MortalityPredictors.org: a manually-curated database of published biomarkers of human all-cause mortality.

Abstract:

:Biomarkers of all-cause mortality are of tremendous clinical and research interest. Because of the long potential duration of prospective human lifespan studies, such biomarkers can play a key role in quantifying human aging and quickly evaluating any potential therapies. Decades of research into mortality biomarkers have resulted in numerous associations documented across hundreds of publications. Here, we present MortalityPredictors.org, a manually-curated, publicly accessible database, housing published, statistically-significant relationships between biomarkers and all-cause mortality in population-based or generally healthy samples. To gather the information for this database, we searched PubMed for appropriate research papers and then manually curated relevant data from each paper. We manually curated 1,576 biomarker associations, involving 471 distinct biomarkers. Biomarkers ranged in type from hematologic (red blood cell distribution width) to molecular (DNA methylation changes) to physical (grip strength). Via the web interface, the resulting data can be easily browsed, searched, and downloaded for further analysis. MortalityPredictors.org provides comprehensive results on published biomarkers of human all-cause mortality that can be used to compare biomarkers, facilitate meta-analysis, assist with the experimental design of aging studies, and serve as a central resource for analysis. We hope that it will facilitate future research into human mortality and aging.

journal_name

Aging (Albany NY)

journal_title

Aging

authors

Peto MV,De la Guardia C,Winslow K,Ho A,Fortney K,Morgen E

doi

10.18632/aging.101280

subject

Has Abstract

pub_date

2017-08-31 00:00:00

pages

1916-1925

issue

8

issn

1945-4589

pii

101280

journal_volume

9

pub_type

杂志文章

相关文献

Aging-US文献大全
  • The IL1β-HER2-CLDN18/CLDN4 axis mediates lung barrier damage in ARDS.

    abstract:OBJECTIVE:The high mortality rate associated with acute respiratory distress syndrome (ARDS) is a major challenge for intensive care units. In the present study, we applied bioinformatics and animal models to identify core genes and potential corresponding pathways in ARDS. RESULTS:Using bioinformatics analysis, IL-1β...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102804

    authors: Ma X,Yu X,Zhou Q

    更新日期:2020-02-15 00:00:00

  • Pyridoxine 5'-phosphate oxidase is correlated with human breast invasive ductal carcinoma development.

    abstract::Pyridoxine 5'-phosphate oxidase (PNPO) is a converting enzyme for an active form of vitamin B6. This study aims to evaluate the biological function and the regulatory mechanism of PNPO in human breast invasive ductal carcinoma (IDC). We unveiled for the first time that PNPO was upregulated in patients with IDC and was...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101908

    authors: Ren W,Guan W,Zhang J,Wang F,Xu G

    更新日期:2019-04-14 00:00:00

  • Identifying hub genes of clear cell renal cell carcinoma associated with the proportion of regulatory T cells by weighted gene co-expression network analysis.

    abstract:BACKGROUND:Numerous patients with clear cell renal cell carcinoma (ccRCC) experience drug resistance after immunotherapy. Regulatory T (Treg) cells may work as a suppressor for anti-tumor immune response. PURPOSE:We performed bioinformatics analysis to better understand the role of Treg cells in ccRCC. RESULTS:Module...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102397

    authors: Chen YH,Chen SH,Hou J,Ke ZB,Wu YP,Lin TT,Wei Y,Xue XY,Zheng QS,Huang JB,Xu N

    更新日期:2019-10-31 00:00:00

  • Aberrantly glycosylated integrin α3β1 is a unique urinary biomarker for the diagnosis of bladder cancer.

    abstract::Bladder cancer (BC) is the most common malignancy of the urinary tract. We developed a new and ELISA kit for detecting aberrantly glycosylated integrin α3β1 (AG31) in human urine. We analysed urine samples (n=408) of patients with BC, renal cell carcinoma (RCC), prostate cancer (PC), cystitis, nephritis, and prostatit...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103297

    authors: Jin D,Zhang R,Chen H,Li C

    更新日期:2020-06-13 00:00:00

  • Long-time qingyan formula extract treatment exerts estrogenic activities on reproductive tissues without side effects in ovariectomized rats and via active ER to ERE-independent gene regulation.

    abstract::The reproductive tissues are negatively influenced by estrogens in hormone therapy. Qingyan formula ethanol extract (QYFE)'s estrogenic effects and safety on reproductive tissues after long-term administration and its mechanism via estrogen receptor (ER) pathway haven't been studied. Here, we characterized its estroge...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102035

    authors: Zheng HX,Zhao Y,Xu Y,Zhang ZJ,Zhu JJ,Fan YF,Lin N

    更新日期:2019-06-19 00:00:00

  • A novel six-microRNA-based model to improve prognosis prediction of breast cancer.

    abstract::Current tumor-node-metastasis (TNM) stage is unable to accurately predict the overall survival (OS) in breast cancer (BC) patients. This study aimed to construct a microRNA (miRNA)-based model to improve survival prediction of BC. We confirmed 99 differentially expressed miRNAs (DEMs) in 1044 BC samples compared to 10...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101767

    authors: Lai J,Wang H,Pan Z,Su F

    更新日期:2019-01-30 00:00:00

  • Personality, self-rated health, and cognition in centenarians: do personality and self-rated health relate to cognitive function in advanced age?

    abstract::Personality and self-rated health have been linked previously to cognitive outcome in late life. However, these associations have not been shown among the oldest old. This study examined relationships between personality, self-rated health, and cognitive function in a selected sample of Ashkenazi Jewish centenarians (...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100545

    authors: Kato K,Zweig R,Schechter CB,Verghese J,Barzilai N,Atzmon G

    更新日期:2013-03-01 00:00:00

  • Meta‐analysis of genetic variants associated with human exceptional longevity.

    abstract::Despite evidence from family studies that there is a strong genetic influence upon exceptional longevity, relatively few genetic variants have been associated with this trait. One reason could be that many genes individually have such weak effects that they cannot meet standard thresholds of genome wide significance, ...

    journal_title:Aging

    pub_type: 杂志文章,meta分析

    doi:10.18632/aging.100594

    authors: Sebastiani P,Bae H,Sun FX,Andersen SL,Daw EW,Malovini A,Kojima T,Hirose N,Schupf N,Puca A,Perls TT

    更新日期:2013-09-01 00:00:00

  • Clinical application values of neutrophil-to-lymphocyte ratio in intracranial aneurysms.

    abstract::Inflammation plays an important role in the pathogenesis and growth of intracranial aneurysms (IAs). We investigated the clinical value of the neutrophil-to-lymphocyte ratio (NLR) as a marker of systemic subclinical inflammation in patients with IAs. Consecutive patients with IAs who underwent endovascular treatment (...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202445

    authors: Zhang B,Lin L,Yuan F,Song G,Chang Q,Wu Z,Miao Z,Mo D,Huo X,Liu A

    更新日期:2021-02-01 00:00:00

  • Aging and circadian disruption: causes and effects.

    abstract::The relationship between aging and daily "circadian" behavior in humans is bidirectional: on the one hand, dysfunction of circadian clocks promotes age-related maladies; on the other, aging per se leads to changes and disruption in circadian behavior and physiology. For the latter case, recent research suggests that c...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100366

    authors: Brown SA,Schmitt K,Eckert A

    更新日期:2011-08-01 00:00:00

  • Construction and analysis of a joint diagnosis model of random forest and artificial neural network for heart failure.

    abstract::Heart failure is a global health problem that affects approximately 26 million people worldwide. As conventional diagnostic techniques for heart failure have been in practice with various limitations, it is necessary to develop novel diagnostic models to supplement existing methods. With advances and improvements in g...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.202405

    authors: Tian Y,Yang J,Lan M,Zou T

    更新日期:2020-12-26 00:00:00

  • Hypothalamic ΔFosB prevents age-related metabolic decline and functions via SNS.

    abstract::The ventral hypothalamus (VHT) integrates several physiological cues to maintain glucose homeostasis and energy balance. Aging is associated with increased glucose intolerance but the underlying mechanisms responsible for age-related metabolic decline, including neuronal signaling in the VHT, remain elusive. We have s...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101157

    authors: Sato K,Idelevich A,Nagano K,Rowe GC,Gori F,Baron R

    更新日期:2017-01-20 00:00:00

  • Clinical characteristics and prognostic factors of COVID-19 patients progression to severe: a retrospective, observational study.

    abstract::The outbreak of coronavirus disease 2019 (COVID-19) has become a world-wide emergency. The severity of COVID-19 is highly correlated with its mortality rate. We aimed to disclose the clinical characteristics and prognostic factors of COVID-19 patients who developed severe COVID-19. The study enrolled cases (no=1848) w...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103931

    authors: Liao Y,Feng Y,Wang B,Wang H,Huang J,Wu Y,Wu Z,Chen X,Yang C,Fu X,Sun H

    更新日期:2020-10-14 00:00:00

  • Low-abundance mutations in colorectal cancer patients and healthy adults.

    abstract::Detecting low-abundance mutations is very important for cancer diagnosis and treatment. Here we describe an improved targeted sequencing analysis that dramatically increases sequencing depth. Seven colorectal cancer (CRC) patients and seven healthy adults were enrolled in this study. We examined genetic mutations in t...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102657

    authors: Li Y,Dai Z,Huang G,Jin Y,Ning Z,Shen J

    更新日期:2020-01-12 00:00:00

  • Ovulation and ovarian wound healing are impaired with advanced reproductive age.

    abstract::Aging is associated with reduced tissue remodeling efficiency and increased fibrosis, characterized by excess collagen accumulation and altered matrix degradation. Ovulation, the process by which an egg is released from the ovary, is one of the most dynamic cycles of tissue wounding and repair. Because the ovary is on...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103237

    authors: Mara JN,Zhou LT,Larmore M,Johnson B,Ayiku R,Amargant F,Pritchard MT,Duncan FE

    更新日期:2020-05-14 00:00:00

  • Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy.

    abstract::Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following influenza infection; however, this relationship is understudied. We hypothesized...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100882

    authors: Bartley JM,Pan SJ,Keilich SR,Hopkins JW,Al-Naggar IM,Kuchel GA,Haynes L

    更新日期:2016-04-01 00:00:00

  • Increased serum salusin-α by aerobic exercise training correlates with improvements in arterial stiffness in middle-aged and older adults.

    abstract::Aging causes arterial stiffening which can be mitigated by increased physical activity. Although low circulating levels of salusin-α are associated with cardiovascular disease, whether salusin-α decreases with aging and whether the reduced arterial stiffening occurring with exercise training is associated with increas...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102678

    authors: Fujie S,Hasegawa N,Sanada K,Hamaoka T,Maeda S,Padilla J,Martinez-Lemus LA,Iemitsu M

    更新日期:2020-01-09 00:00:00

  • Survival of irradiated recipient mice after transplantation of bone marrow from young, old and "early aging" mice.

    abstract::Bone marrow transplantation is used to examine survival, hematopoietic stem cell function and pathology in recipients of young and old wild type bone marrow derived stem cells (BMDSCs) as well as cells from p53-based models of premature aging. There is no difference in the long term survival of recipients of 8 week-ol...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100867

    authors: Guest I,Ilic Z,Scrable H,Sell S

    更新日期:2015-12-01 00:00:00

  • Longitudinal plasma metabolomics of aging and sex.

    abstract::Understanding how metabolites are longitudinally influenced by age and sex could facilitate the identification of metabolomic profiles and trajectories that indicate disease risk. We investigated the metabolomics of age and sex using longitudinal plasma samples from the Wisconsin Registry for Alzheimer's Prevention (W...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101837

    authors: Darst BF,Koscik RL,Hogan KJ,Johnson SC,Engelman CD

    更新日期:2019-02-24 00:00:00

  • Eryptosis as a marker of Parkinson's disease.

    abstract::A major trend in recent Parkinson's disease (PD) research is the investigation of biological markers that could help in identifying at-risk individuals or to track disease progression and response to therapies. Central to this is the knowledge that inflammation is a known hallmark of PD and of many other degenerative ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100695

    authors: Pretorius E,Swanepoel AC,Buys AV,Vermeulen N,Duim W,Kell DB

    更新日期:2014-10-01 00:00:00

  • Novel cellular evidence of lipophagy within the Sertoli cells during spermatogenesis in the turtle.

    abstract::Spermatogenesis is a complex process producing haploid spermatozoa, and the formation of lipid droplets (LDs) within Sertoli cells is critical to maintaining normal spermatogenesis. However, the utilization of LDs within Sertoli cells is still largely unknown. In the present study, proliferation of spermatogonial cell...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101070

    authors: Ahmed N,Liu Y,Chen H,Yang P,Waqas Y,Liu T,Gandahi JA,Huang Y,Wang L,Song X,Rajput IR,Wang T,Chen Q

    更新日期:2016-10-16 00:00:00

  • Tubastatin A inhibits HDAC and Sirtuin activity rather than being a HDAC6-specific inhibitor in mouse oocytes.

    abstract::Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar body following TubA treatment. However, a previous study demonstrated that homozygous Hdac6 knockout (KO) mice can be viable and fertile. Therefore, we asked wh...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101867

    authors: Choi YJ,Kang MH,Hong K,Kim JH

    更新日期:2019-03-26 00:00:00

  • Expression of Nik-related kinase in smooth muscle cells attenuates vascular inflammation and intimal hyperplasia.

    abstract::Inflammation of the vascular microenvironment modulates distinct types of vascular cells, and plays important roles in promoting atherosclerosis, stenosis/restenosis, and vascular-related diseases. Nik-related kinase (Nrk), a member of the Ste20-type kinase family, has been reported to be selectively expressed in embr...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103104

    authors: Lu YJ,Jan YJ,Ko BS,Liang SM,Chen L,Wu CC,Chin CH,Kuo CC,Yet SF,Liou JY

    更新日期:2020-04-24 00:00:00

  • Mogroside V protects porcine oocytes from in vitro ageing by reducing oxidative stress through SIRT1 upregulation.

    abstract::Postovulatory ageing compromises oocyte quality and subsequent development in various manners. We aimed to assay the protective effects of mogroside V on porcine oocyte quality during in vitro ageing and explore the related causes. We observed that mogroside V can effectively maintain normal oocyte morphology and earl...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102324

    authors: Nie J,Sui L,Zhang H,Zhang H,Yan K,Yang X,Lu S,Lu K,Liang X

    更新日期:2019-10-06 00:00:00

  • TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling.

    abstract::Kidney clear cell carcinoma (KIRC) is the most prevalent kidney malignancy. Accumulating evidence shows that high expression of TIP-B1 correlates with development of tumor progression. However, the detailed functions of TIP-B1 in the KIRC remain to be further elucidated. Here, we firstly found TIP-B1 expression was si...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102298

    authors: Yin L,Gao S,Shi H,Wang K,Yang H,Peng B

    更新日期:2019-09-27 00:00:00

  • Interference between PARPs and SIRT1: a novel approach to healthy ageing?

    abstract::Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. ...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.100326

    authors: Cantó C,Auwerx J

    更新日期:2011-05-01 00:00:00

  • Identification of polymorphisms in cancer patients that differentially affect survival with age.

    abstract::The World Health Organization predicts that the proportion of the world's population over 60 will almost double from 12% to 22% between 2015 and 2050. Ageing is the biggest risk factor for cancer, which is a leading cause of deaths worldwide. Unfortunately, research describing how genetic variants affect cancer progre...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101305

    authors: Doherty A,Kernogitski Y,Kulminski AM,Pedro de Magalhães J

    更新日期:2017-10-20 00:00:00

  • LINC00857 knockdown inhibits cell proliferation and induces apoptosis via involving STAT3 and MET oncogenic proteins in esophageal adenocarcinoma.

    abstract::Esophageal adenocarcinoma (EAC) is one of the leading causes of cancer-related death worldwide, and the molecular biology of this cancer remains poorly understood. Recent evidence indicates that long non-coding RNAs are dysregulated in a variety of cancers including EAC. In this study, siRNA mediated gene knockdown, W...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.101953

    authors: Su W,Wang L,Niu F,Zou L,Guo C,Wang Z,Yang X,Wu J,Lu Y,Zhang J,Beer DG,Yang Z,Chen G

    更新日期:2019-05-13 00:00:00

  • Clinical burden of autosomal dominant polycystic kidney disease.

    abstract::There are no specific therapies for autosomal dominant polycystic kidney disease (ADPKD), and clinical data evaluating the effects of non-specific therapies on ADPKD patients are scarce. We therefore evaluated those effects using data from a longitudinal health insurance database collected from 2000-2010. We individua...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.102858

    authors: Hung PH,Lin CH,Hung KY,Muo CH,Chung MC,Chang CH,Chung CJ

    更新日期:2020-02-24 00:00:00

  • Downregulation of interleukin-6 and C-reactive protein underlies a novel inhibitory role of microRNA-136-5p in acute lower extremity deep vein thrombosis.

    abstract::Deep vein thrombosis (DVT) comprises a critical and common health condition with high incidence, mortality, and long-term adverse sequelae. Several differentially expressed microRNAs (miRNAs) have emerged as promising prognostic markers in DVT. The present study intended to explore the functional relevance of miR-136-...

    journal_title:Aging

    pub_type: 杂志文章

    doi:10.18632/aging.103140

    authors: Ou M,Hao S,Chen J,Zhao S,Cui S,Tu J

    更新日期:2020-11-14 00:00:00