Urinary metabolite signature in bipolar disorder patients during depressive episode.


:The first few episodes of bipolar disorder (BD) are highly likely to be depressive. This phenomenon causes many BD patients to be misdiagnosed as having major depression. Therefore, it is very important to correctly diagnose BD patients during depressive episode. Here, we conducted this study to identify potential biomarkers for young and middle-aged BD patients during depressive episode. Both gas chromatography-mass spectroscopy (GC-MS) and nuclear magnetic resonance (NMR) spectroscopy were used to profile the urine samples from the recruited subjects. In total, 13 differential metabolites responsible for the discrimination between healthy controls (HCs) and patients were identified. Most differential metabolites had a close relationship with energy homeostasis. Meanwhile, a panel consisting of five differential metabolites was identified. This panel could effectively distinguish the patients from HCs with an AUC of 0.998 in the training set and 0.974 in the testing set. Our findings on one hand could be helpful in developing an objective diagnostic method for young and middle-aged BD patients during depressive episode; on the other hand could provide critical insight into the pathological mechanism of BD and the biological mechanisms responsible for the transformation of different episodes.


Aging (Albany NY)




Chen JJ,Xie J,Zeng L,Zhou CJ,Zheng P,Xie P




Has Abstract


2019-02-05 00:00:00














  • PKCζ-dependent upregulation of p27kip1 contributes to oxidative stress induced retinal pigment epithelial cell multinucleation.

    abstract::Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...


    pub_type: 杂志文章


    authors: Rajapakse D,Chen M,Curtis TM,Xu H

    更新日期:2017-10-09 00:00:00

  • The role of commensal microbes in the lifespan of Drosophila melanogaster.

    abstract::Commensal microbes have mutualistic relationships with their host and mainly live in the host intestine. There are many studies on the relationships between commensal microbes and host physiology. However, there are inconsistent results on the effects of commensal microbes on host lifespan. To clarify this controversy...


    pub_type: 杂志文章


    authors: Lee HY,Lee SH,Lee JH,Lee WJ,Min KJ

    更新日期:2019-07-12 00:00:00

  • Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma.

    abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...


    pub_type: 杂志文章


    authors: Zhu Q,Ren H,Li X,Qian B,Fan S,Hu F,Xu L,Zhai B

    更新日期:2020-11-16 00:00:00

  • Clinical significance and prognostic value of TRIM24 expression in esophageal squamous cell carcinoma.

    abstract::Tripartite motif-containing 24 (TRIM24), a member of the transcription intermediary factor 1 family, is defined as a co-regulator with several nuclear receptors, such as RARα. TRIM24 has been reported to be involved in many cancers. In this study, we aimed to investigate the expression pattern and prognostic significa...


    pub_type: 杂志文章


    authors: Chi J,Yang Q,Xie XF,Yang XZ,Zhang MY,Wang HY,Xu GL

    更新日期:2016-09-28 00:00:00

  • Identification of prognostic immune-related genes in the tumor microenvironment of endometrial cancer.

    abstract::Endometrial cancer (EC) is one of the most common gynecologic malignancies. To identify potential prognostic biomarkers for EC, we analyzed the relationship between the EC tumor microenvironment and gene expression profiles. Using the ESTIMATE R tool, we found that immune and stromal scores correlated with clinical da...


    pub_type: 杂志文章


    authors: Chen P,Yang Y,Zhang Y,Jiang S,Li X,Wan J

    更新日期:2020-02-19 00:00:00

  • Overexpression of CBS and CSE genes affects lifespan, stress resistance and locomotor activity in Drosophila melanogaster.

    abstract::Recent experimental studies highlighted the role of hydrogen sulfide (H2S) in aging and longevity. The cystathionine ß-synthase (CBS) and cystathionine γ-lyase (CSE) are the key enzymes responsible for H2S production. Here we investigated the geroprotective effects of CSE and CBS overexpression in Drosophila. Overexpr...


    pub_type: 杂志文章


    authors: Shaposhnikov M,Proshkina E,Koval L,Zemskaya N,Zhavoronkov A,Moskalev A

    更新日期:2018-11-08 00:00:00

  • XRCC1 gene polymorphisms and risk of neuroblastoma in Chinese children.

    abstract::Neuroblastoma is a common pediatric extra-cranial tumor of the sympathetic nervous system. XRCC1 is a scaffold protein that participates in DNA single-strand break repair by complexing with other proteins. XRCC1 gene polymorphisms are being increasingly explored in cancer epidemiology studies. However, the contributio...


    pub_type: 杂志文章,多中心研究


    authors: Zhang J,Zhuo Z,Li W,Zhu J,He J,Su J

    更新日期:2018-10-25 00:00:00

  • IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.

    abstract::Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of I...


    pub_type: 杂志文章


    authors: Wang M,Guo J,Zhao YQ,Wang JP

    更新日期:2020-08-28 00:00:00

  • Biomarkers of aging and lung function in the normative aging study.

    abstract::Elderly individuals who are never smokers but have the same height and chronological age can have substantial differences in lung function. The underlying biological mechanisms are unclear. To evaluate the associations of different biomarkers of aging (BoA) and lung function, we performed a repeated-measures analysis ...


    pub_type: 杂志文章


    authors: Wang C,Just A,Heiss J,Coull BA,Hou L,Zheng Y,Sparrow D,Vokonas PS,Baccarelli A,Schwartz J

    更新日期:2020-06-19 00:00:00

  • Identification of polymorphisms in cancer patients that differentially affect survival with age.

    abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...


    pub_type: 杂志文章


    authors: Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

    更新日期:2017-10-20 00:00:00

  • Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice.

    abstract::Aged liver is usually impaired in response to hepatic injury. Tissue-specific stem cells participate in the repair of tissue injury. However, how oval cells (OCs) respond to injury and how the process is regulated by tissue microenvironment in aged mice have not been fully understood. In this study, taking advantage o...


    pub_type: 杂志文章


    authors: Qian L,Zhang H,Gu Y,Li D,He S,Wang H,Cheng Y,Yang W,Yu H,Zhao X,Cai W,Meng L,Jin M,Wang Y,Zhang Y

    更新日期:2018-12-04 00:00:00

  • N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice.

    abstract::Genetic factors combined with oxidative stress are major determinants of age-related hearing loss (ARHL), one of the most prevalent disorders of the elderly. Dwarf grey mice, Ggt1dwg/dwg, are homozygous for a loss of function mutation of the g-glutamyl transferase 1 gene, which encodes an important antioxidant enzyme ...


    pub_type: 杂志文章


    authors: Ding D,Jiang H,Chen GD,Longo-Guess C,Muthaiah VP,Tian C,Sheppard A,Salvi R,Johnson KR

    更新日期:2016-04-01 00:00:00

  • Coordination of DNA repair by NEIL1 and PARP-1: a possible link to aging.

    abstract::Oxidative DNA damage accumulates with age and is repaired primarily via the base excision repair (BER) pathway. This process is initiated by DNA glycosylases, which remove damaged bases in a substrate-specific manner. The DNA glycosylases human 8-oxoguanine-DNA glycosylase (OGG1) and NEIL1, a mammalian homolog ofEsche...


    pub_type: 杂志文章


    authors: Noren Hooten N,Fitzpatrick M,Kompaniez K,Jacob KD,Moore BR,Nagle J,Barnes J,Lohani A,Evans MK

    更新日期:2012-10-01 00:00:00

  • Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.

    abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...


    pub_type: 杂志文章


    authors: Ren W,Guan W,Zhang J,Wang F,Xu G

    更新日期:2019-04-14 00:00:00

  • Identification of survival-associated alternative splicing events and signatures in adrenocortical carcinoma based on TCGA SpliceSeq data.

    abstract:OBJECTIVE:To explore the correlations among alternative splicing (AS), splicing factors (SF) and survival outcome in adrenocortical carcinoma (ACC) patients. RESULTS:A total of 92 ACC patients were included. Univariate analysis identified 3919 AS events significantly associated with overall survival. Lasso method foll...


    pub_type: 杂志文章


    authors: Xu N,Ke ZB,Lin XD,Lin F,Chen SH,Wu YP,Chen YH,Wei Y,Zheng QS

    更新日期:2020-03-26 00:00:00

  • SNCA Rep1 microsatellite length influences non-motor symptoms in early Parkinson's disease.

    abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...


    pub_type: 杂志文章


    authors: Yong AC,Tan YJ,Zhao Y,Lu Z,Ng EY,Ng SY,Chia NS,Choi X,Heng D,Neo S,Xu Z,Tay KY,Au WL,Tan EK,Tan LC,Ng AS

    更新日期:2020-10-20 00:00:00

  • Birth mass is the key to understanding the negative correlation between lifespan and body size in dogs.

    abstract::Larger dog breeds live shorter than the smaller ones, opposite of the mass-lifespan relationship observed across mammalian species. Here we use data from 90 dog breeds and a theoretical model based on the first principles of energy conservation and life history tradeoffs to explain the negative correlation between lon...


    pub_type: 杂志文章


    authors: Fan R,Olbricht G,Baker X,Hou C

    更新日期:2016-12-08 00:00:00

  • DNA methylation perturbations may link altered development and aging in the lung.

    abstract::Fetal perturbations in DNA methylation during lung development may reveal insights into the enduring impacts on adult lung health and disease during aging that have not been explored altogether before. We studied the association between genome-wide DNA-methylation and post-conception age in fetal-lung (n=78, 42 expose...


    pub_type: 杂志文章


    authors: Kachroo P,Morrow JD,Vyhlidal CA,Gaedigk R,Silverman EK,Weiss ST,Tantisira KG,DeMeo DL

    更新日期:2021-01-19 00:00:00

  • Inverse correlation between longevity and developmental rate among wild C. elegans strains.

    abstract::Genetic studies using model organisms have shown that many long-lived mutants display impaired fitness, such as reduced fecundity and delayed development. However, in several wild animals, the association between longevity and fitness does not seem to be inevitable. Thus, the relationship between longevity and fitness...


    pub_type: 杂志文章


    authors: Lee Y,Hwang W,Jung J,Park S,Cabatbat JJ,Kim PJ,Lee SJ

    更新日期:2016-05-01 00:00:00

  • MicroRNA-141 suppresses growth and metastatic potential of head and neck squamous cell carcinoma.

    abstract::MicroRNAs (miRNAs) serve as regulatory factors in both healthy tissue and various cancers. Here, we used an miRNA microarray to screen for miRNAs differentially expressed between HNSCC and adjacent epithelial tissue. Among these, levels of miR-141 were significantly reduced in HNSCC tissues. Expression levels of epide...


    pub_type: 杂志文章


    authors: Zhao Z,Gao D,Ma T,Zhang L

    更新日期:2019-02-08 00:00:00

  • Autophagy modulates mesenchymal-to-endothelial transition via p53.

    abstract::Mesenchymal-to-endothelial transition (MEndT) is one of the mechanisms that influences cardiac fibrosis, which is a key process in cardiac remodeling. It has been reported that autophagy inhibits endothelial cell transition. However, whether autophagy could modulate MEndT in cardiac fibrosis has not yet been investiga...


    pub_type: 杂志文章


    authors: Hu J,Kong S,Dong T,Lin Z,Zhang Q,Chen X,Gong Y,Fan X,He M,Zhou H

    更新日期:2020-11-13 00:00:00

  • Can Serum Cystatin C predict long-term survival in cardiac surgery patients?

    abstract::Renal dysfunction is a risk factor for morbidity and mortality in cardiac surgery patients. Serum Cystatin C (sCysC) is a well-recognized marker of early renal dysfunction but few reports evaluate its prognostic cardio-vascular role. The aim of the study is to consider the prognostic value of sCysC for cardiovascular ...


    pub_type: 杂志文章


    authors: Rovella V,Marrone G,Dessì M,Ferrannini M,Toschi N,Pellegrino A,Casasco M,Di Daniele N,Noce A

    更新日期:2018-03-27 00:00:00

  • Systems biology approach to exploring the effect of cyclic stretching on cardiac cell physiology.

    abstract::Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 8...


    pub_type: 杂志文章


    authors: Chen CC,Wong TY,Chin TY,Lee WH,Kuo CY,Hsu YC

    更新日期:2020-08-05 00:00:00

  • Cortical neurons develop a senescence-like phenotype promoted by dysfunctional autophagy.

    abstract::Senescent cells accumulate in various tissues and organs with aging altering surrounding tissue due to an active secretome, and at least in mice their elimination extends healthy lifespan and ameliorates several chronic diseases. Whether all cell types senesce, including post-mitotic cells, has been poorly described m...


    pub_type: 杂志文章


    authors: Moreno-Blas D,Gorostieta-Salas E,Pommer-Alba A,Muciño-Hernández G,Gerónimo-Olvera C,Maciel-Barón LA,Konigsberg M,Massieu L,Castro-Obregón S

    更新日期:2019-08-30 00:00:00

  • RasGrf1: genomic imprinting, VSELs, and aging.

    abstract::Increase in life span in RasGrf1-deficient mice revealed that RasGrf1 deficiency promotes longevity. Interestingly, RasGrf1 is one of parentally imprinted genes transcribed from paternally-derived chromosome. Erasure of its imprinting results in RasGrf1 downregulation and has been demonstrated in a population of pluri...


    pub_type: 杂志文章


    authors: Ratajczak MZ,Kucia M,Liu R,Shin DM,Bryndza E,Masternak MM,Tarnowski M,Ratajczak J,Bartke A

    更新日期:2011-07-01 00:00:00

  • Loss of AKR1B10 promotes colorectal cancer cells proliferation and migration via regulating FGF1-dependent pathway.

    abstract::Colorectal cancer (CRC) is a common malignancy worldwide with poor prognosis and survival rates. The aldo-keto reductase family 1 member B10 (AKR1B10) plays an important role in metabolism, cell proliferation and mobility, and is downregulated in CRC. We hypothesized that AKR1B10 would promote CRC genesis via a noncan...


    pub_type: 杂志文章


    authors: Yao Y,Wang X,Zhou D,Li H,Qian H,Zhang J,Jiang L,Wang B,Lin Q,Zhu X

    更新日期:2020-07-02 00:00:00

  • Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure.

    abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...


    pub_type: 杂志文章


    authors: Tian Y,Yang J,Lan M,Zou T

    更新日期:2020-12-26 00:00:00

  • Longitudinal plasma metabolomics of aging and sex.

    abstract::Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...


    pub_type: 杂志文章


    authors: Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

    更新日期:2019-02-24 00:00:00

  • LUCS: a high-resolution nucleic acid sequencing tool for accurate long-read analysis of individual DNA molecules.

    abstract::Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...


    pub_type: 杂志文章


    authors: Annis S,Fleischmann Z,Logan R,Mullin-Bernstein Z,Franco M,Saürich J,Tilly JL,Woods DC,Khrapko K

    更新日期:2020-04-28 00:00:00

  • Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span.

    abstract::Studies in young mammals on the molecular effects of food restriction leading to prolong adult life are scares. Here, we used high-throughput quantitative proteomic analysis of whole rat livers to address the molecular basis for growth arrest and the apparent life-prolonging phenotype of the food restriction regimen. ...


    pub_type: 杂志文章


    authors: Gat-Yablonski G,Finka A,Pinto G,Quadroni M,Shtaif B,Goloubinoff P

    更新日期:2016-08-01 00:00:00