Abstract:
:Multiple recent advances in machine learning enabled computer systems to exceed human performance in many tasks including voice, text, and speech recognition and complex strategy games. Aging is a complex multifactorial process driven by and resulting in the many minute changes transpiring at every level of the human organism. Deep learning systems trained on the many measurable features changing in time can generalize and learn the many biological processes on the population and individual levels. The deep age predictors can help advance aging research by establishing causal relationships in non-linear systems. Deep aging clocks can be used for identification of novel therapeutic targets, evaluating the efficacy of the various interventions, data quality control, data economics, prediction of health trajectories, mortality, and many other applications. Here we present the current state of development of the deep aging clocks in the context of the pharmaceutical research and development and clinical applications.
journal_name
Aging (Albany NY)journal_title
Agingauthors
Zhavoronkov A,Li R,Ma C,Mamoshina Pdoi
10.18632/aging.102475subject
Has Abstractpub_date
2019-11-25 00:00:00pages
10771-10780issue
22issn
1945-4589pii
102475journal_volume
11pub_type
杂志文章,评审相关文献
Aging-US文献大全abstract::Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100326
更新日期:2011-05-01 00:00:00
abstract::Senescent cells (SCs) have been considered a source of age-related chronic sterile systemic inflammation and a target for anti-aging therapies. To understand mechanisms controlling the amount of SCs, we analyzed the phenomenon of rapid clearance of human senescent fibroblasts implanted into SCID mice, which can be ove...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100991
更新日期:2016-07-01 00:00:00
abstract::The lack of a univocal definition of frailty, a condition frequently found in the elderly population which is correlated with an increased risk of mortality, has prompted the search for clinical and laboratory parameters associated with this condition. Whereas OPG is a protein involved in different pathophysiological ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102083
更新日期:2019-07-17 00:00:00
abstract::Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of renal cell carcinoma, and immune-related genes (IRGs) are key contributors to its development. In this study, the gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database and the...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102548
更新日期:2019-12-10 00:00:00
abstract::Metabolic reprogramming for adaptation to the tumor microenvironment is recognized as a hallmark of cancer. Although many altered metabolic genes have been reported to be associated with tumor pathological processes, systematic analysis of metabolic genes implicated in hepatocellular carcinoma prognosis remains rare. ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104122
更新日期:2020-11-12 00:00:00
abstract::Increase in life span in RasGrf1-deficient mice revealed that RasGrf1 deficiency promotes longevity. Interestingly, RasGrf1 is one of parentally imprinted genes transcribed from paternally-derived chromosome. Erasure of its imprinting results in RasGrf1 downregulation and has been demonstrated in a population of pluri...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100354
更新日期:2011-07-01 00:00:00
abstract::One important process in liver cancer growth and progression is angiogenesis. Vascular endothelial growth factor (VEGF) has the significant role in liver cancer angiogenesis. sFlt1 (soluble Fms-like tyrosine kinase-1) is the promising inhibitor of VEGF and can be used as the new method of inhibiting angiogenesis. MSCs...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101146
更新日期:2016-12-28 00:00:00
abstract::Glomerulosclerosis and renal interstitial fibrosis occur with the aging kidney. In this study, we examined the expression of miR-21, peroxisome proliferator-activated receptor(PPARα), hypoxia-inducible factor(HIF-1α) in the kidney of 3-month-old rats fed ad libitum (YAL), 24-month-old rats fed ad libitum (OAL) and 24-...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103591
更新日期:2020-08-27 00:00:00
abstract::Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies; However, the phenotype and mechanism of action of UBE2M in hepatocellular carcinoma (HCC) remain elusive. Here, we report that UBE2M is overexpressed and correlated with poor prognosis in HCC patients. The UBE2M lev...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102749
更新日期:2020-02-03 00:00:00
abstract::For nearly a decade, sorafenib has served as a first-line chemotherapeutic drug for the treatment of hepatocellular carcinoma (HCC), but it displays only limited efficacy against advanced drug-resistant HCC. Regorafenib, the first second-line drug approved for treatment after sorafenib failure, can reverse resistance ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104028
更新日期:2020-11-16 00:00:00
abstract::Numerous studies have investigated the differences in the mean functional connectivity (FC) strength between amnestic mild cognitive impairment (aMCI) patients and normal subjects using resting-state functional magnetic resonance imaging. However, whether the mean FC is increased, decreased or unchanged in aMCI patien...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102986
更新日期:2020-04-01 00:00:00
abstract::Right ventricular (RV) dysfunction induced type II cardiorenal syndrome (CRS) has a high mortality rate, but little attention has been paid to this disease, and its unique molecular characteristics remain unclear. This study aims to investigate the transcriptomic expression profile in this disease and identify key RNA...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202385
更新日期:2021-01-20 00:00:00
abstract::Increased activation of catabolic pathways, including apoptosis causes sarcopenia. However, the precise molecular mechanism that initiates apoptosis during aging is not well understood. Here, we report that aging alters miRNA expression profile in mouse skeletal muscle as evidenced by miRNA microarray and real-time PC...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101207
更新日期:2017-03-22 00:00:00
abstract::Cellular senescence, a form of cell cycle arrest, is one of the cellular responses to different types of exogenous and endogenous damage. The senescence phenotype can be induced in vitro by oncogene overexpression and/or DNA damage. Recently, we have reported a novel mechanism of cellular senescence induction by mild ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101065
更新日期:2016-10-14 00:00:00
abstract::Patients with end-stage renal disease (ESRD) display phenotypic features of premature biological aging, characterized by disproportionately high morbidity and mortality at a younger age. Nuclear factor erythroid 2-related factor 2 (Nrf2) activity, a master regulator of antioxidative responses, declines with age and is...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103685
更新日期:2020-07-13 00:00:00
abstract::Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was si...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102298
更新日期:2019-09-27 00:00:00
abstract::Wilms tumor is a type of pediatric solid tumor that arises partly due to somatic and germline mutations. Single-nucleotide polymorphisms (SNPs) in the RAS gene reportedly modify the risk for several types of human malignancies. We conducted a multicenter study to investigate whether RAS gene variants predispose indivi...
journal_title:Aging
pub_type: 杂志文章,多中心研究
doi:10.18632/aging.101855
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102397
更新日期:2019-10-31 00:00:00
abstract::The development and progression of hepatocellular carcinoma (HCC) is accompanied with persistent oxidative stress, but the molecular basis is not well defined. Superoxide dismutase 2 (SOD2) is an important mitochondrial antioxidant and a key aging factor. Here we investigated the expression and clinical significance o...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100967
更新日期:2016-06-01 00:00:00
abstract::Aging has been regarded as a treatable condition, and delaying aging could prevent some diseases. Ovarian aging, a special type of organ senescence, is the earliest-aging organ, as ovaries exhibit an accelerated rate of aging with characteristics of gradual declines in ovarian follicle quantity and quality since birth...
journal_title:Aging
pub_type: 杂志文章,评审
doi:10.18632/aging.101784
更新日期:2019-01-23 00:00:00
abstract::Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease characterized by glucose metabolic disorders, and gluconeogenesis inhibiting is a promisingly therapeutic strategy for T2DM. Glucocorticoid receptor (GR) is tightly implicated in the regulation of gluconeogenesis, although the underlying mechanism remains ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202275
更新日期:2020-12-09 00:00:00
abstract::Long alpha-synuclein gene (SNCA) promoter (Rep1) allele-carriers are linked to higher risk for Parkinson's disease (PD) and faster motor progression. Non-motor symptoms including autonomic, neuropsychiatric, and sleep disorders are common in PD. However, the relationship between SNCA Rep1 microsatellite lengths and no...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.104111
更新日期:2020-10-20 00:00:00
abstract::Little is known on how well senescence markers in vitro and in situ correlate within individual donors. We studied correlations between the same and different in vitro markers. Furthermore, we tested correlations between in vitro markers with in situ p16INK4a positivity.From 100 donors (20-91 years), cultured dermal f...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101389
更新日期:2018-02-28 00:00:00
abstract::The main aspects of severe COVID-19 disease pathogenesis include hyper-induction of proinflammatory cytokines, also known as 'cytokine storm', that precedes acute respiratory distress syndrome (ARDS) and often leads to death. COVID-19 patients often suffer from lung fibrosis, a serious and untreatable condition. There...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202500
更新日期:2021-01-19 00:00:00
abstract::Radiotherapy resistance is one of the main causes for treatment failure in colorectal cancer (CRC), and it is associated with the deregulation of certain microRNAs. In this study, we constructed the microRNA-mRNA network consisting of 2275 microRNAs and 7045 target genes, collected the known microRNAs related to CRC-r...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.103907
更新日期:2020-10-08 00:00:00
abstract::Diabetic foot (DF) is a common complication of high severity for diabetes, a prevalent metabolic disorder that affects billions of people worldwide. Mesenchymal stem cells (MSCs) have a demonstrative therapeutic effect on DF, through their generation of pro-angiogenesis factors, like vascular endothelial growth factor...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.102562
更新日期:2019-12-21 00:00:00
abstract::Cellular senescence is associated with aging and is considered a potential contributor to age-associated neurodegenerative disease. Exposure to ionizing radiation increases the risk of developing premature neurovascular degeneration and dementia but also induces premature senescence. As cells of the cerebrovascular en...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.101225
更新日期:2017-04-01 00:00:00
abstract::Compounds that delay aging in model organisms may be of significant interest to anti-aging medicine, since these substances potentially provide pharmaceutical approaches to promote healthy lifespan in humans. We here aimed to test whether pharmaceutical concentrations of three fibrates, pharmacologically established s...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100548
更新日期:2013-04-01 00:00:00
abstract:UNLABELLED:Centenarians' offspring represent a suitable model to study age-dependent variables (e.g. IGF-I) potentially involved in the modulation of the lifespan. The aim of the present study was to investigate the role of the IGF-I in human longevity. We evaluated circulating IGF-I bioactivity measured by an innovati...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.100484
更新日期:2012-09-01 00:00:00
abstract::Dysregulation of α(1,6)-fucosyltransferase (FUT8) plays significant roles in development of a variety of malignant tumor types. We collected as many relevant articles and microarray datasets as possible to assess the prognostic value of FUT8 expression in malignant tumors. For this purpose, we systematically searched ...
journal_title:Aging
pub_type: 杂志文章
doi:10.18632/aging.202239
更新日期:2020-12-11 00:00:00