,Chang CH,Chung CJ

更新日期：2020-02-24 00:00:00

abstract：:A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...

journal_title：Aging

authors： Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

更新日期：2014-10-01 00:00:00

abstract：:Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

journal_title：Aging

authors： Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

更新日期：2020-04-24 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...

journal_title：Aging

authors： Ma X,Yu X,Zhou Q

更新日期：2020-02-15 00:00:00

abstract：:Increasing attentions have been paid to the role of circRNAs in the etiology of triple-negative breast cancer (TNBC), and we strived to figure out the association of circRNA AKT3/miRNA axis with TNBC chemo-resistance. Altogether 207 BC patients were divided into TNBC group (n=83) and non-TNBC group (n=124), and MCF-10...

journal_title：Aging

authors： Li H,Xu W,Xia Z,Liu W,Pan G,Ding J,Li J,Wang J,Xie X,Jiang D

更新日期：2021-01-20 00:00:00

abstract：:Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...

journal_title：Aging

authors： Hall BM,Balan V,Gleiberman AS,Strom E,Krasnov P,Virtuoso LP,Rydkina E,Vujcic S,Balan K,Gitlin I,Leonova K,Polinsky A,Chernova OB,Gudkov AV

更新日期：2016-07-01 00:00:00

abstract：:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. W...

journal_title：Aging

authors： Hur JH,Cho J,Walker DW

更新日期：2010-01-26 00:00:00