Quantitative acetylome and phosphorylome analysis reveals Girdin affects pancreatic cancer progression through regulating Cortactin.

abstract：:Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular en...

journal_title：Aging

authors： McRobb LS,McKay MJ,Gamble JR,Grace M,Moutrie V,Santos ED,Lee VS,Zhao Z,Molloy MP,Stoodley MA

更新日期：2017-04-01 00:00:00

abstract：:To assist in the study of cellular aging, we established a new method of enriching physiologically aged bone marrow stromal cells (BMSCs) in animals of any age using a Percoll density gradient centrifugation technique. BMSCs from mice 2 months of age were isolated, and their cellular age determined (over 80% Scal-1+ C...

journal_title：Aging

authors： Xu F,Zhang Q,Wang H

更新日期：2020-07-25 00:00:00

abstract：:Perioperative neurocognitive disorders are common in elderly patients who have undergone surgical procedures. Neuroinflammation induced by microglial activation is a hallmark of these neurological disorders. Acetate can suppress inflammation in the context of inflammatory diseases. We employed an exploratory laparotom...

journal_title：Aging

authors： Wen C,Xie T,Pan K,Deng Y,Zhao Z,Li N,Bian J,Deng X,Zha Y

更新日期：2020-02-26 00:00:00

abstract：:Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human ...

journal_title：Aging

authors： Zhavoronkov A,Li R,Ma C,Mamoshina P

更新日期：2019-11-25 00:00:00

abstract：:The Mitochondrial Free Radical Theory of Aging (MFRTA) is currently one of the most widely accepted theories used to explain aging. From MFRTA three basic predictions can be made: long-lived individuals or species should produce fewer mitochondrial Reactive Oxygen Species (mtROS) than short-lived individuals or specie...

journal_title：Aging

authors： Sanz A,Fernández-Ayala DJ,Stefanatos RK,Jacobs HT

更新日期：2010-04-01 00:00:00

abstract：:Many studies have reported that estrogen (E2) promotes lung cancer by binding to nuclear estrogen receptors (ER), and altering ER related nuclear protein expressions. With the GEO database analysis, Human centromere protein F (CENPF) is highly expressed in lung adenocarcinoma (LUAD), and the co-expression of CENPF and...

journal_title：Aging

authors： Hexiao T,Yuquan B,Lecai X,Yanhong W,Li S,Weidong H,Ming X,Xuefeng Z,Gaofeng P,Li Z,Minglin Z,Zheng T,Zetian Y,Xiao Z,Yi C,Lanuti M,Jinping Z

更新日期：2021-01-10 00:00:00

abstract：:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential bio...

journal_title：Aging

authors： Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P

更新日期：2019-02-05 00:00:00

abstract：:According to cancer statistics reported in 2020, breast cancer constitutes 30% of new cancer cases diagnosed in American women. Histological markers of breast cancer are expressions of the estrogen receptor (ER), the progesterone receptor (PR), and human epidermal growth factor receptor (HER)-2. Up to 80% of breast ca...

journal_title：Aging

authors： Chen PS,Hsu HP,Phan NN,Yen MC,Chen FW,Liu YW,Lin FP,Feng SY,Cheng TL,Yeh PH,Omar HA,Sun Z,Jiang JZ,Chan YS,Lai MD,Wang CY,Hung JH

更新日期：2021-01-10 00:00:00

abstract：:Gradual changes in the DNA methylation landscape occur throughout aging virtually in all human tissues. A widespread reduction of 5-methylcytosine (5mC), associated with highly reproducible site-specific hypermethylation, characterizes the genome in aging. Therefore, an equilibrium seems to exist between general and d...

journal_title：Aging

authors： Valentini E,Zampieri M,Malavolta M,Bacalini MG,Calabrese R,Guastafierro T,Reale A,Franceschi C,Hervonen A,Koller B,Bernhardt J,Slagboom PE,Toussaint O,Sikora E,Gonos ES,Breusing N,Grune T,Jansen E,Dollé ME,Moreno-Vi

更新日期：2016-08-29 00:00:00

abstract：:Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

journal_title：Aging

authors： Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

更新日期：2019-11-13 00:00:00

abstract：:The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...

journal_title：Aging

authors： Brown SA,Schmitt K,Eckert A

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:There is increasing evidence that circular RNAs (circRNAs) participate in regulating cancer progression. However, the function and potential molecular mechanisms of circRNA in triple negative breast cancer (TNBC) are currently largely unclear. RESULTS:We found that circAHNAK1 was significantly down-regulate...

journal_title：Aging

authors： Xiao W,Zheng S,Zou Y,Yang A,Xie X,Tang H,Xie X

更新日期：2019-12-19 00:00:00

abstract：:Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...

journal_title：Aging

authors： Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

更新日期：2018-10-25 00:00:00

abstract：:Myocardial infarction is a cardiovascular disease with high mortality. Human umbilical cord mesenchymal stem cells (hUC-MSCs) with strong self-renewal capacity and multipotency, provide the possibility of replacing injured cardiomyocytes. hUC-MSCs were cultured on polyacrylamide hydrogels with stiffnesses correspondin...

journal_title：Aging

authors： Sun Y,Liu J,Xu Z,Lin X,Zhang X,Li L,Li Y

更新日期：2020-12-09 00:00:00

abstract：:The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

journal_title：Aging

authors： Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

更新日期：2019-07-22 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...

journal_title：Aging

authors： Xu X,Chen Y,Zhu D,Zhao T,Xu R,Wang J,Hu L,Shen X

更新日期：2020-12-09 00:00:00

abstract：:This study aimed to investigate the risk factors of second primary cancer among female breast cancer (BC) survivors, with emphasis on the prediction of the individual risk conditioned on the patient's characteristics. We identified 208,474 BC patients diagnosed between 2004 and 2010 from the Surveillance, Epidemiology...

journal_title：Aging

authors： Qian X,Jia H,Zhang Y,Ma B,Qin G,Wu Z

更新日期：2020-10-13 00:00:00

abstract：:Bladder cancer is the most commonly diagnosed malignant tumor in urological system worldwide. The relationship between GSG2 and bladder cancer has not been demonstrated and remains unclear. In this study, it was demonstrated that GSG2 was up-regulated in bladder cancer tissues compared with the normal tissues and its ...

journal_title：Aging

authors： Chen Y,Fu D,Zhao H,Cheng W,Xu F

更新日期：2020-05-21 00:00:00

abstract：:Angiogenesis - the growth of new blood capillaries- is impaired in aging animals. Biophysical factors such as changes in cell size control endothelial cell (EC) proliferation and differentiation. However, the effects of aging on EC size and the mechanism by which changes in cell size control age-dependent decline in E...

journal_title：Aging

authors： Mammoto T,Torisawa YS,Muyleart M,Hendee K,Anugwom C,Gutterman D,Mammoto A

更新日期：2019-09-05 00:00:00

abstract：:Elderly patients with type 2 diabetes mellitus (T2DM) exhibit considerable periodontitis frequency, which causes tooth loss and poor quality of life. To investigate the impact of periodontitis on gut microbiota, we used 16S rRNA amplicon sequencing to characterize the composition and structure of gut microbiota among ...

journal_title：Aging

authors： Li J,Lu H,Wu H,Huang S,Chen L,Gui Q,Zhou W,Yang Y,Wu Y,Zhang H,Zhang Q,Yang Y

更新日期：2020-11-25 00:00:00

abstract：:The C. elegans germline and somatic gonad are actively developing until the animal reaches adulthood, and then continue to undergo striking changes as the animal ages. Reported changes include a depletion of available sperm, a decrease in oocyte quality up till mid-life, a reduction in germline nuclei, a decrease in f...

journal_title：Aging

authors： McGee MD,Day N,Graham J,Melov S

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:We analyzed clinical parameters and risk factors for coronavirus disease 2019 (COVID-19)-related liver damage. RESULTS:Of the 332 COVID-19 patients, 306 and 26 were included in the non-critical and critical groups, respectively. The median time from onset to admission was 4.0 (2.0-8.0) days. Of the 332 COVID...

journal_title：Aging

authors： Guo H,Zhang Z,Zhang Y,Liu Y,Wang J,Qian Z,Zou Y,Lu H

更新日期：2020-10-01 00:00:00

abstract：:Qigesan (QGS) has been used to effectively treat esophageal cancer (EC) for decades in China, but the mechanism by which it suppresses EC metastasis remains unknown. In this study, we examined the effects of QGS on EC cell mobility. Using immunohistochemistry and immunofluorescence, expression of Gas6 and Axl, which p...

journal_title：Aging

authors： Kong L,Lu X,Chen X,Wu Y,Zhang Y,Shi H,Li J

更新日期：2020-05-20 00:00:00

abstract：:The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

journal_title：Aging

authors： Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

更新日期：2019-06-19 00:00:00

abstract：:Salvia miltiorrhiza bunge(SM) is a popular herb for alleviating menopausal symptoms, although the scientific evidence of applying SM to estrogen replacement therapy is limited. In this study, we characterized the estrogenic activity of SM using in vivo models of immature and ovariectomized (OVX) mice and performed in ...

journal_title：Aging

authors： Xu Y,Chen T,Li X,Qu YK,An JN,Zheng HX,Zhang ZJ,Lin N

更新日期：2016-12-20 00:00:00

abstract：:Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...

journal_title：Aging

authors： Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

更新日期：2020-02-19 00:00:00

abstract：AIMS:We identified an autosomal dominant non‐sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC‐CMs) from an affected patient...

journal_title：Aging

authors： Siu CW,Lee YK,Ho JC,Lai WH,Chan YC,Ng KM,Wong LY,Au KW,Lau YM,Zhang J,Lay KW,Colman A,Tse HF

更新日期：2012-11-01 00:00:00

abstract：:Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated fr...

journal_title：Aging

authors： Sgarbi G,Matarrese P,Pinti M,Lanzarini C,Ascione B,Gibellini L,Dika E,Patrizi A,Tommasino C,Capri M,Cossarizza A,Baracca A,Lenaz G,Solaini G,Franceschi C,Malorni W,Salvioli S

更新日期：2014-04-01 00:00:00

abstract：:Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy. However, these changes in the metabolic profile of stromal cancer-associated fibroblasts and their imp...

journal_title：Aging

authors： Peiris-Pagès M,Smith DL,Győrffy B,Sotgia F,Lisanti MP

更新日期：2015-10-01 00:00:00

abstract：:Topoisomerase II (Top2) removes topological linkages between replicated chromosomes. Top2 inhibition leads to mitotic catastrophe (MC) when cells unsuccessfully try to split their genetic material between the two daughter cells. Herein, we have characterized the fate of these daughter cells in the budding yeast. Clono...

journal_title：Aging

authors： Ramos-Pérez C,Dominska M,Anaissi-Afonso L,Cazorla-Rivero S,Quevedo O,Lorenzo-Castrillejo I,Petes TD,Machín F

更新日期：2019-12-08 00:00:00