Silencing KIF14 reverses acquired resistance to sorafenib in hepatocellular carcinoma.

abstract：:Alterations in KEAP1/ NF-E2 p45-related factor 2 (NFE2L2/Nrf2) signaling pathway have been reported in 23% lung adenocarcinoma patients, suggesting that deregulation of the pathway is a major cancer driver. Here we report that mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) drives tumor growth and drug re...

journal_title：Aging

authors： Wang H,Liu K,Chi Z,Zhou X,Ren G,Zhou R,Li Y,Tang X,Wang XJ

更新日期：2019-12-06 00:00:00

abstract：:Nucleic acid sequence analyses are fundamental to all aspects of biological research, spanning aging, mitochondrial DNA (mtDNA) and cancer, as well as microbial and viral evolution. Over the past several years, significant improvements in DNA sequencing, including consensus sequence analysis, have proven invaluable fo...

journal_title：Aging

authors： Annis S,Fleischmann Z,Logan R,Mullin-Bernstein Z,Franco M,Saürich J,Tilly JL,Woods DC,Khrapko K

更新日期：2020-04-28 00:00:00

abstract：:Chronic inflammation, increased reactivity to self-antigens and incidences of cancer are hallmarks of aging. However, the underlying mechanisms are not well understood. Age-associated alterations in the DNA either due to oxidative damage, defects in DNA repair or epigenetic modifications such as methylation that lead ...

journal_title：Aging

authors： Agrawal A,Tay J,Yang GE,Agrawal S,Gupta S

更新日期：2010-03-20 00:00:00

abstract：:Retinal pigment epithelial (RPE) cells increase in size and multinucleate during aging. We have shown using human and mouse cell lines that oxidised photoreceptor outer segments (oxPOS)-induced cytokinesis failure is related to RPE cell multinucleation, although the underlying mechanism remains unknown. This study inv...

journal_title：Aging

authors： Rajapakse D,Chen M,Curtis TM,Xu H

更新日期：2017-10-09 00:00:00

abstract：:In this study, we analyzed the role of circular RNAs in the growth and progression of bladder cancer. Direct Sanger sequencing and quantitative RT-PCR analysis showed that circ_0006332 was significantly upregulated in bladder cancer tissues. Sequencing analysis showed that circ_0006332 is generated from splicing of ex...

journal_title：Aging

authors： Li M,Liu Y,Liu J,Li W,Li N,Xue D,Zhang X,Wang P

更新日期：2019-11-22 00:00:00

abstract：:Salivary gland dysfunction is a common symptom that occurs after menopause. This study was performed to investigate the mechanism of salivary gland dysfunction to confirm the relationship between ferroptosis and salivary gland dysfunction by ovariectomy. Forty-eight female rats were randomly divided into four groups (...

journal_title：Aging

authors： Kwon HK,Kim JM,Shin SC,Sung ES,Kim HS,Park GC,Cheon YI,Lee JC,Lee BJ

更新日期：2020-11-05 00:00:00

abstract：:Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...

journal_title：Aging

authors： Jin D,Zhang R,Chen H,Li C

更新日期：2020-06-13 00:00:00

abstract：:The aim of this study was to investigate the expression level of Ras homolog gene family, member A (RhoA) in patients with hepatocellular carcinoma (HCC) and to investigate the prognostic and diagnostic value of RhoA. Data mining from various data bases and wet experiments on samples from Peking Union Medical College ...

journal_title：Aging

authors： Bai Y,Xie F,Miao F,Long J,Huang S,Huang H,Lin J,Wang D,Yang X,Bian J,Mao J,Wang X,Mao Y,Sang X,Zhao H

更新日期：2019-07-22 00:00:00

abstract：:Background: Aging has often been linked to age-related vascular disorders. The elucidation of the putative genes and pathways underlying vascular aging likely provides useful insights into vascular diseases at advanced ages. Transcriptional regulatory network analysis is the key to describing genetic interactions betw...

journal_title：Aging

authors： Li H,Wang X,Lu X,Zhu H,Li S,Duan S,Zhao X,Zhang F,Alterovitz G,Wang F,Li Q,Tian XL,Xu M

更新日期：2019-09-12 00:00:00

abstract：:Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers ...

journal_title：Aging

authors： Peto MV,De la Guardia C,Winslow K,Ho A,Fortney K,Morgen E

更新日期：2017-08-31 00:00:00

abstract：:Post-transplant liver fibrosis (PTLF) is a common and severe complication in liver recipients. In this study, we assessed the impact of donor liver genetics on the development of PTLF. A total of 232 patients undergoing liver transplantation were included. Twenty-two single nucleotide polymorphisms (SNPs) associated w...

journal_title：Aging

authors： Wang C,Zhang X,Ling Q,Zheng S,Xu X

更新日期：2020-12-03 00:00:00

abstract：:The tumor suppressor LKB1 has emerged as a critical regulator of cell polarity and energy‐metabolism. Studies in diverse model organisms continue to unravel the pathways downstream of LKB1; the emerging picture is that the outcomes of LKB1 signaling are mediated by a plethora of tissue‐specific and context‐dependent e...

journal_title：Aging

authors： van der Velden YU,Haramis AP

更新日期：2011-04-01 00:00:00

abstract：:Osteoarthritis is a common joint disease that disrupts the lives of millions of people worldwide. To date, a safe and reliable treatment has not yet been announced. Excessive production of pro-inflammatory cytokines such as TNF-α plays an important role in the pathological development of OA. Dehydrocostus lactone (DHC...

journal_title：Aging

authors： Wang L,Yang M,Zhang C,Huang F

更新日期：2020-09-14 00:00:00

abstract：:Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...

journal_title：Aging

authors： Li Y,Dai Z,Huang G,Jin Y,Ning Z,Shen J

更新日期：2020-01-12 00:00:00

abstract：:Cancer immunotherapy has achieved positive clinical responses in the treatment of various cancers, including gastric cancer (GC). In this study, we characterized the heterogeneity of T cells isolated from GC patients at the single-cell level using single-cell RNA sequencing. We identified different immune cell subtype...

journal_title：Aging

authors： Fu K,Hui B,Wang Q,Lu C,Shi W,Zhang Z,Rong D,Zhang B,Tian Z,Tang W,Cao H,Wang X,Chen Z

更新日期：2020-02-10 00:00:00

abstract：:Clinical and experimental data have shown that the receptor for advanced glycation end products (RAGE) is implicated in the pathogenesis of respiratory disorders. In this study, we genotyped five widely-evaluated variants in RAGE gene, aiming to assess their association with the risk for chronic obstructive pulmonary ...

journal_title：Aging

authors： Niu H,Niu W,Yu T,Dong F,Huang K,Duan R,Qumu S,Lu M,Li Y,Yang T,Wang C

更新日期：2019-05-29 00:00:00

abstract：:Hepatoblastoma (HB) is a malignant embryonal tumor of the liver that consists of heterogenous populations of stem/progenitor cells. Although circular RNAs (circRNAs) play an essential role in tumor development, the effects of circRNA on the proliferation of HB cells, especially cancer stem cells (CSCs), remain unclear...

journal_title：Aging

authors： Chen L,Shi J,Wu Y,Qiu R,Zeng L,Lou L,Su J,Liao M,Deng X

更新日期：2020-10-14 00:00:00

abstract：:Over the last two decades, there have been no significant changes in patient outcomes in relation to the treatment of osteosarcoma, an aggressive malignant neoplasm. It is known that vascular endothelial growth factor-A (VEGF-A) plays a crucial role in angiogenesis and in osteosarcoma. Moreover, VEGF-A expression corr...

journal_title：Aging

authors： Tsai HC,Cheng SP,Han CK,Huang YL,Wang SW,Lee JJ,Lai CT,Fong YC,Tang CH

更新日期：2019-11-13 00:00:00

abstract：:Histones and their variants are subjected to several post-translational modifications (PTMs). Histones PTMs play an important role in the regulation of gene expression and are critical for the development and progression of many types of cancer, including breast cancer. In this study, we used two-dimensional TAU/SDS e...

journal_title：Aging

authors： Perri AM,Agosti V,Olivo E,Concolino A,Angelis M,Tammè L,Fiumara CV,Cuda G,Scumaci D

更新日期：2019-12-08 00:00:00

abstract：:Senescent cells secrete inflammatory cytokines, proteases, and other factors, which are indicated as senescence-associated secretory phenotype (SASP). There are contrasting studies on the role of the SASP in cancer. Studies suggested that cancer cells may misuse the senescent secretome for their growth. Other investig...

journal_title：Aging

authors： Alessio N,Aprile D,Squillaro T,Di Bernardo G,Finicelli M,Melone MA,Peluso G,Galderisi U

更新日期：2019-08-14 00:00:00

abstract：:Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...

journal_title：Aging

authors： Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

更新日期：2019-02-24 00:00:00

abstract：:Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

journal_title：Aging

authors： Ren W,Guan W,Zhang J,Wang F,Xu G

更新日期：2019-04-14 00:00:00

abstract：:This study compares the longitudinal histological characteristics of proximal humeral implants with different spatial structures in rabbits. Thirty skeletally-mature male rabbits were divided into a trabecular structure group and regular hexahedron structure group according to the different spatial structures of a bio...

journal_title：Aging

authors： Xue Z,Pei Z,Zhang H,Tang C,Jia J,Zhang K,Zhang K,Wang L,Guan Z

更新日期：2021-01-20 00:00:00

abstract：:In this study, we constructed a model using a Cox proportional hazards model based on the expression of eight immune-related genes that were associated with prognosis in prostate cancer: EDNRB, ANGPTL2, TNFSF15, TNFRSF10D, EDN2, BMP2, NLRP14, and PLK1. We then identified associations between risk scores calculated wit...

journal_title：Aging

authors： Liu Z,Zhong J,Cai C,Lu J,Wu W,Zeng G

更新日期：2020-11-10 00:00:00

abstract：:The regulation of mechanistic target of rapamycin (mTOR) signaling contributes to the metabolic effects of a calorie restriction (CR) diet. We assayed the effect of CR on the activity of mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) in the liver of mice at six different times across the day. CR effects on mTORC1...

journal_title：Aging

authors： Tulsian R,Velingkaar N,Kondratov R

更新日期：2018-07-16 00:00:00

abstract：:As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is as...

journal_title：Aging

authors： Asselta R,Paraboschi EM,Mantovani A,Duga S

更新日期：2020-06-05 00:00:00

abstract：:Progressive loss of ovarian estrogen (E2) production is a hallmark feature of, if not a driving force behind, reproductive aging and the menopause. Recent genetic studies in mice have shown that female germline or oogonial stem cells (OSCs) contribute to maintenance of adult ovarian function and fertility under physio...

journal_title：Aging

authors： Satirapod C,Wang N,MacDonald JA,Sun M,Woods DC,Tilly JL

更新日期：2020-04-17 00:00:00

abstract：:There are various factors that alter physiological characteristics in skin. Elucidating the underlying mechanism of transcriptional alterations by intrinsic and extrinsic factors may lead us to understand the aging process of skin. To identify the transcriptomic changes of the aging skin, we analyzed publicly availabl...

journal_title：Aging

authors： Cho BA,Yoo SK,Seo JS

更新日期：2018-07-18 00:00:00

abstract：:Hirschsprung disease (HSCR) is a genetic disorder characterized by the absence of neural crest cells in parts of the intestine. This study aims to investigate the association of vesicle-associated membrane protein 5 (VAMP5) and mutated in colorectal cancer (MCC) genetic polymorphisms and their correlated risks with HS...

journal_title：Aging

authors： Zhao J,Xie X,Yao Y,He Q,Zhang R,Xia H,Zhang Y

更新日期：2018-04-25 00:00:00

abstract：:Dysregulation of the circadian timing system (CTS) frequently appears during colorectal cancer (CRC) progression. In order to better understand the role of the circadian clock in CRC progression, this study evaluated in vitro how knockdown of a core circadian protein BMAL1 (BMAL1-KD) influenced the behavior of two pri...

journal_title：Aging

authors： Zhang Y,Devocelle A,Souza L,Foudi A,Tenreira Bento S,Desterke C,Sherrard R,Ballesta A,Adam R,Giron-Michel J,Chang Y

更新日期：2020-05-10 00:00:00