Abstract:
OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β was identified as the core gene of ARDS. Cell experiments showed that up-regulation of IL-1β downregulates claudin18 to promote lung barrier function damage by regulating the IL-1β-HER2/HER3 axis, further promoting the development of ARDS. This was validated in the animal models. CONCLUSION:IL-1β promotes the development of ARDS by regulating the IL-1β-HER2/HER3 axis. These findings deepen the understanding of the pathological mechanisms of ARDS. METHODS:Transcription data sets related to ARDS were subjected to differential expression gene analysis, functional enrichment analysis, and receiver operating characteristic curve analysis and, so as to identify core genes in ARDS. Cell experiments were used to further explore the effects of core genes on lung barrier function damage. Animal models were applied to validate the effects of core gene in mediating biological signal pathways in ARDS.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Ma X,Yu X,Zhou Qdoi
10.18632/aging.102804subject
Has Abstractpub_date
2020-02-15 00:00:00pages
3249-3265issue
4issn
1945-4589pii
102804journal_volume
12pub_type
杂志文章相关文献
Aging-US文献大全abstract::DNA methyltransferases (DNMTs) by regulating DNA methylation play crucial roles in the progression of hematologic malignancies, especially for acute myeloid leukemia (AML). Accumulating investigations have identified the high incidence of DNMT3A mutation in AML, and it is correlated with poor prognosis. Although a few...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103520
更新日期:2020-06-26 00:00:00
abstract::Patients with end-stage renal disease (ESRD) display phenotypic features of premature biological aging, characterized by disproportionately high morbidity and mortality at a younger age. Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103685
更新日期:2020-07-13 00:00:00
abstract::Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202303
更新日期:2021-01-10 00:00:00
abstract::Natural killer cells lacking expression of CD56 (CD56neg NK cells) have been described in chronic HIV and hepatitis C virus infection. Features and functions of CD56neg NK cells in the context of latent infection with CMV and / or EBV with age are not known. In a cohort of healthy donors >60 years of age, we found tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101774
更新日期:2019-01-27 00:00:00
abstract::Recently, over-expression of LAIR-1 has been found in some solid cancers, including ovarian cancer. The role of LAIR-1 in cancer progression needs further investigation. In this study, we identified the LAIR-1 cDNA sequence of the ovarian cancer cells HO8910. Using SKOV3 cells, we confirmed the finding from our previo...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103589
更新日期:2020-09-05 00:00:00
abstract:BACKGROUND:Nucleus accumbens-associated protein 1 (NAC1) has multifaceted roles in cancer pathogenesis and progression, including the development of drug resistance, promotion of cytokinesis, and maintenance of "stem cell-like" phenotypes. NAC1 is a transcriptional co-regulator belonging to the bric-a-brac tramtrack br...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103203
更新日期:2020-05-14 00:00:00
abstract::In this study, we investigated the role of macrophage stimulating 1 (Mst1) and the AMPK-Sirt1 signaling pathway in the oxidative stress-induced mitochondrial dysfunction and apoptosis seen in rheumatoid arthritis-related fibroblast-like synoviocytes (RA-FLSs). Mst1 mRNA and protein expression was significantly higher ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103643
更新日期:2020-07-21 00:00:00
abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202405
更新日期:2020-12-26 00:00:00
abstract::The actin-binding protein Girdin is involved in a variety of cellular processes, including pancreatic cancer. The objective of this study is to explore the role and the mechanism of Girdin in pancreatic cancer by quantitative acetylome and phosphorylome analysis. We firstly found that Girdin was overexpressed in pancr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103032
更新日期:2020-05-05 00:00:00
abstract::We aimed to perform a pan-metastatic cancer analysis on survival and prognostic factors and to create a prognosis-based classification system. We selected distant metastasis patients from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between the characteristics of the patients at ad...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103467
更新日期:2020-08-27 00:00:00
abstract::Lung cancer remains the most lethal cancer worldwide because of its high metastasis potential. Epithelial-mesenchymal transition (EMT) is known as the first step of the metastasis cascade, but the potential regulatory mechanisms of EMT have not been clearly established. In this study, we first found that low CUEDC1 ex...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103329
更新日期:2020-10-25 00:00:00
abstract::Cognitive dysfunction caused by chronic cerebral hypoperfusion is a common underlying cause of many cognition-related neurodegenerative diseases. The mechanisms of cognitive dysfunction caused by CCH are not clear. Long non-coding RNA is involved in synaptic plasticity and cognitive function, but whether lncRNA is inv...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103901
更新日期:2020-10-11 00:00:00
abstract::Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies; However, the phenotype and mechanism of action of UBE2M in hepatocellular carcinoma (HCC) remain elusive. Here, we report that UBE2M is overexpressed and correlated with poor prognosis in HCC patients. The UBE2M lev...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102749
更新日期:2020-02-03 00:00:00
abstract::The estrogen membrane receptor GPR30 (also known as G-protein coupled receptor 30) has recently been shown to be involved in the regulation of oocyte maturation and cumulus expansion. However, whether GPR30 expression is regulated by gonadotropin stimulation and how it participates in the regulation of the maturation ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104029
更新日期:2020-10-28 00:00:00
abstract::SIRT6 is an important member of sirtuin family that represses inflammation, aging and DNA damage, three of which are causing factors for endothelial dysfunction. SIRT6 expression is decreased in atherosclerotic lesions from ApoE(-/-) mice and human patients. However, the role of SIRT6 in regulating vascular endothelia...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100975
更新日期:2016-05-01 00:00:00
abstract::Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103297
更新日期:2020-06-13 00:00:00
abstract::Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpr...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101630
更新日期:2018-11-08 00:00:00
abstract::Sarcopenia is the degenerative loss of muscle mass and strength with aging. Although a role of mitochondrial metabolism in muscle function and in the development of many diseases has been described, the role of mitochondrial topology and dynamics in the process of muscle aging is not fully understood. This work shows ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101358
更新日期:2018-01-04 00:00:00
abstract::To evaluate the effects of short-term administration of enriched branched-chain amino acids (BCAAs) on subjects with pre-sarcopenia or sarcopenia, our quasi-experimental study enrolled 33 subjects (12 pre-sarcopenia/21 sarcopenia; 6 men/27 women; mean age 66.6 ± 10.3 years) to take one sachet (3.6 g) of enriched BCAA ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103576
更新日期:2020-07-26 00:00:00
abstract::Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clono...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102573
更新日期:2019-12-08 00:00:00
abstract::The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202500
更新日期:2021-01-19 00:00:00
abstract::Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103237
更新日期:2020-05-14 00:00:00
abstract::Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102856
更新日期:2020-02-26 00:00:00
abstract::In this study, we investigated the effects of G-protein coupled estrogen receptor (GPER) activation in the early phase of retinopathy of prematurity (ROP) and its association with endoplasmic reticulum (ER) stress using primary murine retinal microglia as an experimental model. Fluorescence microscopy results show tha...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103733
更新日期:2020-09-13 00:00:00
abstract::Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101145
更新日期:2016-12-20 00:00:00
abstract::The p53 family member p73 controls a wide range of cellular function. Deletion of p73 in mice results in increased tumorigenesis, infertility, neurological defects and altered immune system. Despite the extensive effort directed to define the molecular underlying mechanism of p73 function a clear definition of its tra...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101669
更新日期:2018-12-08 00:00:00
abstract::Growing evidence suggests that circRNAs exert a critical role in tumorigenesis and cancer progression. To date, the molecular mechanisms underlying circRNAs in triple-negative breast cancer (TNBC) are still poorly known. Here, circRNA expression profile was investigated by RNA sequencing in TNBC tissues and matched pa...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103311
更新日期:2020-06-04 00:00:00
abstract::Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101299
更新日期:2017-10-09 00:00:00
abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101065
更新日期:2016-10-14 00:00:00
abstract::Uveal melanoma (UM) is the most common primary intraocular tumour in adults. The most accurate prognostic factor of UM is classification by gene expression profiling. Currently, the role of epigenetics is much less defined compared to genetic mechanisms. We recently showed a strong prognostic role of the expression le...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103241
更新日期:2020-05-12 00:00:00